Clinical Pharmacology
Welkom by Universiteit Stellenbosch

Afdeling Kliniese Farmakologie​



Die navorsingsareas waarop ons fokus is behandeling van MIV, tuberkulose, vergiftigings en die onwikkeling van surfactant.

Ons eweknie-geëvalueerde publikasies vanaf 2012 is hieronder gelys.


Publikasies in 2016

1. Marks C, van Hoving N, Edwards N, Kanema C, Kapindula D, Menge, Nyadedzor C, Roberts C, Tagwireyi D, Tempowski J. A promising poison information centre model for Africa. African Journal of Emergency Medicine 2016, 6: 64-69


2. Opladen T, Lindner M, Das AM, Marquardt T, Khan A, Emre SH, Burton BK, Barshop BA, Böhm T, Meyburg J, Zangerl K, Mayorandam S, Bugard P, Dürr UHN, Rosenkranz B, Rennecke J, Derbinski J, Yudkoff M, Hoffmann GF. In vivo monitoring of urea cycle activity with 13C-acetate as tracer of ureagenesis. Molecular Genetics and Metabolism 2016, 117: 19-26.


3. Thomford NE, Awortwe C, Dzobo K, Adu F, Chopera D, Wonkam A, Skelton M, Blackhurst D, Dandara C. Inhibiton of CYP2B6 by Medicinal Plant Extracts: Implications for use of Efavirenz and Nevirapine-Based Highly Active Anti-Retroviral Therapy (HAART) in Resource-Limited Settings. Molecules 2016, 211


4. Kasten-Hilka T, Abulfathi A, Rosenkranz B, Bennett B, Schwenkglenks M, Sinanovic E. Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis – a systematic review of global literature with focus on South Africa. Health and Quality of Life Outcomes 2016, 14: 42 doi: 10.1186/s12955-016-0442-6 (2016).


5. Van Zyl GU, Decloedt EH. Is HIV-1C risk factor for protease inhibitor failure? The Lancet 2016.


6. Du Toit R, Herbst PG, van Rensburg A, du Plessis LM, Reuter H, Doubell AF. Clinical features and outcome of lupus myocarditis in the Western Cape, South Africa. Lupus 2016 0: 1 – 10.


7. Kastien-Hilka T, Rosenkranz B, Bennett B, Sinanovic E, Schwenkglenks M. How to Evaluate Health-Related Quality of Life and Its Association with Medication Adherence in Pulmonary Tuberculosis – Designing a Prospective Observational Study in South Africa. Front Pharmacol 2016 7: 125 doi: 10.3389/fphar.2016.00125 (2016).


8. Visser Kift E, Freeman N, Cook C, Myer L. Retinopathy of prematurity screening criteria and workload implications at Tygerberg Children's Hospital, South Africa: A cross-sectional study. SAMJ 2016 106(6): 602 – 606.


9. Lewandowksi LB, Schanberg LE, Thielman N, Phuti A, Kalla AA, Okpechi I, Nourse P, Gajjar P, Faller G, Ambaram P, Reuter H, Spittal G, Scott C. Severe disease presentation and poor outcomes among pediatric systemic lupus erythematosus patients in South Africa. Lupus 2016 0: 1 – 9.


10. Abulfathi AA, Greyling T, Makiwane M, Esser M, Decloedt E. Angio-oedema associated with colistin. SAMJ 2016 106(10): 990-991.


11. Patel O, Muller C, Joubert E, Louw J, Rosenkranz B, Awortwe C. Inhibitory Interactions of Aspalathus linearis (Rooibos) Extracts and Compounds, Aspalathin and Z-2-(β-D-Glucopyranosyloxy)-3-phenylpropenoic Acid, on Cytochromes Metabolizing Hypoglycemic and Hypolipidemic Drugs. Molecules 2016 21 1515; doi:10.3390/molecules21111515.


12. Marks CJ, Van Hoving DJ. A 3-year survey of acute poisoning exposures in infants reported in telephone calls made to the Tygerberg Poison Information Centre, South Africa. S Afr J Child Health 2016; 10 (1): 43-46


13. Harmse L, Reuter H. An overview of the biological disease modifying drugs available for arthritic conditions in South Africa. South African Family Practice 2016; 58(6):18-22


14. Decloedt EH, Freeman C, Howells F, Casson-Crook M, Lesosky M, Koutsilieri E, Lovestone S, Maartens G,. Joska JA. Moderate to severe HIV-associated neurocognitive impairment: A randomized placebo-controlled trial of lithium. Medicine 2016 95(46): e5401


15. Decloedt EH, Müller GJ. Haemotoxic snakebite in rural KwaZulu-Natal, South Africa. S Afr Med J 2016 106(8): DOI:10.7196/SAMJ.2016.v106i8.11119


Publikasies in 2015

1. Kerpel-Fronius S, Rosenkranz B, Allen E, Bass R, Mainard JD, Dodoo A, Dubois DJ, Hela M, Kern S, Massud J, Silva H, Whitty J. Education and training for medicines development, regulation, and clinical research in emerging countries. Frontiers in Pharmacology 2015; 6: 1 – 8.

2. Ticha LA, Klaasen JA, Green IR, Naidoo S, Baker B, Pietersen R. Phytochemical and Antimicrobial Screening of Glavanones and Chalcones from Galenia Africana and Dicerothamnus rhinocerotis. Natural product communication 2015; 10(7): 1185-1190.

3. Dhoro M, Zvada S, Ngara B, Nhachi C, Kadzirange G, Chonzi P, Masimirembwa C. CYP2B6*6, CYP2B6*18, Body weight and sex are predictors of efavirenz pharmacokinetics and treatment response: population pharmacokinetic modelling in and HIV/AIDS and TB cohort in Zimbabwe. BMC Pharmacology & Toxicology 2015; 16(4): 1 – 10.

4. Ying Q, Naidoo S, Vaivars G. Function of titanium oxide coated on carbon nanotubes as support for platinum catalysts. Physica Scripta 90(9), 094021.

5. Awortwe C, Manda VK, Avonto C, Khan SI, Khan IA, Walker LA, Bouic PJ, Rosenkranz B. Echinacea purpurea up-regulates CYP1A2, CYP3A4 and MDR1 gene expression by activation of pregnane X receptor pathway. Xenobiotica 2015, 45(3): 218-229.

6. Awortwe C, Manda VK, Avonto C, Khan SI, Khan IA, Walker LA, Bouic PJ, Rosenkranz B. In Vitro evaluation of Reversible and Time-Dependent inhibitory effects of Kalanchoe Crenata on CYP2C19 and CYP3A4 activity. Drug Metabolish Letter 2015; 9: 48-62.

7. Sy SKB, Malmberg R, Matsushima A, Asin-Prieto E, Rosenkranz B, Cotton MF, Derendorf H, Innes S. Effect of reducing the paediatric stavudine dose by half: A physiolgogically-based pharmacokinetic model. International Journal of Antimicrobial Agents 2015, 45: 413-419.

8. Decloedt EH, Rosenkranz B, Maartens G, Joska J. Central Nervous system penetration of antiretroviral drugs: Pharmacokinetic, Pharmacodynamic and Pharmacogenomic considerations. Clinical Pharmacokinetics 2015, 54(6): 581-598.

9. Sy SK, de Kock L, Diacon AH, Werely CJ, Xia H, Rosenkranz B, van der Merwe L, Donald PR. N-acetyltransferase genotypes and the pharmacokinetics and tolerability of para-aminosalicylic acid in drug-resistant pulmonary tuberculosis patients. Antimicrobial Agents in Chemotherapy 2015, 59(7): 4129-4138.

10. Ying Q, Naidoo S, Vaivars G. Investigation of Activities for Pt-M Bimetallic Nanoparticles Catalysts on the Oxygen Reduction Reaction. Ferroelectrics 484(1): 101-107.

11. Rosenkranz B, Reid M, Allen E. Medicines development and regulation in Africa. Journal of Medicines Development Sciences 1(2): 33-36.


Publikasies in 2014

1.  Von Birbra M, Rosenkranz B, Pretorius E, Rabie H, Edson C, Lenker U, Cotton M, Klinker H. Are lopinavir and efavirenz serum concentrations in HV-infected children in the therapeutic range in clinical practice? Paediatrics and International Child Health 2014; 34(2): 138-141.

2. Awortwe C, Bouic PJ, Masimirembwa CM, Rosenkranz B. Inhibition of Major Drug Metabolizing CYPs by Common Herbal Medicines used by HIV/AIDS patients in Africa – Implications for Herb-drug interactions. Drug Metabolism Letters 2014; 7: 83-95.

3. Flepisi TB, Bouic P, Sissolak G, Rosenkranz B. Drug-drug interactions in HIV positive cancer patients. Biomedicine & Pharmacotherapy 2014; 68(5): 665-77.

4. Fasinu PS, Bouic P, Rosenkranz B. The inhibitory activity of the extracts of popular medicinal herbs on cyp1a2, 2c9, 2c19 and 3a4 and the implications for herb-drug interaction. Afr J Tradit Complement Altern Med 2014; 11(4): 54-61.

5. Manda VK, Dale OR, Awortwe C, Ali Z, Khan IA, Walker LA, Khan SI. Evaluation of drug interaction potential of Labisia pumila (Kacip Fatimah) and its constituents. Frontiers in Pharmacology 2014; 5 (178): 1-13.

6. de Kock L, Sy SKB, Rosenkranz B, Diacon AH, Prescott K, Hernandez KR, Yu M, Derendorf H, Donald PR. Pharmacokinetics of para-Aminosalicylic Acid in HIV-Uninfected and HIV-Coinfected Tuberculosis Patients Receiving Antiretroviral Therapy, Managed for Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis. Antimicrobial Agents and Chemotherapy 2014; 58(10): 6242-6250.

7. Awortwe C, Manda CK, Avonto C, Khan SI, Khan IA, Walker LA, Bouic PJ, Rosenkranz B. Echinacea purpurea up-regulates CYP1A2, CYP3A4 and MDR1 gene expression by activation of pregnane X receptor pathway. Xenobiotica 2014; 7: 1 – 12.

8. Flepisi BT, Bouic P, Sissolak G, Rosenkranz B. Biomarkers of HIV-associated cancer. Biomark Cancer 2014; 6: 11 – 20.

9. Awortwe C, Fasinu PS, Rosenkranz B. Application of Gaco-2 cell line in herb-drug interaction studies. Current approaches and challenges. J Pharm Pharm Sci 2014; 17(1): 1 – 19.

10. Sy SK, Innes S, Derendorf H, Cotton MF, Rosenkranz B. Estimation of intracellular concentration of stavudine triphosphate in HIV-infected children given a reduced dose of 0.5 milligrams per kilogram twice daily. Antimicrob Agents Chemother 2014; 58(2): 1084-91.

11.  Asiedu-Gyekye IJ, Mahmood SA, Awortwe C, Nyarko AK. A Preliminary safety evaluation of Polyhexamethylene Guanidine Hydrochloride. Int J Toxicol 2014; 33(6): 523-31.

12. Asiedu-Gyekye IJ, Frimpong Monso S, Awortwe C, Antwe DA, Nyarko AK. Micro- and Macro elemental composition and safety evaluation of nutraceutical maringa oleifera leaves. J Toxicol 2014.

13. Awortwe C, Asiedu-Gyekye IJ, Nkansah E, Adjei S. Unsweetend natural cocoa has anti-asthmatic potential. Int J Immunopathol Pharmacol 2014; 27(2): 203-12.

14.  Asiedu-Gyekye IJ, Antwi DA, Awortwe C, N'guessan BB, Nyarko AK. Short-term administration of an aqueous extract of kalanchoe integra var. crenata (Andr.) Cuf leaves produces no major organ damage in Sprague-dawley rats. J Ehhnopharmacol 2014; 151(2): 891-6.

15. Bekker A, Schaaf HS, Seifart HI, Draper HR, Werely CH, Cotton MF, Hesseling AC. Pharmacokinetics of Isoniazid in Low-Birth-Weight and Premature Infants. Antimicrobial Agents and Chemotherapy 2014; 58(4): 2229-2234.


Publikasies in 2013

1. Fasinu PS; Gutmann H; Schiller H; Alexander-David J; Bouic PJ; Rosenkranz B. The potential of Sutherlandia frutescens for Herb-Drug interaction. Drug Metab Dispos 2013; 41: 488-497.

2. Veale DJH; Wium CA; Müller GJ. Toxicovigilance I: A survey of acute poisonings in South Africa based on Tygerberg Poison Information Centre data. S Afr Med J 2013; 103(5): 293-297.

3. Veale DJH; Wium CA; Müller GJ. Toxicovigilance II: A survey of the spectrum of acute poisoning and current practices in the initial management of poisoning cases admitted to South African hospitals. S Afr Med J 2013; 103(5): 198-303.

4. Cawello W; Rosenkranz B; Schmid B; Wierich W. Pharmacodynamic and pharmacokinetic evaluation of coadministration of lacosamide and an oral contraceptive (levonorgestrel plus ethinylestradiol) in healthy female volunteers. Epilepsia 2013; 54(3): 530-536.

5. Van Zyl JM; Smith J; Hawtrey A. The effect of a peptide-containing synthetic lung surfactant on gas exchange and lung mechanics in a rabbit model of surfactant depletion. Drug Design, Development and Therapy 2013; 7: 139-148.

6. Hawtrey AO; Ariatti M; van Zyl JM. Polymerization of Glycine and L-Phenylalanine to short Homooligopeptides by Nitrobiuret under Aqueous Conditions. International Journal of Scientific Researhc 2013; 2(6): 20-21.

7. Flepisi TB; Lochner A; Huisamen B. The Consequences of Long-Term Glycogen Synthase Kinase-3 Inhibition on Normal and Insulin Rat Hearts. Cardiovasc Drug Ther DOI 10.1007/s10557-013-6467-8.

8. Fasinu PS; Gutmann H; Schiller H; Bouic PJ; Rosenkranz B. The potential of Hypoxis hemerocallidea for herb-drug interaction. Pharmaceutical Biology DOI 10.3109/13880208.2013.796393

9. Fasinu P, Orisakwe OE. Heavy Metal Pollution in Sub-Saharan Africa and Possible Implications in Cancer Epidemiology. Asian Pacific Journal of Cancer Prevention 2013; 14(6): 3393-3402.

10. Fasinu P, Choonara YE, Khan RZ, Du Toit LC, Kumar P, Ndesendo VMK, Pillay V. Flavonoids and Polymer Derivatives as CYP3A4 inhibitors for imrproved oral drug bioavailability. Journal of Pharmaceutical Sciences 2013; 102(2): 541 – 555.

11. Walubo A, Barnes K, Kwizera E, Greeff O, Rosenkranz B, Maartens G. Clinical Pharmacology becomes a speciality in South Africa. SAMJ 2013; 301(3): 150 – 151.

12. Naidoo S, Africa A, Dalvie MA. Exposures to CCA-treated wood amongst food caterers and residents in informal areas of Cape Town. SAJS 2013; 109(7/8): 1-7.

13. Van Zyl JM, Smith J. Surfactant treatment before first breath for respiratory distress syndrome in preterm lambs: comparison of a peptide-containing synthetic lung surfactant with porcine-derived surfactant. Drug Design, Development and Therapy 2013; 7: 905-916.

14. Koegelenberg CFN, Nortje A, Lalla U, Enslin A, Irusen EM, Rosenkranz B, Seifart HI, Bolliger CT. The pharmacokinetics of enteral antituberculosis drugs in patients requiring intensive care. SAMJ 2013; 103(6): 394-398.

15. Decloedt EH, Maartens G. Neuronal toxicity of efavirenz: a systemic review. Expert Opin Drug Saf. 2013; 12(6): 841-6


Publikasies 2012

1. Fasinu P, Bouic P, Rosenkranz B. Liver-based in vitro technologies for drug biotransformation studies – a review. Curr Drug Metabol 2012; 13: 215-224.

2. Fasinu PS, Bouic PJ, Rosenkranz B. An overview of the evidence and mechanisms of herb-drug interactions. Frontiers in pharmacology 2012; 3(69): 1-19.

3. Fasinu PSRosenkranz B. Drug-drug interaction in ageing HIV-infected individuals. African Journal of Pharmacology 2012; 6(38): 2710-2723.

4. Rosenkranz B. Snake bites, spider bites and scorpion stings. CME 2012; 30(10): 355.

5. Müller GJMödler HWium CAVeale DJH. Scorpion sting in southern Africa: diagnosis and management. CME 2012; 30(10): 356-361.

6. Müller GJMödler HWium CAVeale DJHMarks CJ. Snake bite in southern Africa: diagnosis and management. CME 2012; 30(10): 362-381.

7. Müller GJWium CA, Marks CJ, Du Plessis CEVeale DJH. Spider bite in southern Africa: diagnosis and management. CME 2012; 30(10): 382-391.

8. Njovani XWFasinu PSRosenkranz B. Comparative evaluation of warfarin utilisation in two primary healthcare clinics in the Cape Town area. Cardiovascular journal of Africa 2012; 23: DOI 10.5830/CVJA-2012-072.

9. Fasinu PS. When garlic makes you pregnant. New voices in Sciences 2013, 29.

10. Nachega JB, Rosenkranz B, Pham PA. Twice daily versus once daily antiretroviral therapy and coformulation strategies in HIV infected adults: benefits, risk or burden? Patient preference and adherence 2011; 5: 645-651.

11. Huisamen B, Dietrich D, Bezuidenhout N, Lopes J, Flepisi B, Blackhurst D, Lochner A. Early cardiovascular changes occurring in diet-induced, obese insulin-resistant rats. Mol Cell Biochem 2012; 368: 37-45.

12. Fasinu P, Choonara YE, Khan RA, Du Toit LC, Kumar P, Ndesendo VMK, Pillay V. Flavonoids and polymer derivatives as CYP3A4 inhibitors for improved oral drug bioavailability. Journal of Pharmaceutical Sciences 2012; DOI 10.1002 l jps.23382.