Clinical Pharmacology
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Division of Clinical Pharmacology

​​​​​​​​​​​​​Publications 2020

  1. Abena PM, Decloedt EH, Bottieau E, Suleman F, Adejumo P, Et Al, Nachega JB. Chloroquine and Hydroxychloroquine for the Prevention or Treatment of COVID-19 in Africa: Caution for Inappropriate Off-label Use in Healthcare Settings. American Journal of Tropical Medicine and Hygiene 2020; 102(6):1184-1188. DOI: 10.4269/ajtmh.20-0290
  2. Abulfathi AA, Assawasuwannakit P, Donald PR, Diacon AH, Reuter H, Svensson EM. Probability of mycobactericidal activity of para-aminosalicylic acid with novel dosing regimens. European Journal of Clinical Pharmacology 2020; 76(11):1557-1565. DOI: 10.1007/s00228-020-02943-8
  3. Abulfathi AA, Donald PR, Adams KT, Svensson EM, Diacon AH, Reuter H. The pharmacokinetics of para-aminosalicylic acid and its relationship to efficacy and intolerance. British Journal of Clinical Pharmacology 2020; 86(11):2123-2132. DOI: 10.1111/bcp.14395
  4. Adams KT, Donald PR, Abulfathi AA, Diacon AH, Stander MA, Reuter H. Pharmacokinetics of Para-Aminosalicylic Acid and Its 2 Major Metabolites: A Potential Relationship to the Development of Gastrointestinal Intolerance. Journal of Clinical Pharmacology 2020; 604(4):489-494. DOI: 10.1002/jcph.1542
  5. Allwood BW, Koegelenberg CFN, Irusen EM, Lalla U, Davids MR, Chothia M, Davids RA, Prozesky HW, Taljaard JJ, Parker A, Decloedt EH, Jordan PJ, Lahri S, Moosa MR, Schrueder N, Du Toit R, Viljoen A, English RG, Ayele BT, Nyasulu P. Clinical evolution, management and outcomes of patients with COVID-19 admitted at Tygerberg Hospital, Cape Town, South Africa: a research protocol. BMJ Open 2020; 10(8):1-6. DOI: 10.1136/bmjopen-2020-039455
  6. Anderson SG, Mccaul MG, Khoo S, Wiesner L, Saktor N, Joska JA, Decloedt E. The neurologic phenotype of South African patients with HIV-associated neurocognitive impairment. Neurology: Clinical Practice 2020; 10(1):15-22. DOI: 10.1212/CPJ.0000000000000687
  7. Balme K, Stephen C, Curling I, Mohamed F, Du Plessis CE, Marks C, Pillay-Fuentes Lorente V, Van Rensburg R. The economics of poisoning: The role of telemedicine and toxicovigilance. SAMJ South African Medical Journal 2020; 110(12):1152. DOI: 10.7196/SAMJ.2020.v110i12.15296
  8. Bekker A, Decloedt EH, Slade G, Cotton MF, Rabie H, Cressey TR. Single Dose Abacavir Pharmacokinetics and Safety in Neonates Exposed to Human Immunodeficiency Virus (HIV). Clinical Infectious Diseases 2020; 00(0):1-3. DOI: 10.1093/cid/ciaa1026
  9. Corbett C, Pillay-Fuentes Lorente V, Muller GJ, Van Rensburg R. Boomslang (Dispholidus typus) envenomation in a patient on warfarin therapy. SAMJ South African Medical Journal 2020; 110(10):999-1002. DOI: 10.7196/SAMJ.2020.v110i10.15137
  10. Davids EL, Kredo T, Gerritsen AAM, Mathews C, Slingers N, Nyirenda M, Abdullah F. Adolescent girls and young women: Policy-to-implementation gaps for addressing sexual and reproductive health needs in South Africa. SAMJ South African Medical Journal 2020; 110(9):855-857. DOI: 10.7196/SAMJ.2020.v110i9.14785
  11. Decloedt EH, Reuter H, Allwood BW, Parker A, Koegelenberg CFN, Blockman M, Taljaard JJ. Benefit v. risk when using chloroquine in patients with severe COVID-19 disease. SAMJ South African Medical Journal 2020; 110(5):336. DOI: 10.7196/SAMJ.2020.v110i5.14761
  12. Du Toit R, Herbst PG, Ackermann C, Pecoraro AJK, Claassen DJJ, Cyster HP, Reuter H, Doubell AF. Outcome of clinical and subclinical myocardial injury in systemic lupus erythematosus – A prospective cohort study. Lupus 2020; 0(0):1-13. DOI: 10.1177/0961203320976960
  13. Du Toit R, Herbst PG, Ackermann C, Pecoraro AJK, Du Toit HR, Hassan KM, Joubert LH, Reuter H, Doubell AF. Myocardial injury in systemic lupus erythematosus according to cardiac magnetic resonance tissue characterization: clinical and echocardiographic features. Lupus 2020; 29(11):1461-1468. DOI: 10.1177/0961203320936748
  14. Du Toit R, Reuter H, Walzl G, Snyders CI, Chegou NN, Herbst PG, Doubell AF. Serum cytokine levels associated with myocardial injury in systemic lupus erythematosus. Rheumatology 2020; 00:1-12. DOI: 10.1093/rheumatology/keaa540
  15. Du Toit T, Esterhuizen T, Tiffin N, Abulfathi AA, Reuter H, Decloedt EH. Incident tuberculosis disease in patients receiving biologic therapies in the Western Cape, South Africa from 2007 to 2018. BMC Infectious Diseases 2020; 20(1):1-8. DOI: 10.1186/s12879-020-05624-0
  16. Engelbreght A, Wiesner L, Norman J, Rabie H, Decloedt EH. Pediatric Antiretroviral Therapeutic Drug Monitoring: A Five and a Half Year Experience from a South African Tertiary Hospital. Journal of Tropical Pediatrics 2020; 66(4):385-394. DOI: 10.1093/tropej/fmz077
  17. Hlengwa N, Muller CJF, Basson AK, Bowles S, Louw J, Awortwe C. Herbal supplements interactions with oral oestrogen-based contraceptive metabolism and transport. Phytotherapy Research 2020; 34(7):1519-1529. DOI: 10.1002/ptr.6623
  18. Kapepula PM, Kabengele JK, Van Bambeke F, Tulkens PM, Kishabongo AS, Decloedt EH, Et Al, Nachega JB. Artemisia Spp. Derivatives for COVID-19 Treatment: Anecdotal Use, Political Hype, Treatment Potential, Challenges, and Road Map to Randomized Clinical Trials. American Journal of Tropical Medicine and Hygiene 2020; 103(3):960-964. DOI: 10.4269/ajtmh.20-0820
  19. Kredo T, Cooper S, Abrams AL, Muller J, Schmidt B-M, Volmink JA, Atkins S. 'Building on shaky ground'-challenges to and solutions for primary care guideline implementation in four provinces in South Africa: a qualitative study. BMJ Open 2020; 10(5):1-11. DOI: 10.1136/bmjopen-2019-031468
  20. Kumar S, Bouic PJD, Rosenkranz BF. In Vitro Assessment of the Interaction Potential of Ocimum basilicum (L.) Extracts on CYP2B6, 3A4, and Rifampicin Metabolism. Frontiers in Pharmacology 2020; 11(517):1-24. DOI: 10.3389/fphar.2020.00517
  21. Marks C, Louw AJN, Couper ID. Core competencies required by toxicology graduates in order to function effectively in a Poisons Information Centre: A Delphi study. African Journal of Emergency Medicine 2020; 10:173-180. DOI: 10.1016/j.afjem.2020.05.011
  22. McCaul MG, Durao S, Kredo T, Garner P, Young TN, Rohwer AC. Evidence synthesis workshops: moving from face-to-face to online learning. BMJ Evidence-Based Medicine 2020; 00(0):1-6. DOI: 10.1136/bmjebm-2020-111394
  23. Mearns H, Otiku PK, Shelton M, Kredo T, Kagina BMN, Schmidt B-M. Screening strategies for adults with type 2 diabetes mellitus: a systematic review protocol. Systematic Reviews 2020; 9(156):1-11. DOI: 10.1186/s13643-020-01417-3
  24. Moshobane MC, Bertero A, Marks C, Stephen C, Mothapo NP, Middleton L, Caloni F. Plants and mushrooms associated with animal poisoning incidents in South Africa. Veterinary Record Open 2020; 7(1):1-7. DOI: 10.1136/vetreco-2020-000402
  25. Park JJH, Decloedt EH, Rayner CR, Cotton MF, Mills E. Clinical trials of disease stages in COVID 19: complicated and often misinterpreted. Lancet Global Health 2020; 8(10):e1249-e1250. DOI: 10.1016/S2214-109X(20)30365-X
  26. Pillay-Fuentes Lorente V, Van Rensburg R, Cloete DA, Lahri S, Decloedt EH. Vasopressor therapy in atypical antipsychotic overdose. SAMJ South African Medical Journal 2020; 110(10):1003-1005. DOI: 10.7196/SAMJ.2020.v110i10.14771
  27. Rayner CR, Dron L, Park JJH, Decloedt EH, Cotton MF, Et Al. Accelerating Clinical Evaluation of Repurposed Combination Therapies for COVID-19. American Journal of Tropical Medicine and Hygiene 2020; 103(4):1354-1366. DOI: 10.4269/ajtmh.20-0995
  28. Smith J, Coetzee A, Van Zyl JM. An overview of acute lung injury in general and in particular viral infections with specific reference to nebulized surfactant and anticoagulation. Journal of Respiratory Diseases and Medicine 2020; 2:1-26. DOI:10.15761/JRDM.1000126 
  29. Thomford NE, Yahaya ES, Ekor M, Awortwe C. Turning Up the Volume for Precision Herbal Medicine in Africa in an Era of COVID-19 and Planetary Biodiversity Loss. Omics-A Journal of Integrative Biology 2020; 24(12):682-684. DOI: 10.1089/omi.2020.0150
  30. Van Rensburg L, Van Zyl JM, Smith J. Comparative study of pulmonary surfactants: Immunoactive properties of Synsurf, Curosurf and Liposurf. Current Topics in Pharmacology 2020; 24:27-47.
  31. Van Rensburg R, Pillay-Fuentes Lorente V, Blockman M, Moodley K, Wilmshurst JM, Decloedt EH. Medical cannabis: What practitioners need to know. SAMJ South African Medical Journal 2020; 110(3):192-196. DOI: 10.7196/SAMJ.2020.v110i3.14403
  32. Van Rensburg R, Pillay-Fuentes Lorente V, Decloedt EH. Current evidence for directed and supportive investigational therapies against COVID-19. African Journal of Thoracic and Critical Care Medicine (Previously South African Respiratory Journal) 2020; 26(2):45-50. DOI: 10.7196/AJTCCM.2020.v26i2.072
  33. Young TN, Dizon JM, Kredo T, McCaul MG, Ochodo EA, Grimmer KA, Louw QA. Enhancing capacity for clinical practice guidelines in South Africa. Pan African Medical Journal 2020; 36:a18, 11 pages. DOI: 10.11604/pamj.2020.36.18.20800