Respiratory Research Unit​

Recent publications

Internal Medicine


Journal Articles (subsidised)

ALLI NA, PATEL M, ALLI HD, BASSA FC, COETZEE MJ, DAVIDSON A, ESSOP MR, LAKHA A, LOUW VJ, NOVITZKY N, PHILIP V. Recommendations for the management of sickle cell disease in South Africa. SAMJ South African Medical Journal 2014; 104(11) : 743-751.

AZZOPARDI M, PORCEL JM, KOEGELENBERG CFN, LEE YCG, FYSH ETH. Current controversies in the management of malignant pleural effusions. Seminars in Respiratory and Critical Care Medicine 2014; 35(6) : 723-731.

BADENHORST PJ. Coeliac disease. South African Family Practice (Geneeskunde: The Medicine Journal) 2014; 56(1) : 31-34.

BALKEMA C, IRUSEN E, TALJAARD JJ, KOEGELENBERG CFN. Tuberculosis in the intensive care unit: a prospective observational study. International Journal of Tuberculosis and Lung Disease 2014; 18(7) : 824-830.

BARI V, MARCHI A, DE MARIA B, GIRARDENGO G, GEORGE AL, BRINK PA, CERUTTI S, CROTTI L, SCHWARTZ PJ, PORTA A. Low-pass filtering approach via empirical mode decoomposition improves short-scale entropy-based complexity estimation of QT interval variability in long QT syndrome Type 1 patients. Entropy 2014; 16 : 4839-4854.

BARI V, VALENCIA JF, VALLVERDÚ M, GIRARDENGO G, MARCHI A, BASSANI T, CAMINAL P, CERUTTI S, GEORGE AL, BRINK PA, CROTTI L, SCHWARTZ PJ, PORTA A. Multiscale complexity analysis of the cardiac control identifies asymptomatic and symptomatic patients in long QT syndrome Type 1. PLoS ONE 2014; 9(4) : 1-10.

BOHLIUS J, VALERI F, MASKEW M, PROZESKY HW, GARONE D, SENGAYI M, FOX MP, DAVIES M-A, EGGER M. Kaposi's sarcoma in HIV-infected patients in South Africa: Multicohort study in the antiretroviral therapy era. International Journal of Cancer 2014; 135 : 2644-2652.

BREY N, HENNING F. Relapsing neuromyelitis optica temporally related to recurrent pulmonary tuberculosis. International Journal of Tuberculosis and Lung Disease 2014; 18(5) : 632-633.

CARR J, VAN COLLER R. A putative founder effect for Parkinson's disease in South African Afrikaners. SAMJ South African Medical Journal 2014; 104(6) : 411-412.

CATTEEUW J, KOEGELENBERG CFN, BRUWER JW, SISSOLAK G, SCHROETER L, MOHAMED N, IRUSEN E. A 54-year-old man referred with nonresolving pneumonia. Chest 2014; 146(3) : e92-e96.

CHOTHIA M, HALPERIN ML, RENSBURG MA, HASSAN S, DAVIDS MR. Bolus administration of intravenous glucose in the treatment of hyperkalemia: A randomized controlled trial. Nephron Physiology 2014; 126 : 1-8.  (Captured by Chemical Pathology)

CHOTHIA MY , HALPERIN ML, RENSBURG MA, HASSAN MS, DAVIDS MR. Bolus administration of intravenous glucose in the treatment of hyperkalemia: a randomized controlled trial. Nephron Physiology 2014; 126 : 1-8.

CONRADIE M, ASCOTT-EVANS BH. An interesting D-lemma: what is all the excitement about vitamin D?. Journal of Endocrinology, Metabolism and Diabetes of South Africa (JEMDSA) 2014; 19(2) : 63-66.

CONRADIE M, CONRADIE MM, KIDD M, HOUGH FS. Bone Density in Black and White South African Women: Contribution of Ethnicity, Body Weight and Lifestyle. **MISSING JOURNAL** 2014; 9 : 193.

DAVIDS MR, CHIKTE UME, GRIMMER-SOMERS K, HALPERIN ML. Usability testing of a multimedia e-learning resource for electrolyte and acid-base disorders. British Journal of Educational Technology 2014; 45(2) : 367-381.

DAVIDS MR, CHIKTE UME, HALPERIN ML. Effect of improving the usability of an e-learning resource: a randomized trial. Advances in Physiology Education 2014; 38 : 155-160.

DORUYTER AG, HARTLEY T, AMEYO JW, DAVIDS MR, WARWICK JM. Hybrid imaging using low-dose, localizing computed tomography enhances lesion localization in renal hyperparathyroidism. Nuclear Medicine Communications 2014; 35(8) : 884-889.

ESTRELLA MM, MOOSA MR, NACHEGA JB. Risks and benefits of Tenofovir in the context of kidney dysfunction in Sub-Saharan Africa. Clinical Infectious Diseases 2014; 58(10) : 1481-1483.

FLEPISI BT, BOUIC PJ, SISSOLAK G, ROSENKRANZ B. Drug-drug interactions in HIV positive cancer patients. Biomedicine & Pharmacotherapy 2014; 68(5) : 665-677.

GELDENHUYS G, GLANZMANN B, LOMBARD D, BOOLAY S, CARR J, BARDIEN S. Identification of a common founder couple for 40 South African Afrikaner families with Parkinson's disease. SAMJ South African Medical Journal 2014; 104(6) : 413-419.

GLANZMANN B, LOMBARD D, CARR J, BARDIEN S. Screening of two indel polymorphisms in the 5'UTR of the DJ-1 gene in South African Parkinson's disease patients. Journal of Neural Transmission 2014; 121(2) : 135-138.

HEYS I, TALJAARD JJ, ORTH H. An emmonsia species causing disseminated infection in South Africa. New England Journal of Medicine 2014; 370(3) : 283-284.

JEFFERS L, VAN RENSBURG CJ, BANKS A, SCHECHTER M, SCHMIDT SJ, HU W, LLAMOSO C, PARANA R. Antiviral efficacy of entecavir in nucleos(t)ide-naïve patients of Black/African descent with chronic hepatitis B. Journal of Viral Hepatitis 2014; 21 : 74-76.

KOEGELENBERG CFN, BRUWER JW, BOLLIGER CT. Endobronchial valves in the management of recurrent haemoptysis. Respiration 2014; 87 : 84-88.

KOEGELENBERG CFN, CALLIGARO G. Transthoracic ultrasound for the categorization of pleural effusions as malignant: an adjunct, but not the answer?. Respiration 2014; 87 : 265-266.

KOEGELENBERG CFN, NOOR F, BATEMAN ED, VAN ZYL-SMIT RN, BRUNING A, O'BRIEN J, SMITH C, ABDOOL-GAFFAR MS, EMANUEL S, ESTERHUIZEN TM, IRUSEN E. Efficacy of Varenicline combined with nicotine replacement therapy vs Varenicline alone for smoking cessation: A randomized clinical trial. Jama-Journal of the American Medical Association 2014; 312(2) : 155-161.

KOEGELENBERG CFN, NOOR F, BATEMAN ED, VAN ZYL-SMIT RN, BRUNING A, SMITH C, ABDOOL-GAFFAR MS, EMANUEL S, ESTERHUIZEN TM, IRUSEN EM. Efficacy of Varenicline Combined With Nicotine Replacement Therapy vs Varenicline Alone for Smoking Cessation A Randomized Clinical Trial. Jama-Journal of the American Medical Association 2014; 312(2) : 155-161.  (Captured by Centre for Evidence-Based Healthcare)

LEE R H, LYLES KW, PEARSON M, BARNARD K, COLÓN-EMERIC C. Osteoporosis screening and treatment among veterans with recent fracture after implementation of an electronic consult service. Calcified Tissue International 2014; 94 : 659-665.

MASH RJ, DE VILLIERS MR, MOODLEY K, NACHEGA JB. Guiding the development of Family Medicine training in Africa through collaboration with the medical education partnership initiative. Academic Medicine 2014; 89(8) : S73-S77.

MOSES J, KYRIAKAKIS C, WEICH HSVH, ROSSOUW P, HERBST PG, DOUBELL AF. Persistant left superior vena cava - the value of an agitated saline constrast study. SA Heart 2014; 11(3) : 152-153.

NACHEGA JB, PARIENTI J-J, UTHMAN OA, GROSS R, DOWDY DW, SAX PE, GALLANT JE, MUGAVERO MJ, MILLS EJ, GIORDANO TP. Lower pill burden and once-daily antiretroviral treatment regimens for HIV infection: A meta-analysis of randomized controlled trials. Clinical Infectious Diseases 2014; 58(9) : 1297-1307.

NACHEGA JB, UTHMAN OA, DEL RIO C, MUGAVERO MJ, REES H, MILLS EJ. Addressing the Achilles' Heel in the HIV care continuum for the success of a test-and-treat strategy to achieve an AIDS-free generation. Clinical Infectious Diseases 2014; 59(S1) : S21-S27.

PECORARO AJK. Management of aortic stenosis in pregnancy. SA Heart 2014; 11(2) : 76-79.

ROHNER E, VALERI F, MASKEW M, PROZESKY HW, RABIE H, GARONE D, DICKINSON D, CHIMBETETE C, LUMANO-MULENGA P, SIKAZWE I, WYSS N, CLOUGH-GORR K, EGGER M, CHI BH, BOHLIUS J. Incidence rate of Kaposi Sarcoma in HIV-infected patients on antiretroviral therapy in Southern Africa: A prospective multicohort study. JAIDS-Journal of Acquired Immune Deficiency Syndromes 2014; 67(5) : 547-554.

TCHOKONTE-NANA V, COCKBURN IL, MANDA JK, KOTZE PC, JOHNSON JD. Islet cell research brings hope for a diabetes cure: Meeting report from the 6th annual islet society meeting in Stellenbosch, South Africa. Islets 2014; 6(4) : e963387-1 - e963387-2.

UTHMAN OA, MAGIDSON JF, SAFREN SA, NACHEGA JB. Depression and adherence to antiretroviral therapy in low-, middle- and high-income countries: a systematic review and meta-analysis. Current HIV/AIDS Reports 2014; 11 : 291-307.

VAN DE VYVER M, ANDRAG A, COCKBURN IL, FERRIS WF. Thiazolidinedione-induced lipid droplet formation during osteogenic differentiation. Journal of Endocrinology 2014; 223(2) : 119-132.

VAN DER MERWE C, LOOS B, SWART C, KINNEAR C, HENNING F, VAN DER MERWE L, PILLAY K, MULLER N, ZAHARIE D, ENGELBRECHT L, CARR J, BARDIEN S. Mitochondrial impairment observed in fibroblasts from South African Parkinson's disease patients with parkin mutations. Biochemical and Biophysical Research Communications 2014; 447 : 334-340.

VAN DER MERWE JL, HALL DR, HERBST PG, DOUBELL AF. Patient profile of a tertiary obstetric-cardiac clinic. SA Heart 2014; 11(2) : 80-85.

VAN RENSBURG A, HERBST PG. Image in cardiology. SA Heart 2014; 11(2) : 88-89.

VAN RENSBURG A, NEETHLING GS, SCHUBERT PT, KOEGELENBERG CFN, WRIGHT CA, BOLLIGER CT, BERNASCONI M, DIACON AH. Impact of routine sputum cytology in a population at high risk for bronchial carcinoma. International Journal of Tuberculosis and Lung Disease 2014; 18(5) : 607-612.

VAN ZYL GU, FRENKEL LM, CHUNG MH, PREISER W, MELLORS JW, NACHEGA JB. Emerging antiretroviral drug resistance in sub-Saharan Africa: novel affordable technologies are needed to provide resistance testing for individual and public health benefits. Aids 2014; 28(18) : 2643-2648.

WANDELER G, GERBER F, ROHR J, CHI BH, ORRELL C, CHIMBETETE C, PROZESKY HW, BOULLE A, HOFFMANN CJ, GSPONER T, FOX MP, ZWAHLEN M, EGGER M. Tenofovir or zidovudine in second-line antiretroviral therapy after stavudine failure in Southern Africa. Antiviral Therapy 2014; 19(5) : 521-525.

WEICH HSVH, ACKERMANN C. Closure of pulmonary arterio-venous malformations in a patient with a novel form of hereditary haemorrhagic telangiectasia. SA Heart 2014; 11(1) : 34-35.

WEICH HSVH, BROWN S. Intervention for congenital and structural heart disease: beyond the cradle. SA Heart 2014; 11(1) : 2-3.

ZEIER MD, BOTHA MH, ENGELBRECHT S, MACHEKANO RN, JACOBS GB, ISAACS S, VAN SCHALKWYK M, VAN DER MERWE H, MASON D, NACHEGA JB. Combination antiretroviral therapy reduces the detection risk of cervical human papilloma virus infection in women living with HIV. **MISSING JOURNAL** 2014; 00 : 1-8.  (Captured by Centre for Evidence-Based Healthcare – a 2015 article)

ZÖLLNER EW, LOMBARD CJ, GALAL U, HOUGH S, IRUSEN E, WEINBERG E. Screening for hypothalamic-pituitary-ad renal axis suppression (HPAS) in asthmatic children is not possible when employing clinical and biochemical parameters. Current Allergy & Clinical Immunology 2014; 27(3) : 236-237.  (Capture by Paediatrics – a 2013 article)


Journal Articles (NON-subsidised)

BAPOO NA, NEL JD. New onset diabetes after transplantation in renal transplant recipients at Tygerberg Hospital. African Journal of Nephrology 2014; 17(1) : 11-20.

BLANCKENBERG J, NTSAPI C, CARR J, BARDIEN S. EIF4G1 R1205H and VPS35 D620N mutations are rare in Parkinson's disease from South Africa. 445.e1-445.e3. Neurobiology of Aging 2014; 35 : 445.e1-445.e3.

CALLIGARO G, KOEGELENBERG CFN. Pleural ultrasound-guided interventions: advances and future potentials. Current Respiratory Care Reports 2014; 3 : 45-51.

CONRADIE M, CONRADIE M M, KIDD M, HOUGH FS. Bone density in black and white South African women: contribution of ethnicity, body weight and lifestyle. Archives of Osteoporosis 2014; 9(193) : 1-12.

DURCAN PJ, CONRADIE JD, VAN DE VYVER M, MYBURGH KH. Identification of novel Kirrel3 gene splice variants in adult human skeletal muscle. BMC Physiology 2014; 14(11) : 1-11.

FLEPISI BT, BOUIC P, SISSOLAK G, ROSENKRANZ B. Biomarkers of HIV-associated cancer. Biomarkers in Cancer 2014; 6 : 11-20.

OZOH OB, DANIA MG, IRUSEN E. The prevalence of self-reported smoking and validation with urinary cotinine among commercial drivers in major parks in Lagos, Nigeria. Journal of Public Health in Africa 2014; 5(316) : 47-50.

ROSENKRANZ B, NACHEGA JB. Diagnosis and management of malaria: An updated report on a deadly disease of global impact. Infectious Disorders - Drug Targets 2014; 13(4) : 215-216.

SHERER R, SOLOMON S, SCHECHTER M, NACHEGA JB, ROCKSTROH J, ZUNIGA JM. HIV provider-patient communication regarding cardiovascular risk: results from the AIDS treatment for life international survey. Journal of the International Association of Providers of AIDS CARE 2014; 13(4) : 342-345.

Doctoral completed

ZEIER MD. The Effect of Highly Active Antiretroviral Therapy on Human Papilloma Virus Infection and Cervical Dysplasia in Women Living With HIV. PhD, 2014. 157 pp. Promotor: Nachega JB, Botha MH.

Masters completed

BADENHORST PJ. Treatment outcomes in CML patients treated with tyrosine kinase inhibitors at a tertiary teaching hospital in South Africa. MMed, 2014. 24 pp. Studieleier: Sissolak G. Medestudieleier: Swanepoel C, Willem P, Schnugh D.

BEZUIDENHOUT K. The influence of storage time and temperature on the measurement of serum, plasma and urine osmolality. MMed, 2014. 20 pp. Studieleier: Davids MR. Medestudieleier: Rensburg MA.

DU TOIT HR. The diagnostic accuracy of PET/CT in the evaluation of pulmonary mass lesions in a tuberculosis-endemic area. MMed, 2014. 26 pp. Studieleier: Koegelenberg CFN. Medestudieleier: Von Groote-Bidlingmaier F, Warwick J.

PELLIZZON AS. A two year retrospective review of the effect of cigarette smoking on the histological cell types of lung carcinoma in the Western Cape. MMed, 2014. 27 pp. Studieleier: Koegelenberg CFN.

PRETORIUS JSE. Oral versus pulse intravenous cyclophosphamide: a retrospective analysis of adverse events in a high infectious diseases burdened setting. MMed, 2014. 16 pp. Studieleier: Du Toit R, Davids MR.

SIMON D. A survey of Hepatitis B virus infection at Tygerberg Hospital, Cape Town. MMed, 2014. 23 pp. Studieleier: Andersson MI, Taljaard JJ.

SWART ME. Paraparesis or quadriparesis in patients with tuberculous meningitis. MMed, 2014. 15 pp. Studieleier: Henning F.

VORSTER M. CABG shortens QTc post-operatively and shifts peak QTc to later in the day. MMed, 2014. 22 pp. Studieleier: Heradien M.