Distinct Phases of Blood Gene Expression Pattern through Tuberculosis Treatment Reflect Modulation of the Humoral Immune Response.
Cliff JM, Lee JS, Constantinou N, Cho JE, Clark TG, Ronacher K, King EC, Lukey PT, Duncan K, Van Helden PD, Walzl G, Dockrell HM. J Infect Dis. 2013 Jan;207(1):18-29
The Contraceptive Depo Medroxyprogesterone Acetate Impairs Mycobacterial Control and Inhibits Cytokine Secretion in Mice Infected with M tuberculosis
Kleynhans L, Du Plessis N, Allie N, Jacobs M, Kidd M, van Helden PD, Walzl G, Ronacher K. Infect Immun. 2013 Feb;
Acute helminth infection enhances early macrophage mediated control of mycobacterial infection.
Du Plessis N, Kleynhans L, Thiart L, van Helden PD, Brombacher F, Horsnell WG, Walzl G. Mucosal Immunol. 2012 Dec 19
Diversity of Mycobacterium tuberculosis Isolates from New Pulmonary Tuberculosis Cases in Addis Ababa, Ethiopia.
Mihret A, Bekele Y, Loxton AG, Jordan AM, Yamuah L, Aseffa A, Howe R, Walzl G.Tuberc Res Treat. 2012;2012:892079. Epub 2012 Nov 22.
Detecting Tuberculosis Infection in HIV-Infected Children: A Study of Diagnostic Accuracy, Confounding and Interaction.
Mandalakas AM, van Wyk S, Kirchner HL, Walzl G, Cotton M, Rabie H, Kriel B, Gie RP, Schaaf HS, Hesseling AC. Pediatr Infect Dis J. 2012 Nov 28.
Plasma cytokines and chemokines differentiate between active disease and non-active tuberculosis infection.
Mihret A, Bekele Y, Bobosha K, Kidd M, Aseffa A, Howe R, Walzl G. J Infect. 2012 Nov 20. doi:pii: S0163-4453(12)00339-8.
Serodiagnostic markers for the prediction of the outcome of intensive phase tuberculosis therapy.
Baumann R, Kaempfer S, Chegou NN, Nene NF, Veenstra H, Spallek R, Bolliger CT, Lukey PT, van Helden PD, Singh M, Walzl G. Tuberculosis (Edinb). 2012 Nov 2
BDNF Val66Met and DRD2 Taq1A polymorphisms interact to influence PTSD symptom severity: a preliminary investigation in a South African population.
Hemmings SM, Martin LI, Klopper M, van der Merwe L, Aitken L, de Wit E, Black GF, Hoal EG, Walzl G, Seedat S. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:273-80
Plasma Level of IL-4 Differs in Patients Infected with Different Modern Lineages of M. tuberculosis.
Mihret A, Bekele Y, Loxton AG, Aseffa A, Howe R, Walzl G. J Trop Med. 2012;2012:518564
Effect of Ascaris Lumbricoides specific IgE on tuberculin skin test responses in children in a high-burden setting: a cross-sectional community-based study.
Van Soelen N, Mandalakas AM, Kirchner HL, Walzl G, Grewal HM, Jacobsen M, Hesseling AC. BMC Infect Dis. 2012 Sep 11;12:211
Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients.
Weiner J 3rd, Parida SK, Maertzdorf J, Black GF, Repsilber D, Telaar A, Mohney RP, Arndt-Sullivan C, Ganoza CA, Faé KC, Walzl G, Kaufmann SH. PLoS One. 2012;7(7):e40221
Detection and treatment of subclinical tuberculosis.
Robertson BD, Altmann D, Barry C, Bishai B, Cole S, Dick T, Duncan K, Dye C, Ehrt S, Esmail H, Flynn J, Hafner R, Handley G, Hanekom W, van Helden P, Kaplan G, Kaufmann SH, Kim P, Lienhardt C, Mizrahi V, Rubin E, Schnappinger D, Sherman D, Thole J, Vandal O, Walzl G, Warner D, Wilkinson R, Young D. Tuberculosis (Edinb). 2012 Nov;92(6):447-52
Potential of host markers produced by infection phase-dependent antigen-stimulated cells for the diagnosis of tuberculosis in a highly endemic area.
Chegou NN, Essone PN, Loxton AG, Stanley K, Black GF, van der Spuy GD, van Helden PD, Franken KL, Parida SK, Klein MR, Kaufmann SH, Ottenhoff TH, Walzl G. PLoS One. 2012;7(6):e38501
Well-quantified tuberculosis exposure is a reliable surrogate measure of tuberculosis infection.
Mandalakas AM, Kirchner HL, Lombard C, Walzl G, Grewal HM, Gie RP, Hesseling AC. Int J Tuberc Lung Dis. 2012 Aug;16(8):1033-9
Development of a diagnostic gene expression assay for tuberculosis and its use under field conditions in African buffaloes (Syncerus caffer).
Parsons SD, Menezes AM, Cooper D, Walzl G, Warren RM, van Helden PD. Vet Immunol Immunopathol. 2012 Aug 15;148(3-4):337-42
Effect of standard tuberculosis treatment on plasma cytokine levels in patients with active pulmonary tuberculosis.
Riou C, Perez Peixoto B, Roberts L, Ronacher K, Walzl G, Manca C, Rustomjee R, Mthiyane T, Fallows D, Gray CM, Kaplan G. PLoS One. 2012;7(5):e36886
Symptomatic vaginal discharge is a poor predictor of sexually transmitted infections and genital tract inflammation in high-risk women in South Africa.
Mlisana K, Naicker N, Werner L, Roberts L, van Loggerenberg F, Baxter C, Passmore JA, Grobler AC, Sturm AW, Williamson C, Ronacher K, Walzl G, Abdool Karim SS.
J Infect Dis. 2012 Jul 1;206(1):6-14
Heparin-binding hemagglutinin induces IFN-γ(+) IL-2(+) IL-17(+) multifunctional CD4(+) T cells during latent but not active tuberculosis disease.
Loxton AG, Black GF, Stanley K, Walzl G. Clin Vaccine Immunol. 2012 May;19(5):746-51
Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting.
Chegou NN, Black GF, Loxton AG, Stanley K, Essone PN, Klein MR, Parida SK, Kaufmann SH, Doherty TM, Friggen AH, Franken KL, Ottenhoff TH, Walzl G. BMC Infect Dis. 2012 Jan 20;12:10
Baseline predictors of sputum culture conversion in pulmonary tuberculosis: importance of cavities, smoking, time to detection and W-Beijing genotype.
Visser ME, Stead MC, Walzl G, Warren R, Schomaker M, Grewal HM, Swart EC, Maartens G. PLoS One. 2012;7(1)
Genital tract inflammation during early HIV-1 infection predicts higher plasma viral load set point in women.
Roberts L, Passmore JA, Mlisana K, Williamson C, Little F, Bebell LM, Walzl G, Abrahams MR, Woodman Z, Abdool Karim Q, Abdool Karim SS. J Infect Dis. 2012 Jan 15;205(2):194-203
The influence of different helminth infection phenotypes on immune responses against HIV in co-infected adults in South Africa.
Mkhize-Kwitshana ZL, Taylor M, Jooste P, Mabaso ML, Walzl G. BMC Infect Dis. 2011 Oct 14;11:273. doi: 10.1186/1471-2334-11-273
Medroxyprogesterone acetate alters Mycobacterium bovis BCG-induced cytokine production in peripheral blood mononuclear cells of contraceptive users.
Kleynhans L, Du Plessis N, Black GF, Loxton AG, Kidd M, van Helden PD, Walzl G, Ronacher K. PLoS One. 2011;6(9):e24639
Molecular bacterial load assay, a culture-free biomarker for rapid and accurate quantification of sputum Mycobacterium tuberculosis bacillary load during treatment.
Honeyborne I, McHugh TD, Phillips PP, Bannoo S, Bateson A, Carroll N, Perrin FM, Ronacher K, Wright L, van Helden PD, Walzl G, Gillespie SH. J Clin Microbiol. 2011 Nov;49(11):3905
Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis.
Matthews K, Wilkinson KA, Kalsdorf B, Roberts T, Diacon A, Walzl G, Wolske J, Ntsekhe M, Syed F, Russell J, Mayosi BM, Dawson R, Dheda K, Wilkinson RJ, Hanekom WA, Scriba TJ. Tuberculosis (Edinb). 2011 Nov;91(6):587-93
Tuberculosis assays: past, present and future.
Chegou NN, Hoek KG, Kriel M, Warren RM, Victor TC, Walzl G. Expert Rev Anti Infect Ther. 2011 Apr;9(4):457-69
Immunological biomarkers of tuberculosis.
Walzl G, Ronacher K, Hanekom W, Scriba TJ, Zumla A. Nat Rev Immunol. 2011 May;11(5):343-54
The effect of vitamin A and zinc supplementation on treatment outcomes in pulmonary tuberculosis: a randomized controlled trial.
Visser ME, Grewal HM, Swart EC, Dhansay MA, Walzl G, Swanevelder S, Lombard C, Maartens G. Am J Clin Nutr. 2011 Jan;93(1):93-100
Human gene expression profiles of susceptibility and resistance in tuberculosis.
Maertzdorf J, Repsilber D, Parida SK, Stanley K, Roberts T, Black G, Walzl G, Kaufmann SH. Genes Immun. 2011 Jan;12(1):15-22
