Medical Physiology
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Division of Medical Physiology

​​​​​​​Publications

2018

Journal Articles

  1. ​​Agarwal, A., Sharma, R., Henkel, R., Roychoudhury, S., Sikka, S.C., du Plessis, S., Sarda, Y.B., Speyer, C., Nouh, M., Douglas, C., Kayali, Z., Elshaer, A., Sabanegh, E., 2018. Cumene hydroperoxide induced changes in oxidation-reduction potential in fresh and frozen seminal ejaculates. Andrologia 50, e12796. https://doi.org/10.1111/and.12796​
  2. Aggerbeck, H., Ruhwald, M., Hoff, S.T., Borregaard, B., Hellstrom, E., Malahleha, M., Siebert, M., Gani, M., Seopela, V., Diacon, A., Lourens, M., Andersen, P., Dheda, K., 2018. C-Tb skin test to diagnose Mycobacterium tuberculosis infection in children and HIV-infected adults: A phase 3 trial. PLoS One 13, e0204554. https://doi.org/10.1371/journal.pone.0204554
  3. Arokoyo, Dennis Seyi, Oyeyipo, I.P., Du Plessis, S.S., Aboua, Y.G., 2018. Antioxidant Activities of Basella alba Aqueous Leave Extract In Blood, Pancreas, and Gonadal Tissues of Diabetic Male Wistar Rats. Pharmacognosy Res. 10, 31–36. https://doi.org/10.4103/pr.pr_84_17
  4. Arokoyo, Dennis S, Oyeyipo, I.P., Du Plessis, S.S., Chegou, N.N., Aboua, Y.G., 2018. Modulation of Inflammatory Cytokines and Islet Morphology as Therapeutic Mechanisms of Basella alba in Streptozotocin-Induced Diabetic Rats. Toxicol. Res. 34, 325–332. https://doi.org/10.5487/TR.2018.34.4.325
  5. Augustine, T.N., Cairns, C.J., Chetty, S., Dannatt, L.G., Gravett, N., Grey, G., Grobler, G., Jafta, Z., Kamerman, P., Lopes, J., Matsabisa, M.G., Mugabo, P., Mulder, M., Parry, C., Rataemane, S., Siegfried, N., Steenkamp, V., Thomas, E., Van Zyl-Smit, R., 2018. Priority areas for cannabis and cannabinoid product research in South Africa. African J. Prim. Heal. Care Fam. Med. 10, 1–3. https://doi.org/10.4102/phcfm.v10i1.1711
  6. Ayad, Bashir M, Horst, G. Van der, Plessis, S.S. Du, 2018. Revisiting The Relationship between The Ejaculatory Abstinence Period and Semen Characteristics. Int. J. Fertil. Steril. 11, 238–246. https://doi.org/10.22074/ijfs.2018.5192
  7. Ayad, Bashir M., Van der Horst, G., du Plessis, S.S., 2018. Short abstinence: A potential strategy for the improvement of sperm quality. Middle East Fertil. Soc. J. 23, 37–43. https://doi.org/10.1016/J.MEFS.2017.07.005
  8. Cerf, M., 2018a. Cardiac Glucolipotoxicity and Cardiovascular Outcomes. Medicina (B. Aires). 54, 70. https://doi.org/10.3390/medicina54050070
  9. Cerf, M., 2018b. High Fat Programming and Cardiovascular Disease. Medicina (B. Aires). 54, 86. https://doi.org/10.3390/medicina54050086
  10. Chimhashu, T., Malan, L., Baumgartner, J., van Jaarsveld, P.J., Galetti, V., Moretti, D., Smuts, C.M., Zimmermann, M.B., 2018. Sensitivity of fatty acid desaturation and elongation to plasma zinc concentration: a randomised controlled trial in Beninese children. Br. J. Nutr. 119, 610–619. https://doi.org/10.1017/S000711451700366X
  11. Dludla, P.V., Gabuza, K.B., Muller, C.J.F., Joubert, E., Low, J., Johnson, R., 2018. Aspalathin, a C-glucosyl Dihydrochalcone From Rooibos Improves the Hypoglycemic Potential of Metformin in Type 2 Diabetic (db/db) Mice. Physiol. Res. 67, 813–818.
  12. Dludla, Phiwayinkosi V., Dias, S.C., Obonye, N., Johnson, R., Louw, J., Nkambule, B.B., 2018a. A Systematic Review on the Protective Effect of N-Acetyl Cysteine Against Diabetes-Associated Cardiovascular Complications. Am. J. Cardiovasc. Drugs 18, 283–298. https://doi.org/10.1007/s40256-018-0275-2
  13. Dludla, Phiwayinkosi V., Jack, B., Viraragavan, A., Pheiffer, C., Johnson, R., Louw, J., Muller, C.J.F., 2018b. A dose-dependent effect of dimethyl sulfoxide on lipid content, cell viability and oxidative stress in 3T3-L1 adipocytes. Toxicol. Reports 5, 1014–1020. https://doi.org/10.1016/J.TOXREP.2018.10.002
  14. Donald, P.R., Diacon, A.H., Lange, C., Demers, A.-M., von Groote-Biddlingmeier, F., Nardell, E., 2018. Droplets, dust and guinea pigs: an historical review of tuberculosis transmission research, 1878–1940. Int. J. Tuberc. Lung Dis. 22, 972–982. https://doi.org/10.5588/ijtld.18.0173
  15. Everson, F., Genis, A., Ogundipe, T., Boever, P. De, Goswami, N., Lochner, A., Blackhurst, D., Id, H.S., 2018. Treatment with a fixed dose combination antiretroviral therapy drug containing tenofovir , emtricitabine and efavirenz is associated with cardioprotection in high calorie diet-induced obese rats 1–27. https://doi.org/10.1371/journal.pone.0208537
  16. Goedecke, J.H., Mendham, A.E., Clamp, L., Nono Nankam, P.A., Fortuin-de Smidt, M.C., Phiri, L., Micklesfield, L.K., Keswell, D., Woudberg, N.J., Lecour, S., Alhamud, A., Kaba, M., Lutomia, F.M., van Jaarsveld, P.J., de Villiers, A., Kahn, S.E., Chorell, E., Hauksson, J., Olsson, T., 2018. An Exercise Intervention to Unravel the Mechanisms Underlying Insulin Resistance in a Cohort of Black South African Women: Protocol for a Randomized Controlled Trial and Baseline Characteristics of Participants. JMIR Res. Protoc. 7, e75. https://doi.org/10.2196/resprot.9098
  17. Govender, J., Loos, B., Marais, E., Engelbrecht, A.-M., 2018. Melatonin improves cardiac and mitochondrial function during doxorubicin-induced cardiotoxicity: A possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin activity? Toxicol. Appl. Pharmacol. 358, 86–101. https://doi.org/10.1016/J.TAAP.2018.06.031
  18. Govindsamy, A., Naidoo, S., Cerf, M.E., 2018. Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease. J. Nutr. Metab. 2018, 1–12. https://doi.org/10.1155/2018/8547976
  19. Jack, B., Malherbe, C., Willenburg, E., de Beer, D., Huisamen, B., Joubert, E., Muller, C., Louw, J., Pheiffer, C., 2018. Polyphenol-Enriched Fractions of Cyclopia intermedia Selectively Affect Lipogenesis and Lipolysis in 3T3-L1 Adipocytes. Planta Med. 84, 100–110. https://doi.org/10.1055/s-0043-119463
  20. Johnson, R., Beer, D. de, Dludla, P., Ferreira, D., Muller, C., Joubert, E., 2018. Aspalathin from Rooibos (Aspalathus linearis): A Bioactive C-glucosyl Dihydrochalcone with Potential to Target the Metabolic Syndrome. Planta Med. 84, 568–583. https://doi.org/10.1055/s-0044-100622
  21. Kruger, M.J., Conradie, M.M., Conradie, M., Van De Vyver, M., 2018. ADSC-conditioned media elicit an ex vivo anti-inflammatory macrophage response. J. Mol. Endocrinol. 61, 173–184. https://doi.org/10.1530/JME-18-0078
  22. Lange, C., Alghamdi, W.A., Al-Shaer, M.H., Brighenti, S., Diacon, A.H., DiNardo, A.R., Grobbel, H.P., Gröschel, M.I., von Groote-Bidlingmaier, F., Hauptmann, M., Heyckendorf, J., Köhler, N., Kohl, T.A., Merker, M., Niemann, S., Peloquin, C.A., Reimann, M., Schaible, U.E., Schaub, D., Schleusener, V., Thye, T., Schön, T., 2018. Perspectives for personalized therapy for patients with multidrug-resistant tuberculosis. J. Intern. Med. 284, 163–188. https://doi.org/10.1111/joim.12780
  23. Levine, H., Mohri, H., Ekbom, A., Ramos, L., Parker, G., Roldan, E., Jovine, L., Koelle, S., Lindstrand, A., Immler, S., Mortimer, S., Mortimer, D., van der Horst, G., Ishijima, S., Aneck-Hahn, N., Baldi, E., Menkveld, R., Rothmann, S.A., Giwercman, A., Giwercman, Y., Holmberg, M., Kvist, U., Björndahl, L., Holmberg, R., Arver, S., Flanagan, J., Drevet, J.R., 2018. Male reproductive health statement (XIIIth international symposium on Spermatology, may 9th–12th 2018, Stockholm, Sweden. Basic Clin. Androl. 28, 13. https://doi.org/10.1186/s12610-018-0077-z
  24. Lochner, A., Marais, E., Huisamen, B., 2018. Melatonin and cardioprotection against ischaemia/reperfusion injury: What's new? A review. J. Pineal Res. 65, e12490. https://doi.org/10.1111/jpi.12490
  25. Lumkwana, D., Botha, A., Samodien, E., Hanser, S., Lopes, J., 2017. Laminin, laminin-entactin and extracellular matrix are equally appropriate adhesive substrates for isolated adult rat cardiomyocyte culture and experimentation. Cell Adh. Migr. 1–9. https://doi.org/10.1080/19336918.2017.1387693
  26. Mabhida, Sihle E., Dludla, P. V., Johnson, R., Ndlovu, M., Louw, J., Opoku, A.R., Mosa, R.A., 2018. Protective effect of triterpenes against diabetes-induced β-cell damage: An overview of in vitro and in vivo studies. Pharmacol. Res. 137, 179–192. https://doi.org/10.1016/J.PHRS.2018.10.004
  27. Mabhida, Sihle Ephraim, Johnson, R., Ndlovu, M., Sangweni, N.F., Louw, J., Opoku, A., Mosa, R.A., 2018. A Lanosteryl triterpene from Protorhus longifolia augments insulin signaling in type 1 diabetic rats. BMC Complement. Altern. Med. 18, 265. https://doi.org/10.1186/s12906-018-2337-z
  28. Mehrbani Azar, Y., Green, R., Niesler, C.U., van de Vyver, M., 2018. Antioxidant Preconditioning Improves the Paracrine Responsiveness of Mouse Bone Marrow Mesenchymal Stem Cells to Diabetic Wound Fluid. Stem Cells Dev. 27, 1646–1657. https://doi.org/10.1089/scd.2018.0145
  29. Mentoor, I., Engelbrecht, A.-M., van Jaarsveld, P.J., Nell, T., 2018. Chemoresistance: Intricate Interplay Between Breast Tumor Cells and Adipocytes in the Tumor Microenvironment. Front. Endocrinol. (Lausanne). 9, 758. https://doi.org/10.3389/fendo.2018.00758
  30. Mondloch, S.J., Tanumihardjo, S.A., Davis, C.R., van Jaarsveld, P.J., 2018. Hepatic Vitamin A Concentrations in Vervets ( Chlorocebus aethiops ) Supplemented with Carotenoids Derived from Oil Palm. J. Am. Assoc. Lab. Anim. Sci. 57, 456–464. https://doi.org/10.30802/AALAS-JAALAS-17-000148
  31. Murakami, S., Miura, Y., Hattori, M., Matsuda, H., Malherbe, C., Muller, C., Joubert, E., Yoshida, T., 2018. Cyclopia Extracts Enhance Th1-, Th2-, and Th17-type T Cell Responses and Induce Foxp3+ Cells in Murine Cell Culture. Planta Med. 84, 311–319. https://doi.org/10.1055/s-0043-121270
  32. Omolaoye, T.S., Skosana, B.T., du Plessis, S.S., 2018. Diabetes mellitus- induction: Effect of different streptozotocin doses on male reproductive parameters. Acta Histochem. 120, 103–109. https://doi.org/10.1016/J.ACTHIS.2017.12.005
  33. Ordoqui, R., Barrera, N., Montes, J.M., Canepa, M., Bonelli, C., Surka, C., Torrens, A., Cantú, L., Plessis, S.S. du, 2018. A retrospective study on sperm banking: a Uruguayan experience. JBRA Assist. Reprod. 22, 82–88. https://doi.org/10.5935/1518-0557.20180037
  34. Oyeyipo, I.P., Skosana, B.T., Everson, F.P., Strijdom, H., du Plessis, S.S., 2018. Highly Active Antiretroviral Therapy Alters Sperm Parameters and Testicular Antioxidant Status in Diet-Induced Obese Rats. Toxicol. Res. 34, 41–48. https://doi.org/10.5487/TR.2018.34.1.041
  35. Peloquin, C.A., Phillips, P.P.J., Mitnick, C.D., Eisenach, K., Patientia, R.F., Lecca, L., Gotuzzo, E., Gandhi, N.R., Butler, D., Diacon, A.H., Martel, B., Santillan, J., Hunt, K.R., Vargas, D., von Groote-Bidlingmaier, F., Seas, C., Dianis, N., Moreno-Martinez, A., Kaur, P., Horsburgh, C.R., 2018. Increased Doses Lead to Higher Drug Exposures of Levofloxacin for Treatment of Tuberculosis. Antimicrob. Agents Chemother. 62. https://doi.org/10.1128/AAC.00770-18
  36. Pheiffer, C., Pillay-van Wyk, V., Joubert, J.D., Levitt, N., Nglazi, M.D., Bradshaw, D., 2018. The prevalence of type 2 diabetes in South Africa: a systematic review protocol. BMJ Open 8, e021029. https://doi.org/10.1136/bmjopen-2017-021029
  37. Puerta Suárez, J., du Plessis, S.S., Cardona Maya, W.D., 2018. Spermatozoa: A Historical Perspective. Int. J. Fertil. Steril. 12, 182–190. https://doi.org/10.22074/ijfs.2018.5316
  38. Shaw, J.A., Irusen, E.M., Diacon, A.H., Koegelenberg, C.F., 2018. Pleural tuberculosis: A concise clinical review. Clin. Respir. J. 12, 1779–1786. https://doi.org/10.1111/crj.12900
  39. Smit, S., Johnson, R., Van Vuuren, M., Huisamen, B., 2018. Myocardial Glucose Clearance by Aspalathin Treatment in Young, Mature, and Obese Insulin-Resistant Rats. Planta Med. 84, 75–82. https://doi.org/10.1055/s-0043-117415
  40. Svensson, Elin M., du Bois, J., Kitshoff, R., de Jager, V.R., Wiesner, L., Norman, J., Nachman, S., Smith, B., Diacon, A.H., Hesseling, A.C., Garcia-Prats, A.J., 2018. Relative bioavailability of bedaquiline tablets suspended in water: Implications for dosing in children. Br. J. Clin. Pharmacol. 84, 2384–2392. https://doi.org/10.1111/bcp.13696
  41. Svensson, Elin M, Svensson, R.J., te Brake, L.H.M., Boeree, M.J., Heinrich, N., Konsten, S., Churchyard, G., Dawson, R., Diacon, A.H., Kibiki, G.S., Minja, L.T., Ntingiya, N.E., Sanne, I., Gillespie, S.H., Hoelscher, M., Phillips, P.P.J., Simonsson, U.S.H., Aarnoutse, R., 2018. The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis. Clin. Infect. Dis. 67, 34–41. https://doi.org/10.1093/cid/ciy026
  42. Svensson, R.J., Aarnoutse, R.E., Diacon, A.H., Dawson, R., Gillespie, S.H., Boeree, M.J., Simonsson, U.S.H., 2018. A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses. Clin. Pharmacol. Ther. 103, 674–683. https://doi.org/10.1002/cpt.778
  43. Svensson, R.J., Svensson, E.M., Aarnoutse, R.E., Diacon, A.H., Dawson, R., Gillespie, S.H., Moodley, M., Boeree, M.J., Simonsson, U.S.H., 2018. Greater Early Bactericidal Activity at Higher Rifampicin Doses Revealed by Modeling and Clinical Trial Simulations. J. Infect. Dis. 218, 991–999. https://doi.org/10.1093/infdis/jiy242
  44. Temidayo, So., Stefan, S.P., 2018. Diabetes mellitus and male infertility. Asian Pacific J. Reprod. 7, 6. https://doi.org/10.4103/2305-0500.220978
  45. Thomas, M., Davis, T., Loos, B., Sishi, B., Huisamen, B., Strijdom, H., Engelbrecht, A.-M., 2018. Autophagy is essential for the maintenance of amino acids and ATP levels during acute amino acid starvation in MDAMB231 cells. Cell Biochem. Funct. 36, 65–79. https://doi.org/10.1002/cbf.3318
  46. Truter, D., Chellan, N., Strijdom, H., Webster, I., Rawstorne, J., Kotzé, S.H., 2018. Histomorphological changes in the pancreas and kidney and histopathological changes in the liver in male Wistar rats on antiretroviral therapy and melatonin treatment. Acta Histochem. 120, 347–355. https://doi.org/10.1016/J.ACTHIS.2018.03.006
  47. Tweed, Conor D., Crook, A.M., Amukoye, E.I., Dawson, R., Diacon, A.H., Hanekom, M., McHugh, T.D., Mendel, C.M., Meredith, S.K., Murphy, M.E., Murthy, S.E., Nunn, A.J., Phillips, P.P.J., Singh, K.P., Spigelman, M., Wills, G.H., Gillespie, S.H., 2018. Toxicity associated with tuberculosis chemotherapy in the REMoxTB study. BMC Infect. Dis. 18, 317. https://doi.org/10.1186/s12879-018-3230-6
  48. Tweed, Conor Duncan, Wills, G.H., Crook, A.M., Dawson, R., Diacon, A.H., Louw, C.E., McHugh, T.D., Mendel, C., Meredith, S., Mohapi, L., Murphy, M.E., Murray, S., Murthy, S., Nunn, A.J., Phillips, P.P.J., Singh, K., Spigelman, M., Gillespie, S.H., 2018. Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study. BMC Med. 16, 46. https://doi.org/10.1186/s12916-018-1033-7
  49. van der Horst, G., Maree, L., du Plessis, S.S., 2018. Current perspectives of CASA applications in diverse mammalian spermatozoa. Reprod. Fertil. Dev. 30, 875. https://doi.org/10.1071/RD17468
  50. Van Der Meeren, O., Hatherill, M., Nduba, V., Wilkinson, R.J., Muyoyeta, M., Van Brakel, E., Ayles, H.M., Henostroza, G., Thienemann, F., Scriba, T.J., Diacon, A., Blatner, G.L., Demoitié, M.-A., Tameris, M., Malahleha, M., Innes, J.C., Hellström, E., Martinson, N., Singh, T., Akite, E.J., Khatoon Azam, A., Bollaerts, A., Ginsberg, A.M., Evans, T.G., Gillard, P., Tait, D.R., 2018. Phase 2b Controlled Trial of M72/AS01 E Vaccine to Prevent Tuberculosis. N. Engl. J. Med. 379, 1621–1634. https://doi.org/10.1056/NEJMoa1803484
  51. Willmer, T., Johnson, R., Louw, J., Pheiffer, C., 2018. Blood-Based DNA Methylation Biomarkers for Type 2 Diabetes: Potential for Clinical Applications. Front. Endocrinol. (Lausanne). 9, 744. https://doi.org/10.3389/fendo.2018.00744​

2017

Journal Articles

  1. Alsultan, A., Furin, J.J., Du Bois, J., van Brakel, E., Chheng, P., Venter, A., Thiel, B., Debanne, S.A., Boom, W.H., Diacon, A.H., Johnson, J.L., Peloquin, C.A., 2017. Population Pharmacokinetics of AZD-5847 in Adults with Pulmonary Tuberculosis. Antimicrob. Agents Chemother. 61. https://doi.org/10.1128/AAC.01066-17
  2. Ayad, B.M., Horst, G. Van der, Plessis, S.S. Du, 2018. Revisiting The Relationship between The Ejaculatory Abstinence Period and Semen Characteristics. Int. J. Fertil. Steril. 11, 238–246. https://doi.org/10.22074/ijfs.2018.5192

  3. Boeree, M.J., Heinrich, N., Aarnoutse, R., Diacon, A.H., Dawson, R., Rehal, S., Kibiki, G.S., Churchyard, G., Sanne, I., Ntinginya, N.E., Minja, L.T., Hunt, R.D., Charalambous, S., Hanekom, M., Semvua, H.H., Mpagama, S.G., Manyama, C., Mtafya, B., Reither, K., Wallis, R.S., Venter, A., Narunsky, K., Mekota, A., Henne, S., Colbers, A., van Balen, G.P., Gillespie, S.H., Phillips, P.P.J., Hoelscher, M., 2017. High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial. Lancet Infect. Dis. 17, 39–49. https://doi.org/10.1016/S1473-3099(16)30274-2
  4. Bouton, T.C., Phillips, P.P.J., Mitnick, C.D., Peloquin, C.A., Eisenach, K., Patientia, R.F., Lecca, L., Gotuzzo, E., Gandhi, N.R., Butler, D., Diacon, A.H., Martel, B., Santillan, J., Hunt, K.R., Vargas, D., von Groote-Bidlingmaier, F., Seas, C., Dianis, N., Moreno-Martinez, A., Horsburgh, C.R., 2017. An optimized background regimen design to evaluate the contribution of levofloxacin to multidrug-resistant tuberculosis treatment regimens: study protocol for a randomized controlled trial. Trials 18, 563. https://doi.org/10.1186/s13063-017-2292-x
  5. Bowles, S., Joubert, E., de Beer, D., Louw, J., Brunschwig, C., Njoroge, M., Lawrence, N., Wiesner, L., Chibale, K., Muller, C., 2017. Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin. Molecules 22, 554. https://doi.org/10.3390/molecules22040554
  6. De Jager, V., van der Merwe, L., Venter, A., Donald, P.R., Diacon, A.H., 2017. Time Trends in Sputum Mycobacterial Load and Two-Day Bactericidal Activity of Isoniazid-Containing Antituberculosis Therapies. Antimicrob. Agents Chemother. 61. https://doi.org/10.1128/AAC.02088-16
  7. Dludla, P., Muller, C., Joubert, E., Louw, J., Essop, M., Gabuza, K., Ghoor, S., Huisamen, B., Johnson, R., 2017. Aspalathin Protects the Heart against Hyperglycemia-Induced Oxidative Damage by Up-Regulating Nrf2 Expression. Molecules 22, 129. https://doi.org/10.3390/molecules22010129
  8. Dludla, P. V., Essop, M.F., Gabuza, K.B., Muller, C.J.F., Louw, J., Johnson, R., 2017a. Age-dependent development of left ventricular wall thickness in type 2 diabetic (db/db) mice is associated with elevated low-density lipoprotein and triglyceride serum levels. Heart Vessels 32, 1025–1031. https://doi.org/10.1007/s00380-017-0978-3
  9. Dludla, P. V., Joubert, E., Muller, C.J.F., Louw, J., Johnson, R., 2017b. Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside. Nutr. Metab. (Lond). 14, 45. https://doi.org/10.1186/s12986-017-0200-8
  10. Dludla, P. V., Nkambule, B.B., Dias, S.C., Johnson, R., 2017c. Cardioprotective potential of N-acetyl cysteine against hyperglycaemia-induced oxidative damage: a protocol for a systematic review. Syst. Rev. 6, 96. https://doi.org/10.1186/s13643-017-0493-8
  11. Jack, B.U., Malherbe, C.J., Huisamen, B., Gabuza, K., Mazibuko-Mbeje, S., Schulze, A.E., Joubert, E., Muller, C.J.F., Louw, J., Pheiffer, C., 2017. A polyphenol-enriched fraction of Cyclopia intermedia decreases lipid content in 3T3-L1 adipocytes and reduces body weight gain of obese db/db mice. South African J. Bot. 110, 216–229. https://doi.org/10.1016/J.SAJB.2016.08.007
  12. Johnson, R., Dludla, P., Muller, C., Huisamen, B., Essop, M., Louw, J., 2017a. The Transcription Profile Unveils the Cardioprotective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model. Molecules 22, 219. https://doi.org/10.3390/molecules22020219
  13. Johnson, R., Shabalala, S., Louw, J., Kappo, A., Muller, C., 2017b. Aspalathin Reverts Doxorubicin-Induced Cardiotoxicity through Increased Autophagy and Decreased Expression of p53/mTOR/p62 Signaling. Molecules 22, 1589. https://doi.org/10.3390/molecules22101589
  14. Kayigire, X.A., Friedrich, S.O., van der Merwe, L., Diacon, A.H., 2017. Acquisition of Rifampin Resistance in Pulmonary Tuberculosis. Antimicrob. Agents Chemother. 61. https://doi.org/10.1128/AAC.02220-16
  15. Kistan, J., Laher, F., Otwombe, K., Panchia, R., Mawaka, N., Lebina, L., Diacon, A., Kana, B., Martinson, N., 2017. Pulmonary TB: varying radiological presentations in individuals with HIV in Soweto, South Africa. Trans. R. Soc. Trop. Med. Hyg. 111, 132–136. https://doi.org/10.1093/trstmh/trx028
  16. Lalinde-Acevedo, P.C., Mayorga-Torres, B.J.M., Agarwal, A., du Plessis, S.S., Ahmad, G., Cadavid, Á.P., Cardona Maya, W.D., 2017. Physically Active Men Show Better Semen Parameters than Their Sedentary Counterparts. Int. J. Fertil. Steril. 11, 156–165. https://doi.org/10.22074/ijfs.2017.4881
  17. Nduhirabandi, F., Huisamen, B., Strijdom, H., Lochner, A., Barbara, H., 2017. Role of melatonin in glucose uptake by cardiomyocytes from insulin-resistant Wistar rats. Cardiovasc. J. Afr. 28, 362–369. https://doi.org/10.5830/CVJA-2017-018
  18. Nel, S., Strijdom, H., Genis, A., Everson, F., Van Wijk, R., Kotzé, S.H., 2017. A histomorphometric study on the effects of antiretroviral therapy (ART) combined with a high-calorie diet (HCD) on aortic perivascular adipose tissue (PVAT). Acta Histochem. 119, 555–562. https://doi.org/10.1016/J.ACTHIS.2017.05.009
  19. Oyeyipo, I.P., van der Linde, M., du Plessis, S.S., 2017. Environmental Exposure of Sperm Sex-Chromosomes: A Gender Selection Technique. Toxicol. Res. 33, 315–323. https://doi.org/10.5487/TR.2017.33.4.315
  20. Patten, V., Chabaesele, I., Sishi, B., Van Vuuren, D., 2017. Cardiomyocyte differentiation: Experience and observations from 2 laboratories. SA Hear. 14, 96–107. https://doi.org/10.24170/14-2-2498
  21. Salie, R., Lochner, A., Loubser, D.J., 2017. The significance of the washout period in preconditioning. Cardiovasc. Ther. 35, e12252. https://doi.org/10.1111/1755-5922.12252
  22. Shabalala, S., Muller, C.J.F., Louw, J., Johnson, R., 2017. Polyphenols, autophagy and doxorubicin-induced cardiotoxicity. Life Sci. 180, 160–170. https://doi.org/10.1016/J.LFS.2017.05.003
  23. Strijdom, H., De Boever, P., Walzl, G., Essop, M.F., Nawrot, T.S., Webster, I., Westcott, C., Mashele, N., Everson, F., Malherbe, S.T., Stanley, K., Kessler, H.H., Stelzl, E., Goswami, N., 2017. Cardiovascular risk and endothelial function in people living with HIV/AIDS: Design of the multi-site, longitudinal EndoAfrica study in the Western Cape Province of South Africa. BMC Infect. Dis. 17, 1–9. https://doi.org/10.1186/s12879-016-2158-y
  24. Svensson, R.J., Aarnoutse, R.E., Diacon, A.H., Dawson, R., Gillespie, S.H., Boeree, M.J., Simonsson, U.S.H., 2017. A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses. Clin. Pharmacol. Ther. 103, 674–683. https://doi.org/10.1002/cpt.778
  25. Truter, D., Strijdom, H., Everson, F., Kotzé, S.H., 2017. Mucin secreting cells in the stomach and colon are altered by combination antiretroviral treatment in an obese rat model. Acta Histochem. 119, 122–128. https://doi.org/10.1016/J.ACTHIS.2016.11.014
  26. van Niekerk, G., Davids, L.M., Hattingh, S.M., Engelbrecht, A.-M., 2017. Cancer stem cells: A product of clonal evolution? Int. J. Cancer 140, 993–999. https://doi.org/10.1002/ijc.30448
  27. Walters, E., Demers, A.-M., van der Zalm, M.M., Whitelaw, A., Palmer, M., Bosch, C., Draper, H.R., Gie, R.P., Hesseling, A.C., 2017. Stool Culture for Diagnosis of Pulmonary Tuberculosis in Children. J. Clin. Microbiol. 55, 3355–3365. https://doi.org/10.1128/JCM.00801-17
  28. Webster, I., Salie, R., Marais, E., Fan, W.-J., Maarman, G., Huisamen, B., Lochner, A., 2017. Myocardial susceptibility to ischaemia/reperfusion in obesity: a re-evaluation of the effects of age. BMC Physiol. 17, 3. https://doi.org/10.1186/s12899-017-0030-y
  29. Webster, Ingrid, Smith, A., Lochner, A., Huisamen, B., 2017. The Role of MKP-1 in Insulin-Induced Cardioprotection. Cardiovasc. Drugs Ther. 31, 247–254. https://doi.org/10.1007/s10557-017-6731-4
  30. Westcott, C., Genis, A., Mthethwa, M., Graham, R., Van Vuuren, D., Huisamen, B., Strijdom, H., 2017. Fenofibrate protects endothelial cells against the harmful effects of TNF-alpha. SAHeart 14, 22–34. https://doi.org/10.24170/14-1-1865​

​2016

Journal Articles

  1. Agarwal, A., Gupta, S., Du Plessis, S., Sharma, R., Esteves, S.C., Cirenza, C., Eliwa, J., Al-Najjar, W., Kumaresan, D., Haroun, N., Philby, S., Sabanegh, E., 2016a. Abstinence Time and Its Impact on Basic and Advanced Semen Parameters. Urology 94, 102–110. https://doi.org/10.1016/J.UROLOGY.2016.03.059
  2. Agarwal, A., Sharma, R., Roychoudhury, S., Du Plessis, S., Sabanegh, E., 2016b. MiOXSYS: a novel method of measuring oxidation reduction potential in semen and seminal plasma. Fertil. Steril. 106, 566-573.e10. https://doi.org/10.1016/J.FERTNSTERT.2016.05.013
  3. Bernasconi, M., Diacon, A.H., Koegelenberg, C.F.N., 2016. Stair Climbing Test Streamlines the Evaluation of Nonmalignant Lung Resection Candidates. Respiration 91, 87–88. https://doi.org/10.1159/000442889
  4. Demers, A.-M., Venter, A., Friedrich, S.O., Rojas-Ponce, G., Mapamba, D., Jugheli, L., Sasamalo, M., Almeida, D., Dorasamy, A., Jentsch, U., Gibson, M., Everitt, D., Eisenach, K.D., Diacon, A.H., 2016. Direct Susceptibility Testing of Mycobacterium tuberculosis for Pyrazinamide by Use of the Bactec MGIT 960 System. J. Clin. Microbiol. 54, 1276–81. https://doi.org/10.1128/JCM.03162-15
  5. Dludla, P., Muller, C., Joubert, E., Louw, J., Gabuza, K., Huisamen, B., Essop, M., Johnson, R., 2016. Phenylpyruvic Acid-2-O-β-D-Glucoside Attenuates High Glucose-Induced Apoptosis in H9c2 Cardiomyocytes. Planta Med. 82, 1468–1474. https://doi.org/10.1055/s-0042-110856
  6. Franzen, D., Diacon, A.H., Freitag, L., Schubert, P.T., Wright, C.A., Schuurmans, M.M., 2016. Ultrathin bronchoscopy for solitary pulmonary lesions in a region endemic for tuberculosis: a randomised pilot trial. BMC Pulm. Med. 16, 62. https://doi.org/10.1186/s12890-016-0225-1
  7. Furin, J., Alirol, E., Allen, E., Fielding, K., Merle, C., Abubakar, I., Andersen, J., Davies, G., Dheda, K., Diacon, A., Dooley, K.E., Dravnice, G., Eisenach, K., Everitt, D., Ferstenberg, D., Goolam-Mahomed, A., Grobusch, M.P., Gupta, R., Harausz, E., Harrington, M., Horsburgh, C.R., Lienhardt, C., McNeeley, D., Mitnick, C.D., Nachman, S., Nahid, P., Nunn, A.J., Phillips, P., Rodriguez, C., Shah, S., Wells, C., Thomas-Nyang'wa, B., du Cros, P., 2016. Drug-resistant tuberculosis clinical trials: proposed core research definitions in adults. Int. J. Tuberc. Lung Dis. 20, 290–294. https://doi.org/10.5588/ijtld.15.0490
  8. Furin, J.J., Du Bois, J., van Brakel, E., Chheng, P., Venter, A., Peloquin, C.A., Alsultan, A., Thiel, B.A., Debanne, S.M., Boom, W.H., Diacon, A.H., Johnson, J.L., 2016. Early Bactericidal Activity of AZD5847 in Patients with Pulmonary Tuberculosis. Antimicrob. Agents Chemother. 60, 6591–6599. https://doi.org/10.1128/AAC.01163-16
  9. Goss, D., Oyeyipo, I.P., Skosana, B.T., Ayad, B.M., du Plessis, S.S., 2016. Ameliorative potentials of quercetin against cotinine-induced toxic effects on human spermatozoa. Asian Pacific J. Reprod. 5, 193–197. https://doi.org/10.1016/J.APJR.2016.03.005
  10. Huisamen, B., George, C., Genade, S., Dietrich, D., 2016a. Cardioprotective and anti-hypertensive effects of Prosopis glandulosa in rat models of pre-diabetes. South African J. Diabetes Vasc. Dis. 13, 61–67.
  11. Huisamen, B., Hafver, T.L., Lumkwana, D., Lochner, A., 2016b. The Impact of Chronic Glycogen Synthase Kinase-3 Inhibition on Remodeling of Normal and Pre-Diabetic Rat Hearts. Cardiovasc. Drugs Ther. 30, 237–246. https://doi.org/10.1007/s10557-016-6665-2
  12. Jayakumar, A., Savic, R.M., Everett, C.K., Benator, D., Alland, D., Heilig, C.M., Weiner, M., Friedrich, S.O., Martinson, N.A., Kerrigan, A., Zamudio, C., Goldberg, S. V, Whitworth, W.C., Davis, J.L., Nahid, P., 2016. Xpert MTB/RIF Assay Shows Faster Clearance of Mycobacterium tuberculosis DNA with Higher Levels of Rifapentine Exposure. J. Clin. Microbiol. 54, 3028–3033. https://doi.org/10.1128/JCM.01313-16
  13. Johnson, R., Dludla, P., Joubert, E., February, F., Mazibuko, S., Ghoor, S., Muller, C., Louw, J., 2016. Aspalathin, a dihydrochalcone C -glucoside, protects H9c2 cardiomyocytes against high glucose induced shifts in substrate preference and apoptosis. Mol. Nutr. Food Res. 60, 922–934. https://doi.org/10.1002/mnfr.201500656
  14. Jordaan, A.E., 2016. The effects of the wild african potato (hypoxis hemerocallidea) supplementation on streptozotocin-induced diabetic wistar rats reproductive function. Andrology 5, 1000165.
  15. Kayigire, X.A., Friedrich, S.O., Karinja, M.N., van der Merwe, L., Martinson, N.A., Diacon, A.H., 2016. Propidium monoazide and Xpert MTB/RIF to quantify Mycobacterium tuberculosis cells. Tuberculosis 101, 79–84. https://doi.org/10.1016/J.TUBE.2016.08.006
  16. Lückhoff, H.K., Kidd, M., van Rensburg, S.J., van Velden, D.P., Kotze, M.J., 2016. Apolipoprotein E genotyping and questionnaire-based assessment of lifestyle risk factors in dyslipidemic patients with a family history of Alzheimer's disease: test development for clinical application. Metab. Brain Dis. 31, 213–224. https://doi.org/10.1007/s11011-015-9737-2
  17. Mfokazi, A., Wright, C.A., Louw, M., Von Groote-Bidlingmaier, F., Schubert, P.T., Koegelenberg, C.F.N., Diacon, A.H., 2016. Direct comparison of liquid-based and smear-based cytology with and without rapid on-site evaluation for fine needle aspirates of thoracic tumors. Diagn. Cytopathol. 44, 363–368. https://doi.org/10.1002/dc.23447
  18. Phillips, P.P.J., Dooley, K.E., Gillespie, S.H., Heinrich, N., Stout, J.E., Nahid, P., Diacon, A.H., Aarnoutse, R.E., Kibiki, G.S., Boeree, M.J., Hoelscher, M., 2016a. A new trial design to accelerate tuberculosis drug development: the Phase IIC Selection Trial with Extended Post-treatment follow-up (STEP). BMC Med. 14, 51. https://doi.org/10.1186/s12916-016-0597-3
  19. Phillips, P.P.J., Mendel, C.M., Burger, D.A., Crook, A.M., Nunn, A.J., Dawson, R., Diacon, A.H., Gillespie, S.H., 2016b. Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials. BMC Med. 14, 19. https://doi.org/10.1186/s12916-016-0565-y
  20. Pym, A.S., Diacon, A.H., Tang, S.-J., Conradie, F., Danilovits, M., Chuchottaworn, C., Vasilyeva, I., Andries, K., Bakare, N., De Marez, T., Haxaire-Theeuwes, M., Lounis, N., Meyvisch, P., Van Baelen, B., van Heeswijk, R.P.G., Dannemann, B., TMC207-C209 Study Group, 2016. Bedaquiline in the treatment of multidrug- and extensively drug-resistant tuberculosis. Eur. Respir. J. 47, 564–74. https://doi.org/10.1183/13993003.00724-2015
  21. van Niekerk, G., Davids, L.M., Hattingh, S.M., Engelbrecht, A.-M., 2017. Cancer stem cells: A product of clonal evolution? Int. J. Cancer 140, 993–999. https://doi.org/10.1002/ijc.30448
  22. van Niekerk, G., Hattingh, S.M., Engelbrecht, A.-M., 2016. Enhanced Therapeutic Efficacy in Cancer Patients by Short-term Fasting: The Autophagy Connection. Front. Oncol. 6, 242. https://doi.org/10.3389/fonc.2016.00242
  23. van Vuuren, D., Marais, E., Genade, S., Lochner, A., 2016. The differential effects of FTY720 on functional recovery and infarct size following myocardial ischaemia/reperfusion. Cardiovasc. J. Afr. 27, 375–386. https://doi.org/10.5830/CVJA-2016-039​

2015

Journal Articles

  1. Boeree, M.J., Diacon, A.H., Dawson, R., Narunsky, K., Du Bois, J., Venter, A., Phillips, P.P.J., Gillespie, S.H., McHugh, T.D., Hoelscher, M., Heinrich, N., Rehal, S., Van Soolingen, D., Van Ingen, J., Magis-Escurra, C., Burger, D., Van Balen, G.P., Aarnoutse, R.E., 2015. A dose-ranging trial to optimize the dose of rifampin in the treatment of tuberculosis. Am. J. Respir. Crit. Care Med. 191, 1058–1065. https://doi.org/10.1164/rccm.201407-1264OC
  2. Bowness, R., Boeree, M.J., Aarnoutse, R., Dawson, R., Diacon, A., Mangu, C., Heinrich, N., Ntinginya, N.E., Kohlenberg, A., Mtafya, B., Phillips, P.P.J., Rachow, A., Plemper van Balen, G., Gillespie, S.H., 2015. The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations. J. Antimicrob. Chemother. 70, 448–455. https://doi.org/10.1093/jac/dku415
  3. Dawson, R., Diacon, A.H., Everitt, D., van Niekerk, C., Donald, P.R., Burger, D.A., Schall, R., Spigelman, M., Conradie, A., Eisenach, K., Venter, A., Ive, P., Page-Shipp, L., Variava, E., Reither, K., Ntinginya, N.E., Pym, A., von Groote-Bidlingmaier, F., Mendel, C.M., 2015. Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase 2b, open-label, partly randomised trial in patients with drug-susceptible or drug-resistant pulmonary tuberculosis. Lancet 385, 1738–1747. https://doi.org/10.1016/S0140-6736(14)62002-X
  4. De Wet, D.R., Wright, C.A., Schubert, P.T., Koegelenberg, C.F.N., Louw, M., Diacon, A.H., 2015. Mediastinal granulomatous lymphadenitis in a population at risk for HIV and tuberculosis. Diagn. Cytopathol. 43, 696–700. https://doi.org/10.1002/dc.23280
  5. Diacon, A.H., Dawson, R., Von Groote-Bidlingmaier, F., Symons, G., Venter, A., Donald, P.R., Van Niekerk, C., Everitt, D., Hutchings, J., Burger, D.A., Schall, R., Mendel, C.M., 2015. Bactericidal activity of pyrazinamide and clofazimine alone and in combinations with pretomanid and bedaquiline. Am. J. Respir. Crit. Care Med. 191, 943–953. https://doi.org/10.1164/rccm.201410-1801OC
  6. Donald, P.R., Diacon, A.H., 2015. Para-aminosalicylic acid: the return of an old friend. Lancet Infect. Dis. 15, 1091–1099. https://doi.org/10.1016/S1473-3099(15)00263-7
  7. du Plessis, Stefan S, Agarwal, A., Mohanty, G., van der Linde, M., 2015. Oxidative phosphorylation versus glycolysis: what fuel do spermatozoa use? Asian J. Androl. 17, 230–5. https://doi.org/10.4103/1008-682X.135123
  8. du Plessis, Stefan S., Agarwal, A., Syriac, A., 2015. Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility. J. Assist. Reprod. Genet. 32, 1575–1588. https://doi.org/10.1007/s10815-015-0553-8
  9. Espach, Y., Lochner, A., Strijdom, H., Huisamen, B., 2015. ATM Protein Kinase Signaling, Type 2 Diabetes and Cardiovascular Disease. Cardiovasc. Drugs Ther. 29, 51–58. https://doi.org/10.1007/s10557-015-6571-z
  10. George, C, Dietrich, D., Huisamen, B., 2015. The Effect of Chronic Prosopis glandulosa Treatment on Muscle Force Development and Fatigue Tolerance in Soleus Muscle. Br. J. Appl. Sci. Technol. 10, 1–10. https://doi.org/10.9734/BJAST/2015/17032
  11. George, Cindy, Smith, C., Isaacs, A., Huisamen, B., 2015. Chronic Prosopis Glandulosa Treatment Blunts Neutrophil Infiltration and Enhances Muscle Repair after Contusion Injury. Nutrients 7, 815–830. https://doi.org/10.3390/nu7020815
  12. Harlev, A., Agarwal, A., Gunes, S.O., Shetty, A., du Plessis, S.S., 2015. Smoking and Male Infertility: An Evidence-Based Review. World J. Mens. Health 33, 143. https://doi.org/10.5534/wjmh.2015.33.3.143
  13. Heinrich, N., Dawson, R., du Bois, J., Narunsky, K., Horwith, G., Phipps, A.J., Nacy, C.A., Aarnoutse, R.E., Boeree, M.J., Gillespie, S.H., Venter, A., Henne, S., Rachow, A., Phillips, P.P.J., Hoelscher, M., Diacon, A.H., Mekota, A.M., Heinrich, N., Rachow, A., Saathoff, E., Hoelscher, M., Gillespie, S., Colbers, A., van Balen, G.P., Aarnoutse, R., Boeree, M., Bateson, A., McHugh, T., Singh, K., Hunt, R., Zumla, A., Nunn, A., Phillips, P., Rehal, S., Dawson, R., Narunsky, K., Diacon, A., du Bois, J., Venter, A., Friedrich, S., Sanne, I., Mellet, K., Churchyard, G., Charalambous, S., Mwaba, P., Elias, N., Mangu, C., Rojas-Ponce, G., Mtafya, B., Maboko, L., Minja, L.T., Sasamalo, M., Reither, K., Jugheli, L., Sam, N., Kibiki, G., Semvua, H., Mpagama, S., Alabi, A., Adegnika, A.A., Amukoye, E., Okwera, A., 2015. Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients. J. Antimicrob. Chemother. 70, 1558–1566. https://doi.org/10.1093/jac/dku553
  14. Karinja, M.N., Esterhuizen, T.M., Friedrich, S.O., Diacon, A.H., 2015. Sputum volume predicts sputum mycobacterial load during the first 2 weeks of antituberculosis treatment. J. Clin. Microbiol. 53, 1087–91. https://doi.org/10.1128/JCM.02379-14
  15. Kayigire, X.A., Friedrich, S.O., van der Merwe, L., Donald, P.R., Diacon, A.H., 2015. Simultaneous staining of sputum smears for acid-fast and lipid-containing Myobacterium tuberculosis can enhance the clinical evaluation of antituberculosis treatments. Tuberculosis 95, 770–779. https://doi.org/10.1016/J.TUBE.2015.08.001
  16. Koegelenberg, C.F.N., Irusen, E.M., von Groote-Bidlingmaier, F., Bruwer, J.W., Batubara, E.M.A., Diacon, A.H., 2015. The utility of ultrasound-guided thoracentesis and pleural biopsy in undiagnosed pleural exudates. Thorax 70, 995–7. https://doi.org/10.1136/thoraxjnl-2014-206567
  17. Mayorga-Torres, B.J.M., Camargo, M., Agarwal, A., du Plessis, S.S., Cadavid, Á.P., Cardona Maya, W.D., 2015. Influence of ejaculation frequency on seminal parameters. Reprod. Biol. Endocrinol. 13, 47. https://doi.org/10.1186/s12958-015-0045-9
  18. Oyeyipo, I.P., Maartens, P.J., du Plessis, S.S., 2015. Diet-induced obesity alters kinematics of rat spermatozoa. Asian Pacific J. Reprod. 4, 235–239. https://doi.org/10.1016/J.APJR.2015.06.008
  19. Rullas, J., Dhar, N., McKinney, J.D., García-Pérez, A., Lelievre, J., Diacon, A.H., Hugonnet, J.-E., Arthur, M., Angulo-Barturen, I., Barros-Aguirre, D., Ballell, L., 2015. Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection. Antimicrob. Agents Chemother. 59, 4997–9. https://doi.org/10.1128/AAC.01063-15
  20. Slabbert, M., du Plessis, S.S., Huyser, C., 2015. Large volume cryoprotectant-free vitrification: an alternative to conventional cryopreservation for human spermatozoa. Andrologia 47, 594–599. https://doi.org/10.1111/and.12307
  21. Solomons, R.S., Visser, D.H., Friedrich, S.O., Diacon, A.H., Hoek, K.G.P., Marais, B.J., Schoeman, J.F., van Furth, A.M., 2015. Improved diagnosis of childhood tuberculous meningitis using more than one nucleic acid amplification test. Int. J. Tuberc. Lung Dis. 19, 74–80. https://doi.org/10.5588/ijtld.14.0394
  22. Sy, S.K.B., de Kock, L., Diacon, A.H., Werely, C.J., Xia, H., Rosenkranz, B., van der Merwe, L., Donald, P.R., 2015. N-acetyltransferase genotypes and the pharmacokinetics and tolerability of para-aminosalicylic acid in patients with drug-resistant pulmonary tuberculosis. Antimicrob. Agents Chemother. 59, 4129–38. https://doi.org/10.1128/AAC.04049-14
  23. Vorster, M.J., Allwood, B.W., Diacon, A.H., Koegelenberg, C.F.N., 2015. Tuberculous pleural effusions: advances and controversies. J. Thorac. Dis. 7, 981–91. https://doi.org/10.3978/j.issn.2072-1439.2015.02.18​

2014

Journal Articles

  1. Agarwal, A., Durairajanayagam, D., du Plessis, S.S., 2014a. Utility of antioxidants during assisted reproductive techniques: an evidence-based review. Reprod. Biol. Endocrinol. 12, 112. https://doi.org/10.1186/1477-7827-12-112
  2. Agarwal, A., Virk, G., Ong, C., du Plessis, S.S., 2014b. Effect of Oxidative Stress on Male Reproduction. World J. Mens. Health 32, 1. https://doi.org/10.5534/wjmh.2014.32.1.1
  3. Bowness, R., Boeree, M.J., Aarnoutse, R., Dawson, R., Diacon, A., Mangu, C., Heinrich, N., Ntinginya, N.E., Kohlenberg, A., Mtafya, B., Phillips, P.P.J., Rachow, A., Plemper van Balen, G., Gillespie, S.H., 2015. The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations. J. Antimicrob. Chemother. 70, 448–455. https://doi.org/10.1093/jac/dku415
  4. Chellan, N., Joubert, E., Strijdom, H., Roux, C., Louw, J., Muller, C., 2014. Aqueous Extract of Unfermented Honeybush (Cyclopia maculata) Attenuates STZ-induced Diabetes and β-cell Cytotoxicity. Planta Med. 80, 622–629. https://doi.org/10.1055/s-0034-1368457
  5. de Kock, L., Sy, S.K.B., Rosenkranz, B., Diacon, A.H., Prescott, K., Hernandez, K.R., Yu, M., Derendorf, H., Donald, P.R., 2014. Pharmacokinetics of para-aminosalicylic acid in HIV-uninfected and HIV-coinfected tuberculosis patients receiving antiretroviral therapy, managed for multidrug-resistant and extensively drug-resistant tuberculosis. Antimicrob. Agents Chemother. 58, 6242–50. https://doi.org/10.1128/AAC.03073-14
  6. Diacon, A.H., Pym, A., Grobusch, M.P., de los Rios, J.M., Gotuzzo, E., Vasilyeva, I., Leimane, V., Andries, K., Bakare, N., De Marez, T., Haxaire-Theeuwes, M., Lounis, N., Meyvisch, P., De Paepe, E., van Heeswijk, R.P.G., Dannemann, B., 2014a. Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline. N. Engl. J. Med. 371, 723–732. https://doi.org/10.1056/NEJMoa1313865
  7. Diacon, A.H., van der Merwe, L., Demers, A.-M., von Groote-Bidlingmaier, F., Venter, A., Donald, P.R., 2014b. Time to positivity in liquid culture predicts colony forming unit counts of Mycobacterium tuberculosis in sputum specimens. Tuberculosis 94, 148–151. https://doi.org/10.1016/J.TUBE.2013.12.002
  8. Diacon, A.H., van der Merwe, L., Demers, A.-M., Von Groote-Bidlingmaier, F., Venter, A., Donald, P.R., 2014c. Pre-treatment mycobacterial sputum load influences individual on-treatment measurements. Tuberculosis 94, 690–694. https://doi.org/10.1016/J.TUBE.2014.08.015
  9. Dludla, P.V., Muller, C.J.F., Louw, J., Joubert, E., Salie, R., Opoku, A.R., Johnson, R., 2014. The cardioprotective effect of an aqueous extract of fermented rooibos (Aspalathus linearis) on cultured cardiomyocytes derived from diabetic rats. Phytomedicine 21, 595–601. https://doi.org/10.1016/J.PHYMED.2013.10.029
  10. Donald, P.R., Diacon, A.H., 2008. The early bactericidal activity of anti-tuberculosis drugs: a literature review. Tuberculosis 88, S75–S83. https://doi.org/10.1016/S1472-9792(08)70038-6
  11. Flint, M., du Plessis, S.S., Menkveld, R., 2014. Revisiting the assessment of semen viscosity and its relationship to leucocytospermia. Andrologia 46, 837–841. https://doi.org/10.1111/and.12157
  12. Govender, J., Loos, B., Marais, E., Engelbrecht, A.-M., 2014. Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin. J. Pineal Res. 57, 367–380. https://doi.org/10.1111/jpi.12176
  13. Kibleur, Y., Brochart, H., Schaaf, H.S., Diacon, A.H., Donald, P.R., 2014. Dose Regimen of Para-Aminosalicylic Acid Gastro-Resistant Formulation (PAS-GR) in Multidrug-Resistant Tuberculosis. Clin. Drug Investig. 34, 269–276. https://doi.org/10.1007/s40261-014-0172-7
  14. Kolwijck, E., Friedrich, S.O., Karinja, M.N., van Ingen, J., Warren, R.M., Diacon, A.H., 2014. Early stationary phase culture supernatant accelerates growth of sputum cultures collected after initiation of anti-tuberculosis treatment. Clin. Microbiol. Infect. 20, O418–O420. https://doi.org/10.1111/1469-0691.12441
  15. Lampiao, F., Huussen, J., Plessis, S.D., 2014. Effects of Nitric Oxide Exposure on Human Sperm Function and Apoptosis Markers. Open Reprod. Sci. J. 6, 17–20. https://doi.org/10.2174/1874255601406010017
  16. Nduhirabandi, F., Huisamen, B., Strijdom, H., Blackhurst, D., Lochner, A., 2014. Short-term melatonin consumption protects the heart of obese rats independent of body weight change and visceral adiposity. J. Pineal Res. 57, 317–332. https://doi.org/10.1111/jpi.12171
  17. Salie, R., Huisamen, B., Lochner, A., 2014. High carbohydrate and high fat diets protect the heart against ischaemia/reperfusion injury. Cardiovasc. Diabetol. 13, 109. https://doi.org/10.1186/s12933-014-0109-8
  18. Slabbert, M., du Plessis, S.S., Huyser, C., 2015. Large volume cryoprotectant-free vitrification: an alternative to conventional cryopreservation for human spermatozoa. Andrologia 47, 594–599. https://doi.org/10.1111/and.12307
  19. Solomons, R.S., Visser, D.H., Friedrich, S.O., Diacon, A.H., Hoek, K.G.P., Marais, B.J., Schoeman, J.F., van Furth, A.M., 2015. Improved diagnosis of childhood tuberculous meningitis using more than one nucleic acid amplification test. Int. J. Tuberc. Lung Dis. 19, 74–80. https://doi.org/10.5588/ijtld.14.0394
  20. Streicher, E.M., Maharaj, K., York, T., Van Heerden, C., Barnard, M., Diacon, A., Mendel, C.M., Bosman, M.E., Hepple, J.A., Pym, A.S., Warren, R.M., van Helden, P.D., 2014. Rapid sequencing of the Mycobacterium tuberculosis pncA gene for detection of pyrazinamide susceptibility. J. Clin. Microbiol. 52, 4056–7. https://doi.org/10.1128/JCM.02438-14
  21. Van Rensburg, A., Neethling, G.S., Schubert, P.T., Koegelenberg, C.F.N., Wright, C.A., Bolliger, C.T., Bernasconi, M., Diacon, A.H., 2014. Impact of routine sputum cytology in a population at high risk for bronchial carcinoma. Int. J. Tuberc. Lung Dis. 18, 607–612. https://doi.org/10.5588/ijtld.13.0806
  22. Wallis, R.S., Dawson, R., Friedrich, S.O., Venter, A., Paige, D., Zhu, T., Silvia, A., Gobey, J., Ellery, C., Zhang, Y., Eisenach, K., Miller, P., Diacon, A.H., 2014. Mycobactericidal Activity of Sutezolid (PNU-100480) in Sputum (EBA) and Blood (WBA) of Patients with Pulmonary Tuberculosis. PLoS One 9, e94462. https://doi.org/10.1371/journal.pone.0094462
  23. Webster, I., Smith, A., Lochner, A., Huisamen, B., 2014. Sanguinarine Non- Versus Re-Circulation During Isolated Heart Perfusion - A Jekyll and Hyde Effect? Cardiovasc. Drugs Ther. 28, 489–491. https://doi.org/10.1007/s10557-014-6543-8
  24. Zhu, T., Friedrich, S.O., Diacon, A., Wallis, R.S., 2014. Population pharmacokinetic/pharmacodynamic analysis of the bactericidal activities of sutezolid (PNU-100480) and its major metabolite against intracellular Mycobacterium tuberculosis in ex vivo whole-blood cultures of patients with pulmonary tuberculosis. Antimicrob. Agents Chemother. 58, 3306–11. https://doi.org/10.1128/AAC.01920-13​

2013
Journal Articles
  1. Brundyn, K., Koegelenberg, C.F.N., Diacon, A.H., Louw, M., Schubert, P., Bolliger, C.T., van den Heuvel, M.M., Wright, C.A., 2013. Transbronchial fine needle aspiration biopsy and rapid on-site evaluation in the setting of superior vena cava syndrome. Diagn. Cytopathol. 41, 324–329. https://doi.org/10.1002/dc.21857
  2. Dawson, R., Diacon, A., 2013. PA-824, moxifloxacin and pyrazinamide combination therapy for tuberculosis. Expert Opin. Investig. Drugs 22, 927–932. https://doi.org/10.1517/13543784.2013.801958
  3. Diacon, A.H., Dawson, R., Von Groote-Bidlingmaier, F., Symons, G., Venter, A., Donald, P.R., Conradie, A., Erondu, N., Ginsberg, A.M., Egizi, E., Winter, H., Becker, P., Mendel, C.M., 2013a. Randomized dose-ranging study of the 14-day early bactericidal activity of bedaquiline (TMC207) in patients with sputum microscopy smear-positive pulmonary tuberculosis. Antimicrob. Agents Chemother. 57, 2199–203. https://doi.org/10.1128/AAC.02243-12
  4. Diacon, A.H., Donald, P.R., Mendel, C.M., 2013b. Early bactericidal activity of new drug regimens for tuberculosis - Authors' reply. Lancet (London, England) 381, 112–3. https://doi.org/10.1016/S0140-6736(13)60042-2
  5. Dooley, K.E., Nuermberger, E.L., Diacon, A.H., 2013. Pipeline of drugs for related diseases: tuberculosis. Curr. Opin. HIV AIDS 8, 579–85. https://doi.org/10.1097/COH.0000000000000009
  6. Du Plessis, S., Gokul, S., Agarwal, A., 2013. Semen hyperviscosity: causes, consequences, and cures. Front. Biosci. 5, 224–231.
  7. Flepisi, T.B., Lochner, A., Huisamen, B., 2013. The Consequences of Long-Term Glycogen Synthase Kinase-3 Inhibition on Normal and Insulin Resistant Rat Hearts. Cardiovasc. Drugs Ther. 27, 381–392. https://doi.org/10.1007/s10557-013-6467-8
  8. Flint, M., Du Plessis, S.S., 2013. Trichomonas vaginalis in Sub-Saharan Africa : occurrence and diagnostic approaches for the male partner. Med. Technol. SA 27, 26–28.
  9. Friedrich, S.O., Rachow, A., Saathoff, E., Singh, K., Mangu, C.D., Dawson, R., Phillips, P.P., Venter, A., Bateson, A., Boehme, C.C., Heinrich, N., Hunt, R.D., Boeree, M.J., Zumla, A., McHugh, T.D., Gillespie, S.H., Diacon, A.H., Hoelscher, M., 2013. Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment. Lancet Respir. Med. 1, 462–470. https://doi.org/10.1016/S2213-2600(13)70119-X
  10. Hamada, A., Sharma, R., du Plessis, S.S., Willard, B., Yadav, S.P., Sabanegh, E., Agarwal, A., 2013. Two-dimensional differential in-gel electrophoresis–based proteomics of male gametes in relation to oxidative stress. Fertil. Steril. 99, 1216-1226.e2. https://doi.org/10.1016/J.FERTNSTERT.2012.11.046
  11. Huisamen, B., George, C., Dietrich, D., Genade, S., 2013. Cardioprotective and anti-hypertensive effects of Prosopis glandulosa in rat models of pre-diabetes. Cardiovasc. J. Afr. 24, 10–6. https://doi.org/10.5830/CVJA-2012-069
  12. Kayigire, X.A., Friedrich, S.O., Venter, A., Dawson, R., Gillespie, S.H., Boeree, M.J., Heinrich, N., Hoelscher, M., Diacon, A.H., Pan African Consortium for the Evaluation of Anti-tuberculosis Antibiotics, 2013. Direct comparison of Xpert MTB/RIF assay with liquid and solid mycobacterial culture for quantification of early bactericidal activity. J. Clin. Microbiol. 51, 1894–8. https://doi.org/10.1128/JCM.03290-12
  13. Koegelenberg, C.F.N., Diacon, A.H., 2013. Image-guided pleural biopsy. Curr. Opin. Pulm. Med. 19, 368–373. https://doi.org/10.1097/MCP.0b013e32835f4c23
  14. Kolwijck, E., Mitchell, M., Venter, A., Friedrich, S.O., Dawson, R., Diacon, A.H., 2013. Short-term storage does not affect the quantitative yield of Mycobacterium tuberculosis in sputum in early-bactericidal-activity studies. J. Clin. Microbiol. 51, 1094–8. https://doi.org/10.1128/JCM.02751-12
  15. Lampiao, F., Du Plessis, S., 2013. New developments of the effect of melatonin on reproduction. World J. Obstet. Gynecol. 2, 15–22.
  16. Liwa, A.C., Schaaf, H.S., Rosenkranz, B., Seifart, H.I., Diacon, A.H., Donald, P.R., 2013. Para-Aminosalicylic Acid Plasma Concentrations in Children in Comparison with Adults after Receiving a Granular Slow-Release Preparation. J. Trop. Pediatr. 59, 90–94. https://doi.org/10.1093/tropej/fms053
  17. Lochner, A., Huisamen, B., Nduhirabandi, F., 2013. Cardioprotective effect of melatonin against ischaemia/reperfusion damage. Front. Biosci. 5, 305–315.
  18. Mor, Z., Leventhal, A., Diacon, A.H., Finger, R., Schoch, O.D., 2013. Tuberculosis screening in immigrants from high-prevalence countries: Interview first or chest radiograph first? A pro/con debate. Respirology 18, 432–438. https://doi.org/10.1111/resp.12054
  19. Sharma, R., Agarwal, A., Mohanty, G., Du Plessis, S.S., Gopalan, B., Willard, B., Yadav, S.P., Sabanegh, E., 2013a. Proteomic analysis of seminal fluid from men exhibiting oxidative stress. Reprod. Biol. Endocrinol. 11, 85. https://doi.org/10.1186/1477-7827-11-85
  20. Sharma, R., Agarwal, A., Mohanty, G., Hamada, A.J., Gopalan, B., Willard, B., Yadav, S., du Plessis, S., 2013b. Proteomic analysis of human spermatozoa proteins with oxidative stress. Reprod. Biol. Endocrinol. 11, 48. https://doi.org/10.1186/1477-7827-11-48
  21. von Groote-Bidlingmaier, F., Koegelenberg, C.F., Bolliger, C.T., Chung, P.K., Rautenbach, C., Wasserman, E., Bernasconi, M., Friedrich, S.O., Diacon, A.H., 2013. The yield of different pleural fluid volumes for Mycobacterium tuberculosis culture. Thorax 68, 290–1. https://doi.org/10.1136/thoraxjnl-2012-202338​

2012
Journal Articles
  1. Aboua, Y.G., Brooks, N., Mahfouz, R.Z., Agarwal, A., du Plessis, S.S., 2012. A red palm oil diet can reduce the effects of oxidative stress on rat spermatozoa. Andrologia 44, 32–40. https://doi.org/10.1111/j.1439-0272.2010.01133.x
  2. Bernasconi, M., Koegelenberg, C.F.N., von Groote-Bidlingmaier, F., Maree, D., Barnard, B.J., Diacon, A.H., Bolliger, C.T., 2012. Speed of Ascent During Stair Climbing Identifies Operable Lung Resection Candidates. Respiration 84, 117–122. https://doi.org/10.1159/000337258
  3. Carr, I.M., Koegelenberg, C.F.N., von Groote-Bidlingmaier, F., Mowlana, A., Silos, K., Haverman, T., Diacon, A.H., Bolliger, C.T., 2012. Blood Loss during Flexible Bronchoscopy: A Prospective Observational Study. Respiration 84, 312–318. https://doi.org/10.1159/000339507
  4. Chellan, N., Muller, C.J.F., de Beer, D., Joubert, E., Page, B.J., Louw, J., 2012. An in vitro assessment of the effect of Athrixia phylicoides DC. aqueous extract on glucose metabolism. Phytomedicine 19, 730–736. https://doi.org/10.1016/J.PHYMED.2012.03.006
  5. Diacon, A., von, G.-B., Donald, P., 2012. From Magic Mountain to Table Mountain. Swiss Med. Wkly. 142. https://doi.org/10.4414/smw.2012.13665
  6. Diacon, Andreas H, Dawson, R., du Bois, J., Narunsky, K., Venter, A., Donald, P.R., van Niekerk, C., Erondu, N., Ginsberg, A.M., Becker, P., Spigelman, M.K., 2012a. Phase II dose-ranging trial of the early bactericidal activity of PA-824. Antimicrob. Agents Chemother. 56, 3027–31. https://doi.org/10.1128/AAC.06125-11
  7. Diacon, Andreas H, Dawson, R., von Groote-Bidlingmaier, F., Symons, G., Venter, A., Donald, P.R., van Niekerk, C., Everitt, D., Winter, H., Becker, P., Mendel, C.M., Spigelman, M.K., 2012b. 14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial. Lancet 380, 986–993. https://doi.org/10.1016/S0140-6736(12)61080-0
  8. Diacon, A H, Donald, P.R., Pym, A., Grobusch, M., Patientia, R.F., Mahanyele, R., Bantubani, N., Narasimooloo, R., De Marez, T., van Heeswijk, R., Lounis, N., Meyvisch, P., Andries, K., McNeeley, D.F., 2012. Randomized pilot trial of eight weeks of bedaquiline (TMC207) treatment for multidrug-resistant tuberculosis: long-term outcome, tolerability, and effect on emergence of drug resistance. Antimicrob. Agents Chemother. 56, 3271–6. https://doi.org/10.1128/AAC.06126-11
  9. Khullar, K., Agarwal, A., du Plessis, S., 2012. A hormonal, physical, and proteomic view of obesity-induced effects on male infertility and possible lifestyle modifications. Asian Pacific J. Reprod. 1, 161–168. https://doi.org/10.1016/S2305-0500(13)60071-8
  10. Louw, M., Brundyn, K., Schubert, P.T., Wright, C.A., Bolliger, C.T., Diacon, A.H., 2012. Comparison of the quality of smears in transbronchial fine-needle aspirates using two staining methods for rapid on-site evaluation. Diagn. Cytopathol. 40, 777–781. https://doi.org/10.1002/dc.21628
  11. Maarman, G., Marais, E., Lochner, A., du Toit, E.F., 2012. Effect of Chronic CPT-1 Inhibition on Myocardial Ischemia-Reperfusion Injury (I/R) in a Model of Diet-Induced Obesity. Cardiovasc. Drugs Ther. 26, 205–216. https://doi.org/10.1007/s10557-012-6377-1
  12. Mudau, M., Genis, A., Lochner, A., Strijdom, H., 2012. Endothelial dysfunction: the early predictor of atherosclerosis. Cardiovasc. J. Afr. 23, 222–231. https://doi.org/10.5830/CVJA-2011-068
  13. Nduhirabandi, F., du Toit, E.F., Lochner,  a., 2012. Melatonin and the metabolic syndrome: A tool for effective therapy in obesity-associated abnormalities? Acta Physiol. 205, 209–223. https://doi.org/10.1111/j.1748-1716.2012.02410.x
  14. Rengan, A.K., Agarwal, A., van der Linde, M., du Plessis, S.S., 2012. An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet. Reprod. Biol. Endocrinol. 10, 92. https://doi.org/10.1186/1477-7827-10-92
  15. Sadie-Van Gijsen, H., Smith, W., du Toit, E.F., Michie, J., Hough, F.S., Ferris, W.F., 2012. Depot-specific and hypercaloric diet-induced effects on the osteoblast and adipocyte differentiation potential of adipose-derived stromal cells. Mol. Cell. Endocrinol. 348, 55–66. https://doi.org/10.1016/J.MCE.2011.07.030
  16. Salie, R., Moolman, J.A., Lochner, A., 2012. The mechanism of beta-adrenergic preconditioning: roles for adenosine and ROS during triggering and mediation. Basic Res. Cardiol. 107, 281. https://doi.org/10.1007/s00395-012-0281-5
  17. Strijdom, H., 2012. Endothelial dysfunction: are we ready to heed the vasculature's early-warning signal? Cardiovasc. J. Afr. 23, 184–5.
  18. van Jaarsveld, F.P., Hattingh, S., 2016. Rapid Induction of Ageing Character in Brandy Products. Ageing and General Overview. South African J. Enol. Vitic. 33. https://doi.org/10.21548/33-2-1122
  19. Walters, E., Gie, R.P., Hesseling, A.C., Friedrich, S.O., Diacon, A.H., Gie, R.P., 2012. Rapid Diagnosis of Pediatric Intrathoracic Tuberculosis From Stool Samples Using the Xpert MTB/RIF Assay. Pediatr. Infect. Dis. J. 31, 1316. https://doi.org/10.1097/INF.0b013e318266c21c
  20. Webster, I., Du Toit, E.F., Huisamen, B., Lochner, A., 2012. The effect of creatine supplementation on myocardial function, mitochondrial respiration and susceptibility to ischaemia/reperfusion injury in sedentary and exercised rats. Acta Physiol. 206, 6–19. https://doi.org/10.1111/j.1748-1716.2012.02463.x​

2011

Journal Articles
  1. Awoniyi, D., Aboua, Y., Marnewick, J., Plesis, S. du, Brooks, N., 2011. Protective effects of rooibos (Aspalathus linearis), green tea (Camellia sinensis) and commercial supplements on testicular tissue of oxidative stress-induced rats. AFRICAN J. Biotechnol. 10, 17317–17322. https://doi.org/10.5897/AJB11.2210
  2. Bernasconi, M., Bolliger, C.T., Irusen, E., Diacon, A.H., 2011. A Left Hemithorax Mystery. Respiration 82, 557–559. https://doi.org/10.1159/000330594
  3. Clark, C., Smith, W., Lochner, A., Toit, E.F.D., 2011. The effects of gender and obesity on myocardial tolerance to ischemia. Physiol. Res. 60, 291–301. https://doi.org/10.33549/physiolres.931999
  4. Diacon, A. H., Dawson, R., Hanekom, M., Narunsky, K., Venter, A., Hittel, N., Geiter, L.J., Wells, C.D., Paccaly, A.J., Donald, P.R., 2011. Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients. Int. J. Tuberc. Lung Dis. 15, 949–954. https://doi.org/10.5588/ijtld.10.0616
  5. Diacon, Andreas H., Maritz, J.S., Donald, P.R., 2011. Chapter 21: Early Bactericidal Activity of Antituberculosis Agents. Karger Publishers, pp. 213–219. https://doi.org/10.1159/000324633
  6. du Plessis, S., Agarwal, A., 2011. Taking the stress out of ART induced oxidative stress. ACE Newsl. Focus 2, 11–14.
  7. DU PLESSIS, S.S., KASHOU, A., VAAMONDE, D., AGARWA, A., 2011. Is There a Link between Exercise and Male Factor Infertility? Open Reprod. Sci. J. 3, 105–113.
  8. du Plessis, S.S., Kashou, A.H., Benjamin, D.J., Yadav, S.P., Agarwal, A., 2011. Proteomics: a subcellular look at spermatozoa. Reprod. Biol. Endocrinol. 9, 36. https://doi.org/10.1186/1477-7827-9-36
  9. Essop, M.F., Chan, W.A., Hattingh, S., 2011. Proteomic analysis of mitochondrial proteins in a mouse model of type 2 diabetes. Cardiovasc. J. Afr. 22, 175–8. https://doi.org/10.5830/CVJA-2010-058
  10. Friedrich, S.O., Venter, A., Kayigire, X.A., Dawson, R., Donald, P.R., Diacon, A.H., 2011a. Suitability of Xpert MTB/RIF and genotype MTBDRplus for patient selection for a tuberculosis clinical trial. J. Clin. Microbiol. 49, 2827–31. https://doi.org/10.1128/JCM.00138-11
  11. Friedrich, S.O., von Groote-Bidlingmaier, F., Diacon, A.H., 2011b. Xpert MTB/RIF assay for diagnosis of pleural tuberculosis. J. Clin. Microbiol. 49, 4341–2. https://doi.org/10.1128/JCM.05454-11
  12. George, C., Lochner, A., Huisamen, B., 2011. The efficacy of Prosopis glandulosa as antidiabetic treatment in rat models of diabetes and insulin resistance. J. Ethnopharmacol. 137, 298–304. https://doi.org/10.1016/J.JEP.2011.05.023
  13. Huisamen, Barbara, Genis, A., Marais, E., Lochner, A., 2011. Pre-treatment with a DPP-4 Inhibitor is Infarct Sparing in Hearts from Obese, Pre-diabetic Rats. Cardiovasc. Drugs Ther. 25, 13–20. https://doi.org/10.1007/s10557-010-6271-7
  14. Huisamen, B., Pêrel, S.J.C., Friedrich, S.O., Salie, R., Strijdom, H., Lochner, A., 2011. ANG II type I receptor antagonism improved nitric oxide production and enhanced eNOS and PKB/Akt expression in hearts from a rat model of insulin resistance. Mol. Cell. Biochem. 349, 21–31. https://doi.org/10.1007/s11010-010-0656-6
  15. Kashou, A.H., Benjamin, D.J., Agarwal, A., du Plessis, S.S., 2011. The Advent of Sperm Proteomics has Arrived. Open Reprod. Sci. J. 3, 92–97. https://doi.org/10.2174/1874255601103010092
  16. KOEGELENBERG, C.F.N., DIACON, A.H., 2011. Pleural controversy: Closed needle pleural biopsy or thoracoscopy-Which first? Respirology 16, 738–746. https://doi.org/10.1111/j.1440-1843.2011.01973.x
  17. Koegelenberg, C.F.N., Diacon, A.H., Irusen, E.M., von Groote-Bidlingmaier, F., Mowlana, A., Wright, C.A., Louw, M., Schubert, P.T., Bolliger, C.T., 2011. The Diagnostic Yield and Safety of Ultrasound-Assisted Transthoracic Biopsy of Mediastinal Masses. Respiration 81, 134–141. https://doi.org/10.1159/000322005
  18. Lampiao, F., Slabbert, M., Plessis, S., 2011. The in vitro anti-fertility effects of Acacia nilotica on human spermatozoa function. Spat. DD - Peer Rev. J. Complement. Med. Drug Discov. 1, 59. https://doi.org/10.5455/spatula.20110321061343
  19. Lochner, A., 2011. Signalling during an ischaemic preconditioning protocol: new role players? Cardiovasc. Res. 90, 5–6. https://doi.org/10.1093/cvr/cvr045
  20. Loos, B., Genade, S., Ellis, B., Lochner, A., Engelbrecht, A.-M., 2011a. At the core of survival: Autophagy delays the onset of both apoptotic and necrotic cell death in a model of ischemic cell injury. Exp. Cell Res. 317, 1437–1453. https://doi.org/10.1016/J.YEXCR.2011.03.011
  21. Loos, B., Lochner, A., Engelbrecht, A.-M., 2011b. Autophagy in heart disease: A strong hypothesis for an untouched metabolic reserve. Med. Hypotheses 77, 52–57. https://doi.org/10.1016/J.MEHY.2011.03.021
  22. McCarthy, J., Lochner, A., Opie, L.H., Sack, M.N., Essop, M.F., 2011. PKCε promotes cardiac mitochondrial and metabolic adaptation to chronic hypobaric hypoxia by GSK3β inhibition. J. Cell. Physiol. 226, 2457–2468. https://doi.org/10.1002/jcp.22592
  23. Nduhirabandi, F., du Toit, F., Blackhurst, D., Marais, D., Lochner, A., Du Toit, E.F., Blackhurst, D., Marais, D., Lochner, A., 2011. Chronic melatonin consumption prevents obesity-related metabolic abnormalities and protects the heart against myocardial ischemia and reperfusion injury in a prediabetic model of diet-induced obesity. J. Pineal Res. 50, 171–182. https://doi.org/10.1111/j.1600-079X.2010.00826.x
  24. Salie, R., Moolman, J.A., Lochner, A., 2011. The Role of β-adrenergic Receptors in the Cardioprotective Effects of Beta-Preconditioning (βPC). Cardiovasc. Drugs Ther. 25, 31–46. https://doi.org/10.1007/s10557-010-6275-3
  25. Sishi, B., Loos, B., Ellis, B., Smith, W., Toit, E.F. du, Engelbrecht, A., 2011. Diet‐induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model. Exp. Physiol. 96, 179–193. https://doi.org/10.1113/EXPPHYSIOL.2010.054189@10.1002
  26. Webster, I., Huisamen, B., Du Toit, E.F., 2011. Creatine and Exercise – Strong Evidence for Stronger Heart Muscle? J. Exerc. Physiol. 14, 85–108. https://doi.org/10.1519/JSC.0b013e3181874564
  27. Webster, I., Toit, E.F. Du, Huisamen, B., 2010. The effects of long term swim training on physiological stress levels in the rat. Med. Technol. South Africa 24, 37–40.​

2010 and Earlier

  1. Aboua Y.G., Du Plessis SS, Brooks N, Y.G., 2007. In vitro Red Palm Oil (RPO) administration to human spermatozoa: Finding a suitable solvent. Med Technol. SA 21, 7–9.
  2. Aboua, Y.G., du Plessis, S.S., Reichgelt, P., Brooks, N., 2009. The in vitro effects of superoxide, some commercially available antioxidants and red palm oil on sperm motility. Asian J. Androl. 11, 695–702. https://doi.org/10.1038/aja.2009.55
  3. Agarwal, A., Du Plessis, S.S., Cabler, S., Sabanegh E., 2010. Fertility fears - fate of the fat. Eur. Urol. Rev.  5, 60–64.
  4. Arvola, L., Bertelsen, E., Lochner, A., Ytrehus, K., 2006. Sustained anti-β-adrenergic effect of melatonin in guinea pig heart papillary muscle. Scand. Cardiovasc. J. 40, 37–42. https://doi.org/10.1080/14017430500339347
  5. Bester, E.P., Mouton, R., Malan, J.F., Lochner, A., 1993. The effect of lithium on the heart. Cardiovasc. J. Afr. 4, 210–214.
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