Radiobiology
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Division of Radiobiology

Peer-reviewed publications

Peer-reviewed publications since 2012

  1. Lombe D, Jeremic B, Akudugu J, McCaul M. Treatment of parotid gland malignancies with neutron radiotherapy - Experience of a tertiary hospital in South Africa. Radiat Oncol (submitted).
  2. Hamman B, Serafin A, Sewram V, Akudugu J. Radiomodifying effects of medicinal plants on pancreatic cancer cells. Radiat Prot Dosim (submitted).
  3. Chinhengo A, Serafin A, Hamman B, Akudugu J. Electromagnetic fields induce frequency-dependent radioprotection and radiosensitization in in vitro cell cultures. Bioelectromagnetics (under review).
  4. Hamunyela R, Serafin A, Akudugu J. Small molecule inhibitors of HER-2, PI3K, mTOR and Bcl-2 in display strong synergism in human breast cancer cells. Toxicol In Vitro (under rereview).
  5. Achel DG, Achoribo  E, Agbenyegah S, Adaboro RM, Donkor S, Adu Bobi NNA-K, Agyekum AA, Akoamoa F, Tagoe SN, Kyei KA, Yarnney J, Serafin A, Akudugu JM. Towards establishing capacity for biological dosimetry at Ghana Atomic Energy Commission. Genome Integrity (in press).
  6. Hamunyela R, Serafin A, Akudugu J. Combined inhibition of PI3K, mTOR and Bcl-2 significantly radiosensitises progesterone and oestrogen receptor negative breast cancer cells. J Cancer Biol Therap 1:101-108, 2016.
  7. Achel DG, Serafin AM, Akudugu JM. Flow cytometry-assisted quantification of γH2AX expression has potential as a rapid high-throughput biodosimetry tool. Radiat Environ Biophys 55:349-357, 2016.
  8. Kemp FW, Portugal F, Akudugu JM, Neti PVSV, Ferraris RP, Howell RW. Vitamins A, C, and E may reduce intestinal Po-210 levels after ingestion. Health Phys 111:52-57, 2016.
  9. Serafin A, Böhm L, Fernandez P, Achel D, Akudugu J. The potential of PAI-1 expression in needle biopsies as a predictive marker for prostate cancer. Cogent Med 3:1183275, 2016. DOI: http://dx.doi.org/10.1080/2331205X.2016.1183275
  10. Hamid M, Hamunyela R, Serafin A, Akudugu J. Inhibition of PI3K and mTOR sensitises oestrogen receptor positive human breast cancer cells to a large fraction of radiation dose. J Cancer Biol Therap 1:93-100, 2016.
  11. Achel DG, Serafin AM, Achoribo EA, Agbenyegah S, Akudugu JM. In vitro cytotoxicity and radiomodifying effects of aqueous extracts of Moringa oleifera (Lam). Elixir Biosciences 90:37431-37435, 2016.
  12. Vawda Z, Pitcher R, Akudugu J, Groenewald W. Diagnostic reference levels for paediatric computed tomography. S Afr J Rad 2015;19(2); Art. #846, 4 pages. http://dx.doi. org/10.4102/sajr.v19i2.846
  13. Akudugu J, Serafin A. Estimation of transition doses for human glioblastoma, neuroblastoma and prostate cell lines using the linear-quadratic formalism. Int J Cancer Ther Oncol 2015; 3(3):3311. DOI: 10.14319/ijcto.33.11
  14. Hamunyela R, Serafin A, Hamid M, Maleka S, Achel D, Akudugu J. A cocktail of specific inhibitors of HER-2, PI3K, and mTOR radiosensitises human breast cancer cells. J Cancer Biol Therap 1:38-45, 2015.
  15. Maleka S, Serafin A, Hamunyela R, Hamid M, Achel D, Akudugu J. NVP-BEZ235 enhances radiosensitivity ofhuman prostate cancer cells but acts as a radioprotector to normal prostate cells. J Cancer Biol Therap 1:46-56, 2015.
  16. Akudugu J, Serafin A, Böhm L. Further evaluation of uPA and PAI-1 as biomarkers for prostatic diseases. J Cancer Res Clin Oncol 141:627–631, 2015.
  17. Serafin A, Akudugu J, Böhm L. Influence of freeze-drying on the recovery of the tumour invasion markers uPA and PAI-1 from prostate cancer resections. Annals Clin Biochem 52(3): 387-394, 2015.
  18. Pasternack JB, Domogauer JD, Khullar A, Akudugu J, Serafin A. The role of Bak-mediated dissipation of mitochondrial membrane potential in radiosensitivity of Bax-negative human prostate cancer cells. J Med Sci Res 3:27-32, 2015. 
  19. Akudugu JM, Howell RW. The advantage of antibody cocktails for targeted alpha therapy depends on specific activity. J Nucl Med 55:2012–1219, 2014.
  20. Böhm L, Serafin AM, Akudugu JM, Fernandez P, van der Merwe A, Aziz NA. uPA/PAI-1 ratios distinguish benign prostatic hyperplasia and prostate cancer. J Cancer Res Clin Oncol 139(7):1221-1228, 2013.
  21. Akudugu JM, Serafin AM, Böhm LJF. In vitro radiosensitization by pentoxifylline does not depend on p53 status. Int J Radiat Biol 89(6), 462-470, 2013.
  22. Akudugu JM, Howell RW. A method to predict response of cell populations to cocktails of chemotherapeutics and radiopharmaceuticals: Validation with daunomycin, doxorubicin, and the alpha particle emitter 210Po. Nucl Med Biol 39(7):954-961, 2012.
  23. Akudugu JM, Azzam EI, Howell RW. Induction of bystander cell killing in human breast cancer cell cultures by DNA-incorporated Iodine-125 depends on phenotype. Int J Radiat Biol 88(12):1028-1038, 2012.
  24. Akudugu JM, Howell RW. Flow cytometry-assisted Monte Carlo simulation predicts clonogenic survival of cell populations with lognormal distributions of radiopharmaceuticals and anticancer drugs. Int J Radiat Biol 88(3): 286-293, 2012.