Publikasie Argief

Publikasies in 2018
Joernaal Artikels (gesubsideer)

ABIDIN MZ, SARAVANAN T, ZHANG J, TEPPER PG, STRAUSS E, POELARENDS GJ. Modular enzymatic cascade synthesis of vitamin B5and its derivatives. CHEMISTRY-A EUROPEAN JOURNAL 2018; 24:17434-17438.

AFRICANDER DJ, STORBECK K. Steroid metabolism in breast cancer: Where are we and what are we missing?. Molecular and Cellular Endocrinology 2018; 466:86-97.

ANECK-HAHN NH, VAN ZIJL MC, SWART P, TRUEBODY BE, GENTHE B, CHARMIER J, DE JAGER C. Estrogenic activity, selected plasticizers and potential health risks associated with bottled water in South Africa. JOURNAL OF WATER AND HEALTH 2018; 16(2):253-262.

BARNARD L, MOSTERT KJ, VAN OTTERLO WAL, STRAUSS E. Developing pantetheinase-resistant pantothenamide antibacterials: Structural modification impacts on PanK interaction and mode of action. ACS Infectious Diseases 2018; 4(5):736-743.

BARNARD M, QUANSON J, MOSTAGHEL E, PRETORIUS E, SNOEP JL, STORBECK K. 11-Oxygenated androgen precursors are the preferred substrates for aldo-keto reductase 1C3 (AKR1C3): Implications for castration resistant prostate cancer. Journal of Steroid Biochemistry and Molecular Biology 2018; 183:192-201.

BURGER H-M, ABEL S, GELDERBLOM WCA. Modulation of key lipid raft constituents in primary rat hepatocytes by fumonisin B1- Implications for cancer promotion in the liver. FOOD AND CHEMICAL TOXICOLOGY 2018; 115:34-41.

CHRISTENSEN C, HOFMEYR JS, ROHWER JM. Delving deeper: Relating the behaviour of a metabolic system to the properties of its components using symbolic metabolic control analysis. PLoS One 2018; 13(11):e0207983 (24 pages).

CHRISTENSEN C, HOFMEYR JS, ROHWER JM. PySCeSToolbox: a collection of metabolic pathway analysis tools. Bioinformatics 2018; 34(1):124-125.

DE BEER DM, BOTES M, CLOETE TE. The microbial community of a biofilm contact reactor for the treatment of winery wastewater. Journal of Applied Microbiology 2018; 124(2):598-610.

DU TOIT A, DE WET S, HOFMEYR JS, MULLER-NEDEBOCK KK, LOOS B. The Precision Control of Autophagic Flux and Vesicle Dynamics - A Micropattern Approach. Cells 2018; 7(8):94, 17 pages.

DU TOIT A, HOFMEYR JS, GNIADEK TJ, LOOS B. Measuring autophagosome flux. Autophagy 2018; 14(6):1060-1071.

DU TOIT T, FINKEN MJJ, HAMER HM, HEIJBOER AC, SWART AC. C11-oxy C19and C11-oxy C21steroids in neonates: UPC2-MS/MS quantification of plasma 11β-hydroxyandrostenedione, 11-ketotestosterone and 11-ketoprogesterone. STEROIDS 2018; 138:1-5.

DU TOIT T, STANDER MA, SWART AC. A high-throughput UPC2-MS/MS method for the separation and quantiﬁcation of C19and C21steroids and their C11-oxy steroid metabolites in the classical, alternative, backdoor and 11OHA4 steroid pathways. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 2018; 1080:71-81.

DU TOIT T, SWART AC. Inefficient UGT-conjugation of adrenal 11ß-hydroxyandrostenedione metabolites highlights C11-oxy C19steroids as the predominant androgens in prostate cancer. Molecular and Cellular Endocrinology 2018; 461:265-276.

GUAN J, BARNARD L, CRESSON J, HOEGL A, CHANG JH, STRAUSS E, AUCLAIR K. Probing the ligand preferences of the three types of bacterial pantothenate kinase. Bioorganic and Medicinal Chemistry 2018; 26:5896-5902.

HALLING PJ, FITZPATRICK PF, RAUSHEL FM, ROHWER JM, SCHNELL S, WITTIG U, WOHLGEMUTH R, KETTNER C. An empirical analysis of enzyme function reporting for experimental reproducibility: Missing/incomplete information in published papers. BIOPHYSICAL CHEMISTRY 2018; 242:22-27.

HAMER HM, FINKEN MJJ, VAN HERWAARDEN AE, DU TOIT T, SWART AC, HEIJBOER AC. Falsely elevated plasma testosterone concentrations in neonates: Importance of LC-MS/MS measurements. CLINICAL CHEMISTRY AND LABORATORY MEDICINE 2018; 56(6):e141-e143.

HOFMEYR JS. Causation, constructors and codes. BIOSYSTEMS 2018; 164:121-127.

HOFMEYR JS. The first special issue on code biology - A bird's-eye view. BIOSYSTEMS 2018; 164:11-15.

JENKINSON C, TAYLOR AE, STORBECK K, HEWISON M. Analysis of multiple vitamin D metabolites by ultra-performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS). JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 2018; 1087-1088:43-48.

JENKINSON C, TAYLOR AE, STORBECK K, HEWISON M. Data comparing the separation and elution of vitamin D metabolites on an ultra performance supercritical fluid chromatography tandem-mass spectrometer (UPSFC-MS/MS) compared to liquid chromatography (LC) and data presenting approaches to UPSFC method optimization. Data in Brief 2018; 20:426-435.

MAGANGANA TP, STANDER MA, MAKUNGA NP. Effect of nitrogen and phosphate on in vitro growth and metabolite profiles of Steviarebaudiana Bertoni (Asteraceae). Plant Cell, Tissue and Organ Culture 2018; 134(1):141-151.

NAGHILOO S, BELLSTEDT DU, CLAßEN-BOCKHOFF R. Nectar protection in arid-adapted flowers of Zygophyllaceae-Zygophylloideae. Perspectives in plant ecology, evolution and systematics 2018; 34:37-50.

OYENIHI OR, KRYGSMAN A, VERHOOG NJD, DE BEER D, SAAYMAN M, MOUTON M, LOUW A. Chemoprevention of LA7-induced mammary tumor growth by SM6Met, a well-characterized CylcopiaExtact. Frontiers in Pharmacology 2018; 9:1-18.

PERKINS MS, LOUW-DU TOIT R, AFRICANDER DJ. Hormone therapy and breast cancer: emerging steroid receptor mechanisms. JOURNAL OF MOLECULAR ENDOCRINOLOGY 2018; 61(4):R133-R160.

SANTOLARIA C, VELÁZQUEZ D, STRAUSS E, ARIÑO J. Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function. Scientific Reports 2018; 8:14701 (12 pages).

SCHIFFER L, ARLT W, STORBECK K. Intracrine androgen biosynthesis, metabolism and action revisited. Molecular and Cellular Endocrinology 2018; 465:4-26.

SHOKO R, MANASA J, MAPHOSA M, MBANGA J, MUDZIWAPASI R, NEMBAWARE V, SANYIKA WT, TINAGO T, CHIKWAMBI Z, MAWERE C, MATIMBA A, MUGUMBATE G, MUFANDAEDZA J, MULDER N, PATTERTON H. Strategies and opportunities for promoting bioinformatics in Zimbabwe. PLoS Computational Biology 2018; 14:1-12.

SMITH C, SWART AC. Aspalathus linearis(Rooibos) - a functional food targeting cardiovascular disease. Food & Function 2018; 9:5041-5058.

STORBECK K, GILLIGAN L, JENKINSON C, BARANOWSKI ES, QUANSON J, ARLT W, TAYLOR AE. The utility of ultra-high performance supercritical fluid chromatography–tandem mass spectrometry (UHPSFC-MS/MS) for clinically relevant steroid analysis. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 2018; 1085:36-41.

SWAINSTON N, BAICI A, BAKKER BM, CORNISH-BOWDEN A, FITZPATRICK PF, HALLING PJ, LEYH TS, O'DONOVAN C, RAUSHEL FM, RESCHEL U, ROHWER JM, SCHNELL S, SCHOMBURG D, TIPTON K, TSAI M-D, WESTERHOFF HV, WITTIG U, WOHLGEMUTH R, KETTNER C. STRENDA DB: enabling the validation and sharing of enzyme kinetics data. FEBS Journal 2018; 285:2193-2204.

TJHIN ET, SPRY C, SEWELL AL, HOEGL A, BARNARD L, SEXTON AE, SIDDIQUI G, HOWIESON VM, MAIER AG, CREEK DJ, STRAUSS E, MARQUEZ R, AUCLAIR K, SALIBA KJ. Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues. PLoS Pathogens 2018; 14(4):e1006918 (30 pages).

VAN ROOYEN D, GENT R, BARNARD L, SWART AC. The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway. Journal of Steroid Biochemistry and Molecular Biology 2018; 178:203-212.

VENTER PB, MULLER MM, VESTNER J, STANDER MA, TREDOUX AGJ, PASCH H, DE VILLIERS AJ. Comprehensive three-dimensional LC x LC × ion mobility spectrometry separation combined with high-resolution MS for the analysis of complex samples. Analytical Chemistry 2018; 90(19):11643-11650.

WEGER M, DIOTEL N, WEGER BD, BEIL T, ZAUCKER A, EACHUS H, OAKES JA, DO REGO JL, STORBECK K, GUT P, STRÄHLE U, RASTEGAR S, MÜLLER F, KRONE N. Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish. JOURNAL OF NEUROENDOCRINOLOGY 2018; 30:e12586 (15 pages).

WENZEL M, RAUTENBACH M, VOSLOO JA, SIERSMA T, AISENBREY CHM, ZAITSEVA E, LAUBSCHER WE, VAN RENSBURG W, BEHRENDS JC, BECHINGER B, HAMOEN LW. The multifaceted antibacterial mechanisms of the pioneering peptide antibiotics Tyrocidine and Gramicidin S. mBio 2018; 9(5):e00802-18 (20 pages).

WILKINSON L, VERHOOG NJD, LOUW A. Disease- and treatment-associated acquired glucocorticoid resistance. Endocrine Connections 2018; 7:R328-R349.

WILKINSON L, VERHOOG NJD, LOUW A. Novel role for receptor dimerization in post-translational processing and turnover of the GRα.Scientific Reports 2018; 8:14266 (17 pages).

Joernaal Artikels (nie-gesubsideer)

GIESSNER C, MILLET V, MOSTERT KJ, GENSOLLEN T, VU MANH T-P, GARIBAL M, DIEME B, ATTAF-BOUABDALLAH N, CHASSON L, BROUILLY N, LAPRIE C, LESLUYES T, BLAY JY, SHINTU L, MARTIN JC, STRAUSS E, GALLAND F, NAQUET P. Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity. Life Science Alliance 2018; 1(4):e201800073 (16 pages).

Patente

LOOS B, HOFMEYR JS, PEROLD WJ. Method and device for determining autophagic flux. Patent No. P3464ZA00SC, South Africa 2018.

Publikasies in 2017

Joernaal Artikels (gesubsideer)

ALBERTS JF, LILLY M, RHEEDER JP, BURGER H-M, SHEPHARD GS, GELDERBLOM WCA. Technological and community-based methods to reduce mycotoxin exposure. FOOD CONTROL 2017; 73:101-109.

BARNARD L, GENT R, VAN ROOYEN D, SWART AC. Adrenal C11-oxy C21 steroids contribute to the C11-oxy C19 steroid pool via the backdoor pathway in the biosynthesis and metabolism of 21-deoxycortisol and 21-deoxycortisone. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 2017; 174:86-95.

BOTES A, HORNE H, PARSONS N, BELLSTEDT DU. Conservation implications of avian malaria exposure for African penguins during rehabilitation. South African Journal of Science 2017; 113(7/8):Art.#2016-0244, 8 pages.

DE VILLIERS M, SPRY C, MACUAMULE CJ, BARNARD L, WELLS G, SALIBA KJ, STRAUSS E. Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target. ACS Infectious Diseases 2017; 3:527-541.

DI MEO I, COLOMBELLI C, SRINIVASAN B, DE VILLIERS M, HAMADA J, JEONG SY, FOX R, WOLTJER RL, TEPPER PG, LAHAYE LL, RIZZETTO E, ET AL . Acetyl-4′-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency. Scientific Reports 2017; 7:11260, 12 pages.

DU PREEZ LL, PATTERTON H. The effect of epigenetic modifications on the secondary structures and possible binding positions of the N-terminal tail of histone H3 in the nucleosome: a computational study. JOURNAL OF MOLECULAR MODELING 2017; 23:137, 15 pages.

DU TOIT T, BLOEM LM, QUANSON J, EHLERS R, SERAFIN AM, SWART AC. Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasma: UPC2-MS/MS quantification of 11β-hydroxytestosterone, 11keto-testosterone and 11keto-dihydrotestosterone. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 2017; 166:54-67.

EACHUS H, ZAUCKER A, OAKES JA, GRIFFIN A, WEGER M, GÜRAN T, TAYLOR AE, HARRIS A, GREENFIELD A, QUANSON J, STORBECK K, CUNLIFFE VT, MÜLLER F. Genetic Disruption of 21-Hydroxylase in Zebrafish Causes Interrenal Hyperplasia. ENDOCRINOLOGY 2017; 158(12):4165-4173.

FIGUEIREDO AS, KOURIL T, ESSER D, HAFERKAMP P, WIELOCH P, SCHOMBURG D, RUOFF P, SIEBERS B, SCHABER J. Systems biology of the modified branched Entner-Doudoroff pathway in Sulfolobus solfataricus. PLoS One 2017; 12(7):e0180331, 25 pages.

GELDERBLOM WCA, JOUBERT E, GAMIELDIEN K, SISSING L, MALHERBE CJ, MARITZ G. Rooibos (Aspalathus linearis), honeybush (Cyclopia intermedia) and cancer bush (Sutherlandia frutescens subsp. microphylla) protect against tobacco-specific mutagenesis in vitro. SOUTH AFRICAN JOURNAL OF BOTANY 2017; 110:194-200.

GOOSEN R, STRAUSS E. Simultaneous quantification of coenzyme A and its salvage pathway intermediates in in vitro and whole cell-sourced samples. RSC Advances 2017; 7:19717-19724.

HAANSTRA J, GERDING A, DOLGA AM, SORGDRAGER FJH, BUIST-HOMAN M, DU TOIT F, FABER KN, HOLZHÜTTER H-G, SZÖÖR B, MATTHEWS R, SNOEP JL, WESTERHOFF HV, BAKKER BM. Targeting pathogen metabolism without collateral damage to the host. Scientific Reports 2017; 7:40406, 15 pages.

HAYWARD S, CILLIERS FP, SWART P. Lipoxygenases: From Isolation to Application. COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY 2017; 16:199-211.

HOFMEYR JS. Mathematics and biology. South African Journal of Science 2017; 113:Art. #a0203, 3 pages.

JONES CM, MALLAPPA A, REISCH N, NIKOLAOU N, KRONE N, HUGHES BA, O'NEIL DM, WHITAKER MJ, TOMLINSON JW, STORBECK K, MERKE DP, ROSS J, ARLT W. Modified-Release and Conventional Glucocorticoids and Diurnal Androgen Excretion in Congenital Adrenal Hyperplasia. Journal of Clinical Endocrinology and Metabolism 2017; 102(6):1797-1806.

KADLEC M, BELLSTEDT DU, LE MAITRE NC, PIRIE MD. Targeted NGS for species level phylogenomics: "made to measure'' or "one size fits all''?. PeerJ 2017; 5:e3569, 25 pages.

KOURIL T, EICHER JJ, SIEBERS B, SNOEP JL. Phosphoglycerate kinase acts as a futile cycle at high temperature. MICROBIOLOGY 2017; 163:1604-1612.

LOUW-DU TOIT R, PERKINS MS, HAPGOOD JP, AFRICANDER DJ. Comparing the androgenic and estrogenic properties of progestins used in contraception and hormone therapy. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2017; 491:140-146.

LOUW-DU TOIT R, STORBECK K, CARTWRIGHT M, CABRAL AA, AFRICANDER DJ. Progestins used in endocrine therapy and the implications for the biosynthesis and metabolism of endogenous steroid hormones. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2017; 441:31-45.

MAREE JP, POVELONES ML, CLARK DJ, RODENKO G, PATTERTON H. Well‑positioned nucleosomes punctuate polycistronic pol II transcription units and flank silent VSG gene arrays in Trypanosoma brucei. Epigenetics and Chromatin 2017; 10:14, 21 pages.

MCMURRY JA, JUTY N, BLOMBERG N, BURDETT T, CONLIN T, CONTE N, COURTOT M, DECK J, DUMONTIER M, FELLOWS DK, SNOEP JL, ET AL . Identifiers for the 21st century: How to design, provision, and reuse persistent identifiers to maximize utility and impact of life science data. PLOS BIOLOGY 2017; 15(6):e2001414, 18 pages.

NAGY B, WATTERS BR, VAN DER MERWE PDW, BELLSTEDT DU, COTTERILL FPD. Nothobranchius cooperi (Teleostei: Cyprinodontiformes): a new species of annual killifish from the Luapula River drainage, northern Zambia. African Journal Of Aquatic Science 2017; 42(3):201-218.

NAGY B, WATTERS BR, VAN DER MERWE PDW, COTTERILL FPD, BELLSTEDT DU. Nothobranchius cooperi (Teleostei: Cyprinodontiformes): a new species of annual killifish from the Luapula River drainage, northern Zambia. African Journal Of Aquatic Science 2017; 42(3):201-218.

NDLOVU T, RAUTENBACH M, KHAN S, KHAN W. Variants of lipopeptides and glycolipids produced by Bacillus amyloliquefaciens and Pseudomonas aeruginosa cultured in different carbon substrates. AMB Express 2017; 7:109, 13 pages.

NDLOVU T, RAUTENBACH M, VOSLOO JA, KHAN S, KHAN W. Characterisation and antimicrobial activity of biosurfactant extracts produced by Bacillus amyloliquefaciens and Pseudomonas aeruginosa isolated from a wastewater treatment plant. AMB Express 2017; 7:108, 19 pages.

O'REILLY MW, KEMPEGOWDA P, JENKINSON C, TAYLOR AE, QUANSON J, STORBECK K, ARLT W. 11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome. Journal of Clinical Endocrinology and Metabolism 2017; 102(3):840-848.

PERKINS MS, LOUW-DU TOIT R, AFRICANDER DJ. A comparative characterization of estrogens used in hormone therapy via estrogen receptor (ER)-α and -β. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 2017; 174:27-39.

PETERS M, EICHER JJ, VAN NIEKERK DD, WALTEMATH D, SNOEP JL. The JWS online simulation database. BIOINFORMATICS 2017; 33(10):1589-1590.

PIRIE KR, OLIVER EGH, GEHRKE B, MUGRABI DE KUPPLER AL, LE MAITRE NC, BELLSTEDT DU. Underestimated regional species diversity in the Cape Floristic Region revealed by phylogenetic analysis of the Erica abietina/E. viscaria clade (Ericaceae). BOTANICAL JOURNAL OF THE LINNEAN SOCIETY 2017; 2(184):185–203.

PRETORIUS E, ARLT W, STORBECK K. A new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2017; 441:76-85.

RAUTENBACH M, VLOK NM, EYEGHE-BICKONG H, STANDER MA. An Electrospray Ionization Mass Spectrometry Study on the "In Vacuo" Hetero-Oligomers Formed by the Antimicrobial Peptides, Surfactin and Gramicidin S. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 2017; 28:1623-1637.

SERGEANT CA, AFRICANDER DJ, SWART P, SWART AC. Sutherlandia frutescens modulates adrenal hormone biosynthesis, acts as a selective glucocorticoid receptor agonist (SEGRA) and displays antimineralocorticoid properties. JOURNAL OF ETHNOPHARMACOLOGY 2017; 202:290-301.

SNYMAN MA, STORBECK K, SWART P. Evaluation of production and reproduction of three South African Angora goat CYP17 genotypes. South African Journal of Animal Sciences 2017; 47(4):478-493.

STANDER MA, VAN WYK B-E, TAYLOR MJC, LONG HS. Analysis of Phenolic Compounds in Rooibos Tea (Aspalathus linearis) with a Comparison of Flavonoid-Based Compounds in Natural Populations of Plants from Different Regions. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2017; 65:10270-10281.

TSHILILO NO, STRAZZULLI A, COBUCCI-PONZANO B, MAURELLI L, IACONO R, BEDINI E, CORSARO MM, STRAUSS E, MORACCI M. The α-Thioglycoligase Derived from a GH89 α-N-Acetylglucosaminidase Synthesises α-N-Acetylglucosamine-Based Glycosides of Biomedical Interest. Advanced Synthesis and Catalysis 2017; 359:663-676.

VAN DER MERWE JD, DE BEER D, SWANEVELDER S, JOUBERT E, GELDERBLOM WCA. Dietary exposure to honeybush (Cyclopia) polyphenol-enriched extracts altered redox status and expression of oxidative stress and antioxidant defence-related genes in rat liver. SOUTH AFRICAN JOURNAL OF BOTANY 2017; 110:230-239.

VAN ROOYEN D, DU TOIT T, LOUW-DU TOIT R, AFRICANDER DJ, SWART P, SWART AC. The metabolic fate and receptor interaction of 16α-hydroxyprogesterone and its 5α-reduced metabolite, 16α-hydroxydihydroprogesterone. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2017; 441:86-98.

VAN WYK B-E, STANDER MA, LONG HS. Senecio angustifolius as the major source of pyrrolizidine alkaloid contamination of rooibos tea (Aspalathus linearis). SOUTH AFRICAN JOURNAL OF BOTANY 2017; 110:124-131.

VAN ZIJL MC, ANECK-HAHN NH, SWART P, HAYWARD S, GENTHE B, DE JAGER C. Estrogenic activity, chemical levels and health risk assessment of municipal distribution point water from Pretoria and Cape Town, South Africa. CHEMOSPHERE 2017; 186:305-313.

VOSLOO JA, BEIMS H, ALLSOPP MH, VAN RENSBURG W, VON DER OHE W, STEINERT M, RAUTENBACH M. Tolerance of honey bee adults and larvae toward tyrothricin peptides derived from Brevibacillus parabrevis. APIDOLOGIE 2017; 48:833-844.

WOLSTENCROFT K, KREBS O, SNOEP JL, STANFORD NJ, BACALL F, GOLEBIEWSKI M, KUZYAKIV R, NGUYEN Q, OWEN S, SOILAND-REYES S, STRASZEWSKI J, VAN NIEKERK DD, WILLIAMS AR, MALMSTRÖM L, RINN B, MÜLLER W, GOBLE C. FAIRDOMHub: a repository and collaboration environment for sharing systems biology research. NUCLEIC ACIDS RESEARCH 2017; 45:D404-D407.

ZHANG Y, KOURIL T, SNOEP JL, SIEBERS B, BARBERIS M, WESTERHOFF HV. The Peculiar Glycolytic Pathway in Hyperthermophylic Archaea: Understanding Its Whims by Experimentation In Silico. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2017; 18:art no 876.

Hoofstukke in Boeke

BELLSTEDT DU, GLAIS L, DAVIE K, LACOMME C. Evolution and origen of PVY. In: Lacomme C, Glais L, BELLSTEDT DU, Dupuis B, Karasev AV, Jacquot E (eds.) Potato virus Y: biodiversity, pathogenicity, epidemiology and management, Springer, Cham, Switzerland, 2017: 77-101.

GLAIS L, BELLSTEDT DU, LACOMME C. Diversity, characterisation and classification of PVY. In: Lacomme C, Glais L, BELLSTEDT DU, Dupuis B, Karasev AV, Jacquot E (eds.) Potato virus Y: biodiversity, pathogenicity, epidemiology and management, Springer, Cham, Swaziland, 2017: 43-76.

HOFMEYR JS. Basic Biological Anticipation. In: Poli R (ed.) Handbook of Anticipation, Springer International Publishing AG, Cham, Switzerland, 2017: 1-15.

HOFMEYR JS. Exploring the Metabolic Marketplace Trough the lens of Systems Biology. In: Green S (ed.) Philosophy of Systems Biology, History, Philosophy and Theory of the Life Sciences, Springer International Publishing AG, Cham, Switzerland, 2017: 117-124.

Publikasies in 2016

Joernaal Artikels (gesubsideer)

DU TOIT T, SWART AC. Perspective on the regulatory role of UGT2B28 as a conjugating enzyme in the progression of prostate cancer. Translational Cancer Research 2016; 5(Suppl 7):S1496-S1502.

GEHRKE B, KANDZIORA M, PIRIE MD. The evolution of dwarf shrubs in alpine environments: a case study of Alchemilla in Africa. ANNALS OF BOTANY 2016; 117:121-131.

HUGHES SJ, BARNARD L, MOTTAGHI K, TEMPEL W, ANTOSHCHENKO T, HONG BS, ALLALI-HASSANI A, SMIL D, VEDADI M, STRAUSS E, PARK H-W. Discovery of potent pantothenamide inhibitors of Staphylococcus aureus pantothenate kinase through a minimal SAR Study: Inhibition is due to trapping of the product. ACS Infectious Diseases 2016; 2:627-641.

KADEREIT JW, ALBACH DC, EHRENDORFER F, GALBANY-CASALS M, GARCIA-JACAS N, GEHRKE B, KADEREIT G, KILIAN N, KLEIN JT, KOCH MA, KROPF M, OBERPRIELER C, PIRIE MD, RITZ CM, RÃ–SER M, SPALIK K, SUSANNA A, WEIGEND M, WELK E, WESCHE K, ZHANG L-B, DILLENBERGER MS. Which changes are needed to render all genera of the German flora monophyletic?. Willdenowia 2016; 46(1):39-91.

LAUTERBACH M, VAN DER MERWE PDW, KEÃŸLER L, PIRIE MD, BELLSTEDT DU, KADEREIT G. Evolution of leaf anatomy in arid environments â€" A case study in southern African Tetraena and Roepera (Zygophyllaceae). MOLECULAR PHYLOGENETICS AND EVOLUTION 2016; 97:129-144.

LOUW-DU TOIT R, PERKINS MS, SNOEP JL, STORBECK K, AFRICANDER DJ. Fourth-generation progestins inhibit 3β-hydroxysteroid dehydrogenase type 2 and modulate the biosynthesis of endogenous steroids. PLoS One 2016; 11(10):e0164170, 23 pages.

MAGCWEBEBA TU, RIEDEL S, SWANEVELDER S, SWART P, DE BEER D, JOUBERT E, GELDERBLOM WCA. The potential role of polyphenols in the modulation of skin cell viability by Aspalathus linearis and Cyclopia spp. herbal tea extracts in vitro. JOURNAL OF PHARMACY AND PHARMACOLOGY 2016; 68:1440-1453.

MAGCWEBEBA TU, SWART P, SWANEVELDER S, JOUBERT E, GELDERBLOM WCA. Anti-inflammatory effects of Aspalathus linearis and Cyclopia spp. extracts in a UVB/keratinocyte (HaCaT) model utilising interleukin-1α accumulation as biomarker. MOLECULES 2016; 21:1323, 21 pages.

MAGCWEBEBA TU, SWART P, SWANEVELDER S, JOUBERT E, GELDERBLOM WCA. In vitro chemopreventive properties of green tea, rooibos and honeybush extracts in skin cells. MOLECULES 2016; 21:1622, 18 pages.

MULDER N, CHRISTOFFELS A, DE OLIVEIRA T, GAMIELDIEN J, HAZELHURST S, JOUBERT F, KUMUTHINI J, PILLAY CS, SNOEP JL, BISHOP OT, TIFFIN N. The development of computational biology in South Africa: Successes achieved and lessons learnt. PLoS Computational Biology 2016; 12(2):e1004395, 15 pages.

NAGY B, COTTERILL FPD, BELLSTEDT DU. Nothobranchius sainthousei, a new species of annual killifish from the Luapula River drainage in northern Zambia (Teleostei: Cyprinodontiformes). ICHTHYOLOGICAL EXPLORATION OF FRESHWATERS 2016; 27(3):233-254.

PILLAY CS, EAGLING BD, DRISCOLL SRE, ROHWER JM. Quantitative measures for redox signaling. FREE RADICAL BIOLOGY AND MEDICINE 2016; 96:290-303.

PIRIE MD, OLIVER EGH, MUGRABI DE KUPPLER AL, GEHRKE B, LE MAITRE NC, KANDZIORA M, BELLSTEDT DU. The biodiversity hotspot as evolutionary hot-bed: spectacular radiation of Erica in the Cape Floristic Region. BMC EVOLUTIONARY BIOLOGY 2016; 16:190, 11 pages.

PRETORIUS E, AFRICANDER DJ, VLOK NM, PERKINS MS, QUANSON J, STORBECK K. 11-Ketotestosterone and 11-ketodihydrotestosterone in castration resistant prostate cancer: Potent androgens which can no longer be ignored. PLoS One 2016; 11(7):e0159867, 17 pages.

QUANSON J, STANDER MA, PRETORIUS E, JENKINSON C, TAYLOR AE, STORBECK K. High-throughput analysis of 19 endogenous androgenic steroids by ultra-performance convergence chromatography tandem mass spectrometry. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 2016; 1031:131-138.

RAUTENBACH M, TROSKIE AM, VOSLOO JA, DATHE M. Antifungal membranolytic activity of the tyrocidines against filamentous plant fungi. BIOCHIMIE 2016; 130:122-131.

RAUTENBACH M, TROSKIE AM, VOSLOO JA. Antifungal peptides: To be or not to be membrane active. BIOCHIMIE 2016; 130:132-145.

RIEDEL S, ABEL S, BURGER H-M, VAN DER WESTHUIZEN L, SWANEVELDER S, GELDERBLOM WCA. Differential modulation of the lipid metabolism as a model for cellular resistance to fumonisin B1â€" induced cytotoxic effects in vitro. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS 2016; 109:39-51.

SIBON OCM, STRAUSS E. Coenzyme A: to make it or uptake it?. NATURE REVIEWS MOLECULAR CELL BIOLOGY 2016; 17:605-606.

SMITH C, SWART AC. Rooibos (Aspalathus linearis) facilitates an anti-inflammatory state, modulating IL-6 and IL-10 while not inhibiting the acute glucocorticoid response to a mild novel stressor in vivo. Journal of Functional Foods 2016; 27:42-54.

SWART AC, SMITH C. Modulation of glucocorticoid, mineralocorticoid and androgen production in H295 cells by Trimesemine ^TM, a mesembrine-rich Sceletium extract. JOURNAL OF ETHNOPHARMACOLOGY 2016; 177:35-45.

THOMPSON GD, RICHARDSON DM, WILSON JR, BELLSTEDT DU, LE ROUX JJ. Genetic diversity and structure of the globally invasive tree, Paraserianthes lophantha subspecies lophantha, suggest an introduction history characterised by varying propagule pressure. Tree Genetics and Genomes 2016; 12(2):Article number 27, 9 pages.

VAN NIEKERK DD, PENKLER GP, DU TOIT F, SNOEP JL. Targeting glycolysis in the malaria parasite Plasmodium falciparum. FEBS Journal 2016; 283:634-646.

VISSER JAK, ZIERAU O, MACEJOVÃ D, GOERL F, MUDERS M, BARETTON GB, VOLLMER G, LOUW A. The phytoestrogenic Cyclopia extract, SM6Met, increases median tumor free survival and reduces tumor mass and volume in chemically induced rat mammary gland carcinogenesis. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 2016; 163:129-135.

WOLF J, STARK H, FAFENROT K, ALBERSMEIER A, PHAM TK, MÃœLLER KB, MEYER BH, HOFFMANN L, SHEN L, ALBAUM SP, KOURIL T, SCHMIDT-HOHAGEN K, NEUMANN-SCHAAL M, BRÃ„SEN C, KALINOWSKI J, WRIGHT PC, ALBERS S-V, SCHOMBURG D, SIEBERS B. A systems biology approach reveals major metabolic changes in the thermoacidophilic archaeon Sulfolobus solfataricus in response to the carbon source L-fucose versus D-glucose. MOLECULAR MICROBIOLOGY 2016; 102(5):882-908.

Joernaal Artikels (nie-gesubsideer)

ROHWER JM, VILJOEN C, CHRISTENSEN C, MASHAMAITE LN, PILLAY CS. Identifying the conditions necessary for the thioredoxin ultrasensitive response. Perspectives in Science 2016; 9:53-59.

Hoofstukke in Boeke

VAN NIEKERK DD, PENKLER GP, DU TOIT F, SNOEP JL, BAKKER BM, HAANSTRA J. Attacking Blood-Borne Parasites with Mathematics. In: MÃ¼ller S, Cerdan R, Radulescu O (eds.) Comprehensive Analysis of Parasite Biology. From Metabolism to Drug Discovery, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2016: 513-541.

Patente

LOOS B, DU TOIT A, HOFMEYR JS. Method of determining autophagosome flux. Patent No. P3086ZA00, South Africa 2016.

Publikasies in 2015

Joernaal Artikels (gesubsideer)

ABRIE JA, MOLERO C, ARIñO J, STRAUSS E. Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal₃ and Vhs₃. Scientific Reports 2015; 5:15774, 17 pages.

BIGGS R, RHODE C, ARCHIBALD S, KUNENE LM, MUTANGA SS, NKUNA N, OCHOLLA PO, PHADIMA LJ. Strategies for managing complex social-ecological systems in the face of uncertainty: examples from South Africa and beyond. Ecology and Society 2015; 20(1):52, 15 pages.

BLOEM LM, STORBECK K, SWART P, DU TOIT T, SCHLOMS L, SWART AC. Advances in the analytical methodologies: Profiling steroids in familiar pathways-challenging dogmas. Journal of Steroid Biochemistry and Molecular Biology 2015; 153:80-92.

CHRISTENSEN C, HOFMEYR JS, ROHWER JM. Tracing regulatory routes in metabolism using generalised supply-demand analysis. BMC Systems Biology 2015; 9:89, 18 pages.

DE VILLIERS M, STRAUSS E. Jump-starting CoA biosynthesis. Nature Chemical Biology 2015; 11:757-758.

FISCHER J, GARDNER TA, BENNETT EM, BALVANERA P, BIGGS R, CARPENTER S, DAW TM, FOLKE C, HILL R, HUGHES TP, LUTHE T, SPIERENBURG MJ, ET AL . Advancing sustainability through mainstreaming a social-ecological systems perspective. Current Opinion in Environmental Sustainability 2015; 14:144-149.

GABRIELLI M, BUICA AS, FRACASSETTI D, STANDER MA, TIRELLI A, DU TOIT WJ. Determination of sotolon content in South African white wines by two novel HPLC-UV and UPLC-MS methods. Food Chemistry 2015; 169:180-186.

HAMANN M, BIGGS R, REYERS B. Mapping social-ecological systems: Identifying "green-loop" and "red-loop" dynamics based on characteristic bundles of ecosystem service use. Global Environmental Change-Human and Policy Dimensions 2015; 34:218-226.

HOMER-DIXON T, WALKER B, BIGGS R, CRéPIN A-S, FOLKE C, LAMBIN EF, PETERSON G, ROCKSTRÃ–M J, SCHEFFER M, STEFFEN W, TROELL M. Synchronous failure: the emerging causal architecture of global crisis. Ecology and Society 2015; 20(3):6, 16 pages.

HOUGH D, STORBECK K, CLOETE SWP, SWART AC, SWART P. Relative contribution of P450c17 towards the acute cortisol response: Lessons from sheep and goats. Molecular and Cellular Endocrinology 2015; 408:107-113.

KINFE HH, LONG HS, STANDER MA, VAN WYK B-E. The major phenolic compound of the roots and leaves of Rafnia amplexicaulis (Fabaceae), a liquorice substitute and traditional tea used in Cape Herbal Medicine. South African Journal of Botany 2015; 100:75-79.

LESOVAYA E, YEMELYANOV A, SWART AC, SWART P, HAEGEMAN G, BUDUNOVA I. Discovery of Compound A - a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activity. Oncotarget 2015; 6(31):30730-30744.

MACUAMULE CJ, TJHIN ET, JANA CE, BARNARD L, KOEKEMOER L, DE VILLIERS M, SALIBA KJ, STRAUSS E. A Pantetheinase-Resistant Pantothenamide with Potent, On-Target, and Selective Antiplasmodial Activity. Antimicrobial Agents and Chemotherapy 2015; 59(6):3666-3668.

MAREE H, PIRIE MD, OOSTHUIZEN K, BESTER R, REES DJG, BURGER JT. Phylogenomic Analysis Reveals Deep Divergence and Recombination in an Economically Important Grapevine Virus. PLoS ONE 2015; 10(5):e0126819.

MASHAMAITE LN, ROHWER JM, PILLAY CS. The glutaredoxin mono- and di-thiol mechanisms for deglutathionylation are functionally equivalent: implications for redox systems biology. Bioscience Reports 2015; 35:e00173, 10 pages.

MORTIMER M, VISSER JAK, DE BEER D, JOUBERT E, LOUW A. Divide and conquer may not be the optimal approach to retain the desirable estrogenic attributes of the Cyclopia nutraceutical extract, SM6Met. PLoS ONE 2015; 10(7):e0132950, 22 pages.

MUGRABI DE KUPPLER AL, FAGúNDEZ J, BELLSTEDT DU, OLIVER EGH, LéON J, PIRIE MD. Testing reticulate versus coalescent origins of Erica lusitanica using aspecies phylogeny of the northern heathers (Ericeae, Ericaceae). Molecular Phylogenetics and Evolution 2015; 88:121-131.

NISHII K, HUGHES M, BRIGGS M, HASTON E, CHRISTIE F, DE VILLIERS MJ, HANEKOM T, ROOS WG, BELLSTEDT DU, MüLLER M. Streptocarpus redefined to include all Afro-Malagasy Gesneriaceae: Molecular phylogenies prove congruent with geographical distribution and basic chromosome numbers and uncover remarkable morphological homoplasies. Taxon 2015; 64(6):1243-1274.

PALMER CG, BIGGS R, CUMMING GS. Applied research for enhancing human well-being and environmental stewardship: using complexity thinking in Southern Africa. Ecology and Society 2015; 20(1):53, 4 pages.

PENKLER GP, DU TOIT F, ADAMS WW, RAUTENBACH M, PALM DC, VAN NIEKERK DD, SNOEP JL. Construction and validation of a detailed kinetic model of glycolysis in Plasmodium falciparum. FEBS Journal 2015; 282:1481-1511.

PIANO F, FRACASSETTI D, BUICA AS, STANDER MA, DU TOIT WJ, BORSA D, TIRELLI A. Development of a novel liquid/liquid extraction and ultra-performance liquid chromatography tandem mass spectrometry method for the assessment of thiols in South African Sauvignon Blanc wines. Australian Journal of Grape and Wine Research 2015; 21:40-48.

PIRIE MD, LITSIOS G, BELLSTEDT DU, SALAMIN N, KISSLING J. Back to Gondwanaland: can ancient vicariance explain (some) Indian Ocean disjunct plant distributions?. Biology Letters 2015; 11:20150086, 4 pages.

PIRIE MD. Phylogenies from concatenated data: Is the end nigh?. Taxon 2015; 64(3):421-423.

RIEDEL S, ABEL S, SWANEVELDER S, GELDERBLOM WCA. Induction of an altered lipid phenotype by two cancer promoting treatments in rat liver. Food and Chemical Toxicology 2015; 78:96-104.

ROCHA J, PETERSON G, BIGGS R. Regime Shifts in the Anthropocene: Drivers, Risks, and Resilience. PLoS ONE 2015; 10(8):e0134639, 16 pages.

ROCHA J, YLETYINEN J, BIGGS R, BLENCKNER T, PETERSON G. Marine Regime Shifts: Drivers and Impacts on Ecosystems Services. Philosophical Transactions of the Royal Society B-Biological Sciences 2015; 370:20130273, 12 pages.

SELOMANE AO, REYERS B, BIGGS R, TALLIS H, POLASKY S. Towards integrated socialâ€"ecological sustainability indicators: Exploring the contribution and gaps in existing global data. Ecological Economics 2015; 118:140-146.

SNOEP JL, GREEN KA, EICHER JJ, PALM DC, PENKLER GP, DU TOIT F, WALTERS N, BURGER R, WESTERHOFF HV, VAN NIEKERK DD. Quantitative analysis of drug effects at the whole-body level: a case study for glucose metabolism in malaria patients. Biochemical Society Transactions 2015; 43:1157-1163.

SPRY C, SALIBA KJ, STRAUSS E. A miniaturized assay for measuring small molecule phosphorylation in the presence of complex matrices. Analytical Biochemistry 2014; 451:76-78.

STANFORD NJ, WOLSTENCROFT K, GOLEBIEWSKI M, KANIA R, JUTY N, TOMLINSON C, OWEN S, BUTCHER S, HERMJAKOB H, LE NOVèRE N, MUELLER W, SNOEP JL, GOBLE C. The evolution of standards and data management practices in systems biology. Molecular Systems Biology 2015; 11:851, 4 pages.

STEFFEN W, RICHARDSON K, ROCKSTRöM J, CORNELL SE, FETZER I, BENNETT EM, BIGGS R, CARPENTER S, DE VRIES W, DE WIT CA, FOLKE C, GERTEN D, HEINKE J, MACE GM, PERSSON LM, RAMANATHAN V, REYERS B, SöRLIN S. Planetary boundaries: Guiding human development on a changing planet. Science 2015; 347(6223):1259855, 10 pages.

STORBECK K, SWART AC, FOX C, SWART P. Cytochrome b5 modulates multiple reactions in steroidogenesis by diverse mechanisms. Journal of Steroid Biochemistry and Molecular Biology 2015; 151:66-73.

SWART AC, STORBECK K. 11β-hydroxyandrostenedione: Downstream metabolism by 11βHSD, 17βHSD and SRD5A produces novel substrates in familiar pathways. Molecular and Cellular Endocrinology 2015; 408:114-123.

THOMPSON GD, BELLSTEDT DU, RICHARDSON DM, WILSON JR, LE ROUX JJ. A tree well travelled: global genetic structure of the invasive tree Acacia saligna. Journal of Biogeography 2015; 42:305-314.

VAN DER MERWE JD, DE BEER D, JOUBERT E, GELDERBLOM WCA. Short-term and sub-chronic dietary exposure to aspalathin-enriched green rooibos (Aspalathus linearis) extract affects rat liver function and antioxidant status. Molecules 2015; 20:22674-22690.

WILLEMSE CM, STANDER MA, VESTNER J, TREDOUX AGJ, DE VILLIERS AJ. Comprehensive two-dimensional hydrophilic interaction chromatography (HILIC) X reversed-phase liquid chromatography coupled to high-resolution mass spectrometry (RP-LC-UV-MS) analysis of anthocyanins and derived pigments in red wine. Analytical Chemistry 2015; 87:12006-12015.

WIUM M, BOTES A, BELLSTEDT DU. The identification of oppA gene homologues as part of the oligopeptide transport system in mycoplasmas. Gene 2015; 558:31-40.

WOLSTENCROFT K, OWEN S, KREBS O, NGUYEN Q, STANFORD NJ, GOLEBIEWSKI M, WEIDEMANN A, BITTKOWSKI M, AN L, SHOCKLEY D, SNOEP JL, MEULLER W, GOBLE C. SEEK: a systems biology data and model management platform. BMC Systems Biology 2015; 9:33, 12 pages.

Joernaal Artikels (nie-gesubsideer)

MUGABO P , ABANIWONDA MI, THERON D, VAN ZYL L, HASSAN SM, STANDER MA, MCILLERON H, MADSEN R. Determination of Kanamycin Plasma Levels Using LC-MS and Its Pharmacokinetics in Patients with Multidrug- Resistant Tuberculosis with and without HIV-Infection. Biochemistry & Pharmacology 2015; 4(1):1000160, 7 pages.

MURABITO E, COLOMBO R, WU C, VERMA M, REHMAN S, SNOEP JL, PENG S-L, GUAN N, LIAO X, WESTERHOFF HV. SupraBiology 2014: Promoting UK-China collaboration on Systems Biology and High Performance Computing. Quantitative Biology 2015; 3(1):46-53.

Hoofstukke in Boeke

BIGGS R, GORDON L, RAUDSEPP-HEARNE C, SCHLüTER M, WALKER B. Principle 3: Manage slow variables and feedbacks. In: BIGGS R, Schlüter M, Schoon ML (eds.) Principles for Building Resilience: Sustaining Ecosystem Services in Social-Ecological Systems, Cambridge University Press, Cambridge, United Kingdom, 2015: 105-141.

BIGGS R, SCHLüTER M, SCHOON ML. An introduction to the resilience approach and principles to sustain ecosystem services in social-ecological systems. In: BIGGS R, Schlüter M, Schoon ML (eds.) Principles for Building Resilience: Sustaining Ecosystem Services in Social-Ecological Systems, Cambridge University Press, Cambridge, United Kingdom, 2015: 1-31.

KOTSCHY K, BIGGS R, DAW TM, FOLKE C, WEST PC. Principle 1: Maintain diversity and redundancy. In: BIGGS R, Schlüter M, Schoon ML (eds.) Principles for Building Resilience: Sustaining Ecosystem Services in Social-Ecological Systems, Cambridge University Press, Cambridge, United Kingdom, 2015: 50-79.

SCHLüTER M, BIGGS R, SCHOON ML, ROBARDS MD, ANDERIES JM. Reflections on building resilience - interactions among principles and implications for governance. In: BIGGS R, Schlüter M, Schoon ML (eds.) Principles for Building Resilience: Sustaining Ecosystem Services in Social-Ecological Systems, Cambridge University Press, Cambridge, United Kingdom, 2015: 251-282.

SCHOON ML, ROBARDS MD, BROWN K, ENGLE N, MEEK C, BIGGS R. Politics and the resilience of ecosystem services. In: BIGGS R, Schlüter M, Schoon ML (eds.) Principles for Building Resilience: Sustaining Ecosystem Services in Socialâ€"Ecological Systems, Cambridge University Press, Cambridge, United Kingdom, 2015: 32-49.

VISSER JC, BELLSTEDT DU. Potato Virus Y in South Africa: Isolate Characterization and Assessment of Potato Cultivar Resistance. In: Low J, Nyongesa M, Quinn S, Parker M (eds.) Potato and Sweetpotato in Africa: Transforming the Value Chains for Food and Nutrition Security, CABI, OXFORDSHIRE, United Kingdom, 2015: 279-288.

Patente

RAUTENBACH M, DE BEER A, TROSKIE AM, VOSLOO JA. Antimicrobial peptide compositions for plants. Patent No. WO/2013/150394, South Africa 2015.

Publikasies in 2014

Joernaal Artikels (gesubsideer)

AFRICANDER D, STORBECK K-H, HAPGOOD JP. A comparative study of the androgenic properties of progesterone and the progestins, medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A). Journal of Steroid Biochemistry and Molecular Biology 2014; 143 : 404-415.

BURGER H-M, LOMBARD MJ, SHEPHARD GS, DANSTER-CHRISTIANS N, GELDERBLOM WCA. Development and Evaluation of a Sensitive Mycotoxin Risk Assessment Model (MYCORAM). Toxicological Sciences 2014; 141(2) : 387-397.

CILLIERS FP, GOUWS PA, KOUTCHMA T, ENGELBRECHT Y, ADRIAANSE C, SWART P. A microbiological, biochemical and sensory characterisation of bovine milk treated by heat and ultraviolet (UV) light for manufacturing Cheddar cheese. Innovative Food Science & Emerging Technologies 2014; 23 : 94-106.

DE VILLIERS M, BARNARD L, KOEKEMOER L, SNOEP JL, STRAUSS E. Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis. FEBS Journal 2014; 281 : 4731-4753.

GAERTNER M, BIGGS R, TE BEEST M, HUI C, MOLOFSKY J, RICHARDSON DM. Invasive plants as drivers of regime shifts: identifying high-priority invaders that alter feedback relationships. Diversity and Distributions 2014; 20(7) : 733-744.

GOVENDER Y, AVENANT C, VERHOOG N, RAY RM, GRANTHAM NJ, AFRICANDER D, HAPGOOD JP. The Injectable-Only Contraceptive Medroxyprogesterone Acetate, Unlike Norethisterone Acetate and Progesterone, Regulates Inflammatory Genes in Endocervical Cells via the Glucocorticoid Receptor. PLoS ONE 2014; 9(5) : e96497.

GROBBELAAR MC, MAKUNGA NP, STANDER MA, KOSSMANN J, HILLS PN. Effect of strigolactones and auxins on growth and metabolite content of Sutherlandia frutescens (L.) R. Br. microplants in vitro. Plant Cell Tissue and Organ Culture 2014; 117 : 401-409.

GUSTAVSSON A-K, VAN NIEKERK DD, ADIELS CB, GOKSÃ–R M, SNOEP JL. Heterogeneity of glycolytic oscillatory behaviour in individual yeast cells. FEBS Letters 2014; 588 : 3-7.

GUSTAVSSON A-K, VAN NIEKERK DD, ADIELS CB, KOOI BW, GOKSöR M, SNOEP JL. Allosteric regulation of phosphofructokinase controls the emergence of glycolytic oscillations in isolated yeast cells. FEBS Journal 2014; 281 : 2784-2793.

HAPGOOD JP, AFRICANDER D, LOUW R, RAY RM, ROHWER JM. Potency of progestogens used in hormonal therapy: Toward understanding differential actions. Journal of Steroid Biochemistry and Molecular Biology 2014; 142 : 39-47.

KÃœHN S, HOFMEYR J-HS. Is the â€œHistone Codeâ€ an Organic Code?. Biosemiotics 2014; 7(2) : 203-222.

LEADLEY P, PROENCA V, FERNÃNDEZ-MANJARRÉS J, PEREIRA HM, ALKEMADE R, BIGGS R, BRULEY E, CHEUNG W, COOPER D, FIGUEIREDO J, GILMAN E, GUÉNETTE S, HURTT G, MBOW C, OBERDORFF T, REVENGA C, SCHARLEMANN JPW, SCHOLES RJ, SMITH MS, SUMAILA RU, WALPOLE M. Interacting Regional-Scale Regime Shifts for Biodiversity and Ecosystem Services. Bioscience 2014; 64(8) : 665-679.

LEUSSA AN-N, RAUTENBACH M. Detailed SAR and PCA of the Tyrocidines and Analogues Towards Leucocin A-Sensitive and Leucocin A-Resistant Listeria monocytogenes. Chemical Biology & Drug Design 2014; 84 : 543-557.

LOOS B, DU TOIT A, HOFMEYR J-HS. Defining and measuring autophagosome flux: concept and reality. Autophagy 2014; 10(11) : 2087-2096.

LOUW-DU TOIT R, HAPGOOD JP, AFRICANDER D. Medroxyprogesterone Acetate Differentially Regulates Interleukin (IL)-12 and IL-10 in a Human Ectocervical Epithelial Cell Line in a Glucocorticoid Receptor (GR)-dependent Manner. Journal of Biological Chemistry 2014; 289(45) : 31136-31149.

MACE GM, REYERS B, ALKEMADE R, BIGGS R, CHAPIN FS, CORNELL SE, DIAZ S, JENNINGS S, LEADLEY P, MUMBY PJ, PURVIS A, SCHOLES RJ, SEDDON AWR, SOLAN M, STEFFEN W, WOODWARD G. Approaches to defining a planetary boundary for biodiversity. Global Environmental Change-Human and Policy Dimensions 2014; 28 : 289-297.

MOOLMAN WJA, DE VILLIERS M, STRAUSS E. Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development. Biochemical Society Transactions 2014; 42(4) : 1080-1086.

MPHAHLELE RR, FAWOLE OA, STANDER MA, OPARA UL. Preharvest and postharvest factors influencing bioactive compounds in pomegranate (Punica granatum L.): A review. Scientia Horticulturae 2014; 178 : 114-123.

MPHAHLELE RR, STANDER MA, FAWOLE OA, OPARA UL. Effect of fruit maturity and growing location on the postharvestcontents of flavonoids, phenolic acids, vitamin C and antioxidantactivity of pomegranate juice (cv. Wonderful). Scientia Horticulturae 2014; 179 : 36-45.

NIEUWOUDT M, LOMBARD N, RAUTENBACH M. Optimised purification and characterisation of lipid transfer protein 1 (LTP1) and its lipid-bound isoform LTP1b from barley malt. Food Chemistry 2014; 157 : 559-567.

PALM DC, ROHWER JM, HOFMEYR J-HS. Incorporating covalent and allosteric effects into rate equations: the case of muscle glycogen synthase. Biochemical Journal 2014; 462 : 525-537.

SCHLOMS L, SMITH C, STORBECK K-H, MARNEWICK JL, SWART P, SWART AC. Rooibos influences glucocorticoid levels and steroid ratios in vivo and in vitro: A natural approach in the management of stress and metabolic disorders?. Molecular Nutrition & Food Research 2014; 58 : 537-549.

SCHLOMS L, SWART AC. Rooibos Flavonoids Inhibit the Activity of Key Adrenal Steroidogenic Enzymes, Modulating Steroid Hormone Levels in H295R Cells. Molecules 2014; 19 : 3681-3695.

SHEPHARD GS, GELDERBLOM WCA. Rapid testing and regulating for mycotoxin concerns: a perspective from developing countries. World Mycotoxin Journal 2014; 7(4) : 431-437.

TROSKIE AM, DE BEER A, VOSLOO JA, JACOBS K, RAUTENBACH M. Inhibition of agronomically relevant fungal phytopathogens by tyrocidines, cyclic antimicrobial peptides isolated from Bacillus aneurinolyticus . Microbiology 2014; 160 : 2089-2101.

TROSKIE AM, RAUTENBACH M, DELATTIN N, VOSLOO JA, DATHE M, CAMMUE BPA, THEVISSEN K. Synergistic Activity of the Tyrocidines, Antimicrobial Cyclodecapeptides from Bacillus aneurinolyticus, with Amphotericin B and Caspofungin against Candida albicans Biofilms. Antimicrobial Agents and Chemotherapy 2014; 58(7) : 3697-3707.

VAN WYK P, VAN DYK JB, GERBER WJ, STANDER MA, DE VILLIERS AJ, KOCH KR. Speciation of [Pt^IVCl_6-nBr_n]^2- (n = 0-6) and some of their mono-aquated [Pt^IVCl_5-nBr_n(H₂O)]^- (n = 0-5) anions in solution at low concentrations by means of ion-pairing reversed-phase ultra-high-performance liquid chromatography coupled to electrospray ionization quadrupole time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry 2014; 28 : 505-519.

VERHOOG N, ALLIE-REID F, VANDEN BERGHE W, SMITH C, HAEGEMAN G, HAPGOOD JP, LOUW A. Inhibition of Corticosteroid-Binding Globulin Gene Expression by Glucocorticoids Involves C/EBPÃŸ. PLoS ONE 2014; 9(10) : e110702.

WILLEMSE CM, STANDER MA, TREDOUX AGJ, DE VILLIERS AJ. Comprehensive two-dimensional liquid chromatographic analysis of anthocyanins. Journal of Chromatography A 2014; 1359 : 189-201.

WRIGHT LP, ROHWER JM, GHIRARDO A, HAMMERBACHER A, ORTIZ-ALCAIDE M, RAGUSCHKE B, SCHNITZLER J-P, GERSHENZON J, PHILLIPS MA. Deoxyxylulose 5-Phosphate Synthase Controls Flux through the Methylerythritol 4-Phosphate Pathway in Arabidopsis¹. Plant Physiology 2014; 165 : 1488-1504.

Joernaal Artikels (nie-gesubsideer)

PAUL S, MÜLLER HP, PREISER R, DE LIMA NETO FB, MARWALA T, DE WILDE P. Developing a management decision-making model based upon a complexity perspective with reference to the Bee Algorithm. Emergence: complexity and organization 2014; 16(1) : 1-12.

PREISER R, STRUTHERS P, MOHAMED S, CAMERON NA, LAWRENCE E. External stakeholders and health promoting schools: complexity and practice in South Africa. Health Education 2014; 114(4) : 260-270.

TIPTON K, ARMSTRONG R, BAKKER BM, BAIROCH A, CORNISH-BOWDEN A, HALLING PJ, HOFMEYR J-HS, LEYH TS, KETTNER C, RAUSHEL FM, ROHWER JM, SCHOMBURG D, STEINBECK C. Standards for Reporting Enzyme Data: The STRENDA Consortium: What it aims to do and why it should be helpful. Perspectives in Science 2014; 1 : 131-137.

Hoofstukke in Boeke

LOOS B, HOFMEYR JS, MÜLLER-NEDEBOCK KK, BOONZAAIER L, KINNEAR CJ. Autophagic Flux, Fusion Dynamics and Cell Death. In Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volume 3, Elsevier, USA, 2014: 39-56.

ROHWER JM, UYS L. Systems Biology and Metabolic Modeling. In SUGERCANE Physiology, Biochemistry and Functional Biology, John Wiley & Sons, Inc, , 2014: 601-622.

ROHWER JM. Applications of Kinetic Modeling to Plant Metabolism. In Plant Metabolism Methods and protocols, Springer Science+Business Media, New York, 2014: 275-286.

Patente

RAUTENBACH M, DE BEER A, TROSKIE AM, VOSLOO JA. Antimicrobial cyclic peptide compositions for plants. Patent No. WO 2013/150394 A1, 2014.

Publikasies in 2013

Joernaal Artikels (gesubsideer)

AFRICANDER D, LOUW R, HAPGOOD JP. Investigating the anti-mineralocorticoid properties of synthetic progestins used in hormone therapy. Biochemical and Biophysical Research Communications 2013; 433 : 305-310.

ALBERTS P, KIDD M, STANDER MA, NIEUWOUDT HH, TREDOUX AGJ, DE VILLIERS AJ. Quantitative survey of 3-alkyl-2-methoxypyrazines and first confirmation of 3-ethyl-2-methoxypyrazine in South African Sauvignon blanc wines. South African Journal of Enology and Viticulture 2013; 34(1) : 54-67.

AUDOUIN M, PREISER R, NIENABER S, DOWNSBOROUGH L, LANZ J, MAVENGAHAMA S. Exploring the implications of critical complexity for the study of social-ecological systems. Ecology and Society 2013; 18(3) : Art.#12.

BLOEM LM, STORBECK K-H, SCHLOMS L, SWART AC. 11ß-Hydroxyandrostenedione returns to the steroid arena: Biosynthesis, metabolism and function. Molecules 2013; 18 : 13228-13244.

BURGER H-M, SHEPHARD GS, LOUW W, RHEEDER JP, GELDERBLOM WCA. The mycotoxin distribution in maize milling fractions under experimental conditions. International Journal of Food Microbiology 2013; 165 : 57-64.

CILLIERS FP, BIGGS HC, BLIGNAUT S, CHOLES AG, HOFMEYR J-HS, JEWITT GPW, ROUX DJ. Complexity, modeling, and natural resource management. Ecology and Society 2013; 18(3) : 1.

DE VILLIERS M, MACUAMULE C, SPRY C, HYUN Y-M, STRAUSS E, SALIBA KJ. Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity. ACS Medicinal Chemistry Letters 2013; 4 : 784-789.

DE VILLIERS MJ, PIRIE MD, HUGHES M, MÖLLER M, EDWARDS TJ, BELLSTEDT DU. An approach to identify putative hybrids in the 'coalescent stochasticity zone', as exemplified in the African plant genus Streptocarpus (Gesneriaceae). New Phytologist 2013; 198 : 284-300.

DU PLESSIS DM, BOTES M, DICKS LMT, CLOETE TE. Immobilization of commercial hydrolytic enzymes on poly (acrylonitrile) nanofibers for anti-biofilm activity. Journal of Chemical Technology and Biotechnology 2013; 88(4) : 585-593.

GEENEN S, DU PREEZ F, SNOEP JL, FOSTER AJ, SARDA S, KENNA JG, WILSON ID, WESTERHOFF H V. Glutathione metabolism modeling: A mechanism for liver drug-robustness and a new biomarker strategy. Biochimica et Biophysica Acta-General Subjects 2013; 1830 : 4943-4959.

GOOSEN P, SWART AC, STORBECK K-H, SWART P. Allosteric interaction between 3ß-hydroxysteroid dehydrogenase/∆ ⁵-∆⁴ isomerase and cytochrome b₅ influences cofactor binding. Faseb Journal 2013; 27 : 322-332.

HOFMEYR J-HS, GQWAKA OPC, ROHWER JM. A generic rate equation for catalysed, template-directed polymerisation. Febs Letters 2013; 587 : 2868-2875.

HOUGH D, CLOETE SWP, STORBECK K-H, SWART AC, SWART P. Cortisol production in sheep is influenced by the functional expression of two cytochrome P450 17á-hydroxylase/17,20-lyase (CYP17) isoforms. Journal of Animal Science 2013; 91 : 1193-1206.

KALILI KM, VESTNER J, STANDER MA, DE VILLIERS AJ. Toward unraveling grape tannin composition: Application of online hydrophilic interaction chromatography x reversed-phase liquid chromatography-time-of-flight mass spectrometry for grape seed analysis. Analytical Chemistry 2013; 85 : 9107-9115.

KOURIL T, ESSER D, KORT J, WESTERHOFF H V, SIEBERS B, SNOEP JL. Intermediate instability at high temperature leads to low pathway efficiency for an in vitro reconstituted system of gluconeogenesis in Sulfolobus solfataricus. Febs Journal 2013; 280 : 4666-4680.

KRITZINGER EC, STANDER MA, DU TOIT WJ. Assessment of glutathione levels in model solution and grape ferments supplemented with glutathione-enriched inactive dry yeast preparations using a novel UPLC-MS/MS method. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment 2013; 30(1) : 80-92.

LOMBARD MJ, STEYN N, BURGER H-M, CHARLTON K, SENEKAL M. A food photograph series for identifying portion sizes of culturally specific dishes in rural areas with high incidence of oesophageal cancer. Nutrients 2013; 5 : 3118-3130.

LOUW A, JOUBERT E, VISSER K. Phytoestrogenic potential of Cyclopia extracts and polyphenols. Planta Medica 2013; 79 : 580-590.

MOLERO C, PETRÉNYI K, GONZÁLEZ A, CARMONA M, GELIS S, ABRIE JA, STRAUSS E, RAMOS J, DOMBRADI V, HIDALGO E, ARIÑO J. The Schizosaccharomyces pombe fusion gene hal3 encodes three distinct activities. Molecular Microbiology 2013; 90(2) : 367-382.

MUNYUKI G, JACKSON GE, VENTER GA, KÖVÉR KE, SZILÁGYI L, RAUTENBACH M, SPATHELF B, BHATTACHARYA B, VAN DER SPOEL D. ß‑Sheet structures and dimer models of the two major tyrocidines, antimicrobial peptides from Bacillus aneurinolyticus. Biochemistry 2013; 52 : 7798-7806.

NAIDOO VB, RAUTENBACH M. Self-assembling organo-peptide bolaphiles with KLK tripeptide head groups display selective antibacterial activity. Journal of Peptide Science 2013; 19 : 784-791.

PALM DC, ROHWER JM, HOFMEYR J-HS. Regulation of glycogen synthase from mammalian skeletal muscle – a unifying view of allosteric and covalent regulation. Febs Journal 2013; 280 : 2-27.

PILLAY CS, HOFMEYR J-HS, MASHAMAITE LN, ROHWER JM. From top-down to bottom-up: Computational modeling approaches for cellular redoxin networks. Antioxidants & Redox Signaling 2013; 18(16) : 2075-2086.

QUINTON-TULLOCH MJ, BRUGGEMAN FJ, SNOEP JL, WESTERHOFF H V. Trade-off of dynamic fragility but not of robustness in metabolic pathways in silico. Febs Journal 2013; 280 : 160-173.

ROBERTSON S, HAPGOOD JP, LOUW A. Glucocorticoid receptor concentration and the ability to dimerize influence nuclear translocation and distribution. Steroids 2013; 78 : 182-194.

ROBERTSON S, ROHWER JM, HAPGOOD JP, LOUW A. Impact of glucocorticoid receptor density on ligand-independent dimerization, cooperative ligand-binding and basal priming of transactivation: A cell culture model. PLoS ONE 2013; 8(5) : e64831.

ROGERS KH, LUTON R, BIGGS H, BIGGS R, BLIGNAUT S, CHOLES AG, PALMER CG, TANGWE P. Fostering Complexity Thinking in Action Research for Change in Social–Ecological Systems. Ecology and Society 2013; 18(2) : Art.#31.

SHEPHARD GS, KIMANYA ME, KPODO KA, GNONLONFIN GJB, GELDERBLOM WCA. The risk management dilemma for fumonisin mycotoxins. Food Control 2013; 34 : 596-600.

SMIT AY, DU TOIT WJ, STANDER MA, DU TOIT M. Evaluating the influence of maceration practices on biogenic amine formation in wine. LWT-Food Science and Technology 2013; 53 : 297-307.

SPRY C, MACUAMULE C, LIN Z, VIRGA KG, LEE RE, STRAUSS E, SALIBA KJ. Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated. PLoS ONE 2013; 8(2) : e54974.

STANDER MA, KÜHN W, HITEN NF. Survey of South African fruit juices using a fast screening HILIC-MS method. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment 2013; 30(9) : 1473-1484.

STORBECK K-H, BLOEM LM, AFRICANDER D, SCHLOMS L, SWART P, SWART AC. 11ß-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: A putative role in castration resistant prostate cancer?. Molecular and Cellular Endocrinology 2013; 377 : 135-146.

STORBECK K-H, SWART AC, GOOSEN P, SWART P. Cytochrome b₅: Novel roles in steroidogenesis. Molecular and Cellular Endocrinology 2013; 371 : 87-99.

SWART AC, BLOEM LM, SCHLOMS L, SWART P, AFRICANDER D, STORBECK K-H. 11ß-Hydroxyandrostenedione is metabolised to novel androgenic C19 steroids in the prostate. International Journal of Molecular Medicine 2013; 32(1) : S21.

SWART AC, SCHLOMS L, STORBECK K-H, BLOEM LM, DU TOIT T, QUANSON JL, RAINEY WE, SWART P. 11â-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5á-reductase yielding 11â-hydroxy-5á-androstanedione. Journal of Steroid Biochemistry and Molecular Biology 2013; 138 : 132-142.

SWART P, SWART AC, LOUW A, DE BOSSCHER K, HAEGEMAN G, BUDONOVA I. Anti-inflammatory and anti-cancer activities of compound A: A synthetic compound derived from a natural product. International Journal of Molecular Medicine 2013; 32(1) : S21.

VAN DER WESTHUIZEN L, SHEPHARD GS, GELDERBLOM WCA, TORRES O, RILEY RT. Fumonisin biomarkers in maize eaters and implications for human disease. World Mycotoxin Journal 2013; 6(3) : 223-232.

VISSER K, MORTIMER M, LOUW A. Cyclopia extracts act as ER¥á antagonists and ER©¬ agonists, in vitro and in vivo. PLoS ONE 2013; 8(11) : e79223.

VOSLOO JA, STANDER MA, LEUSSA AN-N, SPATHELF B, RAUTENBACH M. Manipulation of the tyrothricin production profile of Bacillus aneurinolyticus. Microbiology 2013; 159 : 2200-2211.

WILLEMSE CM, STANDER MA, DE VILLIERS AJ. Hydrophilic interaction chromatographic analysis of anthocyanins. Journal of Chromatography A 2013; 1319 : 127-140.

Joernaal Artikels (nie-gesubsideer)

HOUGH D, SWART P, CLOETE SWP. Exploration of the hypothalamic-pituitary-adrenal axis to improve animal welfare by means of genetic selection: Lessons from the South African Merino. Animals 2013; 3 : 442-474.

SCHEINPFLUG K, NIKOLENKO H, KOMAROV IV, RAUTENBACH M, DATHE M. What goes around comes around-A comparative study of the influence of chemical modifications on the antimicrobial properties of small cyclic peptides. Pharmaceuticals 2013; 6 : 1130-1144.

Verrigtinge Internasionaal

HOUGH D, SWART P, CLOETE JJE, CLOETE SWP. Searching for SNPs that affect sheep robustness: CYP17 SNP affects behavioural responses to psychological stress. Proceeding of the Association for the Advancement of Animal Breeding and Genetics, Massey University, Napier, New Zealand, AAABG Distribution Service 2013: 503-506.

Hoofstukke in Boeke

SNOEP JL. Databases for Kinetic Models. In Encyclopedia of Systems Biology, Springer, New York, USA, 2013: 537-544.

Publikasies in 2012

Joernaal Artikels (gesubsideer)

ABRIE JA, GONZALEZ A, STRAUSS E, ARINO J. Functional mapping of the disparate activities of the yeast moonlighting protein Hal3. Biochemical Journal 2012; 442 : 357-368.

ALBRECHT CF, STANDER MA, GROBBELAAR MC, COLLING J, KOSSMANN J, HILLS PN, MAKUNGA NP. LC-MS-based metabolomics assists with quality assessment and traceability of wild and cultivated plants ofSutherlandia frutescens (Fabaceae). South African Journal of Botany 2012; 82 : 33-45.

J. Reuteran and levan as carbohydrate sinks in transgenic sugarcane. Planta 2012; 236 : 1803-1815.

BAUER R, BASSON CE, BEKKER J, EGBICHI IM, ROHWER JM, UYS L, VAN WYK JH, KOSSMANN J. Reuteran and levan as carbohydrate sinks in transgenic sugarcane. Planta 2012; 236(6) : 1803-1815.

BELLSTEDT DU, GALLEY C, PIRIE MD, LINDER HP. The Migration of the Palaeotropical Arid Flora: Zygophylloideae as an Example. Systematic Botany 2012; 37(4) : 951-959.

CUEVAS JM, DELAUNAY A, VISSER JC, BELLSTEDT DU, JACQUOT E, ELENA SF. Phylogeography and Molecular Evolution of Potato virus Y. PLoS ONE 2012; 7(5) : e37853.

DE BEER D, SCHULZE AE, JOUBERT E, DE VILLIERS AJ, MALHERBE CJ, STANDER MA. Food ingredient extracts of Cyclopia subternata (Honeybush): Variation in phenolic composition and antioxidant capacity. Molecules2012; 17 : 14602-14624.

DU PLESSIS DM, BOTES M, DICKS LMT, CLOETE TE. Immobilization of commercial hydrolytic enzymes on poly (acrylonitrile) nanofibers for anti-biofilm activity . Journal of Chemical Technology and Biotechnology 2013; 88(4) : 585-593.

DU PREEZ F, VAN NIEKERK DD, KOOI BW, ROHWER JM, SNOEP JL. From steady-state to synchronized yeast glycolytic oscillations I: model construction. Febs Journal 2012; 279 : 2810-2822.

DU PREEZ F, VAN NIEKERK DD, SNOEP JL. From steady-state to synchorinized yeast glycolytic oscillations II: model validation. Febs Journal 2012; 279 : 2823-2836.

GEENEN S, DU PREEZ F, REED M, NIJHOUT HF, KENNA JG, WILSON ID, WESTERHOFF HW, SNOEP JL. A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism. European Journal of Pharmaceutical Sciences 2012; 46 : 233-243.

GELDERBLOM WCA, MARASAS WFO. Controversies in fumonisin mycotoxicology and risk assessment. Human & Experimental Toxicology 2012; 3 : 215-235.

GUSTAVSSON A-K, VAN NIEKERK DD, ADIELS CB, DU PREEZ F, GOKSÖR M, SNOEP JL. Sustained glycolytic oscillations in individual isolated yeast cells. Febs Journal 2012; 279 : 2837-2847.

KADEREIT G, ACKERLY D, PIRIE MD. A broader model for C4 photosynthesis evolution in plants inferred from the goosefoot family (Chenopodiaceae s.s.). Proceedings of the Royal Society B-Biological Sciences 2012; 279 : 3304-3311.

KISSLING J. Taxonomy of Exochaenium and Lagenias: Two Resurrected Genera of Tribe Exaceae (Gentianaceae).Systematic Botany 2012; 37(1) : 238-253.

KOLODKIN A, BOOGERD FC, PLANT N, BRUGGEMAN F, GONCHARUK V, LUNSHOF J, MORENO-SANCHEZ R, YILMAZ N, BAKKER BM, SNOEP JL, BALLING R, WESTERHOFF HW. Emergence of the silicon human and network targeting drugs. European Journal of Pharmaceutical Sciences 2012; 46 : 190-197.

LAMPRECHT DA, MUNERI NO, EASTWOOD H , NAIDOO K, STRAUSS E, JARDINE A. An enzyme-initiated Smiles rearrangement enables the development of an assay of MshB, the GlcNAc-Ins deacetylase of mycothil biosynthesis. Organic & Biomolecular Chemistry 2012; 10 : 5278.

LONG HS, STANDER MA, VAN WYK B.-E.. Notes on the occurrence and significance of triterpenoids (asiaticoside and related compounds) and caffeoylquinic acids in Centella species. South African Journal of Botany 2012; 82 : 53-59.

MARASAS WFO, GELDERBLOM WCA, SHEPHARD GS, VISMER HF. Mycotoxicological research in South Africa 1910-2011. World Mycotoxin Journal 2012; 5(1) : 89-102.

NAIDOO VM, RAUTENBACH M. Bidirectional solid phase synthesis of a model oligoglycine bolaamphiphile and purification by rapid self-assembly. Journal of Peptide Science 2012; 18 : 317-325.

PIRIE MD, HUMPHREYS AM, ANTONELLI A, GALLEY C, LINDER HP. Model uncertainty in ancestral are reconstruction: A parsimonious solution?. Taxon 2012; 61(3) : 652-664.

RAUTENBACH M, EYÉGHÉ-BIKONG HA, VLOK NM, STANDER MA, DE BEER A. Direct surfactin-gramicidin S antagonism supports detoxification in mixed producer cultures of Bacillus subtilis and Aneurinibacillus migulanux.Microbiology 2012; 158 : 3072-3082.

ROHWER JM. Kinetic modelling of plant metabolic pathways. Journal of Experimental Botany 2012; 63(6) : 2275-2292.

SCHLOMS L, STORBECK K-H, SWART P, GELDERBLOM WCA, SWART AC. The influence of Aspalathus linearis(Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells. Journal of Steroid Biochemistry and Molecular Biology 2012; 128 : 128-138.

M. On modifying the Arrhenius equation to compensate for temperature changes for reactions within biological systems. Water SA 2012; 38(1) : 149-151.

STORBECK K-H, SWART AC, LOMBARD N, ADRIAANSE C, SWART P. Cytochrome b5 forms homomeric complexies in living cells. Journal of Steroid Biochemistry and Molecular Biology 2012; 132 : 311-321.

THOMPSON GD, BELLSTEDT DU, BYRNE M, MILLAR MA, RICHARDSON DM, WILSON JRU, LE ROUX J. Cultivation shapes genetic novelty in a globally important invader. Molecular Ecology 2012; 21 : 3187-3199.

TROSKIE AM, VLOK NM, RAUTENBACH M. A novel 96-well gel-based assay for determining antifungal activity against filamentous fungi. Journal of Microbiological Methods 2012; 91 : 551-558.

VAN DER MERWE JD, JOUBERT E, MANLEY M, DE BEER D, MALHERBE CJ, GELDERBLOM WCA. Mangiferin glucuronidation: Important hepatic modulation of antioxidant activity. Food and Chemical Toxicology 2012; 50 : 808-815.

VAN DER WESTHUIZEN R, HAMMONS JC, MEIER JL, DAHESH S, MOOLMAN WJA, PELLY SC, NIZET V, BURKART MD, STRAUSS E. The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis. Chemistry & Biology 2012; 19 : 559-571.

VISSER JC, BELLSTEDT DU, PIRIE MD. The Recent Recombinant Evolution of a Major Crop Pathogen, Potato virus Y. PLoS ONE 2012; 7(11) :e50631.

WALLACE BD, EDWARDS JS, WALLEN JR, MOOLMAN WJA, VAN DER WESTHUYZEN R, STRAUSS E, REDINBO MR, CLAIBORNE A. Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights. Biochemistry 2012; 51 : 7699-7711.

Joernaal Artikels (nie-gesubsideer)

EICHER JJ, SNOEP JL, ROHWER JM. Determining Enzyme Kinetics for Systems Biology with Nuclear Magnetic Resonance Spectroscopy. Metabolites 2012; 2 : 818-843.

MAGCWEBEBA T, RIEDEL S, SWANEVELDER S, BOUIC P, SWART P, GELDERBLOM WCA. Interleukin-1alpha Induction in Human Keratinocytes (HaCaT): An In Vitro Model for Chemoprevention in Skin. Journal of Skin Cancer2012; 2012 : 1-10.

Verrigtinge Nasionaal

THOMPSON GD, BELLSTEDT DU, LE ROUX JJ, RICHARDSON DM, WILSON JRU. Acacia saligna invasions: Genetics and species distribution modeling. South African Association of Botanists 38th Conference, University of Pretoria, Pretoria, South Africa, South African Journal of Botany 2012: 215-216.

Boeke

PITT JI, WILD CP, BAAN RA, GELDERBLOM WCA, MILLER JD, RILEY RT, WU F. Improving Public Health Through Mycotoxin Control. The International Agency for Research on Cancer, Lyon Cedex, France 2012:151 pp.

Hoofstukke in Boeke

MARASAS WFO, SHEPHARD GS, VISMER HF, ALBERTS JF, VAN DER WESTHUIZEN L, GELDERBLOM WCA. History and Relevance of Fumonisins. In World Nutrition Forum, Anytine Publishing, Leicestershire, United Kingdom, 2012: 213-240.

Publikasies in 2011

Joernaal Artikels (gesubsideer)

AERTS R, THIJS KW, LEHOUCK V, BEENTJE H, BYTEBIER BLG, MATTHYSEN E, GULINCK H, LENS L, MUYS B. Woody plant communities of isolated Afromontane cloud forests in Taita Hills, Kenya. Plant Ecology 2011; 212 : 639-649.

AFRICANDER D, LOUW R, VERHOOG N, NOETH D, HAPGOOD JP. Differential regulation of endogenous pro-inflammatory cytokine genes by medroxyprogesterone acetate and norethisterone acetate in cell lines of the female genital tract. Contraception 2011; 84(4) : 423-435.

AFRICANDER D, VERHOOG N, HAPGOOD JP. Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception. Steroids 2011; 76 : 636-652.

BYTEBIER BLG, ANTONELLI A, BELLSTEDT DU, LINDER HP. Estimating the age of fire in the Cape flora of South Africa from an orchid phylogeny. Proceedings of the Royal Society B-Biological Sciences 2011; 278 : 188-195.

CLOETE WJ, ADRIAANSE C, SWART P, KLUMPERMAN B. Facile immobilization of enzymes on electrospun poly(styrene-alt-maleic anhydride) nanofibres. Polymer Chemistry 2011; 2 : 1479-1481.

COUVREUR TLP, PIRIE MD, CHATROU LW, SAUNDERS RMK, SU YCF, RICHARDSON JE, ERKENS RHJ. Early evolutionary history of the flowering plant family Annonaceae: steady diversification the boreotropical geodispersal. Journal of Biogeography 2011; 38 : 664-680.

DAVIES TJ, SMITH GF, BELLSTEDT DU, BOATWRIGHT JS, BYTEBIER BLG, COWLING RM, FOREST F, HARMON LJ, MUASYA AM, SCHRIRE B, STEENKAMP Y, VAN DER BANK M, SAVOLAINEN V. Extinction Risk and Diversification Are Linked in a Plant Biodiversity Hotspot. Plos Biology 2011; 9(5) : e1000620.

DEKKER S, CILLIERS P, HOFMEYR J-HS. The complexity of failure: Implications of complexity theory for safety investigations. Safety Science 2011; 49 : 939-945.

GOOSEN P, STORBECK K-H, SWART AC, CONRADIE R, SWART P. Cytochrome b5 augments 3ß-hydroxysteroid dehydrogenase/∆5-∆4 isomerase activity. Journal of Steroid Biochemistry and Molecular Biology 2011; 127 : 238-247.

HADLEY K, LOUW A, HAPGOOD JP. Differential nuclear localisation and promoter occupancy play a role in glucocorticoid receptor ligand-specific transcriptional responses. Steroids 2011; 76 : 1176-1184.

HOFMEYR J-HS, ROHWER JM. Supply-Demand Analysis: A Framework for Exploring the Regulatory Design of Metabolism. Methods in Enzymology 2011; 500(Chapter 25) : 533-554.

LARSSON C, SNOEP JL, NORBECK J, ALBERS E. Flux balance analysis for ethylene formation in genetically engineered Saccharomyces cerevisiae. IET Systems Biology 2011; 5(4) : 245-251.

MFA MEZUI A, SWART P. Effect of UV-C Disinfection of Beer – Sensory Analysis and Consumer Ranking. Journal of the Institute of Brewing 2010; 116(4) : 348-353.

OBERLANDER KC, DREYER LL, BELLSTEDT DU. Molecular phylogenetics and origins of southern African Oxalis. Taxon 2011; 60(6) : 1667-1677.

PILLAY CS, HOFMEYR J-HS, ROHWER JM. The logic of kinetic regulation in the thioredoxin system. BMC SYSTEMS BIOLOGY 2011; 5 : 15.

PIRIE MD, OLIVER EGH, BELLSTEDT DU. A densely sampled ITS phylogeny of the Cape flagship genus Erica L. suggests numerous shifts in floral macro-morphology . Molecular Phylogenetics and Evolution 2011; 61 : 593–601.

SHERIDAN CM, GLASSER D, HILDEBRANDT D, PETERSEN J, ROHWER JM. An Annual and Seasonal

Characterisation of Winery Effluent in South Africa. South African Journal of Enology and Viticulture 2011; 32(1) : 1-8.

SISSING L, MARNEWICK JL, DE KOCK M, SWANEVELDER S, JOUBERT E, GELDERBLOM WCA. Modulating effects of rooibos and honeybush herbal teas on the development of esophageal papillomas in rats. Nutrition and Cancer-An International Journal 2011; 63(4) : 600-610.

VAN DER WESTHUIZEN L, SHEPHARD GS, BURGER H.-M., RHEEDER JP, GELDERBLOM WCA, WILD CP, GONG YY. Fumonisin B1 as a Urinary Biomarker of Exposure in a Maize Invervention Study Among South African Subsistence Farmers. Cancer Epidemiology Biomarkers & Prevention 2011; 20 : 483-489.

VAN DER WESTHUIZEN L, SHEPHARD GS, RHEEDER JP, BURGER H.-M., GELDERBLOM WCA, WILD CP, GONG YY. Optimising sorting and washing of home-grown maize to reduce fumonisin contamination under laboratory-controlled conditions. Food Control 2011; 22 : 396-400.

WALTEMATH D, ADAMS R, BEARD DA, BERGMAN FT, BHALLA U S, BRITTEN R, CHELLIAH V, COOLING MT, COOPER J, CRAMPIN E J , GARNY A, HOOPS S, HUCKA M, HUNTER P, KLIPP E, LAIBE C, MILLER AK, MORARU I, NICKERSON D, NIELSEN P, NIKOLSKI M, SAHLE S, SAURO H, SCHMIDT H,. Minimum Information About a Simulation Experiment (MIASE). Plos Computational Biology 2011; 7(4) : e1001122.

WALTEMATH D, ADAMS R, BERGMANN FT, HUCKA M, KOLPAKOV F, MILLER AK, MORARU I, NICKERSON D, SAHLE S, SNOEP JL, LE NOVÈRE N . Reproducible computational biology experiments with SED-ML – The Simulation Experiment Description Markup Language. BMC SYSTEMS BIOLOGY 2011; 5(198) : 175-0505: 1-10.

WARREN BH, BAKKER FT, BELLSTEDT DU, BYTEBIER BLG, CLABEN-BOCKHOFF R, DREYER LL, EDWARDS D, FOREST F, GALLEY C, HARDY CR, LINDER HP, MUASYA AM, MUMMENHOFF K, OBERLANDER KC, QUINT M, RICHARDSON JE, SAVOLAINEN V, VAN DER NIET T , SCHRIRE B, VAN DER NIET T , . Consistent phenological shifts in the making of a biodiversity hotspot: the Cape flora. BMC Evolutionary Biology 2011; 11(39) : 1-11.

WOLSTENCROFT K, OWEN S, DU PREEZ F, KREBS O, MUELLER W, GOBLE C, SNOEP JL. The Seek: A Platform for Sharing Data and Models in Systems Biology. Methods in Enzymology 2011; 500(Chapter 29) : 629-655.

WOLSTENCROFT K, OWEN S, HORRIDGE M, KREBS O, MUELLER W, SNOEP JL, DU PREEZ F, GOBLE C. RightField: embedding ontology annotation in spreadsheets. Bioinformatics 2011; 27(14) : 2021-2022.

Joernaal Artikels (nie-gesubsideer)

SWAT M, KIELBASA SM, POLAK S, OLIVIER BG, BRUGGEMAN F, TULLOCH MQ, SNOEP JL, VERHOEVEN AJ, WESTERHOFF HW. What it takes to understand and cure a living system: computational systems biology and a systems biology-driven pharmacokinetics-pharmacodynamics platform. Interface Focus 2011; 1 : 16-23.

Hoofstukke in Boeke

HUGENHOLTZ J, HOLS P, SNOEP JL. Metabolic engineering of lactic acid bacteria. In Thirty years of research on lactic acid bacteria. (ISBN 978-90-817671-0-1), 24 Media Labs, Rotterdam, Netherlands, 2011: 113-133.

Publikasies in 2010

Joernaal Artikels (gesubsideer)

APWEILER R, ARMSTRONG R, BAIROCH A, CORNISH-BOWDEN A, HALLING PJ, HOFMEYR J-HS, KETTNER C, LEYH TS, ROHWER JM, SCHOMBURG D, STEINBECK C, TIPTON K. A large-scale protein-function database.Nature Chemical Biology 2010; 6 : 785.

AVENANT C, RONACHER K, STUBSRUD EF, LOUW A, HAPGOOD JP. Role of ligand-dependent GR phosphorylation and half-life in determination of ligand-specific transcriptional activity. Molecular and Cellular Endocrinology 2010; 327 : 72-88.

BELLSTEDT DU, PIRIE MD, VISSER C, DE VILLIERS M, GEHRKE B. A Rapid and Inexpensive Method for the Direct PCR Amplification of DNA from Plants. American Journal of Botany 2010; 97(7) : 65-68.

BURGER H-M, LOMBARD MJ, SHEPHARD GS, RHEEDER JR, VAN DER WESTHUIZEN L, GELDERBLOM WCA. Dietary fumonisin exposure in a rural population of South Africa. Food and Chemical Toxicology 2010; 48 : 2103-2108.

CONRADIE R, BRUGGEMAN F, CILIBERTO A, CSIKASZ-NAGY A, NOVAK B, WESTERHOFF HW, SNOEP JL. Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex. Febs Journal 2010; 277 : 357-367.

DE VILLIERS J, KOEKEMOER L, STRAUSS E. 3-Fluoroaspartate and Pyruvoyl-Dependant Aspartate Decarboxylase: Exploiting the Unique Characteristics of Fluorine To Probe Reactivity and Binding. Chemistry-A European Journal 2010; 16 : 10030-10041.

GOOSEN P, SWART AC, STORBECK K-H, SWART P. Hypocortisolism in the South African Angora goat: The role of 3ßHSD. Molecular and Cellular Endocrinology 2010; 315 : 182-187.

HILPERT K, MCLEOD B, YU J, ELLIOTT MR, RAUTENBACH M, RUDEN S, BURCK J, MUHLE-GOLL C, ULRICH AS, KELLER S, HANCOCK REW. Short Cationic Antimicrobial Peptides Interact with ATP. Antimicrobial Agents and Chemotherapy 2010; 54(10) : 4480-4483.

JOOSTE AEC, MAREE HJ, BELLSTEDT DU, GOSZCZYNSKI DE, PIETERSEN GJ, BURGER JT . Three genetic grapevine leafroll-associated virus 3 variants identified from South African vineyards show high variability in their 5′UTR. Archives of Virology 2010; 155 : 1997-2006.

KOLODKIN A, BRUGGEMAN F, PLANT N, MONÈ MJ , BAKKER BM, CAMPBELL MJ, VAN LEEUWEN JPTM, CARLBERG C, SNOEP JL, WESTERHOFF HW. Design principles of nuclear receptor signaling: how complex networking improves signal transduction. Molecular Systems Biology 2010; 6(446) : 1-14.

LI C, DONIZELLI M, RODRIGUEZ N, DHARURI H, ENDLER L, CHELLIAH V, LI L, HE E, HENRY A, STEFAN MI, SNOEP JL, HUCKA M, LE NOVÈRE N , LAIBE C. BioModels Databse: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC SYSTEMS BIOLOGY 2010; 4(92) : 1-2.

ROBERTSON S, ALLIE-REID F, VANDEN BERGHE W, VISSER K, BINDER A, AFRICANDER D, VISMER M, DE BOSSCHER K, HAPGOOD JP, HAEGEMAN G, LOUW A. Abrogation of Glucocorticoid Receptor Dimerization Correlates with Dissociated Glucocorticoid Behavior of Compound A. Journal of Biological Chemistry 2010; 285(11) : 8061-8075.

ROHWER JM, HOFMEYR J-HS. Kinetic and Thermodynamic Aspects of Enzyme Control and Regulation. Journal of Physical Chemistry B 2010; 114 : 16280-16289.

ROOTMAN I, DE VILLIERS M, BRAND LA, STRAUSS E. Creating Cellulose-Binding Domain Fusions of the Coenzyme A Biosynthetic Enzymes to Enable Reactor-Based Biotransformations. ChemCatChem 2010; 2 : 1239-1251.

SOMDYALA NIM, BRADSHAW D, GELDERBLOM WCA, PARKIN DM. Cancer incidence in a rural population of South Africa, 1998-2002. International Journal of Cancer 2010; 127 : 2420-2429.

STRAUSS E, DE VILLIERS M, ROOTMAN I. Biocatalytic Production of Coenzyme A Analogues.ChemCatChem 2010; 2 : 929-937.

STRAUSS E. Exploiting single-cell variation for new antibiotics. Nature Chemical Biology 2010; 6 : 873-874.

SULPICE R, TRENKAMP S, STEINFATH M, USADEL B, GIBON Y, WITUCKA-WALL H, PYL E-V, TSCHOEP H, STEINHAUSER MC, GUENTHER M, HOEHNE M, ROHWER JM, ALTMANN T, FERNIE AR, STITT M. Network Analysis of Enzyme Activities and Metabolite Levels and Their Relationship to Biomass in a Large Panel ofArabidopsis Accessions. Plant Cell 2010; 22 : 2872-2893.

SWART AC, STORBECK K-H, SWART P. A single amino acid residue, Ala 105, confers 16alpha-hydroxylase activity to human cytochrome P450 17alpha-hydroxylase/17,20 lyase. Journal of Steroid Biochemistry and Molecular Biology 2010; 119 : 112-120.

THEMBO KM, VISMER HF, NYAZEMA NZ, GELDERBLOM WCA, KATERERE DR. Antifungal activity of four weedy plant extracts against selected mycotoxigenic fungi. Journal of Applied Microbiology 2010; 109 : 1479-1486.

VAN DER MERWE JD, JOUBERT E, MANLEY M, DE BEER D, MALHERBE CJ, GELDERBLOM WCA. In vitro hepatic biotransformation of aspalathin and nothofagin, dihydrochalcones of rooibos (Aspalathus linearis), and assessment of metabolite antioxidant activity. Journal of Agricultural and Food Chemistry 2010; 58 : 2214-2220.

VAN DER WESTHUIZEN L, SHEPHARD GS, RHEEDER JP, BURGER H.-M., GELDERBLOM WCA, WILD CP, GONG YY. Simple intervention method to reduce fumonisin exposure in a subsistence maize-farming community in South Africa. Food Additives and Contaminants 2010; 27(11) : 1582-1588.

VAN DER WESTHUYZEN R, STRAUSS E. Michael Acceptor-Containing Coenzyme A Analogues As Inhibitors of the Atypical Coenzyme A Disulfide Reductase from Staphylococcus aureus. Journal of the American Chemical Society 2010; 132 : 12853-12855.

VISSER K, SMITH C, LOUW A. Interplay of the Inflammatory and Stress Systems in a Hepatic Cell Line: Interactions between Glucocorticoid Receptor Agonists and Interleukin-6. Endocrinology 2010; 151(11) : 5279-5293.

Joernaal Artikels (nie-gesubsideer)

SPRY C, VAN SCHALKWYK DA, STRAUSS E, SALIBA KJ. Pantothenate Utilization by Plasmodium as a Target for Antimalarial Chemotherapy. Infectious Disorders – Drug Targets 2010; 10 : 200-216.

Verrigtinge Internasionaal

HOUGH D, STORBECK K-H, CLOETE SWP, SWART P. Improving stress coping ability: Comparison between the CYP17 genotypes of Ovis aries and Capra hircus. 9th World Congress on Genetics Applied to Livestock Production, Congress Centre,Leipzig,Germany, Gesellschaft fur Tierzuchtwissen-schafen e.V. (German Society for Animal Science) 2010: 10-15.

ROHWER JM, HOFMEYR J-HS. Using Generalised Supply-Demand Analysis to Identify Regulatory Metabolites. Experimental Standard Conditions of Enzyme Characterizations – Proceedings of the International Builsstein Symposium, Hotel Jagdschloss Niederwald, Rüdesheim/Rhein, Germany, Logos Verlag Berlin GmbH – ISBN978-3-8325-2606-1 2010: 149-163.

Hoofstukke in Boeke

STRAUSS E. Coenzyme A Biosynthesis and Enzymology. In Comprehensive Natural Products II – Chemistry and Biology. Volume 7 of 10, Elsevier,Oxford,United Kingdom, 2010: 351-410.