EICHER JJ. Understanding glycolysis in Escherichia coli: A systems approach using nuclear magnetic resonance spectroscopy. PhD(Bioch), 2013. 197 pp. Promotor: Rohwer JM. Medepromotor: Snoep JL.
LOUW R. A study of the molecular mechanism of progestin-induced regulation of IL-12 and IL-10 and implications for HIV pathogenesis. PhD(Bioch), 2013. 215 pp. Promotor: Africander D. Medepromotor: Hapgood JP.
MAGCWEBEBA T. Chemopreventive properties of South African herbal teas, Rooibos, (Aspalathus linearis) and Honeybush (Cyclopia spp): Mechanism against skin carcinogenesis. PhD(Bioch), 2013. 269 pp. Promotor: Gelderblom WCA. Medepromotor: Joubert E, Swart P.
PALM DC. The regulatory design of glycogen metabolism in mammalian skeletal muscle. PhD(Bioch), 2013. 285 pp. Promotor: Hofmeyr J-HS. Medepromotor: Rohwer JM.
PENKLER G. A kinetic model of glucose catabolism in Plasmodium falciparum. PhD(Bioch), 2013. 196 pp. Promotor: Snoep JL, Westerhoff H V. Medepromotor: Rautenbach M.
Meesters voltooi
ADRIAANSE C. An investigation into the complex formation of membrane bound cytochrome b5 isolated from ovine liver microsomes. MSc Biochemie, 2013. 103 pp. Studieleier: Swart P. Medestudieleier: Rautenbach M.
CHRISTENSEN CD. Applications of generalised supply-demand analysis. MSc Biochemie, 2013. 134 pp. Studieleier: Rohwer JM. Medestudieleier: Hofmeyr J-HS.
KLOPPER SL. Cloning and functional characterization of thiol disulfide interchange system proteins from Staphylococcus aureus. MSc Biochemie, 2013. 90 pp. Studieleier: Strauss E.
MOCKE L. Kinetic modelling of wine fermentations: Why does yeast prefer glucose to fructose?. MSc Biochemie, 2013. 78 pp. Studieleier: Snoep JL.
ROOS WG. An investigation of prevalence and the detection and race identification of South African potato viruses. MSc Biochemie, 2013. 155 pp. Studieleier: Bellstedt DU.
STRYDOM M. The ostrich mycoplasma Ms02 Partial genome assembly, bioinformatic analysis and the development of three DNA vaccines. MSc Biochemie, 2013. 150 pp. Studieleier: Botes A. Medestudieleier: Bellstedt DU.
VAN TONDER A. Development of an oral vaccine against the ostrich-specific mycoplasma, Mycoplasma struthionis. MSc Biochemie, 2013. 220 pp. Studieleier: Bellstedt DU. Medestudieleier: Botes A.
VAN ZYL J. The quantification of metabolic regulation. MSc Biochemie, 2013. 124 pp. Studieleier: Hofmeyr J-HS. Medestudieleier: Rohwer JM.
Publikasies in 2012
Joernaal Artikels (gesubsideer)
ABRIE
JA, GONZALEZ A, STRAUSS E, ARINO J. Functional mapping of the disparate
activities of the yeast moonlighting protein Hal3. Biochemical Journal 2012; 442 : 357-368.
ALBRECHT
CF, STANDER MA, GROBBELAAR MC, COLLING J, KOSSMANN J, HILLS PN, MAKUNGA
NP. LC-MS-based metabolomics assists with quality assessment and
traceability of wild and cultivated plants ofSutherlandia frutescens (Fabaceae). South African Journal of Botany 2012; 82 : 33-45.
J. Reuteran and levan as carbohydrate sinks in transgenic sugarcane. Planta 2012; 236 : 1803-1815.
BAUER
R, BASSON CE, BEKKER J, EGBICHI IM, ROHWER JM, UYS L, VAN WYK JH,
KOSSMANN J. Reuteran and levan as carbohydrate sinks in transgenic
sugarcane. Planta 2012; 236(6) : 1803-1815.
BELLSTEDT DU, GALLEY C, PIRIE MD, LINDER HP. The Migration of the Palaeotropical Arid Flora: Zygophylloideae as an Example. Systematic Botany 2012; 37(4) : 951-959.
CUEVAS JM, DELAUNAY A, VISSER JC, BELLSTEDT DU, JACQUOT E, ELENA SF. Phylogeography and Molecular Evolution of Potato virus Y. PLoS ONE 2012; 7(5) : e37853.
DE BEER D, SCHULZE AE, JOUBERT E, DE VILLIERS AJ, MALHERBE CJ, STANDER MA. Food ingredient extracts of Cyclopia subternata (Honeybush): Variation in phenolic composition and antioxidant capacity. Molecules2012; 17 : 14602-14624.
DU
PLESSIS DM, BOTES M, DICKS LMT, CLOETE TE. Immobilization of commercial
hydrolytic enzymes on poly (acrylonitrile) nanofibers for anti-biofilm
activity . Journal of Chemical Technology and Biotechnology 2013; 88(4) : 585-593.
DU
PREEZ F, VAN NIEKERK DD, KOOI BW, ROHWER JM, SNOEP JL. From
steady-state to synchronized yeast glycolytic oscillations I: model
construction. Febs Journal 2012; 279 : 2810-2822.
DU PREEZ F, VAN NIEKERK DD, SNOEP JL. From steady-state to synchorinized yeast glycolytic oscillations II: model validation. Febs Journal 2012; 279 : 2823-2836.
GEENEN
S, DU PREEZ F, REED M, NIJHOUT HF, KENNA JG, WILSON ID, WESTERHOFF HW,
SNOEP JL. A mathematical modelling approach to assessing the reliability
of biomarkers of glutathione metabolism. European Journal of Pharmaceutical Sciences 2012; 46 : 233-243.
GELDERBLOM WCA, MARASAS WFO. Controversies in fumonisin mycotoxicology and risk assessment. Human & Experimental Toxicology 2012; 3 : 215-235.
GUSTAVSSON
A-K, VAN NIEKERK DD, ADIELS CB, DU PREEZ F, GOKSÖR M, SNOEP JL.
Sustained glycolytic oscillations in individual isolated yeast cells. Febs Journal 2012; 279 : 2837-2847.
KADEREIT
G, ACKERLY D, PIRIE MD. A broader model for C4 photosynthesis evolution
in plants inferred from the goosefoot family (Chenopodiaceae s.s.). Proceedings of the Royal Society B-Biological Sciences 2012; 279 : 3304-3311.
KISSLING J. Taxonomy of Exochaenium and Lagenias: Two Resurrected Genera of Tribe Exaceae (Gentianaceae).Systematic Botany 2012; 37(1) : 238-253.
KOLODKIN
A, BOOGERD FC, PLANT N, BRUGGEMAN F, GONCHARUK V, LUNSHOF J,
MORENO-SANCHEZ R, YILMAZ N, BAKKER BM, SNOEP JL, BALLING R, WESTERHOFF
HW. Emergence of the silicon human and network targeting drugs. European Journal of Pharmaceutical Sciences 2012; 46 : 190-197.
LAMPRECHT
DA, MUNERI NO, EASTWOOD H , NAIDOO K, STRAUSS E, JARDINE A. An
enzyme-initiated Smiles rearrangement enables the development of an
assay of MshB, the GlcNAc-Ins deacetylase of mycothil biosynthesis. Organic & Biomolecular Chemistry 2012; 10 : 5278.
LONG
HS, STANDER MA, VAN WYK B.-E.. Notes on the occurrence and significance
of triterpenoids (asiaticoside and related compounds) and
caffeoylquinic acids in Centella species. South African Journal of Botany 2012; 82 : 53-59.
MARASAS WFO, GELDERBLOM WCA, SHEPHARD GS, VISMER HF. Mycotoxicological research in South Africa 1910-2011. World Mycotoxin Journal 2012; 5(1) : 89-102.
NAIDOO
VM, RAUTENBACH M. Bidirectional solid phase synthesis of a model
oligoglycine bolaamphiphile and purification by rapid self-assembly. Journal of Peptide Science 2012; 18 : 317-325.
PIRIE
MD, HUMPHREYS AM, ANTONELLI A, GALLEY C, LINDER HP. Model uncertainty
in ancestral are reconstruction: A parsimonious solution?. Taxon 2012; 61(3) : 652-664.
RAUTENBACH
M, EYÉGHÉ-BIKONG HA, VLOK NM, STANDER MA, DE BEER A. Direct
surfactin-gramicidin S antagonism supports detoxification in mixed
producer cultures of Bacillus subtilis and Aneurinibacillus migulanux.Microbiology 2012; 158 : 3072-3082.
ROHWER JM. Kinetic modelling of plant metabolic pathways. Journal of Experimental Botany 2012; 63(6) : 2275-2292.
SCHLOMS L, STORBECK K-H, SWART P, GELDERBLOM WCA, SWART AC. The influence of Aspalathus linearis(Rooibos)
and dihydrochalcones on adrenal steroidogenesis: Quantification of
steroid intermediates and end products in H295R cells. Journal of Steroid Biochemistry and Molecular Biology 2012; 128 : 128-138.
M. On modifying the Arrhenius equation to compensate for temperature changes for reactions within biological systems. Water SA 2012; 38(1) : 149-151.
STORBECK K-H, SWART AC, LOMBARD N, ADRIAANSE C, SWART P. Cytochrome b5 forms homomeric complexies in living cells. Journal of Steroid Biochemistry and Molecular Biology 2012; 132 : 311-321.
THOMPSON
GD, BELLSTEDT DU, BYRNE M, MILLAR MA, RICHARDSON DM, WILSON JRU, LE
ROUX J. Cultivation shapes genetic novelty in a globally important
invader. Molecular Ecology 2012; 21 : 3187-3199.
TROSKIE
AM, VLOK NM, RAUTENBACH M. A novel 96-well gel-based assay for
determining antifungal activity against filamentous fungi. Journal of Microbiological Methods 2012; 91 : 551-558.
VAN
DER MERWE JD, JOUBERT E, MANLEY M, DE BEER D, MALHERBE CJ, GELDERBLOM
WCA. Mangiferin glucuronidation: Important hepatic modulation of
antioxidant activity. Food and Chemical Toxicology 2012; 50 : 808-815.
VAN
DER WESTHUIZEN R, HAMMONS JC, MEIER JL, DAHESH S, MOOLMAN WJA, PELLY
SC, NIZET V, BURKART MD, STRAUSS E. The antibiotic CJ-15,801 is an
antimetabolite that hijacks and then inhibits CoA biosynthesis. Chemistry & Biology 2012; 19 : 559-571.
VISSER JC, BELLSTEDT DU, PIRIE MD. The Recent Recombinant Evolution of a Major Crop Pathogen, Potato virus Y. PLoS ONE 2012; 7(11) :e50631.
WALLACE
BD, EDWARDS JS, WALLEN JR, MOOLMAN WJA, VAN DER WESTHUYZEN R, STRAUSS
E, REDINBO MR, CLAIBORNE A. Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights. Biochemistry 2012; 51 : 7699-7711.
Joernaal Artikels (nie-gesubsideer)
EICHER JJ, SNOEP JL, ROHWER JM. Determining Enzyme Kinetics for Systems Biology with Nuclear Magnetic Resonance Spectroscopy. Metabolites 2012; 2 : 818-843.
MAGCWEBEBA
T, RIEDEL S, SWANEVELDER S, BOUIC P, SWART P, GELDERBLOM WCA.
Interleukin-1alpha Induction in Human Keratinocytes (HaCaT): An In Vitro Model for Chemoprevention in Skin. Journal of Skin Cancer2012; 2012 : 1-10.
Verrigtinge Nasionaal
THOMPSON GD, BELLSTEDT DU, LE ROUX JJ, RICHARDSON DM, WILSON JRU. Acacia saligna invasions: Genetics and species distribution modeling.
South African Association of Botanists 38th Conference, University of
Pretoria, Pretoria, South Africa, South African Journal of Botany 2012:
215-216.
Boeke
PITT JI, WILD CP, BAAN RA, GELDERBLOM WCA, MILLER JD, RILEY RT, WU F. Improving Public Health Through Mycotoxin Control. The International Agency for Research on Cancer, Lyon Cedex, France 2012:151 pp.
Hoofstukke in Boeke
MARASAS WFO, SHEPHARD GS, VISMER HF, ALBERTS JF, VAN DER WESTHUIZEN L, GELDERBLOM WCA. History and Relevance of Fumonisins. In World Nutrition Forum, Anytine Publishing, Leicestershire, United Kingdom, 2012: 213-240.
Doktorale voltooi
ABRIE JA. Investigation of the structural and fundtional diversity of phoshopantothenoylcysteine decarboxylases. PhD(Bioch), 2012. 164 pp. Promotor: Strauss E.
GOOSEN P. The influence of 3âHSD on adrenal steroidogenesis and the facors which influecne its activity. PhD(Bioch), 2012. 135 pp. Promotor: Swart P. Medepromotor: Swart AC.
HOUGH D. Comparison of two CYP17 isoforms: impllications for cortisol production in the South African Merino. PhD(Bioch), 2012. 154 pp. Promotor: Swart P. Medepromotor: Cloete SWP.
MFA MEZUI A. The effect of ultraviolet-C treatment on the biochemical composition of beer. PhD(Bioch), 2012. 186 pp. Promotor: Swart P. Medepromotor: Rautenbach M.
VISSER JC. A study of the strain evolution and recombination of South African isolates of Potato virus Y. PhD(Bioch), 2012. 180 pp. Promotor: Bellstedt DU.
Meesters voltooi
BARNARD A. The optimization of the extraction and purification of horseradish peroxidase from horseradish roots. MSc Biochemie, 2012. 132 pp. Studieleier: Swart P. Medestudieleier: Graz M.BRANDT S. Preliminary investigations into the use of DNA vaccines to elicit protective immune responses against the ostrich mycoplasma MS01. MSc Biochemie, 2012. 121 pp. Studieleier: Bellstedt DU. Medestudieleier: Botes A.
DE WET T. Laboratory optimization of a protease extraction and purification process from bovine pancreas in preparation for industrial scale up. MSc Biochemie, 2012. 198 pp. Studieleier: Swart P. Medestudieleier: Graz M.
DODD JA. Protein immobilisation on magnetic nanoparticles for the production of lactose-free milk. MSc Biochemie, 2012. 112 pp. Studieleier: Swart P. Medestudieleier: Klumperman B.
GOOSEN R. Quantitative in vitro analysis of Coenzyme A salvage pathway metabolites in Escherichia coli: Development and Application. MSc Biochemie, 2012. 91 pp. Studieleier: Strauss E. Medestudieleier: Snoep JL.
MAKOWA H. The relationship between the insecticide dichlorodiphenyl-trichloroethane and chloroquine in Plasmodium falciparum resistance. MSc Biochemie, 2012. 137 pp. Studieleier: Rautenbach M.
MUNERI NO. Biocatalytic preparation and characterization of alternative substrate of MshB, a mycothiol pathway enzyme. MSc Biochemie, 2012. 72 pp. Studieleier: Strauss E.
NOETH D. Regulation of chemokine gene expression by synthetic progestins in a human vaginal epithelial cell line. MSc Biochemie, 2012. 114 pp. Studieleier: Africander D. Medestudieleier: Hapgood JP.
PRETORIUS C. Covalent immobilisation of alpha-Galactosidase from Escherichia coli to commercially available magnetic nanoparticles for the removal of lactose from milk. MSc Biochemie, 2012. 130 pp. Studieleier: Swart P. Medestudieleier: Storbeck K-H
Publikasies in 2011
Joernaal Artikels (gesubsideer)
AERTS
R, THIJS KW, LEHOUCK V, BEENTJE H, BYTEBIER BLG, MATTHYSEN E, GULINCK
H, LENS L, MUYS B. Woody plant communities of isolated Afromontane cloud
forests in Taita Hills, Kenya. Plant Ecology 2011; 212 : 639-649.
AFRICANDER
D, LOUW R, VERHOOG N, NOETH D, HAPGOOD JP. Differential regulation of
endogenous pro-inflammatory cytokine genes by medroxyprogesterone
acetate and norethisterone acetate in cell lines of the female genital
tract. Contraception 2011; 84(4) : 423-435.
AFRICANDER D,
VERHOOG N, HAPGOOD JP. Molecular mechanisms of steroid
receptor-mediated actions by synthetic progestins used in HRT and
contraception. Steroids 2011; 76 : 636-652.
BYTEBIER BLG,
ANTONELLI A, BELLSTEDT DU, LINDER HP. Estimating the age of fire in the
Cape flora of South Africa from an orchid phylogeny. Proceedings of the Royal Society B-Biological Sciences 2011; 278 : 188-195.
CLOETE WJ, ADRIAANSE C, SWART P, KLUMPERMAN B. Facile immobilization of enzymes on electrospun poly(styrene-alt-maleic anhydride) nanofibres. Polymer Chemistry 2011; 2 : 1479-1481.
COUVREUR
TLP, PIRIE MD, CHATROU LW, SAUNDERS RMK, SU YCF, RICHARDSON JE, ERKENS
RHJ. Early evolutionary history of the flowering plant family
Annonaceae: steady diversification the boreotropical geodispersal. Journal of Biogeography 2011; 38 : 664-680.
DAVIES
TJ, SMITH GF, BELLSTEDT DU, BOATWRIGHT JS, BYTEBIER BLG, COWLING RM,
FOREST F, HARMON LJ, MUASYA AM, SCHRIRE B, STEENKAMP Y, VAN DER BANK M,
SAVOLAINEN V. Extinction Risk and Diversification Are Linked in a Plant
Biodiversity Hotspot. Plos Biology 2011; 9(5) : e1000620.
DEKKER S, CILLIERS P, HOFMEYR J-HS. The complexity of failure: Implications of complexity theory for safety investigations. Safety Science 2011; 49 : 939-945.
GOOSEN
P, STORBECK K-H, SWART AC, CONRADIE R, SWART P. Cytochrome b5 augments
3ß-hydroxysteroid dehydrogenase/∆5-∆4 isomerase activity. Journal of Steroid Biochemistry and Molecular Biology 2011; 127 : 238-247.
HADLEY
K, LOUW A, HAPGOOD JP. Differential nuclear localisation and promoter
occupancy play a role in glucocorticoid receptor ligand-specific
transcriptional responses. Steroids 2011; 76 : 1176-1184.
HOFMEYR J-HS, ROHWER JM. Supply-Demand Analysis: A Framework for Exploring the Regulatory Design of Metabolism. Methods in Enzymology 2011; 500(Chapter 25) : 533-554.
LARSSON C, SNOEP JL, NORBECK J, ALBERS E. Flux balance analysis for ethylene formation in genetically engineered Saccharomyces cerevisiae. IET Systems Biology 2011; 5(4) : 245-251.
MFA MEZUI A, SWART P. Effect of UV-C Disinfection of Beer – Sensory Analysis and Consumer Ranking. Journal of the Institute of Brewing 2010; 116(4) : 348-353.
OBERLANDER KC, DREYER LL, BELLSTEDT DU. Molecular phylogenetics and origins of southern African Oxalis. Taxon 2011; 60(6) : 1667-1677.
PILLAY CS, HOFMEYR J-HS, ROHWER JM. The logic of kinetic regulation in the thioredoxin system. BMC SYSTEMS BIOLOGY 2011; 5 : 15.
PIRIE MD, OLIVER EGH, BELLSTEDT DU. A densely sampled ITS phylogeny of the Cape flagship genus Erica L. suggests numerous shifts in floral macro-morphology . Molecular Phylogenetics and Evolution 2011; 61 : 593–601.
SHERIDAN CM, GLASSER D, HILDEBRANDT D, PETERSEN J, ROHWER JM. An Annual and Seasonal
Characterisation of Winery Effluent in South Africa. South African Journal of Enology and Viticulture 2011; 32(1) : 1-8.
SISSING
L, MARNEWICK JL, DE KOCK M, SWANEVELDER S, JOUBERT E, GELDERBLOM WCA.
Modulating effects of rooibos and honeybush herbal teas on the
development of esophageal papillomas in rats. Nutrition and Cancer-An International Journal 2011; 63(4) : 600-610.
VAN
DER WESTHUIZEN L, SHEPHARD GS, BURGER H.-M., RHEEDER JP, GELDERBLOM
WCA, WILD CP, GONG YY. Fumonisin B1 as a Urinary Biomarker of Exposure
in a Maize Invervention Study Among South African Subsistence Farmers. Cancer Epidemiology Biomarkers & Prevention 2011; 20 : 483-489.
VAN
DER WESTHUIZEN L, SHEPHARD GS, RHEEDER JP, BURGER H.-M., GELDERBLOM
WCA, WILD CP, GONG YY. Optimising sorting and washing of home-grown
maize to reduce fumonisin contamination under laboratory-controlled
conditions. Food Control 2011; 22 : 396-400.
WALTEMATH D,
ADAMS R, BEARD DA, BERGMAN FT, BHALLA U S, BRITTEN R, CHELLIAH V,
COOLING MT, COOPER J, CRAMPIN E J , GARNY A, HOOPS S, HUCKA M, HUNTER P,
KLIPP E, LAIBE C, MILLER AK, MORARU I, NICKERSON D, NIELSEN P, NIKOLSKI
M, SAHLE S, SAURO H, SCHMIDT H,. Minimum Information About a Simulation
Experiment (MIASE). Plos Computational Biology 2011; 7(4) : e1001122.
WALTEMATH
D, ADAMS R, BERGMANN FT, HUCKA M, KOLPAKOV F, MILLER AK, MORARU I,
NICKERSON D, SAHLE S, SNOEP JL, LE NOVÈRE N . Reproducible computational
biology experiments with SED-ML – The Simulation Experiment Description
Markup Language. BMC SYSTEMS BIOLOGY 2011; 5(198) : 175-0505: 1-10.
WARREN
BH, BAKKER FT, BELLSTEDT DU, BYTEBIER BLG, CLABEN-BOCKHOFF R, DREYER
LL, EDWARDS D, FOREST F, GALLEY C, HARDY CR, LINDER HP, MUASYA AM,
MUMMENHOFF K, OBERLANDER KC, QUINT M, RICHARDSON JE, SAVOLAINEN V, VAN
DER NIET T , SCHRIRE B, VAN DER NIET T , . Consistent phenological
shifts in the making of a biodiversity hotspot: the Cape flora. BMC Evolutionary Biology 2011; 11(39) : 1-11.
WOLSTENCROFT
K, OWEN S, DU PREEZ F, KREBS O, MUELLER W, GOBLE C, SNOEP JL. The Seek:
A Platform for Sharing Data and Models in Systems Biology. Methods in Enzymology 2011; 500(Chapter 29) : 629-655.
WOLSTENCROFT
K, OWEN S, HORRIDGE M, KREBS O, MUELLER W, SNOEP JL, DU PREEZ F, GOBLE
C. RightField: embedding ontology annotation in spreadsheets. Bioinformatics 2011; 27(14) : 2021-2022.
Joernaal Artikels (nie-gesubsideer)
SWAT
M, KIELBASA SM, POLAK S, OLIVIER BG, BRUGGEMAN F, TULLOCH MQ, SNOEP JL,
VERHOEVEN AJ, WESTERHOFF HW. What it takes to understand and cure a
living system: computational systems biology and a systems
biology-driven pharmacokinetics-pharmacodynamics platform. Interface Focus 2011; 1 : 16-23.
Hoofstukke in Boeke
HUGENHOLTZ J, HOLS P, SNOEP JL. Metabolic engineering of lactic acid bacteria. In Thirty years of research on lactic acid bacteria. (ISBN 978-90-817671-0-1), 24 Media Labs, Rotterdam, Netherlands, 2011: 113-133.
Doktorale voltooi
AKHURST TJ. Symbolic control analysis of cellular systems. PhD(Bioch), 2011. 193 pp. Promotor: Rohwer JM. Medepromotor: Hofmeyr J-HS.
EYÉGHÉ-BIKONG HA. Role of surfactin from Bacillus subtilis in protection against antimicrobial peptides produced by Bacillus species. PhD(Bioch), 2011. 239 pp. Promotor: Rautenbach M.
ROBERTSON S. Receptor concentration affects glucocorticoid action. PhD(Bioch), 2011. 200 pp. Promotor: Louw A. Medepromotor: Hapgood JP.
Meesters voltooi
CROUS C. Supply-demand analysis of anaerobic free-energy metabolism in Zymomonas mobilis. MSc Biochemie, 2011. 85 pp. Studieleier: Rohwer JM. Medestudieleier: Snoep JL.
DU PLESSIS DM. Fabrication and characterization of anti-microbial and biofouling resistant nanofibers with silver nanoparticles and immobilized enzymes for application in water filtration. MSc Biochemie, 2011. 94 pp. Studieleier: Cloete TE. Medestudieleier: Dicks LTM, Swart P.
GQWAKA OPC. A generic rate equotion for catalysed, template-directed polymerisation and its use in computational systems biology. MSc Biochemie, 2011. 111 pp. Studieleier: Hofmeyr J-HS. Medestudieleier: Rohwer JM.
JANA CE. Synthesis and evaluation of pantothenic acid analogues as potential inhibitors of malaria parasites and bacteria. MSc Biochemie, 2011. 99 pp. Studieleier: Strauss E.
JORDAAN S. Supply-demand analysis of energy metabolism in Lactococcus Lactis under anerobic conditions. MSc Biochemie, 2011. 83 pp. Studieleier: Rohwer JM. Medestudieleier: Snoep JL.
Publikasies in 2010
Joernaal Artikels (gesubsideer)
APWEILER
R, ARMSTRONG R, BAIROCH A, CORNISH-BOWDEN A, HALLING PJ, HOFMEYR J-HS,
KETTNER C, LEYH TS, ROHWER JM, SCHOMBURG D, STEINBECK C, TIPTON K. A
large-scale protein-function database.Nature Chemical Biology 2010; 6 : 785.
AVENANT
C, RONACHER K, STUBSRUD EF, LOUW A, HAPGOOD JP. Role of
ligand-dependent GR phosphorylation and half-life in determination of
ligand-specific transcriptional activity. Molecular and Cellular Endocrinology 2010; 327 : 72-88.
BELLSTEDT
DU, PIRIE MD, VISSER C, DE VILLIERS M, GEHRKE B. A Rapid and
Inexpensive Method for the Direct PCR Amplification of DNA from Plants. American Journal of Botany 2010; 97(7) : 65-68.
BURGER
H-M, LOMBARD MJ, SHEPHARD GS, RHEEDER JR, VAN DER WESTHUIZEN L,
GELDERBLOM WCA. Dietary fumonisin exposure in a rural population of
South Africa. Food and Chemical Toxicology 2010; 48 : 2103-2108.
CONRADIE
R, BRUGGEMAN F, CILIBERTO A, CSIKASZ-NAGY A, NOVAK B, WESTERHOFF HW,
SNOEP JL. Restriction point control of the mammalian cell cycle via the
cyclin E/Cdk2:p27 complex. Febs Journal 2010; 277 : 357-367.
DE
VILLIERS J, KOEKEMOER L, STRAUSS E. 3-Fluoroaspartate and
Pyruvoyl-Dependant Aspartate Decarboxylase: Exploiting the Unique
Characteristics of Fluorine To Probe Reactivity and Binding. Chemistry-A European Journal 2010; 16 : 10030-10041.
GOOSEN P, SWART AC, STORBECK K-H, SWART P. Hypocortisolism in the South African Angora goat: The role of 3ßHSD. Molecular and Cellular Endocrinology 2010; 315 : 182-187.
HILPERT
K, MCLEOD B, YU J, ELLIOTT MR, RAUTENBACH M, RUDEN S, BURCK J,
MUHLE-GOLL C, ULRICH AS, KELLER S, HANCOCK REW. Short Cationic
Antimicrobial Peptides Interact with ATP. Antimicrobial Agents and Chemotherapy 2010; 54(10) : 4480-4483.
JOOSTE
AEC, MAREE HJ, BELLSTEDT DU, GOSZCZYNSKI DE, PIETERSEN GJ, BURGER JT .
Three genetic grapevine leafroll-associated virus 3 variants identified
from South African vineyards show high variability in their 5′UTR. Archives of Virology 2010; 155 : 1997-2006.
KOLODKIN
A, BRUGGEMAN F, PLANT N, MONÈ MJ , BAKKER BM, CAMPBELL MJ, VAN LEEUWEN
JPTM, CARLBERG C, SNOEP JL, WESTERHOFF HW. Design principles of nuclear
receptor signaling: how complex networking improves signal
transduction. Molecular Systems Biology 2010; 6(446) : 1-14.
LI
C, DONIZELLI M, RODRIGUEZ N, DHARURI H, ENDLER L, CHELLIAH V, LI L, HE
E, HENRY A, STEFAN MI, SNOEP JL, HUCKA M, LE NOVÈRE N , LAIBE C.
BioModels Databse: An enhanced, curated and annotated resource for
published quantitative kinetic models. BMC SYSTEMS BIOLOGY 2010; 4(92) : 1-2.
ROBERTSON
S, ALLIE-REID F, VANDEN BERGHE W, VISSER K, BINDER A, AFRICANDER D,
VISMER M, DE BOSSCHER K, HAPGOOD JP, HAEGEMAN G, LOUW A. Abrogation of
Glucocorticoid Receptor Dimerization Correlates with Dissociated
Glucocorticoid Behavior of Compound A. Journal of Biological Chemistry 2010; 285(11) : 8061-8075.
ROHWER JM, HOFMEYR J-HS. Kinetic and Thermodynamic Aspects of Enzyme Control and Regulation. Journal of Physical Chemistry B 2010; 114 : 16280-16289.
ROOTMAN
I, DE VILLIERS M, BRAND LA, STRAUSS E. Creating Cellulose-Binding
Domain Fusions of the Coenzyme A Biosynthetic Enzymes to Enable
Reactor-Based Biotransformations. ChemCatChem 2010; 2 : 1239-1251.
SOMDYALA NIM, BRADSHAW D, GELDERBLOM WCA, PARKIN DM. Cancer incidence in a rural population of South Africa, 1998-2002. International Journal of Cancer 2010; 127 : 2420-2429.
STRAUSS E, DE VILLIERS M, ROOTMAN I. Biocatalytic Production of Coenzyme A Analogues.ChemCatChem 2010; 2 : 929-937.
STRAUSS E. Exploiting single-cell variation for new antibiotics. Nature Chemical Biology 2010; 6 : 873-874.
SULPICE
R, TRENKAMP S, STEINFATH M, USADEL B, GIBON Y, WITUCKA-WALL H, PYL E-V,
TSCHOEP H, STEINHAUSER MC, GUENTHER M, HOEHNE M, ROHWER JM, ALTMANN T,
FERNIE AR, STITT M. Network Analysis of Enzyme Activities and Metabolite
Levels and Their Relationship to Biomass in a Large Panel ofArabidopsis Accessions. Plant Cell 2010; 22 : 2872-2893.
SWART
AC, STORBECK K-H, SWART P. A single amino acid residue, Ala 105,
confers 16alpha-hydroxylase activity to human cytochrome P450
17alpha-hydroxylase/17,20 lyase. Journal of Steroid Biochemistry and Molecular Biology 2010; 119 : 112-120.
THEMBO
KM, VISMER HF, NYAZEMA NZ, GELDERBLOM WCA, KATERERE DR. Antifungal
activity of four weedy plant extracts against selected mycotoxigenic
fungi. Journal of Applied Microbiology 2010; 109 : 1479-1486.
VAN
DER MERWE JD, JOUBERT E, MANLEY M, DE BEER D, MALHERBE CJ, GELDERBLOM
WCA. In vitro hepatic biotransformation of aspalathin and nothofagin,
dihydrochalcones of rooibos (Aspalathus linearis), and assessment of metabolite antioxidant activity. Journal of Agricultural and Food Chemistry 2010; 58 : 2214-2220.
VAN
DER WESTHUIZEN L, SHEPHARD GS, RHEEDER JP, BURGER H.-M., GELDERBLOM
WCA, WILD CP, GONG YY. Simple intervention method to reduce fumonisin
exposure in a subsistence maize-farming community in South Africa. Food Additives and Contaminants 2010; 27(11) : 1582-1588.
VAN
DER WESTHUYZEN R, STRAUSS E. Michael Acceptor-Containing Coenzyme A
Analogues As Inhibitors of the Atypical Coenzyme A Disulfide Reductase
from Staphylococcus aureus. Journal of the American Chemical Society 2010; 132 : 12853-12855.
VISSER
K, SMITH C, LOUW A. Interplay of the Inflammatory and Stress Systems in
a Hepatic Cell Line: Interactions between Glucocorticoid Receptor
Agonists and Interleukin-6. Endocrinology 2010; 151(11) : 5279-5293.
Joernaal Artikels (nie-gesubsideer)
SPRY C, VAN SCHALKWYK DA, STRAUSS E, SALIBA KJ. Pantothenate Utilization by Plasmodium as a Target for Antimalarial Chemotherapy. Infectious Disorders – Drug Targets 2010; 10 : 200-216.
Verrigtinge Internasionaal
HOUGH D, STORBECK K-H, CLOETE SWP, SWART P. Improving stress coping ability: Comparison between the CYP17 genotypes of Ovis aries and Capra hircus.
9th World Congress on Genetics Applied to Livestock Production,
Congress Centre,Leipzig,Germany, Gesellschaft fur
Tierzuchtwissen-schafen e.V. (German Society for Animal Science) 2010:
10-15.
ROHWER JM, HOFMEYR J-HS. Using Generalised Supply-Demand Analysis to Identify Regulatory Metabolites.
Experimental Standard Conditions of Enzyme Characterizations –
Proceedings of the International Builsstein Symposium, Hotel Jagdschloss
Niederwald, Rüdesheim/Rhein, Germany, Logos Verlag Berlin GmbH –
ISBN978-3-8325-2606-1 2010: 149-163.
Hoofstukke in Boeke
STRAUSS E. Coenzyme A Biosynthesis and Enzymology. In Comprehensive Natural Products II – Chemistry and Biology. Volume 7 of 10, Elsevier,Oxford,United Kingdom, 2010: 351-410.
Doktorale voltooi
AFRICANDER D. Comparative study of the molecular mechanism of action of the synthetic progestins, Medroxyprogesterone acetate and Norethisterone acetate. PhD(Bioch), 2010. 113 pp. Promotor: Hapgood JP. Medepromotor: Louw A.