​​​​​​​​​​​​​​​​​Division of Molecular Biology and Huma​​n Gene​​tics​​ ​  



No opportunities are currently available.


Project title: Utilisation of whole genome sequencing for clinical patient management​ of tuberculosis

Host: TB Genomics Research Group | Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University​

Scope of Research:

The TB Genomics group has its foundation in the molecular epidemiology of Mycobacterium tuberculosis in a high-incidence setting and has provided new insights into the epidemiology of both drug-susceptible and drug-resistant tuberculosis. Our group focuses on comparative genomics by targeted deep sequencing (TDS), transcriptomics using RNA-seq, and proteomics, allowing us to investigate the epidemiology and evolution of M.tuberculosis. The group is supported by an outstanding microbiology core with expertise in mycobacterial culture, drug susceptibility testing, minimum inhibitory concentration determination, and archiving of clinical isolates. A postdoctoral position in a study linked to the utilisation of WGS for clinical patient management is now available. We are looking for a strong candidate that meets the requirements below.​ For more information on the TB Genomics research activities please visit their website.

 Postdoctoral Position Requirements:

  • PhD in molecular biology, microbiology, biochemistry, genetics 
  • Experience in molecular methods 
  • Experience in DNA extraction 
  • Demonstrated the ability to publish 
  • Good communication skills, collaborative and multidisciplinary interest. 
  • Team player 
  • Computer skills 
  • Able to travel between Tygerberg Medical Campus and the NHLS Greenpoint (added advantage) 
  • Experience in molecular techniques, WGS (added advantage) 
  • Excellent knowledge of English, both oral and written. 
  • Experience in working with M. tuberculosis 
  • Trained to work in a BSL3 facility 

We offer: 

  • A postdoctoral contract beginning in November 2022 
  • Postdoctoral funding from an NIH-funded study 
  • A stimulating international collaborative network 

 How to apply:

To apply, please send your curriculum vitae, academic certificates, two letters of recommendation to Robin M Warren at rw1@sun.ac.za and Nabila Ismail nabilai@sun.ac.za.​​


Project title:  Characterization of lung resident- and peripheral innate cell effector functions in the context of M.tb infection and disease.

Host: Innate Immunity Lab | SU Immunology Research Group | Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University

Summary of fellowship:  A non-taxable fellowship, compliant with SARS regulations, is offered for 2 years with annual renewal contingent on progress, performance reviews, and funding availability.

Scope of Research: 

The Stellenbosch University Immunology Research Group performs cutting-edge research in clinical and basic immunology on TB pathogenesis and biomarker discovery. We are inviting applications for a postdoctoral fellowship hosted by the Stellenbosch University Immunology Research Group (SU-IRG) in the Innate immunity team is immediately available. Human infection with Mycobacterium tuberculosis (M.tb) is known to result in a spectrum of disease outcomes, ranging from cleared infection to severe disease. In pulmonary M.tb infection, peripheral- and lung-resident immune responses are likely important determinants of disease outcome, yet these and subsequent effector functions remain poorly understood. Specifically, the immune composition of TB granulomas along the spectrum of TB infection remains under investigation. Our research focuses on various aspects of peripheral- versus site of disease and granuloma-specific immunity by using high-dimensional mass- and flow cytometry, as well as single-cell transcriptomic data for high-throughput interrogation and characterization of cell populations. Our goal is to better understand the role of innate immune cells at the site of M.tb infection during various stages of disease along with the interconnected function of cells and tissues, from single cell to system level.​

The current post-doctoral position is for a candidate with strong expertise in cell biology techniques, proven experience in flow cytometry, microscopy and ideally knowledge on in vitro 3D organoids or in vivo biopsy techniques. A high level of motivation, responsibility and independence are expected. For more information on the Stellenbosch University Immunology Research group visit their website.​

Key Requirements 

    1. Ph.D degree in a molecular biology field, with immunology as main subject. 
    2. Advanced experience in cell biology. 
    3. Strong expertise in flow cytometry, microscopy, cellular immunology and molecular assays.
    4. Thorough understanding of statistical requirements for analysing multi-dimensional datasets. 
    5. A track record of publications in the field of molecular biology/immunology of infectious diseases. 
    6. Experience in other specialized immunological end-assays will be advantageous.​​
    7. Ability to work independently. 
    8. Good communication and organizational skills. 
    9. Ability to handle multiple projects and priorities with exceptional time management skills. 
    10. Experience in supervising postgraduate students (honours and MSc level).
    11. Be familiar with and trained in accordance to GCLP guidelines. 
    12. BSL3 experience would be advantageous.

Duties and Responsibilities 

The fellowship holder will be expected to 

  • Develop and improve co-culture system to assemble 3D organoid from primary cells 
  • Design and execute the project, analyze and interpret the data. 
  • Provide up-to-date technical expertise, advice and support in immunological techniques, with a particular focus on experiments generating multi-parameter datasets. 
  • Apply solid scientific proficiency, creativity, critical thinking ability to collaborate effectively with others. 
  • Supervision of post-graduate students. 
  • Assist with the operational matters specific to the project. 
  • Record and maintain data and information, as relevant and appropriate. 
  • Contribute to the presentation of results to the group, collaborators, and to the research community in general. 
  • Contribute substantially to the preparation of grant reports and scientific publications. 
  • Comply with University policies, including financial regulations, equal opportunities, promoting race equality policy, health and safety policy, information systems security policy and intellectual property rights. 

How to Apply

Applications or enquiries regarding the fellowship can be directed to A/Prof. N. du Plessis (nelita@sun.ac.za). Please include a letter of motivation, full CV and contact details of 3 referees. 

Closing date for applications: 13​​ January 2023


​No opportunities are currently available.