​Division of Molecular Biology & Human Genetics


​Parkinson's Disease


2021 Publications

Cook L, Schulze J, Verbrugge J, Beck JC, Marder KS, Saunders-Pullman R, Klein C, Naito A, Alcalay RN; ClinGen Parkinson's Disease Gene Curation Expert Panel and the MDS Task Force for Recommendations for Genetic Testing in Parkinson's Disease; Clinical Genome Resource (ClinGen) Parkinson's Disease Gene Curation Expert Panel Authors; Movement Society Disorder (MDS) Task Force on Recommendations for Clinical Genetic Testing in Parkinson's Disease Authors. The commercial genetic testing landscape for Parkinson's disease. Parkinsonism Relat Disord. 2021 Nov;92:107-111. doi: 10.1016/j.parkreldis.2021.10.001. Epub 2021 Oct 19. PMID: 34696975; PMCID: PMC8633166.
URL: https://www.sciencedirect.com/science/article/pii/S1353802021003564?via%3Dihub
Cuttler K, Hassan M, Carr J, Cloete R, Bardien S. Emerging evidence implicating a role for neurexins in neurodegenerative and neuropsychiatric
disorders. Open Biol. 2021 Oct;11(10):210091. doi: 10.1098/rsob.210091. Epub 2021 Oct 6. PMID: 34610269; PMCID: PMC8492176. 
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492176/
Jansen van Rensburg Z, Abrahams S, Bardien S, Kenyon C. Toxic Feedback Loop Involving Iron, Reactive Oxygen Species, α-Synuclein and Neuromelanin in Parkinson's Disease and Intervention with Turmeric. Mol Neurobiol. 2021 Nov;58(11):5920-5936. doi: 10.1007/s12035-021-02516-5. Epub 2021 Aug 23. PMID: 34426907.
URL: https://link.springer.com/article/10.1007/s12035-021-02516-5
Farrer MJ, Bardien S, Hattori N, Lesage S, Ross OA, Mellick GD, Kruger R. Editorial: Celebrating the Diversity of Genetic Research to Dissect the
Pathogenesis of Parkinson's Disease. Front Neurol. 2021 Apr 6;12:648417. doi: 10.3389/fneur.2021.648417. PMID: 33889126; PMCID: PMC8056125.
URL: https://www.frontiersin.org/articles/10.3389/fneur.2021.648417/full​

Müller-Nedebock AC, van der Westhuizen FH, Kõks S, Bardien S. Nuclear genes associated with mitochondrial DNA processes as contributors to Parkinson's disease risk. Mov Disord. 2021

Bekker M, Abrahams S, Loos B, Bardien S. Can the interplay between autophagy and apoptosis be targeted as a novel therapy for Parkinson's disease? Neurobiol Aging. 2021

Abrahams, Shameemah, Katelyn Cuttler, Minke Bekker, Jonathan Carr, Soraya Bardien, and Okobi Ekpo. 2021. Chapter 52 - Antioxidant Effects of Curcumin and Neuroaging." In Factors Affecting Neurological Aging, edited by Colin R Martin, Victor R Preedy, and Rajkumar Rajendram, 603–16. London: Academic Press. https://doi.org/https://doi.org/10.1016/B978-0-12-817990-1.00052-4

Müller-Nedebock AC, Komolafe MA, Fawale MB, Carr JA, van der Westhuizen FH, Ross OA, Bardien S. Copy Number Variation in Parkinson's Disease: An Update from Sub-Saharan Africa. Mov Disord. 2021  doi: 10.1002/mds.28710. Epub ahead of print. PMID: 34228376.

Sebate B, Cuttler K, Cloete R, Britz M, Christoffels A, Williams M, Carr J, Bardien S. Prioritization of candidate genes for a South African family with Parkinson's disease using in-silico tools. PLoS One 2021. 16, e0249324. DOI: 10.1371/journal.pone.0249324

Chetty D, Abrahams S, van Coller R, Carr J, Kenyon C, Bardien S. Movement of prion-like α-synuclein along the gut-brain axis in Parkinson's disease: A potential target of curcumin treatment. Eur J Neurosci. 2021 May 27. doi: 10.1111/ejn.15324.

Abrahams S, Miller HC, Lombard C, van der Westhuizen FH, Bardien S. Curcumin pre-treatment may protect against mitochondrial damage in LRRK2-mutant Parkinson's disease and healthy control fibroblasts.​ Biochemistry and Biophysics Reports. 2021. 27, 101035