Medical Physiology
Welcome to Stellenbosch University

Division of Medical Physiology




1. ABRAHAMS-OCTOBER Z, JOHNSON R, BENJEDDOU M, CLOETE R. The determination of the effect(s) of solute carrier family 22‑member 2 (SLC22A2) haplotype variants on drug binding via molecular dynamic simulation systems. Scientific Reports 2022; 12(16936):1-16.

2. ABRAHAMS-OCTOBER Z, LLOYD S, PEARCE B, JOHNSON R, BENJEDDOU M. Promoter haplotype structure of solute carrier 22 member 2 (SLC22A2) in the Xhosa population of South Africa and their differential effect on gene expression. GENE 2022; 2022(820):1-10.

3. ADAM S, PHEIFFER C, DIAS SC, HLONGWANE T, VANNEVEL V, SOMA-PILLAY P, ABDULLAH F. Coronavirus and Pregnancy: The Challenges of the 21st Century: A Review. Frontiers in Microbiology 2022; 13(923546):1-8.

4. AHRARI K, OMOLAOYE TS, GOSWAMI N, ALSUWAIDI H, DU PLESSIS SS. Effects of space flight on sperm function and integrity: A systematic review. Frontiers in Physiology 2022; 13(904375):1-15.

5. AYAD BM, OMOLAOYE TS, LOUW NT, RAMSUNDER Y, SKOSANA BT, OYEYIPO IP, DU PLESSIS SS. Oxidative Stress and Male Infertility: Evidence From a Research Perspective. Frontiers in Reproductive Health 2022; 4(822257):1-15.

6. BOTHA-LE ROUX S, ELVSTAM O, DE BOEVER P, GOSWAMI N, MAGNUSSON M, NILSSON PM, STRIJDOM H, BJÖRKMAN P, FOURIE CMT. Cardiovascular Profile of South African Adults with Low-Level Viremia during Antiretroviral Therapy. Journal of Clinical Medicine 2022; 11(2812):1-11.

7. CAIRNS ML, JOSEPH DE, ESSOP MF. The dual role of the hexosamine biosynthetic pathway in cardiac physiology and pathophysiology. Frontiers in Endocrinology 2022; 1:13.

8. CAROLUS DC, ELIJAH SS, GOVENDER S, HAMZA M, HOWARD E, KOTZE A, LEEKE RA, LEITE J, OOSTHUIZEN A, ORGOVANYI E, PAYNE C, SANCHEZ S, WILLIAMS CP, MAARMAN GJ. Pulmonary hypertension in developing countries: Limiting factors in time to diagnosis, specialised medications and contextualised recommendations. African Journal of Thoracic and Critical Care Medicine 2022; 28(1):28-32.

9. CHELLAN N, MULLER CJF. Running with Type 1 Diabetes: A Case Report on the Benefit of Sensor Technology. Diabetology International 2022; 2022(3):310-314.

10. DIAS SC, WILLMER T, ADAM S, PHEIFFER C. The role of maternal DNA methylation in pregnancies complicated by gestational diabetes. Frontiers in Clinical Diabetes and Healthcare 2022; 3(982665):1-31.

11. DORSEMANS A-C, ESSOP MF, BOURDON E. Can the introduction of an authentic learning exercise lead to the modulation of breakfast behavior in undergraduate students at La Reunion University? . Advances in Physiology Education 2022; 2022(2022):1-10.

12. DU PLESSIS SS, MAYA WDC, OMOLAOYE TS. Monkeypox and Male Fertility: Is There Any Looming Danger?. Journal of Reproduction and Infertility 2022; 23(4):314-317.

13. DUVURU R, HALABI M, OMOLAOYE TS, DU PLESSIS SS. The genetic causes of male infertility: a Middle East and North Africa perspective. F1000Research 2022; 11(125):1-31.

14. GABUZA KB, BUTHELEZI N, KAPPO AP, MABUDA TI, MOSA RA, LOUW J, MULLER CJF. In vitro and in vivo hepatotoxicity study of Afriplex™ GRT through an inflammatory response. Toxicology Reports 2022; 9(2022):1920-1928.

15. GEERTS LTGM, MEYER R, NOLAN H, NEL L, NEL DG, BRINK LT, ODENDAAL HJ. Reference standards for facial measurements in early third trimester South African fetuses, and the effect of maternal and fetal characteristics. Journal of Maternal-Fetal and Neonatal Medicine 2022; 35(2):1-9.

16. JACK BU, MAMUSHI M, VIRARAGAVAN A, DIAS SC, PHEIFFER C. Comparing the effects of tumor necrosis factor alpha, lipopolysaccharide and palmitic acid on lipid metabolism and inflammation in murine 3T3-L1 adipocytes. Life Sciences 2022; 297(120422):1-12.

17. JOHNSON R, MANGWANA N, SHARMA JR, MULLER CJF, MALEMELA K, MASHAU F, DIAS SC, RAMHARACK P, KINNEAR CJ, GLANZMANN B, VIRARAGAVAN A, LOUW J, SURUJLAL-NAICKER S, NKAMBULE S, WEBSTER C, MDHLULI M, GRAY G, MATHEE A, PREISER W, VORSTER AA, DALVIE S, STREET RA. Delineating the Spread and Prevalence of SARS-CoV-2 Omicron Sublineages (BA.1–BA.5) and Deltacron Using Wastewater in the Western Cape, South Africa. Journal of Infectious Diseases 2022; 2022(jiac356):1-10.

18. JOHNSON R, SHARMA JR, RAMHARACK P, MANGWANA N, KINNEAR CJ, VIRARAGAVAN A, GLANZMANN B, LOUW J, ABDELATIF N, REDDY T, SURUJLAL-NAICKER S, NKAMBULE S, MAHLANGENI N, WEBSTER C, MDHLULI M, GRAY G, MATHEE A, PREISER W, MULLER CJF, STREET RA. Tracking the circulating SARS‑CoV‑2 variant of concern in South Africa using wastewater‑based epidemiology. Scientific Reports 2022; 12(1182):1-12.

19. KAMAU F, ESTERHUIZEN T, MAARTENS G, KHOO S, JOSKA JA, KELLERMANN TA, STRIJDOM H, DECLOEDT EH. Concentrations of Efavirenz, Tenofovir, and Emtricitabine in Obesity: A Cross-Sectional Study. Journal of Acquired Immune Deficiency Syndromes 2022; 91(1):101-108.

20. KOTZE-HORSTMANN LM, BEDADA DT, JOHNSON R, MABASA L, SADIE-VAN GIJSEN H. The effects of a green Rooibos (Aspalathus linearis) extract on metabolic parameters and adipose tissue biology in rats fed different obesogenic diets. Food and Function 2022; 13:12648.

21. KOTZE-HORSTMANN LM, COIS A, JOHNSON R, MABASA L, SHABALALA S, VAN JAARSVELD PJ, SADIE-VAN GIJSEN H. Characterization and Comparison of the Divergent Metabolic Consequences of High-Sugar and High-Fat Diets in Male Wistar Rats. Frontiers in Physiology 2022; 13(904366):1-13.

22. LOCHNER A, BLIGNAUT M. Mitochondrial dynamics in myocardial ischemia/reperfusion injury: Effects of melatonin. Melatonin Research 2022; 5(3):335-373.

23. MAARMAN GJ. Reviewing the suitability of mitochondrial transplantation as therapeutic approach for pulmonary hypertension in the era of personalized medicine. American Journal of Physiology - Lung Cellular and Molecular Physiology 2022; 322(5):L641 - L646.

24. MAARMAN GJ, LECOUR S. The potential benefit of rooibos (aspalathus linearis) in pulmonary arterial hypertension: A short review. South African Journal of Botany 2022; 150(150):840-844.

25. MABASA L, KOTZE A, SHABALALA S, KIMANI C, GABUZA KB, JOHNSON R, SANGWENI NF, MAHARAJ V, MULLER CJF. Sclerocarya birrea (Marula) Extract Inhibits Hepatic Steatosis in db/db Mice. International Journal of Environmental Research and Public Health 2022; 19(3782):1-15.

26. MABHIDA SE, MUHAMED B, SHARMA JR, APALATA T, NOMATSHILA S, MABASA L, BENJEDDOU M, MASILELA C, SHABALALA S, ZIQUBU K, JOHNSON R. Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature. Genes 2022; 13(631):1-14.

27. MABHIDA SE, SHARMA JR, APALATA T, MASILELA C, NOMATSHILA S, MABASA L, FOKKENS H, BENJEDDOU M, MUHAMED B, SHABALALA S, JOHNSON R. The association of MTHFR (rs1801133) with hypertension in an indigenous south African population. Frontiers in Genetics 2022; 13(937639):1-10.

28. MAIKOO S, WILKINS A, QULU L. The effect of oxytocin and an enriched environment on anxiety-like behaviour and corticosterone levels in a prenatally stressed febrile seizure rat model. IBRO Neuroscience Reports 2022; 2022(13):47-56.

29. MALAZA N, MASETE M, ADAM S, DIAS SC, NYAWO TA, PHEIFFER C. A Systematic Review to Compare Adverse Pregnancy Outcomes in Women with Pregestational Diabetes and Gestational Diabetes . International Journal of Environmental Research and Public Health 2022; 19(10846):1-15.

30. MANGWANA N, ARCHER E, MULLER CJF, PREISER W, WOLFAARDT GM, KASPRZYK-HORDERN B, CARSTENS A, BRÖCKER JHL, WEBSTER C, MCCARTHY D, STREET RA, MATHEE A, LOUW J, MDHLULI M, JOHNSON R. Sewage surveillance of SARS-CoV-2 at student campus residences in the Western Cape, South Africa. Science of the Total Environment 2022; 851(158028):1-11.

31. MASETE M, DIAS SC, MALAZA N, ADAM S, PHEIFFER C. A Big Role for microRNAs in Gestational Diabetes Mellitus. Frontiers in Endocrinology 2022; 13(892587):1-15.

32. MAYA WDC, DU PLESSIS SS, VELILLA PA. Semen and viruses: signifcance during the transmission of infections. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 2022; 2022(2022):1-2.

33. MAYA WDC, OMOLAOYE TS, DU PLESSIS SS. Words of Wisdom Re: The Impact of COVID-19 Vaccine on sperm quality. EUROPEAN UROLOGY 2022; 82(2022):327-328.

34. MOENS C, MULLER CJF, BOUWENS L. In vitro comparison of various antioxidants and flavonoids from Rooibos as beta cell protectants against lipotoxicity and oxidative stress-induced cell death. PLoS One 2022; 17(5):1-16.

35. MTHEMBU SXH, DLUDLA PV, NYAMBUYA TM, KAPPO AP, MADOROBA E, ZIQUBU K, NYAWO TA, NKAMBULE BB, SYLVESTRI S, MULLER CJF, MAZIBUKO-MBEJE SE. Experimental models of lipid overload and their relevance in understanding skeletal muscle insulin resistance and pathological changes in mitochondrial oxidative capacity. Biochimie 2022; 196:182-193.

36. MTHEMBU SXH, MAZIBUKO-MBEJE SE, ZIQUBU K, NYAWO TA, OBONYE N, NYAMBUYA TM, NKAMBULE BB, SILVESTRI S, TIANO L, MULLER CJF, DLUDLA PV. Impact of physical exercise and caloric restriction in patients with type 2 diabetes: Skeletal muscle insulin resistance and mitochondrial dysfunction as ideal therapeutic targets. Life Sciences 2022; 297(120467):1-10.

37. MTHEMBU SXH, ORLANDO P, SYLVESTRI S, ZIQUBU K, MAZIBUKO-MBEJE SE, MABHIDA SE, NYAMBUYA TM, MULLER CJF, BASSON AK, TIANO L, DLUDLA PV. Impact of dyslipidemia in the development of cardiovascular complications: Delineating the potential therapeutic role of coenzyme Q10. Biochimie 2022; 204(2023):33-40.

38. MULLER CJF, JOUBERT E, CHELLAN N, MIURA Y, YAGASAKI K. New Insights into the Efficacy of Aspalathin and Other Related Phytochemicals in Type 2 Diabetes—A Review. International Journal of Molecular Sciences 2022; 23(356):1-22.

39. NGALA EM, HEMMINGS SMJ, QULU L. Prenatal maternal stress and offspring aggressive behavior: Intergenerational and transgenerational inheritance. Frontiers in Behavioral Neuroscience 2022; 16:977416, 19 pages.

40. NGUBANE LB, NOTHLING J, MOLETSANE R, WILKINSON A, QULU L. Why men rape: Perspectives from incarcerated rapists in a KwaZulu-Natal prison, South Africa. Frontiers in Psychology 2022; 13:805289, 13 pages.

41. NTAMO Y, ZIQUBU K, CHELLAN N, NKAMBULE BB, NYAMBUYA TM, MAZIBUKO-MBEJE SE, GABUZA KB, ORLANDO P, TIANO L, DLUDLA PV. Clinical use of N-acetyl cysteine during liver transplantation: Implications of oxidative stress and inflammation as therapeutic targets. BIOMEDICINE & PHARMACOTHERAPY 2022; 147(112638):1-9.

42. NYAWO TA, DLUDLA PV, MAZIBUKO-MBEJE SE, MTHEMBU SXH, NYAMBUYA TM, NKAMBULE BB, SADIE-VAN GIJSEN H, STRIJDOM H, PHEIFFER C. A systematic review exploring the significance of measuring epicardial fat thickness in correlation to B‑type natriuretic peptide levels as prognostic and diagnostic markers in patients with or at risk of heart failure. Heart Failure Reviews 2022; 2022(27):665-675.

43. OMOLAOYE TS, SHAHAWY OE, SKOSANA BT, BOILLAT T, LONEY T, DU PLESSIS SS. The mutagenic effect of tobacco smoke on male fertility. Environmental Science and Pollution Research 2022; 2021(2021):1-12.

44. OMOLAOYE TS, HACHIM MY, DU PLESSIS SS. Using publicly available transcriptomic data to identify mechanistic and diagnostic biomarkers in azoospermia and overall male infertility. Scientific Reports 2022; 12(2584):1-17.

45. OMOLAOYE TS, HALABI M, MUBARAK M, CYRIL AC, DUVURU R, RADHAKRISHNAN R, DU PLESSIS SS. Statins and Male Fertility: Is There a Cause for Concern?. Toxics 2022; 10(627):1-19.

46. OMOLAOYE TS, JALALEDDINE N, MAYA WDC, DU PLESSIS SS. Mechanisms of SARS-CoV-2 and Male Infertility: Could Connexin and Pannexin Play a Role?. Frontiers in Physiology 2022; 13(866675):1-12.

47. OMOLAOYE TS, OMOLAOYE VA, KANDASAMY RK, HACHIM MY, DU PLESSIS SS. Omics and Male Infertility: Highlighting the Application of Transcriptomic Data. Life 2022; 12(2)(280):1-21.

48. PATEL O, MULLER CJF, JOUBERT E, ROSENKRANZ BF, LOUW J, AWORTWE C. Aspalathin-rich green rooibos tea in combination with glyburide and atorvastatin enhances lipid metabolism in a db/db mouse model. Frontiers in Clinical Diabetes and Healthcare 2022; 3:963489.

49. RIEDEL - VAN HEERDEN S, DIAS SC, MENDHAM AE, JACK BU, WILLMER T, ESHIBONA N, BENDOU H, PRETORIUS A, GOEDECKE JH. Changes in subcutaneous adipose tissue microRNA expression in response to exercise training in obese African women. Scientific Reports 2022; 12(18408):1-12.

50. RIEDEL - VAN HEERDEN S, PHEIFFER C, JOHNSON R, LOUW J, MULLER CJF. Intestinal Barrier Function and Immune Homeostasis Are Missing Links in Obesity and Type 2 Diabetes Development. Frontiers in Endocrinology 2022; 12(833544):1-17.

51. SALIE R, MARAIS E, LOCHNER A. Beta 3-Adrenergic Receptor (β3-AR) Activation at the End of Sustained Ischemia and / or Early Reperfusion may Prove to be a Valuable Cardioprotective Strategy. CLINICAL CARDIOLOGY 2022; 3(2):47-50.

52. SANGWENI NF, VAN VUUREN D, MABASA L, GABUZA KB, HUISAMEN B, NAIDOO S, BARRY R, JOHNSON R. Prevention of Anthracycline-Induced Cardiotoxicity: The Good and Bad of Current and Alternative Therapies. Frontiers in Cardiovascular Medicine 2022; 9(907266):1-17.

53. SANGWENI NF, GABUZA KB, HUISAMEN B, MABASA L, VAN VUUREN D, JOHNSON R. Molecular insights into the pathophysiology of doxorubicin‑induced cardiotoxicity: a graphical representation. ARCHIVES OF TOXICOLOGY 2022; 2022(96):1541-1550.

54. SHABALALA S, JOHNSON R, BASSON AK, ZIQUBU K, HLENGWA N, MTHEMBU SXH, MABHIDA SE, MAZIBUKO-MBEJE SE, HANSER S, CIRILLI I, TIANO L, DLUDLA PV. Detrimental Effects of Lipid Peroxidation in Type 2 Diabetes: Exploring the Neutralizing Influence of Antioxidants. Antioxidants 2022; 11:2071.

55. SMIT SE, MANIRAFASHA C, MARAIS E, JOHNSON R, HUISAMEN B. Cardioprotective Function of Green Rooibos (Aspalathus linearis) Extract Supplementation in Ex Vivo Ischemic Prediabetic Rat Hearts. Planta Medica 2022; 2022(88):62-78.

56. SWART C, FOURIE CMT, DE BOEVER P, GOSWAMI N, LAMMERTYN L, STRIJDOM H, KAMAU F, BOTHA-LE ROUX S. Comparison of endothelial function and cardiometabolic profiles of people living with HIV in two South African regions: the EndoAfrica study. Cardiovascular Journal of Africa 2022; 33(1):15-20.

57. VANMALI HD, EVERSON FP, DE BEER C. Detection of human rhinovirus in Sudden Unexpected Death in Infancy (SUDI) cases at Tygerberg medico-legal mortuary, Cape Town, South Africa . African Journal of Respiratory Medicine 2022; 17(7):1-12.

58. WANG BJ, HUANG SH, KAO CL, MULLER CJF, WANG TP, CHANG KH, WEN HC, YEH CC, SHIH LJ, KAO YH, HUANG SP, LI CY, CHUU CP. Aspalathus linearis suppresses cell survival and proliferation of enzalutamide-resistant prostate cancer cells via inhibition of c-Myc and stability of androgen receptor. PLoS One 2022; 17(7):1-15.

59. WILLMER T, OOSTHUIZEN A, DIAS SC, MENDHAM AE, GOEDECKE JH, PHEIFFER C. A pilot investigation of genetic and epigenetic variation of FKBP5 and response to exercise intervention in African women with obesity. Scientific Reports 2022; 12(11771):1-12.

60. YAGASAKI K, MULLER CJF. The Effect of Phytochemicals and Food Bioactive Compounds on Diabetes. International Journal of Molecular Sciences 2022; 23(7765):1-3.​


  1. Abrahams-October Z, Zhakaza L, Pearce B, Masilela MC, Benjeddou M, Adeniyi VO, et al. Genetic Association of Solute Carrier Transporter Gene Varients With Metformin Response. BJMG 2021;24:47–56.
  2. Alipour H, Duus RK, Wimmer R, Dardmeh F, Du Plessis SS, Jørgensen N, et al. Seminal plasma metabolomics profiles following long (4–7 days) and short (2 h) sexual abstinence periods. Eur J Obstet Gynecol Reprod Biol 2021;264:178–83.
  3. Ayad BM, Oyeyipo IP, Van der Horst G, Du Plessis SS. Cementing the relationship between conventional and advanced semen parameters. Middle East Fertil Soc J 2021;26:1–10.
  4. Berner K, Gouelle A, Strijdom H, Essop MF, Webster I, Louw Q. Mobility Deviations in Adults With Human Immunodeficiency Virus: A Cross-Sectional Assessment Using Gait Analysis, Functional Performance, and Self-Report. Open Forum Infect Dis 2021;8.
  5. Blignaut M, Harries S, Lochner A, Huisamen B. Ataxia telangiectasia mutated protein kinase: A potential master puppeteer of oxidative stress-induced metabolic recycling. Oxid Med Cell Longev 2021;2021.
  6. Chang X, Lochner A, Wang HH, Wang S, Zhu H, Ren J, et al. Coronary microvascular injury in myocardial infarction: perception and knowledge for mitochondrial quality control. Theranostics 2021;11:6766.
  7. Cilliers K, Muller CJF. Effect of human immunodeficiency virus on the brain: A review. Anat Rec 2021;304:1389–99.
  8. Cilliers K, Muller CJF. Effect of Human Immunodeficiency Virus on Trace Elements in the Brain. Biol Trace Elem Res 2020 1991 2020;199:41–52.
  9. Cilliers K, Muller CJF. Multi-element Analysis of Brain Regions from South African Cadavers. Biol Trace Elem Res 2021;199:425–41.
  10. De Smidt JJA, Odendaal HJ, Nel DG, Nolan H, Du Plessis C, Brink LT, et al. The effects of in utero exposure to teratogens on organ size: a prospective paediatric study. J Dev Orig Health Dis 2021;12:748–57.
  11. Dias S, Adam S, Abrahams Y, Rheeder P, Pheiffer C. Adiponectin DNA methylation in South African women with gestational diabetes mellitus: Effects of HIV infection. PLoS One 2021;16:e0248694.
  12. Dias S, Adam S, Rheeder P, Pheiffer C. No Association Between ADIPOQ or MTHFR Polymorphisms and Gestational Diabetes Mellitus in South African Women. Diabetes, Metab Syndr Obes Targets Ther 2021;14:791.
  13. Dludla P V., Nyambuya TM, Johnson R, Silvestri S, Orlando P, Mazibuko-Mbeje SE, et al. Metformin and heart failure–related outcomes in patients with or without diabetes: a systematic review of randomized controlled trials. Heart Fail Rev 2021;26:1437–45.
  14. Geerts L, Meyer R, Nolan H, Nel L, Nel DG, Brink L, et al. Reference standards for facial measurements in early third trimester South African fetuses, and the effect of maternal and fetal characteristics. Https://DoiOrg/101080/1476705820211977794 2022.
  15. Glanzmann B, Jooste T, Ghoor S, Gordon R, Mia R, Mao J, et al. Human whole genome sequencing in South Africa. Sci Reports 2021 111 2021;11:1–8.
  16. Johnson R, Muller CJF, Ghoor S, Louw J, Archer E, Surujlal-Naicker S, et al. Qualitative and quantitative detection of SARS-CoV-2 RNA in untreated wastewater in Western Cape Province, South Africa. South African Med J 2021;111:198–202.
  17. Lederer AM, Fredriksen PM, Nkeh-Chungag BN, Everson F, Strijdom H, de Boever P, et al. Cardiovascular Effects of Air Pollution: Current Evidence from Animal and Human Studies. Am J Physiol Circ Physiol 2021:1–24.
  18. Lochner A, Wang HH, Reiter RJ, Guo R, Zhou H. Editorial: Role of Mitochondrial Quality Control in Myocardial and Microvascular Physiology and Pathophysiology. Front Physiol 2021;12:1495.
  19. Lucas AF, Gemechu DB, Du Plessis SS, Aboua YG. Fertility and pregnancy outcome among women undergoing assisted reproductive technology treatment in Windhoek, Namibia. J Assist Reprod Genet 2021;38:635–43.
  20. Maarman GJ, Lamont-Mbawuli K. Adolescents in the South African context: The roles of the church, spirituality and mentorship programmes in promoting motivation to overcome disadvantage. African J Soc Work 2021;11.
  21. Maarman GJ, Lecour S. Melatonin against pulmonary arterial hypertension: Is it ready for testing in patients? Cardiovasc J Afr 2021;32:111–2.
  22. Maarman GJ. Could melatonin be an adjunct therapy for post-TB lung disease? Melatonin Res 2021;4:431–9.
  23. Mabhida SE, Mashatola L, Kaur M, Sharma JR, Apalata T, Muhamed B, et al. Hypertension in African Populations: Review and Computational Insights. Genes 2021, Vol 12, Page 532 2021;12:532.
  24. Marincowitz C, Webster I, Westcott C, Goswami N, de Boever P, Seidel G, et al. Vascular health assessment with flow-mediated dilatation and retinal image analysis: a pilot study in an adult population from Cape Town. Cardiovasc J Afr 2021;32:133–40.
  25. Masilela C, Pearce B, Ongole JJ, Adeniyi OV, Johnson R, Benjeddou M. Cross-sectional study of the association of 5 single nucleotide polymorphisms with enalapril treatment response among South African adults with hypertension. Medicine (Baltimore) 2021;100:e27836.
  26. Maya WC, Plessis S Du. Twelve Months Down the Line: do we know Anything more about the Presence of the SARS-CoV-2 in Human Semen? Rev Bras Ginecol e Obs 2021;43:339–40.
  27. Mazibuko-Mbeje SE, Mthembu SXH, Dludla P V., Madoroba E, Chellan N, Kappo AP, et al. Antimycin A-induced mitochondrial dysfunction is consistent with impaired insulin signaling in cultured skeletal muscle cells. Toxicol Vitr 2021;76:105224.
  28. Mazibuko-Mbeje SE, Mthembu SXH, Tshiitamune A, Muvhulawa N, Mthiyane FT, Ziqubu K, et al. Orientin Improves Substrate Utilization and the Expression of Major Genes Involved in Insulin Signaling and Energy Regulation in Cultured Insulin-Resistant Liver Cells. Mol 2021, Vol 26, Page 6154 2021;26:6154.
  29. Mentoor I, Engelbrecht AM, van de Vyver M, van Jaarsveld PJ, Nell T. The paracrine effects of adipocytes on lipid metabolism in doxorubicin-treated triple negative breast cancer cells. Adipocyte 2021;10:505–23.
  30. Mokgalaboni K, Nkambule BB, Ntamo Y, Ziqubu K, Nyambuya TM, Mazibuko-Mbeje SE, et al. Vitamin K: A vital micronutrient with the cardioprotective potential against diabetes-associated complications. Life Sci 2021;286:120068.
  31. Mokgalaboni K, Ntamo Y, Ziqubu K, Nyambuya TM, Nkambule BB, Mazibuko-Mbeje SE, et al. Curcumin supplementation improves biomarkers of oxidative stress and inflammation in conditions of obesity, type 2 diabetes and NAFLD: updating the status of clinical evidence. Food Funct 2021;12:12235–49.
  32. Mthembu SXH, Dludla P V., Nyambuya TM, Kappo AP, Madoroba E, Ziqubu K, et al. Experimental models of lipid overload and their relevance in understanding skeletal muscle insulin resistance and pathological changes in mitochondrial oxidative capacity. Biochimie 2021.
  33. Mthembu SXH, Dludla P V., Ziqubu K, Nyambuya TM, Kappo AP, Madoroba E, et al. The Potential Role of Polyphenols in Modulating Mitochondrial Bioenergetics within the Skeletal Muscle: A Systematic Review of Preclinical Models. Mol 2021, Vol 26, Page 2791 2021;26:2791.
  34. Mthembu SXH, Muller CJF, Dludla P V., Madoroba E, Kappo AP, Mazibuko-Mbeje SE. Rooibos Flavonoids, Aspalathin, Isoorientin, and Orientin Ameliorate Antimycin A-Induced Mitochondrial Dysfunction by Improving Mitochondrial Bioenergetics in Cultured Skeletal Muscle Cells. Mol 2021, Vol 26, Page 6289 2021;26:6289.
  35. Nkeh-Chungag BN, Goswami N, Engwa GA, Sewani-Rusike CR, Mbombela V, Webster I, et al. Relationship between Endothelial Function, Antiretroviral Treatment and Cardiovascular Risk Factors in HIV Patients of African Descent in South Africa: A Cross-Sectional Study. J Clin Med 2021, Vol 10, Page 392 2021;10:392.
  36. Ntamo Y, Samodien E, Burger J, Muller N, Muller CJF, Chellan N. Corrigendum: In vitro Characterization of Insulin–Producing β-Cell Spheroids. Front Cell Dev Biol 2021;9:623889.
  37. Ntamo Y, Ziqubu K, Chellan N, Nkambule BB, Nyambuya TM, Mazibuko-Mbeje SE, et al. Drug-Induced Liver Injury: Clinical Evidence of N-Acetyl Cysteine Protective Effects 2021.
  38. Nyawo TA, Dludla P V., Mazibuko-Mbeje SE, Mthembu SXH, Nyambuya TM, Nkambule BB, et al. A systematic review exploring the significance of measuring epicardial fat thickness in correlation to B-type natriuretic peptide levels as prognostic and diagnostic markers in patients with or at risk of heart failure. Heart Fail Rev 2022;27:665–75.
  39. Nyawo TA, Pheiffer C, Mazibuko-Mbeje SE, Mthembu SXH, Nyambuya TM, Nkambule BB, et al. Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets. Antioxidants 2021, Vol 10, Page 1758 2021;10:1758.
  40. Obasa Z, van Vuuren MA, Huisamen B, Windvogel SL. The modulating effects of green rooibos (Aspalathus linearis) extract on vascular function and antioxidant status in obese Wistar rats. Cardiovasc J Afr 2021;32:87–97.
  41. Omolaoye T, Du Plessis S. Descriptive histomorphological evaluation of the testis and caudal epididymis following treatment with rooibos (Aspalathus linearis), honeybush (Cyclopia intermedia) and sutherlandia (Lessertia frutescens) in healthy and streptozotocin-induced diabetic rats. Asian Pacific J Reprod 2021;10:176.
  42. Omolaoye TS, Adeniji AA, Cardona Maya WD, du Plessis SS. SARS-COV-2 (Covid-19) and male fertility: Where are we? Reprod Toxicol 2021;99:65–70.
  43. Omolaoye TS, Du Plessis SS. The effect of streptozotocin induced diabetes on sperm function: a closer look at AGEs, RAGEs, MAPKs and activation of the apoptotic pathway. Toxicol Res 2021;37:35–46.
  44. Omolaoye TS, El Shahawy O, Skosana BT, Boillat T, Loney T, du Plessis SS. The mutagenic effect of tobacco smoke on male fertility. Environ Sci Pollut Res 2021:1–12.
  45. Omolaoye TS, Windvogel S, Du Plessis SS. Testicular oxidative stress and apoptosis status in streptozotocin-induced diabetic rats after treatment with rooibos (Aspalathus linearis), honeybush (Cyclopia intermedia), and sutherlandia (Lessertia frutescens) infusions. Asian Pacific J Reprod 2021;10:11.
  46. Omolaoye TS, Windvogel SL, Du Plessis SS. The Effect of Rooibos (Aspalathus linearis), Honeybush (Cyclopia intermedia) and Sutherlandia (Lessertia frutescens) on Testicular Insulin Signalling in Streptozotocin-Induced Diabetes in Wistar Rats. Diabetes, Metab Syndr Obes Targets Ther 2021;14:1267.
  47. Patel O, Muller CJF, Joubert E, Rosenkranz B, Louw J, Awortwe C. Therapeutic effects of an aspalathin-rich green rooibos extract, pioglitazone and atorvastatin combination therapy in diabetic db/db mice. PLoS One 2021;16:e0251069.
  48. Pheiffer C, Dias S, Jack B, Malaza N, Adam S. Adiponectin as a Potential Biomarker for Pregnancy Disorders. Int J Mol Sci 2021, Vol 22, Page 1326 2021;22:1326.
  49. Pheiffer C, Wyk VP Van, Turawa E, Levitt N, Kengne AP, Bradshaw D. Prevalence of Type 2 Diabetes in South Africa: A Systematic Review and Meta-Analysis. Int J Environ Res Public Heal 2021, Vol 18, Page 5868 2021;18:5868.
  50. Sadie-Van Gijsen H. Is Adipose Tissue the Fountain of Youth? The Impact of Adipose Stem Cell Aging on Metabolic Homeostasis, Longevity, and Cell-Based Therapies. Adv Exp Med Biol 2021;1286:225–50.
  51. Samodien E, Abrahams Y, Muller C, Louw J, Chellan N. Non-communicable diseases - A catastrophe for South Africa. S Afr J Sci 2021;117.
  52. Samodien E, Chellan N. Hypothalamic neurogenesis and its implications for obesity-induced anxiety disorders. Front Neuroendocrinol 2021;60:100871.
  53. Sangweni NF, Dludla P V., Chellan N, Mabasa L, Sharma JR, Johnson R. The Implication of Low Dose Dimethyl Sulfoxide on Mitochondrial Function and Oxidative Damage in Cultured Cardiac and Cancer Cells. Mol 2021, Vol 26, Page 7305 2021;26:7305.
  54. Sangweni NF, Mosa RA, Dludla P V., Kappo AP, Opoku AR, Muller CJF, et al. The triterpene, methyl-3β-hydroxylanosta-9,24-dien-21-oate (RA3), attenuates high glucose-induced oxidative damage and apoptosis by improving energy metabolism. Phytomedicine 2021;85:153546.
  55. Sharma JR, Mabhida SE, Myers B, Apalata T, Nicol E, Benjeddou M, et al. Prevalence of Hypertension and Its Associated Risk Factors in a Rural Black Population of Mthatha Town, South Africa. Int J Environ Res Public Heal 2021, Vol 18, Page 1215 2021;18:1215.
  56. Street R, Mathee A, Mangwana N, Dias S, Sharma JR, Ramharack P, et al. Spatial and Temporal Trends of SARS-CoV-2 RNA from Wastewater Treatment Plants over 6 Weeks in Cape Town, South Africa. Int J Environ Res Public Heal 2021, Vol 18, Page 12085 2021;18:12085.
  57. Street RA, Mathee A, Johnson R, Muller CJF, Louw J, Mdhluli M, et al. COVID-19 vaccine roll-out in South Africa: The added value of wastewater surveillance for SARS-CoV-2. South African Med J 2021;111:524–5.
  58. Swart C, Fourie C, De Boever P, Goswami N, Lammertyn L, Strijdom H, et al. Comparison of endothelial function and cardiometabolic profiles of people living with HIV in two South African regions: the EndoAfrica study. Cardiovasc J Afr 2021;32:1–6.
  59. Venter P, Malemela K, Mbazima V, Mampuru LJ, Muller CJF, Riedel S. An RP-LC-UV-TWIMS-HRMS and Chemometric Approach to Differentiate between Momordicabalsamina Chemotypes from Three Different Geographical Locations in Limpopo Province of South Africa. Mol 2021, Vol 26, Page 1896 2021;26:1896.
  60. Viraragavan A, Willmer T, Patel O, Basson A, Johnson R, Pheiffer C. Cafeteria diet induces global and Slc27a3-specific hypomethylation in male Wistar rats. Adipocyte 2021;10:108–18.
  61. Williams C, Kamau FM, Everson F, Kgokane B, De Boever P, Goswami N, et al. HIV and Antiretroviral Therapy Are Independently Associated with Cardiometabolic Variables and Cardiac Electrical Activity in Adults from the Western Cape Region of South Africa. J Clin Med 2021, Vol 10, Page 4112 2021;10:4112.
  62. Willmer T, Damerell V, Smyly S, Sims D, Toit M Du, Ncube S, et al. Targeting the oncogenic TBX3:nucleolin complex to treat multiple sarcoma subtypes. Am J Cancer Res 2021;11:5680. /ISSN:2156-6976/ajcr0137198


1. Adams KT, Donald PR, Abulfathi AA, Diacon AH, Stander MA, Reuter H. Pharmacokinetics of Para‐Aminosalicylic Acid and Its 2 Major Metabolites: A Potential Relationship to the Development of Gastrointestinal Intolerance. J Clin Pharmacol 2020; 60: 489–494.

2. Alabi TD, de Villiers C, du Plessis SS, Monsees TK, Brooks NL, Oguntibeju OO. The beneficial role of anchomanes difformis in stz-induced reproductive dysfunction in male wistar rats. Diabetes, Metab Syndr Obes Targets Ther 2020; 13: 4553–4560.

3. Barrera N, Ordoqui R, Montes JM, Canepa M, Bonelli C, Surka C et al. The Uruguayan semen donor population: A twenty‐eight‐year retrospective study. Andrologia 2020; 52: e13502.

4. Bisimwa BC, Nachega JB, Warren RM, Theron G, Metcalfe JZ, Shah M et al. Xpert Mycobacterium tuberculosis/Rifampicin–Detected Rifampicin Resistance is a Suboptimal Surrogate for Multidrug-resistant Tuberculosis in Eastern Democratic Republic of the Congo: Diagnostic and Clinical Implications. Clin Infect Dis 2020. doi:10.1093/cid/ciaa873.

5. Braissant O, Theron G, Friedrich SO, Diacon AH, Bonkat G. Comparison of isothermal microcalorimetry and BACTEC MGIT960 for the detection of the metabolic activity of Mycobacterium tuberculosis in sputum samples. J Appl Microbiol 2020; 128: 1497–1502.

6. Cerf ME. Beta Cell Physiological Dynamics and Dysfunctional Transitions in Response to Islet Inflammation in Obesity and Diabetes. Metabolites 2020; 10: 452.

7. Cerf ME. Developmental Programming and Glucolipotoxicity: Insights on Beta Cell Inflammation and Diabetes. Metabolites 2020; 10: 444.

8. Cilliers K, Muller CJF. Effect of human immunodeficiency virus on the brain: A review. Anat Rec 2020; : ar.24573.

9. Cilliers K, Muller CJF, Page BJ. Trace Element Concentration Changes in Brain Tumors: A Review. Anat Rec 2020; 303: 1293–1299.

10. Dludla P V., Johnson R, Mazibuko-Mbeje SE, Muller CJF, Louw J, Joubert E et al. Fermented rooibos extract attenuates hyperglycemia-induced myocardial oxidative damage by improving mitochondrial energetics and intracellular antioxidant capacity. South African J Bot 2020; 131: 143–150.

11. Dludla P V, Nyambuya TM, Johnson R, Silvestri S, Orlando P, Mazibuko-Mbeje SE et al. Metformin and heart failure-related outcomes in patients with or without diabetes: a systematic review of randomized controlled trials. Heart Fail Rev 2020; : 1–9.

12. Dludla P V., Muller CJF, Louw J, Mazibuko-Mbeje SE, Tiano L, Silvestri S et al. The Combination Effect of Aspalathin and Phenylpyruvic Acid-2-O-β-d-glucoside from Rooibos against Hyperglycemia-Induced Cardiac Damage: An In Vitro Study. Nutrients 2020; 12: 1151.

13. Dludla P V., Nkambule BB, Mazibuko-Mbeje SE, Nyambuya TM, Marcheggiani F, Cirilli I et al. N-Acetyl Cysteine Targets Hepatic Lipid Accumulation to Curb Oxidative Stress and Inflammation in NAFLD: A Comprehensive Analysis of the Literature. Antioxidants 2020; 9: 1283.

14. Dludla P V., Orlando P, Silvestri S, Marcheggiani F, Cirilli I, Nyambuya TM et al. Coenzyme Q10 Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials. Int J Mol Sci 2020; 21: 3247.

15. Dludla P V., Silvestri S, Orlando P, Gabuza KB, Mazibuko-Mbeje SE, Nyambuya TM et al. Exploring the Comparative Efficacy of Metformin and Resveratrol in the Management of Diabetes-Associated Complications: A Systematic Review of Preclinical Studies. Nutrients 2020; 12: 739.

16. Dludla P V., Silvestri S, Orlando P, Mazibuko-Mbeje SE, Johnson R, Marcheggiani F et al. Palmitate-induced toxicity is associated with impaired mitochondrial respiration and accelerated oxidative stress in cultured cardiomyocytes: The critical role of coenzyme Q9/10. Toxicol Vitr 2020; 68: 104948.

17. Erasmus M, Samodien E, Lecour S, Cour M, Lorenzo O, Dludla P et al. Linking LOXL2 to Cardiac Interstitial Fibrosis. Int J Mol Sci 2020; 21: 5913.

18. Eshleman SH, Piwowar‐Manning E, Wilson EA, Lennon D, Fogel JM, Agyei Y et al. Determination of HIV status and identification of incident HIV infections in a large, community‐randomized trial: HPTN 071 (PopART). J Int AIDS Soc 2020; 23: e25452.

19. Everson F, Martens DS, Nawrot TS, Goswami N, Mthethwa M, Webster I et al. Personal exposure to NO2 and benzene in the Cape Town region of South Africa is associated with shorter leukocyte telomere length in women. Environ Res 2020; 182: 108993.

20. Faraj A, Svensson RJ, Diacon AH, Simonsson USH. Drug effect of clofazimine on persisters explains an unexpected increase in bacterial load in patients. Antimicrob Agents Chemother 2020; 64. doi:10.1128/AAC.01905-19.

21. Fourie CMT, Botha-Le Roux S, Smith W, Schutte AE, Breet Y, Mels CMC et al. Vascular function and cardiovascular risk in a HIV infected and HIV free cohort of African ancestry: Baseline profile, rationale and methods of the longitudinal EndoAfrica-NWU study. BMC Infect Dis 2020; 20: 473.

22. Willmer T, Goedecke JH, Dias S, Louw J, Pheiffer C. DNA methylation of FKBP5 in South African women: Associations with obesity and insulin resistance. Clin Epigenetics 2020; 12: 141.

23. Hlengwa N, Muller CJF, Basson AK, Bowles S, Louw J, Awortwe C. Herbal supplements interactions with oral oestrogen‐based contraceptive metabolism and transport. Phyther Res 2020; 34: 1519–1529.

24. Huang SH, Kao YH, Muller CJF, Joubert E, Chuu CP. Aspalathin-rich green Aspalathus linearis extract suppresses migration and invasion of human castration-resistant prostate cancer cells via inhibition of YAP signaling. Phytomedicine 2020; 69: 153210.

25. Hudson P, Woudberg NJ, Kamau F, Strijdom H, Frias MA, Lecour S. HIV-related cardiovascular disease: Any role for high-density lipoproteins? Am. J. Physiol. - Hear. Circ. Physiol. 2020; 319: H1221–H1226.

26. Johnson R, Nxele X, Cour M, Sangweni N, Jooste T, Hadebe N et al. Identification of potential biomarkers for predicting the early onset of diabetic cardiomyopathy in a mouse model. Sci Rep 2020; 10: 12352.

27. Dhanabalan K, Huisamen B, Lochner A. Mitochondrial oxidative phosphorylation and mitophagy in myocardial ischaemia/reperfusion: Effects of chloroquine. Cardiovasc J Afr 2020; 31: 169–179.

28. Dhanabalan K, Mzezewa S, Huisamen B, Lochner A. Mitochondrial Oxidative Phosphorylation Function and Mitophagy in Ischaemic/Reperfused Hearts from Control and High-Fat Diet Rats: Effects of Long-Term Melatonin Treatment. Cardiovasc Drugs Ther 2020; 34: 799–811.

29. Kotzé-Hörstmann LM, Sadie-Van Gijsen H. Modulation of Glucose Metabolism by Leaf Tea Constituents: A Systematic Review of Recent Clinical and Pre-clinical Findings. J. Agric. Food Chem. 2020; 68: 2973–3005.

30. Lochner A. In memoriam: Lionel Opie. J Mol Cell Cardiol 2020; 142: 135–136.

31. Lochner A, Genade S, Genis A, Marais E, Salie R. Long-chain free fatty acids inhibit ischaemic preconditioning of the isolated rat heart. Mol Cell Biochem 2020; 473: 111–132.

32. Maarman GJ. A philosophical perspective on pulmonary hypertension: What is 'rare'? S. Afr. J. Sci. 2020; 116: 1–1.

33. Maarman GJ. Making a case for metallothioneins conferring cardioprotection in pulmonary hypertension. Med Hypotheses 2020; 137: 109572.

34. Maarman GJ, Chakafana G, Sliwa K. World Heart Day: a World Heart Federation communiqué on the future of basic sciences and translational medicine in global cardiovascular research. 2020. doi:10.1152/ajplung.00339.2020.

35. Maarman GJ, Shaw J, Allwood B. Pulmonary hypertension in majority countries: opportunities amidst challenges. Curr Opin Pulm Med 2020; 26: 373–383.

36. Marincowitz C, Webster I, Westcott C, Goswami N, De Boever P, Seidel G et al. Cardiovascular Topics Vascular health assessment with flow-mediated dilatation and retinal image analysis: a pilot study in an adult population from Cape Town. CVJ Africa 2020; 31: 1–8.

37. Cardona Maya WD, Du Plessis SS, Velilla PA. SARS-CoV-2 and the testis: similarity with other viruses and routes of infection. Reprod. Biomed. Online. 2020; 40: 763–764.

38. Mentoor I, Nell T, Emjedi Z, van Jaarsveld PJ, de Jager L, Engelbrecht AM. Decreased Efficacy of Doxorubicin Corresponds With Modifications in Lipid Metabolism Markers and Fatty Acid Profiles in Breast Tumors From Obese vs. Lean Mice. Front Oncol 2020; 10: 306.

39. Millar DA, Bowles S, Windvogel SL, Louw J, Muller CJF. Effect of Rooibos ( Aspalathus linearis ) extract on atorvastatin‐induced toxicity in C3A liver cells. J Cell Physiol 2020; 235: 9487–9496.

40. Mishra H, Reeve BWP, Palmer Z, Caldwell J, Dolby T, Naidoo CC et al. Xpert MTB/RIF Ultra and Xpert MTB/RIF for diagnosis of tuberculosis in an HIV-endemic setting with a high burden of previous tuberculosis: a two-cohort diagnostic accuracy study. Lancet Respir Med 2020; 8: 368–382.

41. Nono Nankam PA, Mendham AE, Jaarsveld PJ, Adams K, Fortuin‐de Smidt MC, Clamp L et al. Exercise Training Alters Red Blood Cell Fatty Acid Desaturase Indices and Adipose Tissue Fatty Acid Profile in African Women with Obesity. Obesity 2020; 28: 1456–1466.

42. Nono Nankam PA, van Jaarsveld PJ, Chorell E, Fortuin-de Smidt MC, Adams K, Blüher M et al. Circulating and Adipose Tissue Fatty Acid Composition in Black South African Women with Obesity: A Cross-Sectional Study. Nutrients 2020; 12: 1619.

43. Ntamo Y, Samodien E, Muller CJF, Louw J, Chellan N. Popular three-dimensional models: Advantages for cancer, Alzheimer's and cardiovascular diseases. Tissue Cell. 2020; 65: 101367.

44. Omolaoye TS, Adeniji AA, Cardona Maya WD, du Plessis SS. SARS-COV-2 (Covid-19) and male fertility: Where are we? Reprod Toxicol 2021; 99: 65–70.

45. Omolaoye TS, du Plessis SS. Male infertility: A proximate look at the advanced glycation end products. Reprod. Toxicol. 2020; 93: 169–177.

46. Omolaoye TS, Du Plessis SS. The effect of streptozotocin induced diabetes on sperm function: a closer look at AGEs, RAGEs, MAPKs and activation of the apoptotic pathway. Toxicol Res 2021; 37: 35–46.

47. Pheiffer C, Dias S, Adam S. Intimate Partner Violence: A Risk Factor for Gestational Diabetes. Int J Environ Res Public Health 2020; 17: 7843.

48. Pheiffer C, Willmer T, Dias S, Abrahams Y, Louw J, Goedecke JH. Ethnic and Adipose Depot Specific Associations Between DNA Methylation and Metabolic Risk. Front Genet 2020; 11. doi:10.3389/fgene.2020.00967.

49. Sadie-Van Gijsen H, Kotzé-Hörstmann L, Huisamen B. An In Vivo/Ex Vivo Study Design to Investigate Effects of Chronic Conditions and Therapeutic Compounds on Adipose Stem Cells in Animal Models. In: Methods in Molecular Biology. Humana Press Inc., 2020, pp 101–118.

50. Sangweni NF, Moremane M, Riedel S, van Vuuren D, Huisamen B, Mabasa L et al. The Prophylactic Effect of Pinocembrin Against Doxorubicin-Induced Cardiotoxicity in an In Vitro H9c2 Cell Model. Front Pharmacol 2020; 11: 1172.

51. Shabalala SC, Dludla P V., Mabasa L, Kappo AP, Basson AK, Pheiffer C et al. The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling. Biomed. Pharmacother. 2020; 131: 110785.

52. Smit M, Coetzee AR, Lochner A. The Pathophysiology of Myocardial Ischemia and Perioperative Myocardial Infarction. J. Cardiothorac. Vasc. Anesth. 2020; 34: 2501–2512.

53. Smit SE, Manirafasha C, Marais E, Johnson R, Huisamen B. Cardioprotective Function of Green Rooibos (Aspalathus linearis) Extract Supplementation in Ex Vivo Ischemic Prediabetic Rat Hearts. Planta Med 2020. doi:10.1055/a-1239-9236.

54. Schalkwyk MS Van, Windvogel S, Strijdom H. Rooibos (Aspalathus linearis) protects against nicotine-induced vascular injury and oxidative stress in Wistar rats. Cardiovasc J Afr 2020; 31: 81–90.

55. Viraragavan A, Hlengwa N, De Beer D, Riedel S, Miller N, Bowles S et al. Model development for predicting: In vitro bio-capacity of green rooibos extract based on composition for application as screening tool in quality control. Food Funct 2020; 11: 3084–3094.

56. Xhakaza L, Abrahams-October Z, Mohammednur MM, Pearce B, Adeniyi OV, Johnson R et al. Socio-demographic and modifiable risk factors of diabetes and hypertension among resource constrained patients from rural areas in mdantsane township in South Africa. Afr Health Sci 2020; 20: 1344–1354.

57. Xhakaza L, Abrahams-October Z, Pearce B, Masilela CM, Adeniyi OV, Johnson R et al. Evaluation of the suitability of 19 pharmacogenomics biomarkers for individualized metformin therapy for type 2 diabetes patients. Drug Metab Pers Ther 2020. doi:10.1515/dmdi-2020-0111.

58. Yoshida T, Malherbe CJ, Okon K, Miura Y, Hattori M, Matsuda H et al. Enhanced production of Th1- and Th2-type antibodies and induction of regulatory T cells in mice by oral administration of Cyclopia extracts with similar phenolic composition to honeybush herbal tea. J Funct Foods 2020; 64: 103704.

59. Ziqubu K, Dludla P V., Joubert E, Muller CJF, Louw J, Tiano L et al. Isoorientin: A dietary flavone with the potential to ameliorate diverse metabolic complications. Pharmacol. Res. 2020; 158: 104867.

60. Windvogel S.  Rooibos ( Aspalathus linearis ) and Honeybush ( Cyclopia spp.): From Bush Teas to Potential Therapy for Cardiovascular Disease. In: Nutraceuticals - Past, Present and Future. IntechOpen, 2020 doi:10.5772/intechopen.86410.


1. ABULFATHI AA, DECLOEDT EH, SVENSSON EM, DIACON AH, DONALD PR, REUTER H. Clinical Pharmacokinetics and Pharmacodynamics of Rifampicin in Human Tuberculosis. CLINICAL PHARMACOKINETICS 2019; 58:1103-1129.

2. ADAMS KT, DONALD PR, ABULFATHI AA, DIACON AH, STANDER MA, REUTER H. Pharmacokinetics of ParaAminosalicylic Acid and Its 2 Major Metabolites: A Potential Relationship to the Development of Gastrointestinal Intolerance. JOURNAL OF CLINICAL PHARMACOLOGY 2019; 0(0) (1-6).

3. AGGERBECK H, RUHWALD M, HOFF ST, TINGSKOV PN, HELLSTROM E, MALAHLEHA M, SIEBERT M, GANI M, DIACON AH, ET AL (ENIGMA CONSORTIUM) C. Interaction between C-Tb and PPD given concomitantly in a split-body randomised controlled trial. International Journal of Tuberculosis and Lung Disease 2019; 23(1):38-44.

4. BERNER K, STRIJDOM JG, ESSOP MF, WEBSTER I, MORRIS LD, LOUW QA. Fall history and associated factors among adults living with HIV-1 in the Cape Winelands, South Africa: An exploratory investigation. Open Forum Infectious Diseases 2019; 6(10):ofz401, 7 pages.

5. BLIGNAUT M, ESPACH Y, VAN VUUREN MA, KARTHIK D, HUISAMEN B. Revisiting the Cardiotoxic Effect of Chloroquine. Cardiovascular Drugs and Therapy 2019; 33:s10557; 11 pages.

6. BLIGNAUT M, LOOS B, BOTCHWAY SW, PARKER AW, HUISAMEN B. Ataxia-Telangiectasia Mutated is located in cardiac mitochondria and impacts oxidative phosphorylation. Scientific Reports 2019; 9(4782):s41598;11 pages.

7. BOOYSEN E, SADIE-VAN GIJSEN H, DEANE SM, FERRIS WF, DICKS LMT. The effect of Vancomycin on the Viability and Osteogenic Potential of Bone-Derived Mesenchymal Stem Cells. Probiotics and Antimicrobial Proteins 2019; 11:1009-1014.

8. BULABULA ANH, NELSON JA, MUSAFIRI EM, MACHEKANO R, SAM-AGUDU NA, DIACON AH, SHAH M, CRESWELL J, THERON GDV, WARREN RM, JACOBSON KR, CHIRAMBIZA JP, KALUMUNA D, BISIMWA B, KATOTO PDMC, GROBUSCH MP, NACHEGA JB, ET AL. Prevalence, Predictors, and Successful Treatment outcomes of expert mtb/rif-identified rifampicin-resistant tuberculosis in post-conflict eastern democratic Republic of the Congo, 2012-2017: A Retrospective Province-Wide Cohort Study. Clinical Infectious Diseases 2019; 69(8):1278-1287.

9. CHRISTOWITZ C, DAVIS TA, ISAACS AW, VAN NIEKERK G, HATTINGH SM, ENGELBRECHT AM. Mechanisms of doxorubicin-induced drug resistance and drug resistant tumor growth in a murine breast tumour model. BMC CANCER 2019; 19(757):s12885; 10 pages.

10. CILLIERS K, MULLER CJF, PAGE B. Human Immunodeficiency Virus in Cadavers: A Review. CLINICAL ANATOMY 2019; 32:603-610.

11. DE SMIDT JJA, ODENDAAL HJ, NEL DG, NOLAN H, DU PLESSIS CA, BRINK LT, OELOFSE A. In utero teratogen exposure and cardiometabolic risk in 5-year-old children: a prospective pediatric study. Journal of Maternal-Fetal and Neonatal Medicine 2019; 24:1-10.

12. DIAS SC, ADAM S, RHEEDER P, LOUW J, PHEIFFER C. Altered Genome-Wide DNA Methylation in Peripheral Blood of South African Women with Gestational Diabetes Mellitus. International Journal of Molecular Sciences 2019; 20:5828;17 pages.

13. DIAS SC, ADAM S, RHEEDER P, PHEIFFER C. Prevalence of and risk factors for gestational diabetes mellitus in South Africa. SAMJ South African Medical Journal 2019; 109(7):463-677.

14. DIAS SC, PHEIFFER C, RHEEDER P, ADAM S. Screening and diagnosis of gestational diabetes mellitus in South Africa: What do we know so far. SAMJ South African Medical Journal 2019; 109(7):457-462.

15. DLUDLA PV, ORLANDO P, SILVESTRI S, MAZIBUKO-MBEJE S, JOHNSON R, MARCHEGGIANI F, CIRILLI I, MULLER CJF, LOUW J, OBONYE NJ, NYAWO TA, ET AL (ENIGMA CONSORTIUM) C. N-Acetyl cysteine ameliorates hyperglycemia-induced cardiomyocyte toxicity by improving mitochondrial energetics and enhancing endogenous Coenzyme Q9/10 levels. Toxicology Reports 2019; 6:1240-1245.

16. DRIESCHER N, JOSEPH DE, HUMAN VR, OJUKA E, COUR M, HADEBE N, BESTER DJ, MARNEWICK JL, LECOUR S, LOCHNER A, ESSOP MF. The impact of sugar-sweetened beverage intake on rat cardiac function. Heliyon 2019; 5:e01357; 28 pages.

17. DUBE KR, KARTHIK D, SALIE R, BLIGNAUT M, HUISAMEN B, LOCHNER A. Melatonin has profound effects on mitochondrial dynamics in myocardial ischaemia/reperfusion. Heliyon 2019; 5:e02659;19 pages.

18. Everson FP, DE BOEVER P, NAWROT TS, GOSWAMI N, MTHETHWA M, WEBSTER I, MARTENS DS, MASHELE N, CHARANIA S, KAMAU F, STRIJDOM JG. Personal NO2 and Volatile Organic Compounds Exposure Levels are Associated with Markers of Cardiovascular Risk in Women in the Cape Town Region of South Africa. International Journal of Environmental Research and Public Health 2019; 16:2284; 18 pages.

19. FRIEDRICH SO, KOLWIJCK E, KARINJA MN, VAN DER MERWE L, DIACON AH. Quantification of viable bacterial load in artificial sputum spiked with Mycobacterium tuberculosis. Tuberculosis 2019; 115:140-145.

20. GOSS DM, AYAD BM, VAN DER HORST G, SKOSANA BT, DU PLESSIS SS. Improved sperm motility after 4h of ejaculatory abstinence: role of accessory sex gland secretions. Reproduction, Fertility and Development 2019; 31(5):1009-1016.

21. HUANG SH, TSENG JC, LIN CY, KUO YY, WANG BJ, KAO YH, MULLER CJF, JOUBERT E, CHUU CP. Rooibos suppresses profileration of castration-resistant prostate cancer cells via inhibition of AKt signaling. PHYTOMEDICINE 2019; 64(0944-7113):1-10.

23. JACK BU, MALHERBE CJ, MAMUSHI MP, MULLER CJF, JOUBERT E, LOUW J, PHEIFFER C. Adipose tissue as a possible therapeutic target for polyphenols: a case for Cyclopia extracts as anti-abesity nutraceuticals. Biomedicine and Pharmacotherapy 2019; 120(0753-3322):0.

24. JOHNSON R, DLUDLA PV, MABHIDA SE, BENJEDDOU M, LOUW J, FEBRUARY MF. Pharmacogenomics of amlodipine and hydrochlorothiazide therapy and the quest for improved control of hypertension: a mini review. HEART FAILURE REVIEWS 2019; 24:343-357.

25. JOHNSON R, SANGWENI NF, MABHIDA SE, DLUDLA PV, MABASA L, RIEDEL-VAN HEERDEN SC, CHAPMAN C, MOSA RA, KAPPO AP, LOUW J, MULLER CJF. An In Vitro Study on the Combination Effect of Metformin and N-Acetyl Cysteine against Hyperglycaemia-Induced Cardiac Damage. Nutrients 2019; 11:2850;19 pages.

26.  F, STRIJDOM JG, MWANGI P, BLACKHURST D, IMPERIAL EG, SALIE R. Antiretroviral drug-induced endothelial dysfunction is improved by dual PPAR alpha/gamma stimulation in obesity. VASCULAR PHARMACOLOGY 2019; 121:106577; 11 pages.

27. KARTHIK D, HUISAMEN B, LOCHNER A. Mitochondrial oxidative phosphorylation and mitophagy in myocardial ischaemia/reperfusion: effects of chloroquine. Cardiovascular Journal of Africa 2019; 30:067; 11 pages.

28. KATOTO PDMC, BYAMUNGU L, BRAND AS, MOKAYA J, STRIJDOM JG, GOSWAMI N, DE BOEVER P, NAWROT TS, NEMERY B. Ambient air pollution and health in Sub-Saharan Africa: Current evidence, perspectives and a call to action. Environmental Research 2019; 173(July 2019):1-31.

29. LAYMAN J, PEREIRA DL, CHELLAN N, HUISAMEN B, KOTZE SH. A histomorphometric study on the hepatoprotective effects of a green rooibos extract in a diet-induced obese rat model. Acta Histochemica 2019; 121:646-656.

30. LOURENS M, PHILIPS L, KLEINHANS C, FRIEDRICH SO, MARTINSON N, VENTER A, VAN DER MERWE L, DIACON AH. Liquid mycobacterial culture outcomes after different sputum collection techniques before and during treatment. Tuberculosis 2019; 116:17-21.

31. MAARMAN GJ. Cardioprotection conferred by rooibos (Aspalathus linearis): A mini review to highlight a potential mechanism of action. South African Journal of Science 2019; 115(7/8):4653, 4 pages.

32. MABASA L, SAMODIEN E, SANGWENI NF, PHEIFFER C, LOUW J, JOHNSON R. In Utero One-Carbon Metabolism Interplay and Metabolic Syndrome in Cardiovascular Disease Risk Reduction. Molecular Nutrition and Food Research 2019; 13:e1900377; 11 pages.

33. MABHIDA SE, JOHNSON R, NDLOVU M, LOUW J, OPOKU AR, MOSA RA. Molecular basis of the anti-hyperglycemic activity of RA-3 in hyperlipidemic and streptozotocin-induced type 2 diabetes in rats. Diabetology and Metabolic Syndrome 2019; 11(27):s13098; 5 pages.

34. MARINCOWITZ MEC, GENIS A, GOSWAMI N, DE BOEVER P, NAWROT TS, STRIJDOM JG. Vascular endothelial dysfunction in the wake of HIV and ART. FEBS Journal 2019; 286:1256-1270.

35. MAZIBUKO SE, DLUDLA PV, JOHNSON R, JOUBERT E, LOUW J, ZIQUBU K, TIANO L, SILVESTRI S, ORLANDO P, OPOKU AR, MULLER CJF. Aspalathin, a natural product with the potential to reverse hepatic insulin resistance by improving energy metabolism and mitochondrial respiration. PLoS One 2019; 14(5):e0216172;16pages.

36. MAZIBUKO SE, DLUDLA PV, ROUX C, JOHNSON R, GHOOR S, JOUBERT E, LOUW J, OPOKU AR, MULLER CJF. Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways. International Journal of Molecular Sciences 2019; 20:633; 16 pages.

37. NIESLER CU, VAN DE VYVER M, MYBURGH KH. Cellular regenerative therapy for acquired non-congenital musculoskeletal disorders. SAMJ South African Medical Journal 2019; 109(8):59-64.

38. ORLANDO P, CHELLAN N, LOUW J, TIANO L, CIRILLI I, DLUDLA PV, JOUBERT E, MULLER CJF. Aspalathin-Rich Green Rooibos Extract Lowers LDL-Cholestrol and Oxidative Status in High-Fat Diet-Induced Diabetic Vervet Monkeys. Molecules 2019; 24:0.

39. PATEL O, MULLER CJF, JOUBERT E, ROSENKRANZ BF, TAYLOR MJC, LOUW J, AWORTWE C. Pharmacokinetic Interaction of Green Rooibos Extract With Atorvastatin and Metformin in Rats. Frontiers in Pharmacology 2019; 10:doi: 10.3389/fphar.2019.01243 (1-8).

40. PHEIFFER C, DIAS SC, RHEEDER P, ADAM S. MicroRNA Profiling in HIV-Infected South African Women with Gestational Diabetes Mellitus. Molecular Diagnosis & Therapy 2019; 23:499-505.

41. RODGERS AL, JAPPIE-MAHOMED D, VAN JAARSVELD PJ. Testing the dogma that total phospholipid fatty acid composition of blood plays a role in kidney stone pathogenesis, using a high-low risk human model: results from a pilot study. Urolithiasis 2019; 47:255-261.

42. SADIE-VAN GIJSEN H. Adipocyte biology: it is time to upgrade to a new model. JOURNAL OF CELLULAR PHYSIOLOGY 2019; 234:2399-2425.

43. SADIE-VAN GIJSEN H. The Regulation of Marrow Fat by Vitamin D: Molecular Mechanisms and Clinical Implications. Current Osteoporosis Reports 2019; 17:405-415.

44. SALIE R, ALSALHIN AKH, MARAIS E, LOCHNER A. Cardioprotective Effects of Beta3-Adrenergic Receptor (Beta3-AR) Pre-, Per-, and Post -treatment in Ischemia-Reperfusion. Cardiovascular Drugs and Therapy 2019; 33:163-177.

45. SAMODIEN E, JOHNSON R, PHEIFFER C, MABASA L, ERASMUS M, LOUW J, CHELLAN N. Diet-induced hypothalamic dysfunction and metabolic disease and the therapeutic potential of polyphenols. Molecular Metabolism 2019; 27:s2212;10 pages.

46. SAMODIEN E, PHEIFFER C, ERASMUS M, MABASA L, LOUW J, JOHNSON R. Diet-induced DNA methylation within the hypothalamic arcuate nucleus and dysregulated leptin and insulin signalling in the pathophysiology of obesity. Food Science & Nutrition 2019; 7:3131-3145.

47. SANGWENI NF, DLUDLA PV, MOSA RA, KAPPO AP, OPOKU AR, MULLER CJF, JOHNSON R. Lanosteryl triterpenes from Protorhus longifolia as a cardioprotective agent: a mini review. HEART FAILURE REVIEWS 209; 24:155-166.

48. SHABALALA S, DLUDLA PV, MULLER CJF, NXELE X, KAPPO AP, LOUW J, JOHNSON R. Aspalathin ameliorates doxorubicin-induced oxidative stress in H9c2 cardiomyoblasts. Toxicology in Vitro 2019; 55:134-139.

49. SHAW JA, DIACON AH, KOEGELENBERG CFN. Tuberculosis pleural effusion. RESPIROLOGY 2019; 24:962-971.

50. SVENSSON EM, DU BOIS J, KITSHOFF R, DE JAGER V, WIESNER L, NORMAN J, NACHMAN S, SMITH B, DIACON AH, HESSELING AC, GARCIA-PRATS AJ. Relative bioavailability of bedaquiline tablets suspended in water: implications for dosing in children. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 2019; 84:2384-2392.


52. TWEED CD, CROOK AM, DAWSON R, DIACON AH, MCHUGH TD, MENDEL CM, MEREDITH SK, MOHAPI L, MURPHY ME, ET AL (ENIGMA CONSORTIUM) C. Toxicity related to standard TB therapy for pulmonary tuberculosis and treatment outcomes in the REMoxTB study according to HIV status. BMC Pulmonary Medicine 2019; 19(152):s12890; 9 pages.

53. TWEED CD, DAWSON R, BURGER DA, CONRADIE A, CROOK AM, MENDEL CM, CONRADIE F, DIACON AH, NTINGINYA E, ET AL (ENIGMA CONSORTIUM) C. Bedaquiline, moxifloxacin, pretomanid and pyrazinamide during the first 8 weeks of treatment of patients with drug-susceptible or drug-resistant pulmonary tuberculosis: a multicentre, open-label, partially randomised, phase 2b trial. Lancet Respiratory Medicine 2019; 7:1048-1058.

54. WARREN RM, ISMAIL N, CHEGOU NN, THERON GDV, WALZL G, MALHERBE ST, KINNEAR CJ, VAN DER SPUY GD, GOOSEN WJ, MILLER MA, DIACON AH, VAN HELDEN PD. Tuberculosis research in South Africa over the past 30 years: From bench to bedside. SAMJ South African Medical Journal 2019; 109(11):45-52.

55. WEBSTER I, IMPERIAL EG, WESTCOTT C, STRIJDOM JG. The cardiovascular effects of Aspalathus linearis supplementation in male Wistar rats receiving fixed-dose combination first-line antiretroviral therapy. Cardiovascular Journal of Africa 2019; 30(2):95-102.


HUISAMEN B, VAN VUUREN MA, PHEIFFER C. Medicinal Effects of Agathosma (Buchu) Extracts. Aosis, Cape Town, South Africa 2019:108 pp.

Book Chapters

1. MAARMAN GJ. Molecular Nutrition Carbohydrates. Elsevier, 2019:442 pp.​

2. MAARMAN GJ. Oxidative Stress in Heart Disease. Springer, Singapore. 2019:596 pp.


Journal Articles

  1. ​​Agarwal, A., Sharma, R., Henkel, R., Roychoudhury, S., Sikka, S.C., du Plessis, S., Sarda, Y.B., Speyer, C., Nouh, M., Douglas, C., Kayali, Z., Elshaer, A., Sabanegh, E., 2018. Cumene hydroperoxide induced changes in oxidation-reduction potential in fresh and frozen seminal ejaculates. Andrologia 50, e12796.​
  2. Aggerbeck, H., Ruhwald, M., Hoff, S.T., Borregaard, B., Hellstrom, E., Malahleha, M., Siebert, M., Gani, M., Seopela, V., Diacon, A., Lourens, M., Andersen, P., Dheda, K., 2018. C-Tb skin test to diagnose Mycobacterium tuberculosis infection in children and HIV-infected adults: A phase 3 trial. PLoS One 13, e0204554.
  3. Arokoyo, Dennis Seyi, Oyeyipo, I.P., Du Plessis, S.S., Aboua, Y.G., 2018. Antioxidant Activities of Basella alba Aqueous Leave Extract In Blood, Pancreas, and Gonadal Tissues of Diabetic Male Wistar Rats. Pharmacognosy Res. 10, 31–36.
  4. Arokoyo, Dennis S, Oyeyipo, I.P., Du Plessis, S.S., Chegou, N.N., Aboua, Y.G., 2018. Modulation of Inflammatory Cytokines and Islet Morphology as Therapeutic Mechanisms of Basella alba in Streptozotocin-Induced Diabetic Rats. Toxicol. Res. 34, 325–332.
  5. Augustine, T.N., Cairns, C.J., Chetty, S., Dannatt, L.G., Gravett, N., Grey, G., Grobler, G., Jafta, Z., Kamerman, P., Lopes, J., Matsabisa, M.G., Mugabo, P., Mulder, M., Parry, C., Rataemane, S., Siegfried, N., Steenkamp, V., Thomas, E., Van Zyl-Smit, R., 2018. Priority areas for cannabis and cannabinoid product research in South Africa. African J. Prim. Heal. Care Fam. Med. 10, 1–3.
  6. Ayad, Bashir M, Horst, G. Van der, Plessis, S.S. Du, 2018. Revisiting The Relationship between The Ejaculatory Abstinence Period and Semen Characteristics. Int. J. Fertil. Steril. 11, 238–246.
  7. Ayad, Bashir M., Van der Horst, G., du Plessis, S.S., 2018. Short abstinence: A potential strategy for the improvement of sperm quality. Middle East Fertil. Soc. J. 23, 37–43.
  8. Cerf, M., 2018a. Cardiac Glucolipotoxicity and Cardiovascular Outcomes. Medicina (B. Aires). 54, 70.
  9. Cerf, M., 2018b. High Fat Programming and Cardiovascular Disease. Medicina (B. Aires). 54, 86.
  10. Chimhashu, T., Malan, L., Baumgartner, J., van Jaarsveld, P.J., Galetti, V., Moretti, D., Smuts, C.M., Zimmermann, M.B., 2018. Sensitivity of fatty acid desaturation and elongation to plasma zinc concentration: a randomised controlled trial in Beninese children. Br. J. Nutr. 119, 610–619.
  11. Dludla, P.V., Gabuza, K.B., Muller, C.J.F., Joubert, E., Low, J., Johnson, R., 2018. Aspalathin, a C-glucosyl Dihydrochalcone From Rooibos Improves the Hypoglycemic Potential of Metformin in Type 2 Diabetic (db/db) Mice. Physiol. Res. 67, 813–818.
  12. Dludla, Phiwayinkosi V., Dias, S.C., Obonye, N., Johnson, R., Louw, J., Nkambule, B.B., 2018a. A Systematic Review on the Protective Effect of N-Acetyl Cysteine Against Diabetes-Associated Cardiovascular Complications. Am. J. Cardiovasc. Drugs 18, 283–298.
  13. Dludla, Phiwayinkosi V., Jack, B., Viraragavan, A., Pheiffer, C., Johnson, R., Louw, J., Muller, C.J.F., 2018b. A dose-dependent effect of dimethyl sulfoxide on lipid content, cell viability and oxidative stress in 3T3-L1 adipocytes. Toxicol. Reports 5, 1014–1020.
  14. Donald, P.R., Diacon, A.H., Lange, C., Demers, A.-M., von Groote-Biddlingmeier, F., Nardell, E., 2018. Droplets, dust and guinea pigs: an historical review of tuberculosis transmission research, 1878–1940. Int. J. Tuberc. Lung Dis. 22, 972–982.
  15. Everson, F., Genis, A., Ogundipe, T., Boever, P. De, Goswami, N., Lochner, A., Blackhurst, D., Id, H.S., 2018. Treatment with a fixed dose combination antiretroviral therapy drug containing tenofovir , emtricitabine and efavirenz is associated with cardioprotection in high calorie diet-induced obese rats 1–27.
  16. Goedecke, J.H., Mendham, A.E., Clamp, L., Nono Nankam, P.A., Fortuin-de Smidt, M.C., Phiri, L., Micklesfield, L.K., Keswell, D., Woudberg, N.J., Lecour, S., Alhamud, A., Kaba, M., Lutomia, F.M., van Jaarsveld, P.J., de Villiers, A., Kahn, S.E., Chorell, E., Hauksson, J., Olsson, T., 2018. An Exercise Intervention to Unravel the Mechanisms Underlying Insulin Resistance in a Cohort of Black South African Women: Protocol for a Randomized Controlled Trial and Baseline Characteristics of Participants. JMIR Res. Protoc. 7, e75.
  17. Govender, J., Loos, B., Marais, E., Engelbrecht, A.-M., 2018. Melatonin improves cardiac and mitochondrial function during doxorubicin-induced cardiotoxicity: A possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin activity? Toxicol. Appl. Pharmacol. 358, 86–101.
  18. Govindsamy, A., Naidoo, S., Cerf, M.E., 2018. Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease. J. Nutr. Metab. 2018, 1–12.
  19. Jack, B., Malherbe, C., Willenburg, E., de Beer, D., Huisamen, B., Joubert, E., Muller, C., Louw, J., Pheiffer, C., 2018. Polyphenol-Enriched Fractions of Cyclopia intermedia Selectively Affect Lipogenesis and Lipolysis in 3T3-L1 Adipocytes. Planta Med. 84, 100–110.
  20. Johnson, R., Beer, D. de, Dludla, P., Ferreira, D., Muller, C., Joubert, E., 2018. Aspalathin from Rooibos (Aspalathus linearis): A Bioactive C-glucosyl Dihydrochalcone with Potential to Target the Metabolic Syndrome. Planta Med. 84, 568–583.
  21. Kruger, M.J., Conradie, M.M., Conradie, M., Van De Vyver, M., 2018. ADSC-conditioned media elicit an ex vivo anti-inflammatory macrophage response. J. Mol. Endocrinol. 61, 173–184.
  22. Lange, C., Alghamdi, W.A., Al-Shaer, M.H., Brighenti, S., Diacon, A.H., DiNardo, A.R., Grobbel, H.P., Gröschel, M.I., von Groote-Bidlingmaier, F., Hauptmann, M., Heyckendorf, J., Köhler, N., Kohl, T.A., Merker, M., Niemann, S., Peloquin, C.A., Reimann, M., Schaible, U.E., Schaub, D., Schleusener, V., Thye, T., Schön, T., 2018. Perspectives for personalized therapy for patients with multidrug-resistant tuberculosis. J. Intern. Med. 284, 163–188.
  23. Levine, H., Mohri, H., Ekbom, A., Ramos, L., Parker, G., Roldan, E., Jovine, L., Koelle, S., Lindstrand, A., Immler, S., Mortimer, S., Mortimer, D., van der Horst, G., Ishijima, S., Aneck-Hahn, N., Baldi, E., Menkveld, R., Rothmann, S.A., Giwercman, A., Giwercman, Y., Holmberg, M., Kvist, U., Björndahl, L., Holmberg, R., Arver, S., Flanagan, J., Drevet, J.R., 2018. Male reproductive health statement (XIIIth international symposium on Spermatology, may 9th–12th 2018, Stockholm, Sweden. Basic Clin. Androl. 28, 13.
  24. Lochner, A., Marais, E., Huisamen, B., 2018. Melatonin and cardioprotection against ischaemia/reperfusion injury: What's new? A review. J. Pineal Res. 65, e12490.
  25. Lumkwana, D., Botha, A., Samodien, E., Hanser, S., Lopes, J., 2017. Laminin, laminin-entactin and extracellular matrix are equally appropriate adhesive substrates for isolated adult rat cardiomyocyte culture and experimentation. Cell Adh. Migr. 1–9.
  26. Mabhida, Sihle E., Dludla, P. V., Johnson, R., Ndlovu, M., Louw, J., Opoku, A.R., Mosa, R.A., 2018. Protective effect of triterpenes against diabetes-induced β-cell damage: An overview of in vitro and in vivo studies. Pharmacol. Res. 137, 179–192.
  27. Mabhida, Sihle Ephraim, Johnson, R., Ndlovu, M., Sangweni, N.F., Louw, J., Opoku, A., Mosa, R.A., 2018. A Lanosteryl triterpene from Protorhus longifolia augments insulin signaling in type 1 diabetic rats. BMC Complement. Altern. Med. 18, 265.
  28. Mehrbani Azar, Y., Green, R., Niesler, C.U., van de Vyver, M., 2018. Antioxidant Preconditioning Improves the Paracrine Responsiveness of Mouse Bone Marrow Mesenchymal Stem Cells to Diabetic Wound Fluid. Stem Cells Dev. 27, 1646–1657.
  29. Mentoor, I., Engelbrecht, A.-M., van Jaarsveld, P.J., Nell, T., 2018. Chemoresistance: Intricate Interplay Between Breast Tumor Cells and Adipocytes in the Tumor Microenvironment. Front. Endocrinol. (Lausanne). 9, 758.
  30. Mondloch, S.J., Tanumihardjo, S.A., Davis, C.R., van Jaarsveld, P.J., 2018. Hepatic Vitamin A Concentrations in Vervets ( Chlorocebus aethiops ) Supplemented with Carotenoids Derived from Oil Palm. J. Am. Assoc. Lab. Anim. Sci. 57, 456–464.
  31. Murakami, S., Miura, Y., Hattori, M., Matsuda, H., Malherbe, C., Muller, C., Joubert, E., Yoshida, T., 2018. Cyclopia Extracts Enhance Th1-, Th2-, and Th17-type T Cell Responses and Induce Foxp3+ Cells in Murine Cell Culture. Planta Med. 84, 311–319.
  32. Omolaoye, T.S., Skosana, B.T., du Plessis, S.S., 2018. Diabetes mellitus- induction: Effect of different streptozotocin doses on male reproductive parameters. Acta Histochem. 120, 103–109.
  33. Ordoqui, R., Barrera, N., Montes, J.M., Canepa, M., Bonelli, C., Surka, C., Torrens, A., Cantú, L., Plessis, S.S. du, 2018. A retrospective study on sperm banking: a Uruguayan experience. JBRA Assist. Reprod. 22, 82–88.
  34. Oyeyipo, I.P., Skosana, B.T., Everson, F.P., Strijdom, H., du Plessis, S.S., 2018. Highly Active Antiretroviral Therapy Alters Sperm Parameters and Testicular Antioxidant Status in Diet-Induced Obese Rats. Toxicol. Res. 34, 41–48.
  35. Peloquin, C.A., Phillips, P.P.J., Mitnick, C.D., Eisenach, K., Patientia, R.F., Lecca, L., Gotuzzo, E., Gandhi, N.R., Butler, D., Diacon, A.H., Martel, B., Santillan, J., Hunt, K.R., Vargas, D., von Groote-Bidlingmaier, F., Seas, C., Dianis, N., Moreno-Martinez, A., Kaur, P., Horsburgh, C.R., 2018. Increased Doses Lead to Higher Drug Exposures of Levofloxacin for Treatment of Tuberculosis. Antimicrob. Agents Chemother. 62.
  36. Pheiffer, C., Pillay-van Wyk, V., Joubert, J.D., Levitt, N., Nglazi, M.D., Bradshaw, D., 2018. The prevalence of type 2 diabetes in South Africa: a systematic review protocol. BMJ Open 8, e021029.
  37. Puerta Suárez, J., du Plessis, S.S., Cardona Maya, W.D., 2018. Spermatozoa: A Historical Perspective. Int. J. Fertil. Steril. 12, 182–190.
  38. Shaw, J.A., Irusen, E.M., Diacon, A.H., Koegelenberg, C.F., 2018. Pleural tuberculosis: A concise clinical review. Clin. Respir. J. 12, 1779–1786.
  39. Smit, S., Johnson, R., Van Vuuren, M., Huisamen, B., 2018. Myocardial Glucose Clearance by Aspalathin Treatment in Young, Mature, and Obese Insulin-Resistant Rats. Planta Med. 84, 75–82.
  40. Svensson, Elin M., du Bois, J., Kitshoff, R., de Jager, V.R., Wiesner, L., Norman, J., Nachman, S., Smith, B., Diacon, A.H., Hesseling, A.C., Garcia-Prats, A.J., 2018. Relative bioavailability of bedaquiline tablets suspended in water: Implications for dosing in children. Br. J. Clin. Pharmacol. 84, 2384–2392.
  41. Svensson, Elin M, Svensson, R.J., te Brake, L.H.M., Boeree, M.J., Heinrich, N., Konsten, S., Churchyard, G., Dawson, R., Diacon, A.H., Kibiki, G.S., Minja, L.T., Ntingiya, N.E., Sanne, I., Gillespie, S.H., Hoelscher, M., Phillips, P.P.J., Simonsson, U.S.H., Aarnoutse, R., 2018. The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis. Clin. Infect. Dis. 67, 34–41.
  42. Svensson, R.J., Aarnoutse, R.E., Diacon, A.H., Dawson, R., Gillespie, S.H., Boeree, M.J., Simonsson, U.S.H., 2018. A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses. Clin. Pharmacol. Ther. 103, 674–683.
  43. Svensson, R.J., Svensson, E.M., Aarnoutse, R.E., Diacon, A.H., Dawson, R., Gillespie, S.H., Moodley, M., Boeree, M.J., Simonsson, U.S.H., 2018. Greater Early Bactericidal Activity at Higher Rifampicin Doses Revealed by Modeling and Clinical Trial Simulations. J. Infect. Dis. 218, 991–999.
  44. Temidayo, So., Stefan, S.P., 2018. Diabetes mellitus and male infertility. Asian Pacific J. Reprod. 7, 6.
  45. Thomas, M., Davis, T., Loos, B., Sishi, B., Huisamen, B., Strijdom, H., Engelbrecht, A.-M., 2018. Autophagy is essential for the maintenance of amino acids and ATP levels during acute amino acid starvation in MDAMB231 cells. Cell Biochem. Funct. 36, 65–79.
  46. Truter, D., Chellan, N., Strijdom, H., Webster, I., Rawstorne, J., Kotzé, S.H., 2018. Histomorphological changes in the pancreas and kidney and histopathological changes in the liver in male Wistar rats on antiretroviral therapy and melatonin treatment. Acta Histochem. 120, 347–355.
  47. Tweed, Conor D., Crook, A.M., Amukoye, E.I., Dawson, R., Diacon, A.H., Hanekom, M., McHugh, T.D., Mendel, C.M., Meredith, S.K., Murphy, M.E., Murthy, S.E., Nunn, A.J., Phillips, P.P.J., Singh, K.P., Spigelman, M., Wills, G.H., Gillespie, S.H., 2018. Toxicity associated with tuberculosis chemotherapy in the REMoxTB study. BMC Infect. Dis. 18, 317.
  48. Tweed, Conor Duncan, Wills, G.H., Crook, A.M., Dawson, R., Diacon, A.H., Louw, C.E., McHugh, T.D., Mendel, C., Meredith, S., Mohapi, L., Murphy, M.E., Murray, S., Murthy, S., Nunn, A.J., Phillips, P.P.J., Singh, K., Spigelman, M., Gillespie, S.H., 2018. Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study. BMC Med. 16, 46.
  49. van der Horst, G., Maree, L., du Plessis, S.S., 2018. Current perspectives of CASA applications in diverse mammalian spermatozoa. Reprod. Fertil. Dev. 30, 875.
  50. Van Der Meeren, O., Hatherill, M., Nduba, V., Wilkinson, R.J., Muyoyeta, M., Van Brakel, E., Ayles, H.M., Henostroza, G., Thienemann, F., Scriba, T.J., Diacon, A., Blatner, G.L., Demoitié, M.-A., Tameris, M., Malahleha, M., Innes, J.C., Hellström, E., Martinson, N., Singh, T., Akite, E.J., Khatoon Azam, A., Bollaerts, A., Ginsberg, A.M., Evans, T.G., Gillard, P., Tait, D.R., 2018. Phase 2b Controlled Trial of M72/AS01 E Vaccine to Prevent Tuberculosis. N. Engl. J. Med. 379, 1621–1634.
  51. Willmer, T., Johnson, R., Louw, J., Pheiffer, C., 2018. Blood-Based DNA Methylation Biomarkers for Type 2 Diabetes: Potential for Clinical Applications. Front. Endocrinol. (Lausanne). 9, 744.​


Journal Articles

  1. Alsultan, A., Furin, J.J., Du Bois, J., van Brakel, E., Chheng, P., Venter, A., Thiel, B., Debanne, S.A., Boom, W.H., Diacon, A.H., Johnson, J.L., Peloquin, C.A., 2017. Population Pharmacokinetics of AZD-5847 in Adults with Pulmonary Tuberculosis. Antimicrob. Agents Chemother. 61.
  2. Ayad, B.M., Horst, G. Van der, Plessis, S.S. Du, 2018. Revisiting The Relationship between The Ejaculatory Abstinence Period and Semen Characteristics. Int. J. Fertil. Steril. 11, 238–246.

  3. Boeree, M.J., Heinrich, N., Aarnoutse, R., Diacon, A.H., Dawson, R., Rehal, S., Kibiki, G.S., Churchyard, G., Sanne, I., Ntinginya, N.E., Minja, L.T., Hunt, R.D., Charalambous, S., Hanekom, M., Semvua, H.H., Mpagama, S.G., Manyama, C., Mtafya, B., Reither, K., Wallis, R.S., Venter, A., Narunsky, K., Mekota, A., Henne, S., Colbers, A., van Balen, G.P., Gillespie, S.H., Phillips, P.P.J., Hoelscher, M., 2017. High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial. Lancet Infect. Dis. 17, 39–49.
  4. Bouton, T.C., Phillips, P.P.J., Mitnick, C.D., Peloquin, C.A., Eisenach, K., Patientia, R.F., Lecca, L., Gotuzzo, E., Gandhi, N.R., Butler, D., Diacon, A.H., Martel, B., Santillan, J., Hunt, K.R., Vargas, D., von Groote-Bidlingmaier, F., Seas, C., Dianis, N., Moreno-Martinez, A., Horsburgh, C.R., 2017. An optimized background regimen design to evaluate the contribution of levofloxacin to multidrug-resistant tuberculosis treatment regimens: study protocol for a randomized controlled trial. Trials 18, 563.
  5. Bowles, S., Joubert, E., de Beer, D., Louw, J., Brunschwig, C., Njoroge, M., Lawrence, N., Wiesner, L., Chibale, K., Muller, C., 2017. Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin. Molecules 22, 554.
  6. De Jager, V., van der Merwe, L., Venter, A., Donald, P.R., Diacon, A.H., 2017. Time Trends in Sputum Mycobacterial Load and Two-Day Bactericidal Activity of Isoniazid-Containing Antituberculosis Therapies. Antimicrob. Agents Chemother. 61.
  7. Dludla, P., Muller, C., Joubert, E., Louw, J., Essop, M., Gabuza, K., Ghoor, S., Huisamen, B., Johnson, R., 2017. Aspalathin Protects the Heart against Hyperglycemia-Induced Oxidative Damage by Up-Regulating Nrf2 Expression. Molecules 22, 129.
  8. Dludla, P. V., Essop, M.F., Gabuza, K.B., Muller, C.J.F., Louw, J., Johnson, R., 2017a. Age-dependent development of left ventricular wall thickness in type 2 diabetic (db/db) mice is associated with elevated low-density lipoprotein and triglyceride serum levels. Heart Vessels 32, 1025–1031.
  9. Dludla, P. V., Joubert, E., Muller, C.J.F., Louw, J., Johnson, R., 2017b. Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside. Nutr. Metab. (Lond). 14, 45.
  10. Dludla, P. V., Nkambule, B.B., Dias, S.C., Johnson, R., 2017c. Cardioprotective potential of N-acetyl cysteine against hyperglycaemia-induced oxidative damage: a protocol for a systematic review. Syst. Rev. 6, 96.
  11. Jack, B.U., Malherbe, C.J., Huisamen, B., Gabuza, K., Mazibuko-Mbeje, S., Schulze, A.E., Joubert, E., Muller, C.J.F., Louw, J., Pheiffer, C., 2017. A polyphenol-enriched fraction of Cyclopia intermedia decreases lipid content in 3T3-L1 adipocytes and reduces body weight gain of obese db/db mice. South African J. Bot. 110, 216–229.
  12. Johnson, R., Dludla, P., Muller, C., Huisamen, B., Essop, M., Louw, J., 2017a. The Transcription Profile Unveils the Cardioprotective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model. Molecules 22, 219.
  13. Johnson, R., Shabalala, S., Louw, J., Kappo, A., Muller, C., 2017b. Aspalathin Reverts Doxorubicin-Induced Cardiotoxicity through Increased Autophagy and Decreased Expression of p53/mTOR/p62 Signaling. Molecules 22, 1589.
  14. Kayigire, X.A., Friedrich, S.O., van der Merwe, L., Diacon, A.H., 2017. Acquisition of Rifampin Resistance in Pulmonary Tuberculosis. Antimicrob. Agents Chemother. 61.
  15. Kistan, J., Laher, F., Otwombe, K., Panchia, R., Mawaka, N., Lebina, L., Diacon, A., Kana, B., Martinson, N., 2017. Pulmonary TB: varying radiological presentations in individuals with HIV in Soweto, South Africa. Trans. R. Soc. Trop. Med. Hyg. 111, 132–136.
  16. Lalinde-Acevedo, P.C., Mayorga-Torres, B.J.M., Agarwal, A., du Plessis, S.S., Ahmad, G., Cadavid, Á.P., Cardona Maya, W.D., 2017. Physically Active Men Show Better Semen Parameters than Their Sedentary Counterparts. Int. J. Fertil. Steril. 11, 156–165.
  17. Nduhirabandi, F., Huisamen, B., Strijdom, H., Lochner, A., Barbara, H., 2017. Role of melatonin in glucose uptake by cardiomyocytes from insulin-resistant Wistar rats. Cardiovasc. J. Afr. 28, 362–369.
  18. Nel, S., Strijdom, H., Genis, A., Everson, F., Van Wijk, R., Kotzé, S.H., 2017. A histomorphometric study on the effects of antiretroviral therapy (ART) combined with a high-calorie diet (HCD) on aortic perivascular adipose tissue (PVAT). Acta Histochem. 119, 555–562.
  19. Oyeyipo, I.P., van der Linde, M., du Plessis, S.S., 2017. Environmental Exposure of Sperm Sex-Chromosomes: A Gender Selection Technique. Toxicol. Res. 33, 315–323.
  20. Patten, V., Chabaesele, I., Sishi, B., Van Vuuren, D., 2017. Cardiomyocyte differentiation: Experience and observations from 2 laboratories. SA Hear. 14, 96–107.
  21. Salie, R., Lochner, A., Loubser, D.J., 2017. The significance of the washout period in preconditioning. Cardiovasc. Ther. 35, e12252.
  22. Shabalala, S., Muller, C.J.F., Louw, J., Johnson, R., 2017. Polyphenols, autophagy and doxorubicin-induced cardiotoxicity. Life Sci. 180, 160–170.
  23. Strijdom, H., De Boever, P., Walzl, G., Essop, M.F., Nawrot, T.S., Webster, I., Westcott, C., Mashele, N., Everson, F., Malherbe, S.T., Stanley, K., Kessler, H.H., Stelzl, E., Goswami, N., 2017. Cardiovascular risk and endothelial function in people living with HIV/AIDS: Design of the multi-site, longitudinal EndoAfrica study in the Western Cape Province of South Africa. BMC Infect. Dis. 17, 1–9.
  24. Svensson, R.J., Aarnoutse, R.E., Diacon, A.H., Dawson, R., Gillespie, S.H., Boeree, M.J., Simonsson, U.S.H., 2017. A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses. Clin. Pharmacol. Ther. 103, 674–683.
  25. Truter, D., Strijdom, H., Everson, F., Kotzé, S.H., 2017. Mucin secreting cells in the stomach and colon are altered by combination antiretroviral treatment in an obese rat model. Acta Histochem. 119, 122–128.
  26. van Niekerk, G., Davids, L.M., Hattingh, S.M., Engelbrecht, A.-M., 2017. Cancer stem cells: A product of clonal evolution? Int. J. Cancer 140, 993–999.
  27. Walters, E., Demers, A.-M., van der Zalm, M.M., Whitelaw, A., Palmer, M., Bosch, C., Draper, H.R., Gie, R.P., Hesseling, A.C., 2017. Stool Culture for Diagnosis of Pulmonary Tuberculosis in Children. J. Clin. Microbiol. 55, 3355–3365.
  28. Webster, I., Salie, R., Marais, E., Fan, W.-J., Maarman, G., Huisamen, B., Lochner, A., 2017. Myocardial susceptibility to ischaemia/reperfusion in obesity: a re-evaluation of the effects of age. BMC Physiol. 17, 3.
  29. Webster, Ingrid, Smith, A., Lochner, A., Huisamen, B., 2017. The Role of MKP-1 in Insulin-Induced Cardioprotection. Cardiovasc. Drugs Ther. 31, 247–254.
  30. Westcott, C., Genis, A., Mthethwa, M., Graham, R., Van Vuuren, D., Huisamen, B., Strijdom, H., 2017. Fenofibrate protects endothelial cells against the harmful effects of TNF-alpha. SAHeart 14, 22–34.​


Journal Articles

  1. Agarwal, A., Gupta, S., Du Plessis, S., Sharma, R., Esteves, S.C., Cirenza, C., Eliwa, J., Al-Najjar, W., Kumaresan, D., Haroun, N., Philby, S., Sabanegh, E., 2016a. Abstinence Time and Its Impact on Basic and Advanced Semen Parameters. Urology 94, 102–110.
  2. Agarwal, A., Sharma, R., Roychoudhury, S., Du Plessis, S., Sabanegh, E., 2016b. MiOXSYS: a novel method of measuring oxidation reduction potential in semen and seminal plasma. Fertil. Steril. 106, 566-573.e10.
  3. Bernasconi, M., Diacon, A.H., Koegelenberg, C.F.N., 2016. Stair Climbing Test Streamlines the Evaluation of Nonmalignant Lung Resection Candidates. Respiration 91, 87–88.
  4. Demers, A.-M., Venter, A., Friedrich, S.O., Rojas-Ponce, G., Mapamba, D., Jugheli, L., Sasamalo, M., Almeida, D., Dorasamy, A., Jentsch, U., Gibson, M., Everitt, D., Eisenach, K.D., Diacon, A.H., 2016. Direct Susceptibility Testing of Mycobacterium tuberculosis for Pyrazinamide by Use of the Bactec MGIT 960 System. J. Clin. Microbiol. 54, 1276–81.
  5. Dludla, P., Muller, C., Joubert, E., Louw, J., Gabuza, K., Huisamen, B., Essop, M., Johnson, R., 2016. Phenylpyruvic Acid-2-O-β-D-Glucoside Attenuates High Glucose-Induced Apoptosis in H9c2 Cardiomyocytes. Planta Med. 82, 1468–1474.
  6. Franzen, D., Diacon, A.H., Freitag, L., Schubert, P.T., Wright, C.A., Schuurmans, M.M., 2016. Ultrathin bronchoscopy for solitary pulmonary lesions in a region endemic for tuberculosis: a randomised pilot trial. BMC Pulm. Med. 16, 62.
  7. Furin, J., Alirol, E., Allen, E., Fielding, K., Merle, C., Abubakar, I., Andersen, J., Davies, G., Dheda, K., Diacon, A., Dooley, K.E., Dravnice, G., Eisenach, K., Everitt, D., Ferstenberg, D., Goolam-Mahomed, A., Grobusch, M.P., Gupta, R., Harausz, E., Harrington, M., Horsburgh, C.R., Lienhardt, C., McNeeley, D., Mitnick, C.D., Nachman, S., Nahid, P., Nunn, A.J., Phillips, P., Rodriguez, C., Shah, S., Wells, C., Thomas-Nyang'wa, B., du Cros, P., 2016. Drug-resistant tuberculosis clinical trials: proposed core research definitions in adults. Int. J. Tuberc. Lung Dis. 20, 290–294.
  8. Furin, J.J., Du Bois, J., van Brakel, E., Chheng, P., Venter, A., Peloquin, C.A., Alsultan, A., Thiel, B.A., Debanne, S.M., Boom, W.H., Diacon, A.H., Johnson, J.L., 2016. Early Bactericidal Activity of AZD5847 in Patients with Pulmonary Tuberculosis. Antimicrob. Agents Chemother. 60, 6591–6599.
  9. Goss, D., Oyeyipo, I.P., Skosana, B.T., Ayad, B.M., du Plessis, S.S., 2016. Ameliorative potentials of quercetin against cotinine-induced toxic effects on human spermatozoa. Asian Pacific J. Reprod. 5, 193–197.
  10. Huisamen, B., George, C., Genade, S., Dietrich, D., 2016a. Cardioprotective and anti-hypertensive effects of Prosopis glandulosa in rat models of pre-diabetes. South African J. Diabetes Vasc. Dis. 13, 61–67.
  11. Huisamen, B., Hafver, T.L., Lumkwana, D., Lochner, A., 2016b. The Impact of Chronic Glycogen Synthase Kinase-3 Inhibition on Remodeling of Normal and Pre-Diabetic Rat Hearts. Cardiovasc. Drugs Ther. 30, 237–246.
  12. Jayakumar, A., Savic, R.M., Everett, C.K., Benator, D., Alland, D., Heilig, C.M., Weiner, M., Friedrich, S.O., Martinson, N.A., Kerrigan, A., Zamudio, C., Goldberg, S. V, Whitworth, W.C., Davis, J.L., Nahid, P., 2016. Xpert MTB/RIF Assay Shows Faster Clearance of Mycobacterium tuberculosis DNA with Higher Levels of Rifapentine Exposure. J. Clin. Microbiol. 54, 3028–3033.
  13. Johnson, R., Dludla, P., Joubert, E., February, F., Mazibuko, S., Ghoor, S., Muller, C., Louw, J., 2016. Aspalathin, a dihydrochalcone C -glucoside, protects H9c2 cardiomyocytes against high glucose induced shifts in substrate preference and apoptosis. Mol. Nutr. Food Res. 60, 922–934.
  14. Jordaan, A.E., 2016. The effects of the wild african potato (hypoxis hemerocallidea) supplementation on streptozotocin-induced diabetic wistar rats reproductive function. Andrology 5, 1000165.
  15. Kayigire, X.A., Friedrich, S.O., Karinja, M.N., van der Merwe, L., Martinson, N.A., Diacon, A.H., 2016. Propidium monoazide and Xpert MTB/RIF to quantify Mycobacterium tuberculosis cells. Tuberculosis 101, 79–84.
  16. Lückhoff, H.K., Kidd, M., van Rensburg, S.J., van Velden, D.P., Kotze, M.J., 2016. Apolipoprotein E genotyping and questionnaire-based assessment of lifestyle risk factors in dyslipidemic patients with a family history of Alzheimer's disease: test development for clinical application. Metab. Brain Dis. 31, 213–224.
  17. Mfokazi, A., Wright, C.A., Louw, M., Von Groote-Bidlingmaier, F., Schubert, P.T., Koegelenberg, C.F.N., Diacon, A.H., 2016. Direct comparison of liquid-based and smear-based cytology with and without rapid on-site evaluation for fine needle aspirates of thoracic tumors. Diagn. Cytopathol. 44, 363–368.
  18. Phillips, P.P.J., Dooley, K.E., Gillespie, S.H., Heinrich, N., Stout, J.E., Nahid, P., Diacon, A.H., Aarnoutse, R.E., Kibiki, G.S., Boeree, M.J., Hoelscher, M., 2016a. A new trial design to accelerate tuberculosis drug development: the Phase IIC Selection Trial with Extended Post-treatment follow-up (STEP). BMC Med. 14, 51.
  19. Phillips, P.P.J., Mendel, C.M., Burger, D.A., Crook, A.M., Nunn, A.J., Dawson, R., Diacon, A.H., Gillespie, S.H., 2016b. Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials. BMC Med. 14, 19.
  20. Pym, A.S., Diacon, A.H., Tang, S.-J., Conradie, F., Danilovits, M., Chuchottaworn, C., Vasilyeva, I., Andries, K., Bakare, N., De Marez, T., Haxaire-Theeuwes, M., Lounis, N., Meyvisch, P., Van Baelen, B., van Heeswijk, R.P.G., Dannemann, B., TMC207-C209 Study Group, 2016. Bedaquiline in the treatment of multidrug- and extensively drug-resistant tuberculosis. Eur. Respir. J. 47, 564–74.
  21. van Niekerk, G., Davids, L.M., Hattingh, S.M., Engelbrecht, A.-M., 2017. Cancer stem cells: A product of clonal evolution? Int. J. Cancer 140, 993–999.
  22. van Niekerk, G., Hattingh, S.M., Engelbrecht, A.-M., 2016. Enhanced Therapeutic Efficacy in Cancer Patients by Short-term Fasting: The Autophagy Connection. Front. Oncol. 6, 242.
  23. van Vuuren, D., Marais, E., Genade, S., Lochner, A., 2016. The differential effects of FTY720 on functional recovery and infarct size following myocardial ischaemia/reperfusion. Cardiovasc. J. Afr. 27, 375–386.​


Journal Articles

  1. Boeree, M.J., Diacon, A.H., Dawson, R., Narunsky, K., Du Bois, J., Venter, A., Phillips, P.P.J., Gillespie, S.H., McHugh, T.D., Hoelscher, M., Heinrich, N., Rehal, S., Van Soolingen, D., Van Ingen, J., Magis-Escurra, C., Burger, D., Van Balen, G.P., Aarnoutse, R.E., 2015. A dose-ranging trial to optimize the dose of rifampin in the treatment of tuberculosis. Am. J. Respir. Crit. Care Med. 191, 1058–1065.
  2. Bowness, R., Boeree, M.J., Aarnoutse, R., Dawson, R., Diacon, A., Mangu, C., Heinrich, N., Ntinginya, N.E., Kohlenberg, A., Mtafya, B., Phillips, P.P.J., Rachow, A., Plemper van Balen, G., Gillespie, S.H., 2015. The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations. J. Antimicrob. Chemother. 70, 448–455.
  3. Dawson, R., Diacon, A.H., Everitt, D., van Niekerk, C., Donald, P.R., Burger, D.A., Schall, R., Spigelman, M., Conradie, A., Eisenach, K., Venter, A., Ive, P., Page-Shipp, L., Variava, E., Reither, K., Ntinginya, N.E., Pym, A., von Groote-Bidlingmaier, F., Mendel, C.M., 2015. Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase 2b, open-label, partly randomised trial in patients with drug-susceptible or drug-resistant pulmonary tuberculosis. Lancet 385, 1738–1747.
  4. De Wet, D.R., Wright, C.A., Schubert, P.T., Koegelenberg, C.F.N., Louw, M., Diacon, A.H., 2015. Mediastinal granulomatous lymphadenitis in a population at risk for HIV and tuberculosis. Diagn. Cytopathol. 43, 696–700.
  5. Diacon, A.H., Dawson, R., Von Groote-Bidlingmaier, F., Symons, G., Venter, A., Donald, P.R., Van Niekerk, C., Everitt, D., Hutchings, J., Burger, D.A., Schall, R., Mendel, C.M., 2015. Bactericidal activity of pyrazinamide and clofazimine alone and in combinations with pretomanid and bedaquiline. Am. J. Respir. Crit. Care Med. 191, 943–953.
  6. Donald, P.R., Diacon, A.H., 2015. Para-aminosalicylic acid: the return of an old friend. Lancet Infect. Dis. 15, 1091–1099.
  7. du Plessis, Stefan S, Agarwal, A., Mohanty, G., van der Linde, M., 2015. Oxidative phosphorylation versus glycolysis: what fuel do spermatozoa use? Asian J. Androl. 17, 230–5.
  8. du Plessis, Stefan S., Agarwal, A., Syriac, A., 2015. Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility. J. Assist. Reprod. Genet. 32, 1575–1588.
  9. Espach, Y., Lochner, A., Strijdom, H., Huisamen, B., 2015. ATM Protein Kinase Signaling, Type 2 Diabetes and Cardiovascular Disease. Cardiovasc. Drugs Ther. 29, 51–58.
  10. George, C, Dietrich, D., Huisamen, B., 2015. The Effect of Chronic Prosopis glandulosa Treatment on Muscle Force Development and Fatigue Tolerance in Soleus Muscle. Br. J. Appl. Sci. Technol. 10, 1–10.
  11. George, Cindy, Smith, C., Isaacs, A., Huisamen, B., 2015. Chronic Prosopis Glandulosa Treatment Blunts Neutrophil Infiltration and Enhances Muscle Repair after Contusion Injury. Nutrients 7, 815–830.
  12. Harlev, A., Agarwal, A., Gunes, S.O., Shetty, A., du Plessis, S.S., 2015. Smoking and Male Infertility: An Evidence-Based Review. World J. Mens. Health 33, 143.
  13. Heinrich, N., Dawson, R., du Bois, J., Narunsky, K., Horwith, G., Phipps, A.J., Nacy, C.A., Aarnoutse, R.E., Boeree, M.J., Gillespie, S.H., Venter, A., Henne, S., Rachow, A., Phillips, P.P.J., Hoelscher, M., Diacon, A.H., Mekota, A.M., Heinrich, N., Rachow, A., Saathoff, E., Hoelscher, M., Gillespie, S., Colbers, A., van Balen, G.P., Aarnoutse, R., Boeree, M., Bateson, A., McHugh, T., Singh, K., Hunt, R., Zumla, A., Nunn, A., Phillips, P., Rehal, S., Dawson, R., Narunsky, K., Diacon, A., du Bois, J., Venter, A., Friedrich, S., Sanne, I., Mellet, K., Churchyard, G., Charalambous, S., Mwaba, P., Elias, N., Mangu, C., Rojas-Ponce, G., Mtafya, B., Maboko, L., Minja, L.T., Sasamalo, M., Reither, K., Jugheli, L., Sam, N., Kibiki, G., Semvua, H., Mpagama, S., Alabi, A., Adegnika, A.A., Amukoye, E., Okwera, A., 2015. Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients. J. Antimicrob. Chemother. 70, 1558–1566.
  14. Karinja, M.N., Esterhuizen, T.M., Friedrich, S.O., Diacon, A.H., 2015. Sputum volume predicts sputum mycobacterial load during the first 2 weeks of antituberculosis treatment. J. Clin. Microbiol. 53, 1087–91.
  15. Kayigire, X.A., Friedrich, S.O., van der Merwe, L., Donald, P.R., Diacon, A.H., 2015. Simultaneous staining of sputum smears for acid-fast and lipid-containing Myobacterium tuberculosis can enhance the clinical evaluation of antituberculosis treatments. Tuberculosis 95, 770–779.
  16. Koegelenberg, C.F.N., Irusen, E.M., von Groote-Bidlingmaier, F., Bruwer, J.W., Batubara, E.M.A., Diacon, A.H., 2015. The utility of ultrasound-guided thoracentesis and pleural biopsy in undiagnosed pleural exudates. Thorax 70, 995–7.
  17. Mayorga-Torres, B.J.M., Camargo, M., Agarwal, A., du Plessis, S.S., Cadavid, Á.P., Cardona Maya, W.D., 2015. Influence of ejaculation frequency on seminal parameters. Reprod. Biol. Endocrinol. 13, 47.
  18. Oyeyipo, I.P., Maartens, P.J., du Plessis, S.S., 2015. Diet-induced obesity alters kinematics of rat spermatozoa. Asian Pacific J. Reprod. 4, 235–239.
  19. Rullas, J., Dhar, N., McKinney, J.D., García-Pérez, A., Lelievre, J., Diacon, A.H., Hugonnet, J.-E., Arthur, M., Angulo-Barturen, I., Barros-Aguirre, D., Ballell, L., 2015. Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection. Antimicrob. Agents Chemother. 59, 4997–9.
  20. Slabbert, M., du Plessis, S.S., Huyser, C., 2015. Large volume cryoprotectant-free vitrification: an alternative to conventional cryopreservation for human spermatozoa. Andrologia 47, 594–599.
  21. Solomons, R.S., Visser, D.H., Friedrich, S.O., Diacon, A.H., Hoek, K.G.P., Marais, B.J., Schoeman, J.F., van Furth, A.M., 2015. Improved diagnosis of childhood tuberculous meningitis using more than one nucleic acid amplification test. Int. J. Tuberc. Lung Dis. 19, 74–80.
  22. Sy, S.K.B., de Kock, L., Diacon, A.H., Werely, C.J., Xia, H., Rosenkranz, B., van der Merwe, L., Donald, P.R., 2015. N-acetyltransferase genotypes and the pharmacokinetics and tolerability of para-aminosalicylic acid in patients with drug-resistant pulmonary tuberculosis. Antimicrob. Agents Chemother. 59, 4129–38.
  23. Vorster, M.J., Allwood, B.W., Diacon, A.H., Koegelenberg, C.F.N., 2015. Tuberculous pleural effusions: advances and controversies. J. Thorac. Dis. 7, 981–91.​


Journal Articles

  1. Agarwal, A., Durairajanayagam, D., du Plessis, S.S., 2014a. Utility of antioxidants during assisted reproductive techniques: an evidence-based review. Reprod. Biol. Endocrinol. 12, 112.
  2. Agarwal, A., Virk, G., Ong, C., du Plessis, S.S., 2014b. Effect of Oxidative Stress on Male Reproduction. World J. Mens. Health 32, 1.
  3. Bowness, R., Boeree, M.J., Aarnoutse, R., Dawson, R., Diacon, A., Mangu, C., Heinrich, N., Ntinginya, N.E., Kohlenberg, A., Mtafya, B., Phillips, P.P.J., Rachow, A., Plemper van Balen, G., Gillespie, S.H., 2015. The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations. J. Antimicrob. Chemother. 70, 448–455.
  4. Chellan, N., Joubert, E., Strijdom, H., Roux, C., Louw, J., Muller, C., 2014. Aqueous Extract of Unfermented Honeybush (Cyclopia maculata) Attenuates STZ-induced Diabetes and β-cell Cytotoxicity. Planta Med. 80, 622–629.
  5. de Kock, L., Sy, S.K.B., Rosenkranz, B., Diacon, A.H., Prescott, K., Hernandez, K.R., Yu, M., Derendorf, H., Donald, P.R., 2014. Pharmacokinetics of para-aminosalicylic acid in HIV-uninfected and HIV-coinfected tuberculosis patients receiving antiretroviral therapy, managed for multidrug-resistant and extensively drug-resistant tuberculosis. Antimicrob. Agents Chemother. 58, 6242–50.
  6. Diacon, A.H., Pym, A., Grobusch, M.P., de los Rios, J.M., Gotuzzo, E., Vasilyeva, I., Leimane, V., Andries, K., Bakare, N., De Marez, T., Haxaire-Theeuwes, M., Lounis, N., Meyvisch, P., De Paepe, E., van Heeswijk, R.P.G., Dannemann, B., 2014a. Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline. N. Engl. J. Med. 371, 723–732.
  7. Diacon, A.H., van der Merwe, L., Demers, A.-M., von Groote-Bidlingmaier, F., Venter, A., Donald, P.R., 2014b. Time to positivity in liquid culture predicts colony forming unit counts of Mycobacterium tuberculosis in sputum specimens. Tuberculosis 94, 148–151.
  8. Diacon, A.H., van der Merwe, L., Demers, A.-M., Von Groote-Bidlingmaier, F., Venter, A., Donald, P.R., 2014c. Pre-treatment mycobacterial sputum load influences individual on-treatment measurements. Tuberculosis 94, 690–694.
  9. Dludla, P.V., Muller, C.J.F., Louw, J., Joubert, E., Salie, R., Opoku, A.R., Johnson, R., 2014. The cardioprotective effect of an aqueous extract of fermented rooibos (Aspalathus linearis) on cultured cardiomyocytes derived from diabetic rats. Phytomedicine 21, 595–601.
  10. Donald, P.R., Diacon, A.H., 2008. The early bactericidal activity of anti-tuberculosis drugs: a literature review. Tuberculosis 88, S75–S83.
  11. Flint, M., du Plessis, S.S., Menkveld, R., 2014. Revisiting the assessment of semen viscosity and its relationship to leucocytospermia. Andrologia 46, 837–841.
  12. Govender, J., Loos, B., Marais, E., Engelbrecht, A.-M., 2014. Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin. J. Pineal Res. 57, 367–380.
  13. Kibleur, Y., Brochart, H., Schaaf, H.S., Diacon, A.H., Donald, P.R., 2014. Dose Regimen of Para-Aminosalicylic Acid Gastro-Resistant Formulation (PAS-GR) in Multidrug-Resistant Tuberculosis. Clin. Drug Investig. 34, 269–276.
  14. Kolwijck, E., Friedrich, S.O., Karinja, M.N., van Ingen, J., Warren, R.M., Diacon, A.H., 2014. Early stationary phase culture supernatant accelerates growth of sputum cultures collected after initiation of anti-tuberculosis treatment. Clin. Microbiol. Infect. 20, O418–O420.
  15. Lampiao, F., Huussen, J., Plessis, S.D., 2014. Effects of Nitric Oxide Exposure on Human Sperm Function and Apoptosis Markers. Open Reprod. Sci. J. 6, 17–20.
  16. Nduhirabandi, F., Huisamen, B., Strijdom, H., Blackhurst, D., Lochner, A., 2014. Short-term melatonin consumption protects the heart of obese rats independent of body weight change and visceral adiposity. J. Pineal Res. 57, 317–332.
  17. Salie, R., Huisamen, B., Lochner, A., 2014. High carbohydrate and high fat diets protect the heart against ischaemia/reperfusion injury. Cardiovasc. Diabetol. 13, 109.
  18. Slabbert, M., du Plessis, S.S., Huyser, C., 2015. Large volume cryoprotectant-free vitrification: an alternative to conventional cryopreservation for human spermatozoa. Andrologia 47, 594–599.
  19. Solomons, R.S., Visser, D.H., Friedrich, S.O., Diacon, A.H., Hoek, K.G.P., Marais, B.J., Schoeman, J.F., van Furth, A.M., 2015. Improved diagnosis of childhood tuberculous meningitis using more than one nucleic acid amplification test. Int. J. Tuberc. Lung Dis. 19, 74–80.
  20. Streicher, E.M., Maharaj, K., York, T., Van Heerden, C., Barnard, M., Diacon, A., Mendel, C.M., Bosman, M.E., Hepple, J.A., Pym, A.S., Warren, R.M., van Helden, P.D., 2014. Rapid sequencing of the Mycobacterium tuberculosis pncA gene for detection of pyrazinamide susceptibility. J. Clin. Microbiol. 52, 4056–7.
  21. Van Rensburg, A., Neethling, G.S., Schubert, P.T., Koegelenberg, C.F.N., Wright, C.A., Bolliger, C.T., Bernasconi, M., Diacon, A.H., 2014. Impact of routine sputum cytology in a population at high risk for bronchial carcinoma. Int. J. Tuberc. Lung Dis. 18, 607–612.
  22. Wallis, R.S., Dawson, R., Friedrich, S.O., Venter, A., Paige, D., Zhu, T., Silvia, A., Gobey, J., Ellery, C., Zhang, Y., Eisenach, K., Miller, P., Diacon, A.H., 2014. Mycobactericidal Activity of Sutezolid (PNU-100480) in Sputum (EBA) and Blood (WBA) of Patients with Pulmonary Tuberculosis. PLoS One 9, e94462.
  23. Webster, I., Smith, A., Lochner, A., Huisamen, B., 2014. Sanguinarine Non- Versus Re-Circulation During Isolated Heart Perfusion - A Jekyll and Hyde Effect? Cardiovasc. Drugs Ther. 28, 489–491.
  24. Zhu, T., Friedrich, S.O., Diacon, A., Wallis, R.S., 2014. Population pharmacokinetic/pharmacodynamic analysis of the bactericidal activities of sutezolid (PNU-100480) and its major metabolite against intracellular Mycobacterium tuberculosis in ex vivo whole-blood cultures of patients with pulmonary tuberculosis. Antimicrob. Agents Chemother. 58, 3306–11.​

Journal Articles
  1. Brundyn, K., Koegelenberg, C.F.N., Diacon, A.H., Louw, M., Schubert, P., Bolliger, C.T., van den Heuvel, M.M., Wright, C.A., 2013. Transbronchial fine needle aspiration biopsy and rapid on-site evaluation in the setting of superior vena cava syndrome. Diagn. Cytopathol. 41, 324–329.
  2. Dawson, R., Diacon, A., 2013. PA-824, moxifloxacin and pyrazinamide combination therapy for tuberculosis. Expert Opin. Investig. Drugs 22, 927–932.
  3. Diacon, A.H., Dawson, R., Von Groote-Bidlingmaier, F., Symons, G., Venter, A., Donald, P.R., Conradie, A., Erondu, N., Ginsberg, A.M., Egizi, E., Winter, H., Becker, P., Mendel, C.M., 2013a. Randomized dose-ranging study of the 14-day early bactericidal activity of bedaquiline (TMC207) in patients with sputum microscopy smear-positive pulmonary tuberculosis. Antimicrob. Agents Chemother. 57, 2199–203.
  4. Diacon, A.H., Donald, P.R., Mendel, C.M., 2013b. Early bactericidal activity of new drug regimens for tuberculosis - Authors' reply. Lancet (London, England) 381, 112–3.
  5. Dooley, K.E., Nuermberger, E.L., Diacon, A.H., 2013. Pipeline of drugs for related diseases: tuberculosis. Curr. Opin. HIV AIDS 8, 579–85.
  6. Du Plessis, S., Gokul, S., Agarwal, A., 2013. Semen hyperviscosity: causes, consequences, and cures. Front. Biosci. 5, 224–231.
  7. Flepisi, T.B., Lochner, A., Huisamen, B., 2013. The Consequences of Long-Term Glycogen Synthase Kinase-3 Inhibition on Normal and Insulin Resistant Rat Hearts. Cardiovasc. Drugs Ther. 27, 381–392.
  8. Flint, M., Du Plessis, S.S., 2013. Trichomonas vaginalis in Sub-Saharan Africa : occurrence and diagnostic approaches for the male partner. Med. Technol. SA 27, 26–28.
  9. Friedrich, S.O., Rachow, A., Saathoff, E., Singh, K., Mangu, C.D., Dawson, R., Phillips, P.P., Venter, A., Bateson, A., Boehme, C.C., Heinrich, N., Hunt, R.D., Boeree, M.J., Zumla, A., McHugh, T.D., Gillespie, S.H., Diacon, A.H., Hoelscher, M., 2013. Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment. Lancet Respir. Med. 1, 462–470.
  10. Hamada, A., Sharma, R., du Plessis, S.S., Willard, B., Yadav, S.P., Sabanegh, E., Agarwal, A., 2013. Two-dimensional differential in-gel electrophoresis–based proteomics of male gametes in relation to oxidative stress. Fertil. Steril. 99, 1216-1226.e2.
  11. Huisamen, B., George, C., Dietrich, D., Genade, S., 2013. Cardioprotective and anti-hypertensive effects of Prosopis glandulosa in rat models of pre-diabetes. Cardiovasc. J. Afr. 24, 10–6.
  12. Kayigire, X.A., Friedrich, S.O., Venter, A., Dawson, R., Gillespie, S.H., Boeree, M.J., Heinrich, N., Hoelscher, M., Diacon, A.H., Pan African Consortium for the Evaluation of Anti-tuberculosis Antibiotics, 2013. Direct comparison of Xpert MTB/RIF assay with liquid and solid mycobacterial culture for quantification of early bactericidal activity. J. Clin. Microbiol. 51, 1894–8.
  13. Koegelenberg, C.F.N., Diacon, A.H., 2013. Image-guided pleural biopsy. Curr. Opin. Pulm. Med. 19, 368–373.
  14. Kolwijck, E., Mitchell, M., Venter, A., Friedrich, S.O., Dawson, R., Diacon, A.H., 2013. Short-term storage does not affect the quantitative yield of Mycobacterium tuberculosis in sputum in early-bactericidal-activity studies. J. Clin. Microbiol. 51, 1094–8.
  15. Lampiao, F., Du Plessis, S., 2013. New developments of the effect of melatonin on reproduction. World J. Obstet. Gynecol. 2, 15–22.
  16. Liwa, A.C., Schaaf, H.S., Rosenkranz, B., Seifart, H.I., Diacon, A.H., Donald, P.R., 2013. Para-Aminosalicylic Acid Plasma Concentrations in Children in Comparison with Adults after Receiving a Granular Slow-Release Preparation. J. Trop. Pediatr. 59, 90–94.
  17. Lochner, A., Huisamen, B., Nduhirabandi, F., 2013. Cardioprotective effect of melatonin against ischaemia/reperfusion damage. Front. Biosci. 5, 305–315.
  18. Mor, Z., Leventhal, A., Diacon, A.H., Finger, R., Schoch, O.D., 2013. Tuberculosis screening in immigrants from high-prevalence countries: Interview first or chest radiograph first? A pro/con debate. Respirology 18, 432–438.
  19. Sharma, R., Agarwal, A., Mohanty, G., Du Plessis, S.S., Gopalan, B., Willard, B., Yadav, S.P., Sabanegh, E., 2013a. Proteomic analysis of seminal fluid from men exhibiting oxidative stress. Reprod. Biol. Endocrinol. 11, 85.
  20. Sharma, R., Agarwal, A., Mohanty, G., Hamada, A.J., Gopalan, B., Willard, B., Yadav, S., du Plessis, S., 2013b. Proteomic analysis of human spermatozoa proteins with oxidative stress. Reprod. Biol. Endocrinol. 11, 48.
  21. von Groote-Bidlingmaier, F., Koegelenberg, C.F., Bolliger, C.T., Chung, P.K., Rautenbach, C., Wasserman, E., Bernasconi, M., Friedrich, S.O., Diacon, A.H., 2013. The yield of different pleural fluid volumes for Mycobacterium tuberculosis culture. Thorax 68, 290–1.​

Journal Articles
  1. Aboua, Y.G., Brooks, N., Mahfouz, R.Z., Agarwal, A., du Plessis, S.S., 2012. A red palm oil diet can reduce the effects of oxidative stress on rat spermatozoa. Andrologia 44, 32–40.
  2. Bernasconi, M., Koegelenberg, C.F.N., von Groote-Bidlingmaier, F., Maree, D., Barnard, B.J., Diacon, A.H., Bolliger, C.T., 2012. Speed of Ascent During Stair Climbing Identifies Operable Lung Resection Candidates. Respiration 84, 117–122.
  3. Carr, I.M., Koegelenberg, C.F.N., von Groote-Bidlingmaier, F., Mowlana, A., Silos, K., Haverman, T., Diacon, A.H., Bolliger, C.T., 2012. Blood Loss during Flexible Bronchoscopy: A Prospective Observational Study. Respiration 84, 312–318.
  4. Chellan, N., Muller, C.J.F., de Beer, D., Joubert, E., Page, B.J., Louw, J., 2012. An in vitro assessment of the effect of Athrixia phylicoides DC. aqueous extract on glucose metabolism. Phytomedicine 19, 730–736.
  5. Diacon, A., von, G.-B., Donald, P., 2012. From Magic Mountain to Table Mountain. Swiss Med. Wkly. 142.
  6. Diacon, Andreas H, Dawson, R., du Bois, J., Narunsky, K., Venter, A., Donald, P.R., van Niekerk, C., Erondu, N., Ginsberg, A.M., Becker, P., Spigelman, M.K., 2012a. Phase II dose-ranging trial of the early bactericidal activity of PA-824. Antimicrob. Agents Chemother. 56, 3027–31.
  7. Diacon, Andreas H, Dawson, R., von Groote-Bidlingmaier, F., Symons, G., Venter, A., Donald, P.R., van Niekerk, C., Everitt, D., Winter, H., Becker, P., Mendel, C.M., Spigelman, M.K., 2012b. 14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial. Lancet 380, 986–993.
  8. Diacon, A H, Donald, P.R., Pym, A., Grobusch, M., Patientia, R.F., Mahanyele, R., Bantubani, N., Narasimooloo, R., De Marez, T., van Heeswijk, R., Lounis, N., Meyvisch, P., Andries, K., McNeeley, D.F., 2012. Randomized pilot trial of eight weeks of bedaquiline (TMC207) treatment for multidrug-resistant tuberculosis: long-term outcome, tolerability, and effect on emergence of drug resistance. Antimicrob. Agents Chemother. 56, 3271–6.
  9. Khullar, K., Agarwal, A., du Plessis, S., 2012. A hormonal, physical, and proteomic view of obesity-induced effects on male infertility and possible lifestyle modifications. Asian Pacific J. Reprod. 1, 161–168.
  10. Louw, M., Brundyn, K., Schubert, P.T., Wright, C.A., Bolliger, C.T., Diacon, A.H., 2012. Comparison of the quality of smears in transbronchial fine-needle aspirates using two staining methods for rapid on-site evaluation. Diagn. Cytopathol. 40, 777–781.
  11. Maarman, G., Marais, E., Lochner, A., du Toit, E.F., 2012. Effect of Chronic CPT-1 Inhibition on Myocardial Ischemia-Reperfusion Injury (I/R) in a Model of Diet-Induced Obesity. Cardiovasc. Drugs Ther. 26, 205–216.
  12. Mudau, M., Genis, A., Lochner, A., Strijdom, H., 2012. Endothelial dysfunction: the early predictor of atherosclerosis. Cardiovasc. J. Afr. 23, 222–231.
  13. Nduhirabandi, F., du Toit, E.F., Lochner,  a., 2012. Melatonin and the metabolic syndrome: A tool for effective therapy in obesity-associated abnormalities? Acta Physiol. 205, 209–223.
  14. Rengan, A.K., Agarwal, A., van der Linde, M., du Plessis, S.S., 2012. An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet. Reprod. Biol. Endocrinol. 10, 92.
  15. Sadie-Van Gijsen, H., Smith, W., du Toit, E.F., Michie, J., Hough, F.S., Ferris, W.F., 2012. Depot-specific and hypercaloric diet-induced effects on the osteoblast and adipocyte differentiation potential of adipose-derived stromal cells. Mol. Cell. Endocrinol. 348, 55–66.
  16. Salie, R., Moolman, J.A., Lochner, A., 2012. The mechanism of beta-adrenergic preconditioning: roles for adenosine and ROS during triggering and mediation. Basic Res. Cardiol. 107, 281.
  17. Strijdom, H., 2012. Endothelial dysfunction: are we ready to heed the vasculature's early-warning signal? Cardiovasc. J. Afr. 23, 184–5.
  18. van Jaarsveld, F.P., Hattingh, S., 2016. Rapid Induction of Ageing Character in Brandy Products. Ageing and General Overview. South African J. Enol. Vitic. 33.
  19. Walters, E., Gie, R.P., Hesseling, A.C., Friedrich, S.O., Diacon, A.H., Gie, R.P., 2012. Rapid Diagnosis of Pediatric Intrathoracic Tuberculosis From Stool Samples Using the Xpert MTB/RIF Assay. Pediatr. Infect. Dis. J. 31, 1316.
  20. Webster, I., Du Toit, E.F., Huisamen, B., Lochner, A., 2012. The effect of creatine supplementation on myocardial function, mitochondrial respiration and susceptibility to ischaemia/reperfusion injury in sedentary and exercised rats. Acta Physiol. 206, 6–19.​


Journal Articles
  1. Awoniyi, D., Aboua, Y., Marnewick, J., Plesis, S. du, Brooks, N., 2011. Protective effects of rooibos (Aspalathus linearis), green tea (Camellia sinensis) and commercial supplements on testicular tissue of oxidative stress-induced rats. AFRICAN J. Biotechnol. 10, 17317–17322.
  2. Bernasconi, M., Bolliger, C.T., Irusen, E., Diacon, A.H., 2011. A Left Hemithorax Mystery. Respiration 82, 557–559.
  3. Clark, C., Smith, W., Lochner, A., Toit, E.F.D., 2011. The effects of gender and obesity on myocardial tolerance to ischemia. Physiol. Res. 60, 291–301.
  4. Diacon, A. H., Dawson, R., Hanekom, M., Narunsky, K., Venter, A., Hittel, N., Geiter, L.J., Wells, C.D., Paccaly, A.J., Donald, P.R., 2011. Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients. Int. J. Tuberc. Lung Dis. 15, 949–954.
  5. Diacon, Andreas H., Maritz, J.S., Donald, P.R., 2011. Chapter 21: Early Bactericidal Activity of Antituberculosis Agents. Karger Publishers, pp. 213–219.
  6. du Plessis, S., Agarwal, A., 2011. Taking the stress out of ART induced oxidative stress. ACE Newsl. Focus 2, 11–14.
  7. DU PLESSIS, S.S., KASHOU, A., VAAMONDE, D., AGARWA, A., 2011. Is There a Link between Exercise and Male Factor Infertility? Open Reprod. Sci. J. 3, 105–113.
  8. du Plessis, S.S., Kashou, A.H., Benjamin, D.J., Yadav, S.P., Agarwal, A., 2011. Proteomics: a subcellular look at spermatozoa. Reprod. Biol. Endocrinol. 9, 36.
  9. Essop, M.F., Chan, W.A., Hattingh, S., 2011. Proteomic analysis of mitochondrial proteins in a mouse model of type 2 diabetes. Cardiovasc. J. Afr. 22, 175–8.
  10. Friedrich, S.O., Venter, A., Kayigire, X.A., Dawson, R., Donald, P.R., Diacon, A.H., 2011a. Suitability of Xpert MTB/RIF and genotype MTBDRplus for patient selection for a tuberculosis clinical trial. J. Clin. Microbiol. 49, 2827–31.
  11. Friedrich, S.O., von Groote-Bidlingmaier, F., Diacon, A.H., 2011b. Xpert MTB/RIF assay for diagnosis of pleural tuberculosis. J. Clin. Microbiol. 49, 4341–2.
  12. George, C., Lochner, A., Huisamen, B., 2011. The efficacy of Prosopis glandulosa as antidiabetic treatment in rat models of diabetes and insulin resistance. J. Ethnopharmacol. 137, 298–304.
  13. Huisamen, Barbara, Genis, A., Marais, E., Lochner, A., 2011. Pre-treatment with a DPP-4 Inhibitor is Infarct Sparing in Hearts from Obese, Pre-diabetic Rats. Cardiovasc. Drugs Ther. 25, 13–20.
  14. Huisamen, B., Pêrel, S.J.C., Friedrich, S.O., Salie, R., Strijdom, H., Lochner, A., 2011. ANG II type I receptor antagonism improved nitric oxide production and enhanced eNOS and PKB/Akt expression in hearts from a rat model of insulin resistance. Mol. Cell. Biochem. 349, 21–31.
  15. Kashou, A.H., Benjamin, D.J., Agarwal, A., du Plessis, S.S., 2011. The Advent of Sperm Proteomics has Arrived. Open Reprod. Sci. J. 3, 92–97.
  16. KOEGELENBERG, C.F.N., DIACON, A.H., 2011. Pleural controversy: Closed needle pleural biopsy or thoracoscopy-Which first? Respirology 16, 738–746.
  17. Koegelenberg, C.F.N., Diacon, A.H., Irusen, E.M., von Groote-Bidlingmaier, F., Mowlana, A., Wright, C.A., Louw, M., Schubert, P.T., Bolliger, C.T., 2011. The Diagnostic Yield and Safety of Ultrasound-Assisted Transthoracic Biopsy of Mediastinal Masses. Respiration 81, 134–141.
  18. Lampiao, F., Slabbert, M., Plessis, S., 2011. The in vitro anti-fertility effects of Acacia nilotica on human spermatozoa function. Spat. DD - Peer Rev. J. Complement. Med. Drug Discov. 1, 59.
  19. Lochner, A., 2011. Signalling during an ischaemic preconditioning protocol: new role players? Cardiovasc. Res. 90, 5–6.
  20. Loos, B., Genade, S., Ellis, B., Lochner, A., Engelbrecht, A.-M., 2011a. At the core of survival: Autophagy delays the onset of both apoptotic and necrotic cell death in a model of ischemic cell injury. Exp. Cell Res. 317, 1437–1453.
  21. Loos, B., Lochner, A., Engelbrecht, A.-M., 2011b. Autophagy in heart disease: A strong hypothesis for an untouched metabolic reserve. Med. Hypotheses 77, 52–57.
  22. McCarthy, J., Lochner, A., Opie, L.H., Sack, M.N., Essop, M.F., 2011. PKCε promotes cardiac mitochondrial and metabolic adaptation to chronic hypobaric hypoxia by GSK3β inhibition. J. Cell. Physiol. 226, 2457–2468.
  23. Nduhirabandi, F., du Toit, F., Blackhurst, D., Marais, D., Lochner, A., Du Toit, E.F., Blackhurst, D., Marais, D., Lochner, A., 2011. Chronic melatonin consumption prevents obesity-related metabolic abnormalities and protects the heart against myocardial ischemia and reperfusion injury in a prediabetic model of diet-induced obesity. J. Pineal Res. 50, 171–182.
  24. Salie, R., Moolman, J.A., Lochner, A., 2011. The Role of β-adrenergic Receptors in the Cardioprotective Effects of Beta-Preconditioning (βPC). Cardiovasc. Drugs Ther. 25, 31–46.
  25. Sishi, B., Loos, B., Ellis, B., Smith, W., Toit, E.F. du, Engelbrecht, A., 2011. Diet‐induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model. Exp. Physiol. 96, 179–193.
  26. Webster, I., Huisamen, B., Du Toit, E.F., 2011. Creatine and Exercise – Strong Evidence for Stronger Heart Muscle? J. Exerc. Physiol. 14, 85–108.
  27. Webster, I., Toit, E.F. Du, Huisamen, B., 2010. The effects of long term swim training on physiological stress levels in the rat. Med. Technol. South Africa 24, 37–40.​

2010 and Earlier

  1. Aboua Y.G., Du Plessis SS, Brooks N, Y.G., 2007. In vitro Red Palm Oil (RPO) administration to human spermatozoa: Finding a suitable solvent. Med Technol. SA 21, 7–9.
  2. Aboua, Y.G., du Plessis, S.S., Reichgelt, P., Brooks, N., 2009. The in vitro effects of superoxide, some commercially available antioxidants and red palm oil on sperm motility. Asian J. Androl. 11, 695–702.
  3. Agarwal, A., Du Plessis, S.S., Cabler, S., Sabanegh E., 2010. Fertility fears - fate of the fat. Eur. Urol. Rev.  5, 60–64.
  4. Arvola, L., Bertelsen, E., Lochner, A., Ytrehus, K., 2006. Sustained anti-β-adrenergic effect of melatonin in guinea pig heart papillary muscle. Scand. Cardiovasc. J. 40, 37–42.
  5. Bester, E.P., Mouton, R., Malan, J.F., Lochner, A., 1993. The effect of lithium on the heart. Cardiovasc. J. Afr. 4, 210–214.
  6. Botha, M., Kruger, T., Agarwal, A., du Plessis, S., 2009. Fertility sparing surgery for female cancer patients complementing cryotechniques. Arch. Med. Sci. Spec. Issues 2009, 183–183.
  7. Brunner, F., Mouton, R., Lochner, A., Opie, L.H. 1995. Defective Stretch-Induced Release of Atrial Natriuretic Peptide from Aging Hypertensive Rat Heart. J. Cardiovasc. Pharmacol. 25, 168–176.
  8. Cabler, S., Agarwal, A., Flint, M., du Plessis, S.S., 2010. Obesity: modern man's fertility nemesis. Asian J. Androl. 12, 480–9.
  9. Carstens, N., van der Merwe, L., Revera, M., Heradien, M., Goosen, A., Brink, P.A., Moolman-Smook, J.C., 2011. Genetic variation in angiotensin II type 2 receptor gene influences extent of left ventricular hypertrophy in hypertrophic cardiomyopathy independent of blood pressure. J. Renin. Angiotensin. Aldosterone. Syst. 12, 274–80.
  10. Chegou, N.N., Walzl, G., Bolliger, C.T., Diacon, A.H., van den Heuvel, M.M., 2008. Evaluation of Adapted Whole-Blood Interferon-γ Release Assays for the Diagnosis of Pleural Tuberculosis. Respiration 76, 131–138.
  11. Cilhers, G.D., Lochner, A., 1993. Radiation-induced damage of the Wistar rat heart: biochemistry and function. Radiother. Oncol. 27, 216–222.
  12. Cilliers, F.J., Warren, R.M., Hauman, J.H., Wiid, I.J., van Helden, P.D., 1997. Oligonucleotide (GTG)5 as an epidemiological tool in the study of nontuberculous mycobacteria. J. Clin. Microbiol. 35, 1545–9.
  13. Cilliers, G.D., Lochner, A., 1993. Biochemical and functional effects of radiation-induced damage of the Wistar rat heart. S. Afr. J. Sci. 89, 537–541.
  14. Coetzee, A., Moolman, J., 1997. Regional pressure-length relations during acute myocardial ischaemia and prolonged post-ischaemic dysfunction (stunning). Cardiovasc. J. South Africa.
  15. Coetzee, A., Skein, W., Genade, S., Lochner, A. 1993. Enflurane and Isoflurane Reduce Reperfusion Dysfunction in the Isolated Rat Heart. Anesth. Analg. 76, 602–608.
  16. COETZEE, I.H., HARPER, I.S., GENADE, S., LOCHNER, A., 1994. Effect of H2O2 on the ultrastructure, sarcolemmal permeability and mechanical performance of the isolated rat heart. S. Afr. J. Sci. 90, 17–21.
  17. Coetzee, I.H., Lochner, A., IH, C., A., L., 1993. Free radical effects on myocardial membrane microviscosity. Cardioscience 4, 205–15.
  18. Coetzee, J.F., le Roux, P.J., Genade, S., Lochner, A., 2000. Reduction of Postischemic Contractile Dysfunction of the Isolated Rat Heart by Sevoflurane: Comparison with Halothane. Anesth. Analg. 90, 1089–1097.
  19. Daniels, W. M. U., Pietersen, C.Y., Carstens, M.E., Stein, D.J., 2004a. Maternal Separation in Rats Leads to Anxiety-Like Behavior and a Blunted ACTH Response and Altered Neurotransmitter Levels in Response to a Subsequent Stressor. Metab. Brain Dis. 19, 3–14.
  20. Daniels, W. M. U., Richter, L., Stein, D.J., 2004b. The Effects of Repeated Intra-Amygdala CRF Injections on Rat Behavior and HPA Axis Function After Stress. Metab. Brain Dis. 19, 15–23.
  21. Daniels, W.M.U., Fairbairn, L.R., van Tilburg, G., McEvoy, C.R.E., Zigmond, M.J., Russell, V.A., Stein, D.J., 2009. Maternal separation alters nerve growth factor and corticosterone levels but not the DNA methylation status of the exon 17 glucocorticoid receptor promoter region. Metab. Brain Dis. 24, 615–627.
  22. Daniels, W.M.U., Hendricks, J., Salie, R., Taljaard, J.J.F., 2001. The Role of the MAP-Kinase Superfamily in β-Amyloid Toxicity. Metab. Brain Dis. 16, 175–185.
  23. Daniels, W.M.U., Rensburg, S.J., Zyl, J.M., Taljaard, J.J.F., 1998. Melatonin prevents ?-amyloid-induced lipid peroxidation. J. Pineal Res. 24, 78–82.
  24. Daniels, W.M.U., van Rensburg, S.J., van Zyl, J.M., van der Walt, B.J., Taljaard, J.J.F., WM, D., SJ,  van R., JM,  van Z., BJ,  van der W., JJ., T., 1996. Free radical scavenging effects of melatonin and serotonin. Neuroreport 7, 1593–1596.
  25. Daniels, Willie M. U., Hendricks, J., Salie, R., van Rensburg, S.J., 2004. A Mechanism for Zinc Toxicity in Neuroblastoma Cells. Metab. Brain Dis. 19, 79–88.
  26. Davids, M.R., Muller, C.J., Rossouw, D.J., Doubell, A.F., 1998. The role of the endothelium in the reduction of restenosis following balloon angioplasty (568). Cardiovasc. J. Afr. 5, 1–1.
  27. de Glanville, N., Lochner, A. & Coetzee, A., 1998. Effects of adrenaline, administered early or later after ischaemia, and reperfusion on the isolated rat heart. Cardiovasc. J. Afr. 9, 35–39.
  28. Diacon, A.H., 2010. Iodopovidone as a pleurodesis agent: Setting standards for clinical pleural research. Respirology 15, 4–5.
  29. Diacon, A.H., Koegelenberg, C.F.N., Schubert, P., Brundyn, K., Louw, M., Wright, C.A., Bolliger, C.T., 2010. Rapid on-site evaluation of transbronchial aspirates: randomised comparison of two methods. Eur. Respir. J. 35, 1216–20.
  30. Diacon, A.H., Maritz, J.S., Venter, A., Helden, P.D., Andries, K., McNeeley, D.F., Donald, P.R., 2010. Time to detection of the growth of Mycobacterium tuberculosis in MGIT 960 for determining the early bactericidal activity of antituberculosis agents. Eur. J. Clin. Microbiol. Infect. Dis. 29, 1561–1565.
  31. Diacon, A.H., Pym, A., Grobusch, M., Patientia, R., Rustomjee, R., Page-Shipp, L., Pistorius, C., Krause, R., Bogoshi, M., Churchyard, G., Venter, A., Allen, J., Palomino, J.C., De Marez, T., van Heeswijk, R.P.G., Lounis, N., Meyvisch, P., Verbeeck, J., Parys, W., de Beule, K., Andries, K., Neeley, D.F.M., 2009. The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis. N. Engl. J. Med. 360, 2397–2405.
  32. Diacon, Andreas H, Dawson, R., Hanekom, M., Narunsky, K., Maritz, S.J., Venter, A., Donald, P.R., van Niekerk, C., Whitney, K., Rouse, D.J., Laurenzi, M.W., Ginsberg, A.M., Spigelman, M.K., 2010. Early bactericidal activity and pharmacokinetics of PA-824 in smear-positive tuberculosis patients. Antimicrob. Agents Chemother. 54, 3402–7.
  33. Djoba Siawaya, J.F., Chegou, N.N., Heuvel, M.M. van den, Diacon, A.H., Beyers, N., Helden, P. van, Walzl, G., 2009. Differential cytokine/chemokines and KL-6 profiles in patients with different forms of tuberculosis. Cytokine 47, 132–136.
  34. Donald, P.R., Diacon, A.H., 2008. The early bactericidal activity of anti-tuberculosis drugs: a literature review. Tuberculosis 88, S75–S83.
  35. Donthi, R. V., Huisamen, B., Lochner, A., 2000. Effect of Vanadate and Insulin on Glucose Transport in Isolated Adult Rat Cardiomyocytes. Cardiovasc. Drugs Ther. 14, 463–470.
  36. Du Plessis, S. S., McAllister, D.A., Luu, A., Savia, J., Agarwal, A., Lampiao, F., 2010. Effects of H2O2 exposure on human sperm motility parameters, reactive oxygen species levels and nitric oxide levels. Andrologia 42, 206–210.
  37. Du Plessis, S., 2006. Reactive oxygen species measurement in human spermatozoa by flow cytometry using the fluorescent probe, 2',7'-dichlorofluorescein-diacetate (DCFH-DA). Med. Technol. SA 20, 9–10.
  38. du Plessis, S.., van Niekerk, F.., Coetzer, W.., 1999a. The effect of dietary molybdenum and sulphate on the oestrus cycle and ovulation in ewes after manipulation with exogenous progesterone alone or in combination with FSH and LH. Small Rumin. Res. 33, 63–69.
  39. du Plessis, S.., Van Niekerk, F.., Coetzer, W.., 1999b. The effect of dietary molybdenum and sulphate on sexual activity and plasma progesterone concentrations of ewes. Small Rumin. Res. 33, 71–76.
  40. Du Plessis, S.S., Aboua, Y.G., Brooks, N., Awoniyi, D.O., 2009. Red palm oil : a natural good samaritan for sperm apoptosis? Med. Technol. SA 1, 8–10.
  41. du Plessis, S.S., de Jongh, P.S., Franken, D.R., 2004. Effect of acute in vivo sildenafil citrate and in vitro 8-bromo-cGMP treatments on semen parameters and sperm function. Fertil. Steril. 81, 1026–1033.
  42. Du Plessis, S.S., Franken, D.R., Baldi, E., Luconi, M., 2004. Phosphatidylinositol 3-kinase inhibition enhances human sperm motility and sperm-zona pellucida binding. Int. J. Androl. 27, 19–26.
  43. du Plessis, S.S., Hagenaar, K., Lampiao, F., 2010. The in vitro effects of melatonin on human sperm function and its scavenging activities on NO and ROS. Andrologia 42, 112–116.
  44. du Plessis, S.S., Makker, K., Desai, N.R., Agarwal, A., 2008. Impact of oxidative stress on IVF. Expert Rev. Obstet. Gynecol. 3, 539–554.
  45. du Plessis, S.S., Page, C., Franken, D.R., 2001. The zona pellucida-induced acrosome reaction of human spermatozoa involves extracellular signal-regulated kinase activation. Andrologia 33, 337–342.
  46. Du Plessis, S.S., Page, C., Franken, D.R., 2002. Extracellular signal-regulated kinase activation involved in human sperm-zona pellucida binding. Andrologia 34, 55–59.
  47. Du Plessis, Stefan S., Cabler, S., McAlister, D.A., Sabanegh, E., Agarwal, A., 2010. The effect of obesity on sperm disorders and male infertility. Nat. Rev. Urol. 7, 153–161.
  48. du Toit, E F, Genis, A., Opie, L.H., Pollesello, P., Lochner, A., 2008. A role for the RISK pathway and K ATP channels in pre- and post-conditioning induced by levosimendan in the isolated guinea pig heart. Br. J. Pharmacol. 154, 41–50.
  49. du Toit, E., Hofmann, D., McCarthy, J., Pineda, C., 2001. Effect of levosimendan on myocardial contractility, coronary and peripheral blood flow, and arrhythmias during coronary artery ligation and reperfusion in the in vivo pig model. Heart 86, 81–7.
  50. du Toit, E.F., Genade, S., Carlini, S., Moolman, J.A., Brunner, F., Lochner, A., 2007. Efficacy of ischaemic preconditioning in the eNOS overexpressed working mouse heart model. Eur. J. Pharmacol. 556, 115–120.
  51. Du Toit, E.F., Meiring, J., Opie, L.H., 2001. Relation of cyclic nucleotide ratios to ischemic and reperfusion injury in nitric oxide-donor treated rat hearts. J. Cardiovasc. Pharmacol. 38, 529–538.
  52. du Toit, E.F., Rossouw, E., Salie, R., Opie, L.H., Lochner, A., 2005. Effect of Sildenafil on Reperfusion Function, Infarct Size, and Cyclic Nucleotide Levels in the Isolated Rat Heart Model. Cardiovasc. Drugs Ther. 19, 23–31.
  53. du Toit, Eugene F., Smith, W., Muller, C., Strijdom, H., Stouthammer, B., Woodiwiss, A.J., Norton, G.R., Lochner, A., 2008. Myocardial susceptibility to ischemic-reperfusion injury in a prediabetic model of dietary-induced obesity. Am. J. Physiol. Circ. Physiol. 294, H2336–H2343.
  54. Edoute, Y., Giris, J., Ben-Haim, S.A., Lochner, A., Weizman, A., Hayam, G., Katz, Y., Gavish, M., 1993. Ro 5-4864 and PK 11195, but Not Diazepam, Depress Cardiac Function in an Isolated Working Rat Heart Model. Pharmacology 46, 224–230.
  55. Engelbrecht, A.-M., Engelbrecht, P., Genade, S., Niesler, C., Page, C., Smuts, M., Lochner, A., 2005. Long-chain polyunsaturated fatty acids protect the heart against ischemia/reperfusion-induced injury via a MAPK dependent pathway. J. Mol. Cell. Cardiol. 39, 940–954.
  56. Engelbrecht, A.-M., Esterhuyse, J., du Toit, E.F., Lochner, A., van Rooyen, J., 2006a. p38-MAPK and PKB/Akt, possible role players in red palm oil-induced protection of the isolated perfused rat heart? J. Nutr. Biochem. 17, 265–271.
  57. Engelbrecht, A.-M., Esterhuyse, J., du Toit, E.F., Lochner, A., van Rooyen, J., 2006b. p38-MAPK and PKB/Akt, possible role players in red palm oil-induced protection of the isolated perfused rat heart? J. Nutr. Biochem. 17, 265–271.
  58. Engelbrecht, A.M., Louw, L., Cloete, F., 1998. Comparison of the fatty acid compositions in intraepithelial and infiltrating lesions of the cervix: part II, free fatty acid profiles. Prostaglandins, Leukot. Essent. Fat. Acids 59, 253–257.
  59. Engelbrecht, A.-M., Niesler, C., Page, C., Lochner, A., 2004. p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes. Basic Res. Cardiol. 99, 338–350.
  60. Engelbrecht, A.-M., Odendaal, L., Du Toit, E.F., Kupai, K., Czont, T., Ferdinandy, P., van Rooyen, J., 2009. The effect of dietary red palm oil on the functional recovery of the ischaemic/reperfused isolated rat heart: the involvement of the PI3-Kinase signaling pathway. Lipids Health Dis. 8, 18.
  61. Essop, M.F., Anna Chan, W.Y., Valle, A., García-Palmer, F.J., Du Toit, E.F., 2009. Impaired contractile function and mitochondrial respiratory capacity in response to oxygen deprivation in a rat model of pre-diabetes. Acta Physiol. 197, 289–296.
  62. Esterhuyse, A.J., du Toit, E.F., Benadè, A.J.S., van Rooyen, J., 2005. Dietary red palm oil improves reperfusion cardiac function in the isolated perfused rat heart of animals fed a high cholesterol diet. Prostaglandins, Leukot. Essent. Fat. Acids 72, 153–161.
  63. Esterhuyse, J.S., van Rooyen, J., Strijdom, H., Bester, D., du Toit, E.F., 2006. Proposed mechanisms for red palm oil induced cardioprotection in a model of hyperlipidaemia in the rat. Prostaglandins, Leukot. Essent. Fat. Acids 75, 375–384.
  64. Fan, W.-J., Genade, S., Genis, A., Huisamen, B., Lochner, A., 2009. Dexamethasone-induced cardioprotection: A role for the phosphatase MKP-1? Life Sci. 84, 838–846.
  65. Fan, W.J., Vuuren, D., Genade, S., Lochner, A., 2010. Kinases and phosphatases in ischaemic preconditioning: a re-evaluation. Basic Res. Cardiol. 105, 495–511.
  66. Faure, J., Stein, D.J., Daniels, W., 2009. Maternal separation fails to render animals more susceptible to methamphetamine-induced conditioned place preference. Metab. Brain Dis. 24, 541–559.
  67. Faure, J., Uys, J.D.K., Marais, L., Stein, D.J., Daniels, W.M.U., 2007. Early maternal separation alters the response to traumatization: resulting in increased levels of hippocampal neurotrophic factors. Metab. Brain Dis. 22, 183–195.
  68. Faure, J., Uys, J.D.K., Marais, L., Stein, D.J., Daniels, W.M.U., 2006. Early maternal separation followed by later stressors leads to dysregulation of the HPA-axis and increases in hippocampal NGF and NT-3 levels in a rat model. Metab. Brain Dis. 21, 172–179.
  69. Faure, J.J., Hattingh, S.M., Stein, D.J., Daniels, W.M., 2009. Proteomic analysis reveals differentially expressed proteins in the rat frontal cortex after methamphetamine treatment. Metab. Brain Dis. 24, 685–700.
  70. Fourie, P.R., Coetzee, A.R., 1993. Effect of compliance on a time-domain estimate of the characteristic impedance of the pulmonary artery during acute pulmonary hypertension. Med. Biol. Eng. Comput. 31, 468–474.
  71. Fourie, P.R., Coetzee, A.R., Bolliger, C.T., 1992. Pulmonary artery compliance: its role in right ventricular-arterial coupling. Cardiovasc. Res. 26, 839–844.
  72. Fuglesteg, B.N., Suleman, N., Tiron, C., Kanhema, T., Lacerda, L., Andreasen, T. V., Sack, M.N., Jonassen, A.K., Mjøs, O.D., Opie, L.H., Lecour, S., 2008. Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion. Basic Res. Cardiol. 103, 444–453.
  73. Genade, B., Schoonwinkel, A., Wessels, J., 1996. Overview and comparison of methologies for 3D human motion analysis. Elektron 13, 30-32.
  74. Genade, S., Genis, A., Ytrehus, K., Huisamen, B., Lochner, A., 2008. Melatonin receptor-mediated protection against myocardial ischaemia/reperfusion injury: role of its anti-adrenergic actions. J. Pineal Res. 45, 449–458.
  75. Genade, S., Moolman, J.A., Lochner, A., 2001. Opioid receptor stimulation acts as mediator of protection in ischaemic preconditioning. Cardiovasc. J. South. Africa 18, 8–16.
  76. Georgescu, E.S., Goldberg, J.M., du Plessis, S.S., Agarwal, A., 2008. Present and Future Fertility Preservation Strategies for Female Cancer Patients. Obstet. Gynecol. Surv. 63, 725–732.
  77. Gross, A.M., Diacon, A.H., Van Den Heuvel, M.M., Van Rensburg, J., Harris, D., Bolliger, C.T., 2009. Management of life-threatening haemoptysis in an area of high tuberculosis incidence. Int. J. Tuberc. Lung Dis. 13, 875–880.
  78. Hampton, P.C., Schach, S.R., Koeslag, J.H. 1993. Has Tay-Sachs disease become common? S. Afr. Med. J. 83, 877–8.
  79. Hattingh, P., Coetzee, A., Harper, I., Genade, S., Lochner, A., 1993. Effects of beta-blockers and Ca2+ -antagonists on the response of the isolated working rat heart to adrenergic stimulants after cardioplegic arrest. Cardiovasc. Drugs Ther. 7, 851–861.
  80. Hattingh, P.W., Lochner, A., Tromp, E., Coetzee, A., 1997. Alpha-adrenergic receptor stimulation improves myocardial inotropy in the presence of chronic adrenergic antagonists and calcium channel blockers in the isolated rat heart after cardioplegic arrest. Cardiovasc. J. Afr. 87, C277–C284.
  81. Hofmeyr, L., Moolman, J., Brice, E., Weich, H., 2009. An Unusual Presentation of an Anomalous Left Coronary Artery Arising from the Pulmonary Artery (ALCAPA) in an Adult: Anterior Papillary Muscle Rupture Causing Severe Mitral Regurgitation. Echocardiography 26, 474–477.
  82. Hugo, C., Seier, J., Mdhluli, C., Daniels, W., Harvey, B.H., Du Toit, D., Wolfe-Coote, S., Nel, D., Stein, D.J., 2003. Fluoxetine decreases stereotypic behavior in primates. Prog. Neuro-Psychopharmacology Biol. Psychiatry 27, 639–643.
  83. Huisamen, B., 2003. PKB in diabetic myocardiopathy. Mol. Cell. Biochem. 249, 31–38.
  84. Huisamen, B., Donthi, R. V., Lochner, A., 2001a. Insulin in Combination with Vanadate Stimulates Glucose Transport in Isolated Cardiomyocytes from Obese Zucker Rats. Cardiovasc. Drugs Ther. 15, 445–452.
  85. Huisamen, B., Ellis, E., van Dyk, M., Lochner, A., 1996. Characterization of inositolpolyphosphate binding to myocardial membranes. Mol. Cell. Biochem. 162, 1–9.
  86. Huisamen, B., Genade, S., Lochner, A., 2008. Signalling pathways activated by glucagon-like peptide-1 (7-36) amide in the rat heart and their role in protection against ischaemia. Cardiovasc. J. Afr. 19, 77–83.
  87. Huisamen, B., Lochner, A., 1996. Inositolpolyphosphates and their binding proteins alpha-a short review. Mol. Cell. Biochem. 157, 229–232.
  88. Huisamen, B., Lochner, A., 2005. Exercise modulates myocardial protein kinase B/Akt in Zucker obese rats. Heart 91, 227–8.
  89. Huisamen, B., Marais, E., Genade, S., Lochner, A., 2001b. Serial changes in the myocardial β-adrenergic signalling system in two models of non-insulin dependent diabetes mellitus. Mol. Cell. Biochem. 219, 73–82.
  90. Huisamen, B., Mouton, R., Opie, L.H., Lochner, A., 1994a. Effects of ischaemia, reperfusion and α1 receptor stimulation on the inositoltrisphosphate receptor population in rat heart atria and ventricles. Mol. Cell. Biochem. 140, 23–30.
  91. Huisamen, B., Mouton, R., Opie, L.H., Lochner, A., 1994b. Demonstration of a Specific [3H]INS(1,4,5)P3 Binding Site in Rat Heart Sarcoplasmic Reticulum. J. Mol. Cell. Cardiol. 26, 341–349.
  92. Huisamen, B., Upton, J., Lochner, A., 2004. A Role for the α 1 -Adrenergic Signalling Pathway in the Response of Papillary Muscles from Type 2 Diabetic Hearts to Anoxia-Reoxygenation. Cardiovasc. Drugs Ther. 18, 247–255.
  93. Huisamen, B., van Zyl, M., Keyser, A., Lochner, A., 2001c. The effects of insulin and β-adrenergic stimulation on glucose transport, glut 4 and PKB activation in the myocardium of lean and obese non-insulin dependent diabetes mellitus rats. Mol. Cell. Biochem. 223, 15–25.
  94. Koegelenberg, C. F. N., Irusen, E.M., Cooper, R., Diacon, A.H., Taljaard, J.J., Mowlana, A., von Groote-Bidlingmaier, F., Bolliger, C.T., 2010. High mortality from respiratory failure secondary to swine-origin influenza A (H1N1) in South Africa. QJM 103, 319–325.
  95. Koegelenberg, C., Diacon, A., 2008. Pleural biopsy for patients with suspected malignant effusions. South African Respir. J. 14, 82–83.
  96. Koegelenberg, C., Diacon, A., 2010a. Ultrasound-assisted pleural biopsies. Int. Pleural Newsl. 2, 8–9.
  97. Koegelenberg, C., Diacon, A., 2010b. Ultrasound-assisted pleural biopsies. South African Respir. J.  16, 88.
  98. Koegelenberg, C.F.N., Bolliger, C.T., Plekker, D., Wright, C.A., Brundyn, K., Louw, M., Schubert, P., van den Heuvel, M.M., Diacon, A.H., 2009. Diagnostic yield and safety of ultrasound-assisted biopsies in superior vena cava syndrome. Eur. Respir. J. 33, 1389–95.
  99. Koegelenberg, C.F.N., Diacon, A.H., Irani, S., Bolliger, C.T., 2008a. Stair Climbing in the Functional Assessment of Lung Resection Candidates. Respiration 75, 374–379.
  100. Koegelenberg, C.F.N., Diaconi, A.H., Bolligeri, C.T., 2008b. Parapneumonic Pleural Effusion and Empyema. Respiration 75, 241–250.
  101. Koegelenberg, Coenraad Frederik N, Bolliger, C.T., Theron, J., Walzl, G., Wright, C.A., Louw, M., Diacon, A.H., 2010. Direct comparison of the diagnostic yield of ultrasound-assisted Abrams and Tru-Cut needle biopsies for pleural tuberculosis. Thorax 65, 857–862.
  102. Koen, C., Koeslag, J., 1995. On the Stability of Subatmospheric Intrapleural and Intracranial Pressures. Physiology 10, 176–178.
  103. Koeslag, J., Saunders, P., 2004. The Role of Chromogranins and Other Statins in Homeostasis: An Explanation of the Precise Regulation of Glucose and Ionised Calcium in the Blood; An Overview. Curr. Med. Chem. Endocr. Metab. Agents 4, 235–249.
  104. Koeslag, J.D., Koeslag, P.D., 1993. The mechanics of bi-articular muscles. S. Afr. J. Sci. 89, 73–76.
  105. Koeslag, J.H., 1993. What is normal? South African Med. J. 83, 47–50.
  106. Koeslag, J.H., 1994. Koinophilia Replaces Random Mating in Populations Subject to Mutations with Randomly Varying Fitnesses. J. Theor. Biol. 171, 341–345.
  107. Koeslag, J.H., 1995. On the Engine of Speciation. J. Theor. Biol. 177, 401–409.
  108. Koeslag, J.H., 1997. Sex, The Prisoner's Dilemma Game, and the Evolutionary Inevitability of Cooperation. J. Theor. Biol. 189, 53–61.
  109. Koeslag, J.H., Koeslag, P.D., 1993. Evolutionarily Stable Meiotic Sex. J. Hered. 84, 396–399.
  110. Koeslag, J.H., Koeslag, P.D., 1994. Koinophilia. J. Theor. Biol. 167, 55–65.
  111. Koeslag, J.H., Saunders, P.T., Terblanche, E., 2003. A Reappraisal of the Blood Glucose Homeostat which Comprehensively Explains the Type 2 Diabetes Mellitus-Syndrome X Complex. J. Physiol. 549, 333–346.
  112. Koeslag, J.H., Saunders, P.T., Wessels, J.A., 1997. Glucose homeostasis with infinite gain: further lessons from the Daisyworld parable? J. Endocrinol. 154, 187–192.
  113. Koeslag, J.H., Saunders, P.T., Wessels, J.A., 1999. The chromogranins and the counter-regulatory hormones: do they make homeostatic sense? J. Physiol. 517, 643.
  114. Koeslag, J.H., Terblanche, E., 2003. Evolution of cooperation: cooperation defeats defection in the cornfield model. J. Theor. Biol. 224, 399–410.
  115. Koeslag, P.D., Koeslag, J.H., 1994. Koinophilia Stabilizes Bi-gender Sexual Reproduction Against Asex in an Unchanging Environment. J. Theor. Biol. 166, 251–260.
  116. Kothari, S., Thompson, A., Agarwal, A., du Plessis, S.S., 2010. Free radicals: Their beneficial and detrimental effects on sperm function. Indian J. Exp. Biol. IJEB. 48, 425–435.
  117. Kruger, M.J., Engelbrecht, A.-M., Esterhuyse, J., du Toit, E.F., van Rooyen, J., 2007. Dietary red palm oil reduces ischaemia–reperfusion injury in rats fed a hypercholesterolaemic diet. Br. J. Nutr. 97, 653–660.
  118. Lackner, J.E., Agarwal, A., Mahfouz, R., du Plessis, S.S., Schatzl, G., 2010. The association between leukocytes and sperm quality is concentration dependent. Reprod. Biol. Endocrinol. 8, 12.
  119. Lambert, E. V, Wooding, G., Lambert, M.I., Koeslag, J.H., Noakes, T.D., 1994. Enhanced adipose tissue lipoprotein lipase activity in detrained rats: independent of changes in food intake. J. Appl. Physiol. 77, 2564–71.
  120. Lampiano, F., Strijdom, H., du Plessis, S., 2010. Effects of Sperm Processing Techniques Involving Centrifugation on Nitric Oxide, Reactive Oxygen Species Generation and Sperm Function. Open Androl. J. 2, 1–5.
  121. Lampiao, F., Agarwal, A., du Plessis, S.S., 2009. The role of insulin and leptin in male reproduction. Arch Med Sci 5, S48–S54.
  122. Lampiao, F., du Plessis, S.S., 2006. Comparing the Multi-ZSC one-step standardized swim-up method to the double-wash swim-up method with regard to the effects of sperm separation on morphology, head morphometry, and acrosome reaction inducibility. Fertil. Steril. 86, 739–741.
  123. Lampiao, F., du Plessis, S.S., 2008a. Insulin and leptin enhance human sperm motility, acrosome reaction and nitric oxide production. Asian J. Androl. 10, 799–807.
  124. Lampiao, F., du Plessis, S.S., 2008b. TNF-α and IL-6 affect human sperm function by elevating nitric oxide production. Reprod. Biomed. Online 17, 628–631.
  125. Lampiao, F., du Plessis, S.S., 2009. Effects of tumour necrosis factor alpha and interleukin-6 on progesterone and calcium ionophore-induced acrosome reaction. Int. J. Androl. 32, 274–277.
  126. Lampiao, F., du Plessis, S.S., 2010. Insulin Stimulates Glut8 Expression in Human Spermatozoa. J. Biosci. Technol. 1, 90–93.
  127. Lampiao, F., Krom, D., Plessis, S.S. du, 2008. The in vitro effects of Mondia whitei on human sperm motility parameters. Phyther. Res. 22, 1272–1273.
  128. Lampiao, F., Strijdom, H., du Plessis, S.S., 2006. Direct nitric oxide measurement in human spermatozoa: flow cytometric analysis using the fluorescent probe, diaminofluorescein. Int. J. Androl. 29, 564–567.
  129. Lochner, A., 2008. Sarcolemmal permeability changes during ischaemia and reperfusion: release of survival factors. Cardiovasc. Res. 79, 545–546.
  130. Lochner, A., Genade, S., 1998. Ischemic preconditioning of the isolated perfused working guinea pig heart. Cardiovasc. Drugs Ther. 12, 495–497.
  131. Lochner, A., Genade, S., Davids, A., Ytrehus, K., Moolman, J.A., 2006. Short- and long-term effects of melatonin on myocardial post-ischemic recovery. J. Pineal Res. 40, 56–63.
  132. Lochner, A., Genade, S., Hattingh, S., Marais, E., Huisamen, B., Moolman, J.A., 2003a. Comparison Between Ischaemic and Anisomycin-Induced Preconditioning: Role of p38 MAPK. Cardiovasc. Drugs Ther. 17, 217–230.
  133. Lochner, A., Genade, S., Moolman, J.A., 2003b. Ischemic preconditioning: Infarct size is a more reliable endpoint than functional recovery. Basic Res. Cardiol. 98, 337–346.
  134. Lochner, A., Genade, S., Tromp, E., Opie, L., Moolman, J., Thomas, S., Podzuweit, T., 1998a. Role of cyclic nucleotide phosphodiesterases in ischemic preconditioning. Mol. Cell. Biochem. 186, 169–175.
  135. Lochner, A., Genade, S., Tromp, E., Theron, S., Trollip, G., 1998b. Postcardioplegic Myocardial Recovery: Effects of Halothane, Nifedipine, HOE 694, and Quinacrine. Cardiovasc. Drugs Ther. 12, 267–277.
  136. Lochner, A., Genade, S., Tromp, E., Theron, S., Trollip, G., 1998c. Postcardioplegic Myocardial Recovery: Effects of Halothane, Nifedipine, HOE 694, and Quinacrine. Cardiovasc. Drugs Ther. 12, 267–277.
  137. Lochner, A., Harper, I.S., Rudwaan, S., Genade, S., Coetzee, A.R., 1994. Halothane Protects the Isolated Rat Myocardium Against Excessive Total Intracellular Calcium and Structural Damage During Ischemia and Reperfusion. Anesth. Analg. 79, 226–233.
  138. Lochner, A., Huisamen, B., 2010. GSK-3 protein and the heart : friend or foe? SA Hear. 7, 48–57.
  139. Lochner, A., Koeslag, J.H., Du Toit, E.F., Huisamen, B., Moolman, J.A., Van Rooyen, J., 2004. Cellular injury in ischaemia: editorial comment. Cardiovasc. J. South Africa 15, 2005–2006.
  140. Lochner, A., Marais, E., Genade, S., Moolman, J.A., 2000. Nitric oxide: a trigger for classic preconditioning? Am. J. Physiol. Circ. Physiol. 279, H2752–H2765.
  141. LOCHNER, A., MARAIS, E., TOIT, E. DU, MOOLMAN, J., 2002. Nitric Oxide Triggers Classic Ischemic Preconditioning. Ann. N. Y. Acad. Sci. 962, 402–414.
  142. Lochner, A., Moolman, J.A., 2006. The Many Faces of H89: A Review. Cardiovasc. Drug Rev. 24, 261–274.
  143. Lochner, A., Pentz, A., Williams, K., Tromp, E., Harper, I.S., 1996. Substrate effects on sarcolemmal permeability in the normoxic and hypoxic perfused rat heart. Basic Res. Cardiol. 91, 64–78.
  144. Lochner, A., Tromp, E., Mouton, R., 1996. Signal transduction in myocardial ischaemia and reperfusion, in: Biochemical Mechanisms in Heart Function. Springer US, Boston, MA, pp. 129–136.
  145. Lochner, Amanda, Marais, E., Genade, S., Huisamen, B., Strijdom, H., Moolman, J.A., 2003. Ischaemic and Pharmacological Preconditioning Is Associated with Attenuation of p38 MAPK Activation During Sustained Ischaemia and Reperfusion. Springer, Boston, MA, pp. 249–273.
  146. Lochner, C., Kinnear, C.J., Hemmings, S.M.J., Seller, C., Niehaus, D.J.H., Knowles, J.A., Daniels, W., Moolman-Smook, J.C., Seedat, S., Stein, D, J., 2005. Hoarding in obsessive-compulsive disorder: Clinical and genetic correlates. J. Clin. Psychiatry  66, 1155–1160.
  147. Lochner, J.D., Schneider, D.J., JD, L., DJ., S., 1994. The relationship between tuberculosis, vitamin D, potassium and AIDS. A message for South Africa? S. Afr. Med. J. 84, 79–82.
  148. Louw, L., Engelbrecht, A.M., Cloete, F., 1998a. Comparison of the fatty acid compositions in intraepithelial and infiltrating lesions of the cervix: part I, total fatty acid profiles. Prostaglandins, Leukot. Essent. Fat. Acids 59, 247–251.
  149. Louw, L., Engelbrecht, A.M., Cloete, F., 1998b. Comparison of the fatty acid compositions in intraepithelial and infiltrating lesions of the cervix: part III, saturated and unsaturated fatty acid profiles. Prostaglandins, Leukot. Essent. Fat. Acids 59, 259–264.
  150. Lubbe, W.W., Bolliger, C.T., Barnard, B.J., Diacon, A.H., 2008. Cardiac arrest following pneumonectomy. Respiration 76, 225–227.
  151. Mahfouz, R.Z., du Plessis, S.S., Aziz, N., Sharma, R., Sabanegh, E., Agarwal, A., 2010. Sperm viability, apoptosis, and intracellular reactive oxygen species levels in human spermatozoa before and after induction of oxidative stress. Fertil. Steril. 93, 814–821.
  152. Majane, O.H.I., Vengethasamy, L., du Toit, E.F., Makaula, S., Woodiwiss, A.J., Norton, G.R., 2009. Dietary-induced obesity hastens the progression from concentric cardiac hypertrophy to pump dysfunction in spontaneously hypertensive rats. Hypertens. (Dallas, Tex.  1979) 54, 1376–83.
  153. Makaula, S., Lochner, A., Genade, S., Sack, M.N., Awan, M.M., Opie, L.H., 2005. H-89, a Non-Specific Inhibitor of Protein Kinase A, Promotes Post-Ischemic Cardiac Contractile Recovery and Reduces Infarct Size. J. Cardiovasc. Pharmacol. 45, 341–347.
  154. Marais, E., Genade, S., Huisamen, B., Strijdom, J.G., Moolman, J.A., Lochner, A., 2001. Activation of p38 MAPK Induced by a Multi-cycle Ischaemic Preconditioning Protocol is Associated with Attenuated p38 MAPK Activity During Sustained Ischaemia and Reperfusion. J. Mol. Cell. Cardiol. 33, 769–778.
  155. Marais, E., Genade, S., Lochner, A., 2008. CREB Activation and Ischaemic Preconditioning. Cardiovasc. Drugs Ther. 22, 3–17.
  156. Marais, E., Genade, S., Salie, R., Huisamen, B., Maritz, S., Moolman, J.A., Lochner, A., 2005a. The temporal relationship between p38 MAPK and HSP27 activation in ischaemic and pharmacological preconditioning. Basic Res. Cardiol. 100, 35–47.
  157. Marais, E., Genade, S., Salie, R., Huisamen, B., Maritz, S., Moolman, J.A., Lochner, A., 2005b. The temporal relationship between p38 MAPK and HSP27 activation in ischaemic and pharmacological preconditioning. Basic Res. Cardiol. 100, 35–47.
  158. Marais, Erna, Genade, S., Strijdom, H., Moolman, J.A., Lochner, A., 2001. p38 MAPK Activation Triggers Pharmacologically-induced β -adrenergic Preconditioning, but Not Ischaemic Preconditioning. J. Mol. Cell. Cardiol. 33, 2157–2177.
  159. Marais, L., Daniels, W., Brand, L., Viljoen, F., Hugo, C., Stein, D.J., 2006. Psychopharmacology of maternal separation anxiety in vervet monkeys. Metab. Brain Dis. 21, 191–200.
  160. Marais, L., Hattingh, S.M., Stein, D.J., Daniels, W.M.U., 2009a. A proteomic analysis of the ventral hippocampus of rats subjected to maternal separation and escitalopram treatment. Metab. Brain Dis. 24, 569–586.
  161. Marais, L., Stein, D.J., Daniels, W.M.U., 2009b. Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats. Metab. Brain Dis. 24, 587–597.
  162. Marais, L., van Rensburg, S.J., van Zyl, J.M., Stein, D.J., Daniels, W.M.U., 2008. Maternal separation of rat pups increases the risk of developing depressive-like behavior after subsequent chronic stress by altering corticosterone and neurotrophin levels in the hippocampus. Neurosci. Res. 61, 106–112.
  163. Maree, L., du Plessis, S.S., Menkveld, R., van der Horst, G., 2010. Morphometric dimensions of the human sperm head depend on the staining method used. Hum. Reprod. 25, 1369–1382.
  164. McCarthy, J., Lochner, A., Genade, S., Ping, P., Essop, M.F., Sack, M.N., Opie, L.H., 2008. Hypoxic hearts overexpressing activated PKC epsilon (aPKCe) have decreased cardiac function on exposure to fatty acid perfusate. J. Mol. Cell. Cardiol. 44, 761.
  165. Melchiorri, D., Ortiz, G., Reiter, R., Sewerynek, E., Daniels, W.M., Pablos, M.., Nisticò, G., 1998. Melatonin reduces paraquat-induced genotoxicity in mice. Toxicol. Lett. 95, 103–108.
  166. Miller, D.M., Wessels, J.A., 1997. A simple method for the continuous noninvasive estimate of cardiac output using the Maxima breathing system. A pilot study. Anaesth. Intensive Care 25, 23–8.
  167. Moolman, J. A., Genade, S., Tromp, E., Lochner, A., 1996. A comparison between ischemic preconditioning and anti-adrenergic interventions: cAMP, energy metabolism and functional recovery. Basic Res. Cardiol. 91, 219–233.
  168. MOOLMAN, J., 2006. Unravelling the cardioprotective mechanism of action of estrogens. Cardiovasc. Res. 69, 777–780.
  169. Moolman, J.A., 2002. Thyroid hormone and the heart: review article. Cardiovasc. J. South Africa 13, 159-163.
  170. Moolman, J.A., Genade, S., Tromp, E., Opie, L.H., Lochner, A., 1997. Ischaemic preconditioning does not protect hypertrophied myocardium against ischaemia. Cardiovasc. J. Afr. 8, 151–156.
  171. Moolman, J.A., Genade, S., Winterbach, R., Harper, I.S., Williams, K., Lochner, A., 1995. Preconditioning with a single short episode of global ischemia in the isolated working rat heart: Effect on structure, mechanical function, and energy metabolism for various durations of sustained global ischemia. Cardiovasc. Drugs Ther. 9, 103–115.
  172. Moolman, J.A., Genade, S., Winterbach, R., Lochner, A., 1994. Preconditioning with hypoxia versus global ischemia in the isolated rat heart: effect on function and metabolism. Cardioscience 5, 73–80.
  173. Moolman, J.A., Hartley, S., Van Wyk, J., Marais, E., Lochner, A., 2006. Inhibition of Myocardial Apoptosis by Ischaemic and Beta-Adrenergic Preconditioning is Dependent on p38 MAPK. Cardiovasc. Drugs Ther. 20, 13–25.
  174. Moolman, J.A., Lochner, A., 1994. Ischaemic preconditioning - laboratory phenomenon or relevant to clinical practice? Cardiovasc. J. Afr. 5, 127–134.
  175. MOOLMAN, J.A., REITH, S., UHL, K., BAILEY, S., GAUTEL, M., JESCHKE, B., FISCHER, C., OCHS, J., McKENNA, W.J., KLUES, H., VOSBERG, H.-P., 2000. A newly created splice donor site in exon 25 of the MyBP-C gene is responsible for inherited hypertrophic cardiomyopathy with incomplete disease penetrance. Circulation 101, 1396–1402.
  176. Moolman, Johannes Albertus, Genade, S., Tromp, E., Lochner, A., 1996. No evidence for mediation of ischemic preconditioning by alpha1-adrenergic signal transduction pathway or protein kinase C in the isolated rat heart. Cardiovasc. Drugs Ther. 10, 125–136.
  177. Pan African Society of Cardiology., S., Ytrehus, K., Lochner, A., 2006. Melatonin prevents cardioprotection inducedby a multi-cycle ischaemic preconditioning protocol in the isolated perfused rat heart: cardiovascular topics. Cardiovasc. J. South Africa 17, 239–244.
  178. Pienaar, I.S., Schallert, T., Hattingh, S., Daniels, W.M.U., 2009. Behavioral and quantitative mitochondrial proteome analyses of the effects of simvastatin: implications for models of neural degeneration. J. Neural Transm. 116, 791–806.
  179. Plekker, D., Ellis, T., Irusen, E.M., Bolliger, C.T., Diacon, A.H., 2008. Clinical and Radiological Grading of Superior Vena Cava Obstruction. Respiration 76, 69–75.
  180. Rensburg, S.J. van, Daniels, W.M.U., Potocnik, F.C.V., Zyl, J.M. van, Taljaard, J.J.F., Emsley, R.A., 1997. A new model for the pathophysiology of Alzheimer's disease: Aluminium toxicity is exacerbated by hydrogen peroxide and attenuated by an amyloid protein fragment and melatonin. South African Med. J. 87, 1111–1115.
  181. Rustomjee, R., Diacon, A.H., Allen, J., Venter, A., Reddy, C., Patientia, R.F., Mthiyane, T.C.P., De Marez, T., van Heeswijk, R., Kerstens, R., Koul, A., De Beule, K., Donald, P.R., McNeeley, D.F., 2008. Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis. Antimicrob. Agents Chemother. 52, 2831–5.
  182. Salie, R., Harper, I., Cillie, C., Genade, S., Huisamen, B., Moolman, J., Lochner, A., 2001. Melatonin Protects Against Ischaemic-reperfusion Myocardial Damage. J. Mol. Cell. Cardiol. 33, 343–357.
  183. Saunders, P.T., Koeslag, J.H., Wessels, J.A., 1998. Integral Rein Control in Physiology. J. Theor. Biol. 194, 163–173.
  184. SAUNDERS, P.T., KOESLAG, J.H., WESSELS, J.A., 2000. Integral Rein Control in Physiology II: a General Model. J. Theor. Biol. 206, 211–220.
  185. Smit, E., Conradie, M., Wessels, J., Witbooi, I., Otto, R., 2003. Measurement of the magnitude of force applied by students when learning a mobilisation technique. South African J. Physiother. 59, 3–8.
  186. Sorokin, A., Weich, H., Doubell, A., Moolman, J.A., 2006. Bilateral ostial coronary stenosis and rheumatic aortic valve stenosis. Acute Card. Care 8, 113–115.
  187. Stein, D.J., Collins, M., Daniels, W., Noakes, T.D., Zigmond, M., 2007. Mind and Muscle: The Cognitive-Affective Neuroscience of Exercise. CNS Spectr. 12, 19–22.
  188. Stein, D.J., Daniels, W., Emsley, R., Harvey, B., Blackburn, J., Carey, P., Ellis, G., Illing, N., Flisher, A., Moolman-Smook, H., Mwaba, K., Ramesar, R., Russell, V., Seedat, S., Tredoux, C., Vaughan, C.L., Vythilingum, B., Warwick, J., 2006. A brain-behaviour initiative for South Africa: the time is right. Metab. Brain Dis. 21, 266–271.
  189. Stein, D.J., Harvey, B.H., Uys, J., Daniels, W., 2005. Suffer the Children: The Psychobiology of Early Adversity. CNS Spectr. 10, 612–615.
  190. Strijdom, H., Chamane, N., Lochner, A., 2009a. Nitric oxide in the cardiovascular system: a simple molecule with complex actions. Cardiovasc. J. Afr. 20, 303–10.
  191. Strijdom, H., Friedrich, S.O., Hattingh, S., Chamane, N., Lochner, A., 2009b. Hypoxia-induced regulation of nitric oxide synthase in cardiac endothelial cells and myocytes and the role of the PI3-K/PKB pathway. Mol. Cell. Biochem. 321, 23–35.
  192. Strijdom, H., Genade, S., Lochner, A., 2004a. Nitric Oxide Synthase (NOS) Does Not Contribute to Simulated Ischaemic Preconditioning in an Isolated Rat Cardiomyocyte Model. Cardiovasc. Drugs Ther. 18, 99–112.
  193. Strijdom, H., Jacobs, S., Hattingh, S., Page, C., Lochner, A., 2006. Nitric oxide production is higher in rat cardiac microvessel endothelial cells than ventricular cardiomyocytes in baseline and hypoxic conditions: a comparative study. FASEB J. 20, 314–316.
  194. Strijdom, H., Lochner, A., 2009. Cardiac endothelium : more than just a barrier : cardiac endothelium. SA Hear. 6, 174–185.
  195. Strijdom, H., Muller, C., Lochner, A., 2004b. Direct intracellular nitric oxide detection in isolated adult cardiomyocytes: flow cytometric analysis using the fluorescent probe, diaminofluorescein. J. Mol. Cell. Cardiol. 37, 897–902.
  196. STRIJDOM, J.G., MARAIS, B.J., KOESLAG, J.H., 1992. Ascorbic acid causes spuriously low blood glucose measurements. South African Med. J. 81, 379–389.
  197. Terblanche, E., Cloete, W.A., du Plessis, P.A.L., Sadie, J.N., Strauss, A., Unger, M., 2003. The metabolic transition speed between backward walking and running. Eur. J. Appl. Physiol. 90, 520–525.
  198. Terblanche, E., Page, C., Kroff, J., Venter, R.E., 2005. The Effect of Backward Locomotion Training on the Body Composition and Cardiorespiratory Fitness of Young Women. Int. J. Sports Med. 26, 214–219.
  199. Terblanche, E., Wessels, J.A., Stewart, R.I., Koeslag, J.H., 1999. A computer simulation of free-range exercise in the laboratory. J. Appl. Physiol. 87, 1386–1391.
  200. Terblanche, Elmarie, Fourie, P.R., Wessels, J.A., 1999. Assessment of a peak flow whistle in nonasthmatic children. Pediatr. Pulmonol. 27, 428–431.<428::AID-PPUL11>3.0.CO;2-O
  201. Toit, E.F., Nabben, M., Lochner, A., 2005. A potential role for angiotensin II in obesity induced cardiac hypertrophy and ischaemic/reperfusion injury. Basic Res. Cardiol. 100, 346–354.
  202. Tromp, S., Lochner, E., Lochner, R.C., 1998. Effects of halothane on post-cardiplegic functional recovery - the role of cardioplegic solution. Cardiovasc. J. Afr. 9, 96–98.
  203. Upton, J.J., Huisamen, B., Lochner, A., 2002. Manipulation of papillary muscle cyclic nucleotides during anoxia-reoxygenation: Effects on contractility. Cardiovasc. J. South Africa 13, 10–16.
  204. Uys, J.D.K., Hattingh, S.M., Stein, D.J., Daniels, W.M.U., 2008. Large Scale Hippocampal Cellular Distress may Explain the Behavioral Consequences of Repetitive Traumatic Experiences-A Proteomic Approach. Neurochem. Res. 33, 1724–1734.
  205. UYS, J.D.K., MARAIS, L., FAURE, J., PREVOO, D., SWART, P., MOHAMMED, A.H., STEIN, D.J., DANIELS, W.M.U., 2006. Developmental Trauma is Associated with Behavioral Hyperarousal, Altered HPA Axis Activity, and Decreased Hippocampal Neurotrophin Expression in the Adult Rat. Ann. N. Y. Acad. Sci. 1071, 542–546.
  206. Uys, J.D.K., Muller, C.J.F., Marais, L., Harvey, B.H., Stein, D.J., Daniels, W.M.U., 2006. Early life trauma decreases glucocorticoid receptors in rat dentate gyrus upon adult re-stress: Reversal by escitalopram. Neuroscience 137, 619–625.
  207. Uys, J.D.K., Stein, D.J., Daniels, W.M.U., Harvey, B.H., 2003. Animal models of anxiety disorders. Curr. Psychiatry Rep. 5, 274–281.
  208. Uys, Joachim D. K., Stein, D.J., Daniels, W.M.U., 2006. Neuroproteomics: Relevance to anxiety disorders. Curr. Psychiatry Rep. 8, 286–290.
  209. van Jaarsveld, F.P., Hattingh, S., 2012. Rapid induction of ageing character in brandy products. Ageing and general overview. South African J. Enol. Vitic. 33, 225–252.
  210. van Jaarsveld, F.P., Hattingh, S., Minnaar, P., 2009. Rapid induction of ageing character in brandy products - Part III. Influence of toasting. South African J. Enol. Vitic. 30, 24–37.
  211. van Rensburg, S.J., van Zyl, J., Hon, D., Daniels, W., Hendricks, J., Potocnik, F., Erasmus, R., 2004. Biochemical Model for Inflammation of the Brain: The Effect of Iron and Transferrin on Monocytes and Lipid Peroxidation. Metab. Brain Dis. 19, 97–112.
  212. van Rensburg, S.J., van Zyl, J.M., Potocnik, F.C. V., Daniels, W.M.U., Uys, J., Marais, L., Hon, D., van der Walt, B.J., Erasmus, R.T., 2006. The effect of stress on the antioxidative potential of serum: implications for Alzheimer's disease. Metab. Brain Dis. 21, 163–171.
  213. Van Rooyen, J., Du Toit, E.F., Lochner, A., Rossouw, E., 2005. Proposed mechanisms for the anabolic steroid-induced increase in myocardial susceptibility to ischaemia / reperfusion injury : cardiovascular topic. Cardiovasc. J. South Africa 16, 21–28.
  214. Van Rooyen, J., Esterhuyse, A.J., Engelbrecht, A.M., Du Toit, E.F., 2008. Health benefits of a natural carotenoid rich oil: A proposed mechanism of protection against ischaemia/reperfusion injury. Asia Pac. J. Clin. Nutr. 17, 316–319.
  215. van Vuuren, D., Genis, A., Genade, S., Lochner, A., 2008a. Postconditioning the Isolated Working Rat Heart. Cardiovasc. Drugs Ther. 22, 391–397.
  216. van Vuuren, D., Lochner, A., 2008b. Ischaemic postconditioning: from bench to bedside ... Cardiovasc. J. Afr. 19, 311–20.
  217. Varghese, A.C., du Plessis, S.S., Agarwal, A., 2008a. Male gamete survival at stake: causes and solutions. Reprod. Biomed. Online 17, 866–880.
  218. Varghese, A.C., du Plessis, S.S., Falcone, T., Agarwal, A., 2008b. Cryopreservation/transplantation of ovarian tissue and in vitro maturation of follicles and oocytes: Challenges for fertility preservation. Reprod. Biol. Endocrinol. 6, 47.
  219. Veliotes, D.G.A., Norton, G.R., Correia, R.J., Strijdom, H., Badenhorst, D., Brooksbank, R., Woodiwiss, A.J., 2010. Impact of Aldosterone Receptor Blockade on the Deleterious Cardiac Effects of Adrenergic Activation in Hypertensive Rats. J. Cardiovasc. Pharmacol. 56, 203–211.
  220. Vos, R., Goslett, N., Van Hoogstraten, A., Fourie, P., 1993. Albatros: an innovative low-cost wheelchair. Disabil. Rehabil. 15, 44–46.
  221. Vosberg, H.-P., Moolman, J., Döhlemann, C., McKeown, P., Reith, S., 2000. Analysis of inherited causes of hypertrophic cardiomyopathy as part of clinical practice, in: From Molecule to Men. Steinkopff, Heidelberg, pp. 69–75.
  222. Webster, I., Friedrich, S.O., Lochner, A., Huisamen, B., 2010. AMP kinase activation and glut4 translocation in isolated cardiomyocytes. Cardiovasc. J. Afr. 21, 72–8.
  223. Wiid, I.J., Huisamen, B., 1993. An inexpensive approach to ultracentrifugation of small volume suspensions. Biotechniques 14, 564.
  224. Yapo, G.A., Stefan, S. du P., Nicole, B., 2009. Impact of organic hydroperoxides on rat testicular tissue and epididymal sperm. African J. Biotechnol. 8, 6416–6424.
  225. Yarom, R., Harper, I.S., Wynchank, S., van Schalkwyk, D., Madhoo, J., Williams, K., Salie, R., Genade, S., Lochner, A., 1993. Effect of Captopril on Changes in Rats' Hearts Induced by Long-Term Irradiation. Radiat. Res. 133, 187.