TB Drugs
Welcome to Stellenbosch University

Division of Molecular Biology & Human Genetics

Host-directed Therapy

​​​​PUBLICATIONS (last 5 years)

​​​​​​​​​1. Mehtar S, Wiid IJ, Todorov SD. (2008) The antimicrobial activity of copper and copper alloys against nosocomial pathogens and Mycobacterium tuberculosis isolated from healthcare facilities in the Western Cape: an in-vitro study. Journal of Hospital Infection 68, 45e51​

2. Todorov SD, Brink M, Guigas C; Schillinger U; Wiid IJ, Wachsman M, Holzapfel W, Dicks L. (2008) Boza, a natural source of probiotic lactic acid bacteria. Journal of Applied Microbiology ​

3. Harper C, Hayward D, Wiid IJ, van Helden PD. (2008) Regulation of Nitrogen Metabolism: A comparison of mechanisms in Corynebacterium glutamicum and Mycobacterium tuberculosis. Accepted for publication in IUBMB Life 60(10):643-650.

4. Sirgel FA, Wiid IJ, van Helden PD. (2008) Measuring Minimum Inhibitory Concentrations in Mycobacteria. The Humana Press Inc., Vol 465, ch 11​

5. Hayward, D, van Helden, PD, Wiid, IJF. (2009) Glutamine synthetase sequence evolution in mycobacteria and their use as molecular markers for Actino bacteria speciation. BMC Evol Biol. 9:48​

6. Onajole OK, Govender K, Govender P, van Helden PD, Kruger HG, Maguire GE, Muthusamy K, Pillay M, Wiid IJ, Govender T. (2009) Pentacyclo-undecane derived cyclic tetra-amines: Synthesis and evaluation as potent anti-tuberculosis agents. European Journal of Medicinal Chemistry 44:4297-4305.​

7. Harper CJ, Hayward D, Kidd M, Wiid IJ, van Helden PD. (2010) Glutamate dehydrogenase and glutamine synthetase are regulated in response to nitrogen availability in Myocbacterium smegmatis. BMC Microbiol. 11;10:138.

8. Onajole OK, Govender P, van Helden PD, Kruger HG, Maguire GE, Wiid I, Govender T. (2010) Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates. Eur J Med Chem. 45(5):2075-2079.​

9. Onajole OK, Sosibo S, Govender P, Govender T, van Helden PD, Maguire GE, Mlinarić-Majerski K, Wiid I, Kruger HG. (2011) Novel linear diamine disubstituted polycyclic 'cage' derivatives as potential antimycobacterial candidates. Chem Biol Drug Des. 78(6):1022-1030.​

10. Macingwana L, Baker B, Ngwane A, Harper C, Cotton M, Hesseling A, Diacon A, Van Helden P, Wiid I. (2012) Sulfamethoxazole enhances the antimycobacterial activity of Rifampicin. Journal of Antimicrobial Chemotherapy 67(12):2908-2911.​

11. Sao Emani C, Williams MJ, Hiten NF, Viljoen A, van Helden PD, Wiid IJ, Baker B. (2013) Ergothioneine is a secreted antioxidant of Mycobacterium Smegmatis. Antimicrobial Agents Chemotherapy 57(7):3202-3207.​

12. Viljoen AJ, Kirsten CJ, Baker B, van Helden PD, Wiid IJ. (2013) The Role of Glutamine Oxoglutarate Aminotransferase and Glutamate Dehydrogenase in Nitrogen Metabolism in Mycobacterium bovis BCG. PLoS One 8(12):e84452.​