​​​​Research focus

• Myeloproliferative Neoplasm (MPN)
• Cancer drug resistance in CML
• Driver mutation testing in MPNs
• Cancer drug resistance and diagnostic test development
• Molecular tests for cancer diagnosis, monitoring and prognosis
• Flow cytometry applications
• Myeloma
• Methods of establishing tumour burden
• Business Administration, Leadership and Management in pathology service
• Promotional practices
• Future and ethics of business and finance in research
• Preanalytical and analytical factors in the Haematology Laboratory
• COVID-19 in haematology​
  

Publications from the last 3 years

2023

2022

• Alzanad F, Feyaza M, Chapanduka Z. A study of patient-reported pain during bone marrow aspiration and biopsy using local anaesthesia alone compared with local anaesthesia with intravenous midazolam coadministration at a tertiary academic hospital in South Africa. Health Sci Rep. 2022;5:e902
• RK Lohlan, ZC Chapanduka. Factors associated with bone marrow involvement in lymphoma staging bone marrow examination: A South African single centre retrospective study. S Afr J Onc. 2022; 6(0), a211
• E Nell, I Abdullah, C Griesel, N Subramony, LA du Pisani, ZC Chapanduka. Epidemiology of Adult T-cell Leukaemia/Lymphoma in South Africa over a 10-year period. Journal of Cancer Epidemiology.2022. Article ID 2058280.
• I Abdullah, N Subramony, E Musekwa, E Nell, F Alzanad, C Chetty, E Gantana, RK Lohlun, W Cerfontein, B Cochrane, ZC Chapanduka. Indications and diagnostic value of bone marrow examination in HIV-positive individuals: A 3-year review at Tygerberg Hospital. South African Journal of Infectious Diseases. 2021;36(1):a273
• S Louw, BF Jacobson, TM Wiggill, ZC Chapanduka, ES Mayne. HIV-associated thrombotic thrombocytopenic purpura (HIV-TTP): A practical guide and review of the literature. HIV Med. 2022. Online ahead of print.
• CM Kriel, J Opie, V Louw, E Musekwa, S Brett, C Zelaya. Clover leaf nuclear morphology in chronic lymphocytic leukaemia with typical immunophenotype and absence of trisomy 12. Br J Haematol. 2022 Jul;198(1):8.
• H Cornelissen, EM Musekwa, RH Glashoff, M Esser, M Zunza, DR Abraham, ZC Chapanduka. Peripheral blood cytopenia, an early indicator of inborn errors of  immunity. Br J Haematol 2022 Sep;198(5):875-886.
• M du Toit, ZC Chapanduka, AE Zemlin. The impact of laboratory staff training workshops on coagulation specimen rejection rates. PLoS ONE. 2022;17(6):e0268764
• Gebreslassie, KS, Bassa FC, Chapanduka ZC, Warwick JM. The relationship between bone marrow involvement on 18-FDG PET/CT and bone marrow biopsy in patients with multiple myeloma and other plasma cell neoplasms. South African Journal of Oncology. 2022 DOI: 10.4102/sajo.v6i0.197
• Sigwadhi LN, Tamuzi JL, Zemlin AE, Chapanduka ZC, Allwood et al. Latent class analysis: an innovative approach for identification of clinical and laboratory markers of disease severity among COVID-19 patients admitted to the intensive care unit. IJID. 2022;5:154-162
• Chapanduka ZC, I Abdullah, Allwood B, Koegelenberg CF, Irusen E et al. Haematological predictors of poor outcome among COVID-19 patients admitted to an intensive care unit of a tertiary hospital in South Africa.PLoS ONE. 2022;17(11): e0275832
• Nyasulu PS, Ayele BT, Koegelenberg CF… ZC Chapanduka et al. Clinical characteristics associated with mortality of COVID-19 patients admitted to an intensive care unit of a tertiary hospital in South Africa. PLoS ONE. 2022;17(2):e0279565
• Abdullah I, Cornelissen HM, Musekwa E, Zemlin A, Jalavu T, Mashigo N, Chetty C, Nkosi N, Chapanduka ZC. Haematological findings in adult patients with SARS CoV-2 infection at Tygerberg Hospital Cape Town South Africa. Health Sci Rep. 2022;5:e550
• Zemlin, AE, Allwood B, Sigwadi LN, Wiese OJ, Jalavu TP, Chapanduka ZC et al. The association between acid-base status and clinical outcome in critically ill COVID-19 patients admitted to intensive care unit with an emphasis on high anion gap metabolic acidosis. Annals of Clinical Biochemistry. 2022;0(0):1-6
• DC Petersen, C Steyl, D Scholtz, B Baker, I Abdullah, C Uren, M Moller. African genetic representation in the context of SARS-CoV-2 infection and COVID-19 severity. Front. Genet. 2022:13:909117
• BW Allwood, CF Koegelenberg, VD Ngah...ZC Chapanduka et al., Preventing COVID-19 outcomes from clinical and laboratory parameters in an intensive care facility during the second wave of the pandemic in South Africa. IJID Regions. 2022:3;242-247
• U Lalla, CFN Koegelenberg, BW Allwood...ZC Chapanduka, et al., Comparison of patients with severe COVID-19 admitted to an intensive care unit in South Africa during the first and second wave of the COVID-19 pandemic. Afr J Thorac Crit Care Med. 2021; 27(4): 10.7196
• T Jalavu, ZC Chapanduka, I Abdullah, H Cornelissen, E Musekwa, N Mashigo, C Chetty, A Zemlin. Biochemical laboratory findings in adult patients with conoravirus disease 2019 (COVID-19) at a university hospital in Cape Town, South Africa. JMLSTSA. 2022:4(1)
• Zemlin, AE, Allwood, B, Erasmus RT, Masha TA, Chapanduka ZC et al. Prognostic value of biochemical parameters among severe COVID-19 patients admitted to an intensive care unit of a tertiary hospital in South Africa.  IJID Regions. 2022. doi:https://doi.org/10.1016/j.ijregi.2022.01.012
   

2021

• Lalla U, … ZC Chapanduka et al. Comparison of patients with severe COVID-19 admitted to an intensive care unit in South Africa during the first and second wave of COVID-19 pandemic. AJTCCM. 2021;(27)4:156-162
• Musaigwa F, Grewal R, Abayomi A, Swanepoel CC. Chronic lymphocytic leukaemia trends and features at a tertiary hospital in South Africa (2011–2016). S. Afr. J. Oncol. 2021;5(0), a168.
• Gantana E, Mashigo N, Abdullah I, Musekwa E, Lohlun R, Nell E, Chetty C, Ntobongwana M, Chapanduka Z. Evaluation of an innovative new method for quantitation of plasma cells on CD138 immunohistochemistry. J Clin Pathol. 2021 DOI: 10.1136/jclinpath-2021-207828
• Mashigo N, Nell E, Taylor D. A novel 4-way variant of t(8;21) in a patient with acute myeloid leukaemia. Journal of Medical Laboratory Science & Technology of South Africa. 2021;3(2):76-78
• Adams R, Adeleke F, Anderson D, Bawa A, Branson N, Christoffels A…Swanepoel C et al. POPIA Code of Conduct for Research. S Afr J Sci. 2021;117:5(6), a10933.
• Abdullah I, Subramony N, Musekwa E, Nell E, Alzanad F, Chetty C, Gantana E, Lohlun RK, Cerfontein W, Cochrane B, Chapanduka ZC. Indications and diagnostic value of bone marrow examination in HIV-positive individuals: A 3-year review at Tygerberg Hospital. South African Journal of Infectious Diseases. 2021;36(1):a273
• Nell EM, Dicks MJ, Ntobongwana M. Thrombophagocytosis by neutrophils as a spurious cause of thrombocytopenia. eJHaem.  2021. doi:10.1002/jha2.139
• Hinzmann R, Militz D, Zima T, Špaček M, Storm H, Chapanduka Z, Hauss O. Real-world data from Europe and Africa suggest that accuracy of systems for self-monitoring of blood glucose is frequently impaired by low haematocrit. Diabetes Research and Clinical Practice. 2021; 177: 108860.
• Abdullah I, Ntobongwana M, Schoonraad L, Cornelissen H, Chapanduka ZC. T-cell/myeloid mixed phenotype acute leukaemia with KMT2A rearrangement. Journal of Leukemia 9(7): 1000265
• Mashigo N, Esser M. Game of clones: A case of ELANE gene mutation-related neutropenia. The Journal of Medical Laboratory Science & Technology South Africa. 2021;3(1):24-26
• Mutema L, Chapanduka Z, Musaigwa F, Mashigo N. In-depth investigation of turn-around time of full blood count tests requested from a clinical haematology outpatient department in Cape Town, South Africa. Afr J Lab Med. 2021;10(1):1318.
• Adams R, Adeleke F, Anderson D, Swanepoel C et al. POPIA Code of Conduct for Research. South African Journal of Science. 2021;117(5/6)
  

2020

• Staunton C, Swanepoel C, Labuschagine M. Between a rock and a hard place: COVID-19 and South Africa's response. Journal of Law and the Biosciences, 14 July 2020
• Staunton C, Adams R, Anderson D, Croxton T, Kamuya D, Munene M, Swanepoel C. Protection of Personal Information Act 2013 and data protection for health research in South Africa" International Data Privacy Law, 2020
• Bailey J, Louw S, de Koker A, Potgieter JJC, Coetzee MJ, Chapanduka ZC, Opie JJ. Guidelines for lupus anticoagulant testing in South Africa. The Journal of Medical Laboratory Science & Technology South Africa 2020; 2(1):6-12
• Musekwa E, Chapanduka ZC, Bassa F, Kruger M. An 8-year retrospective study of adult and paediatric Burkitt's lymphoma at Tygerberg Hospital, South Africa. SA Journal of Oncology. 2020;4(0), a93.
• Abdullah I, Jafta AD, Chapanduka ZC. The impact of physician education regarding the importance of providing complete clinical information on the request forms of thrombophilia-screen tests at Tygerberg hospital in South Africa. PLoS ONE, 2020; 15(8):e0235826
• Nell E, Parker MA, Mowlana A, Moolla MS, Karamchand S, Murphy L, Lovelock T, Kalombo KS, Parker A, Chapanduka Z. Fever in the returning traveler: Dual infection with SARS-CoV-2 and Plasmodium falciparum malaria. Journal of Medical Laboratory Science and Technology South Africa.  2020;2(2):36-40
• Griesel C, Desmirean M, Esterhuizen T, Pasca S… Swanepoel C et al. Differential Diagnosis of Malignant Lymphadenopathy Using Flow Cytometry on Fine Needle Aspirate: Report on 269 Cases. J. Clin. Med. 2020;9:283
• Abdullah I, Nell E, Chapanduka ZC. Adult T-cell leukaemia/lymphoma in an adolescent patient: Expect the unexpected. SA Journal of Oncology. 2020;4(0),a121
• Mashigo N. Double trouble: A case of synchronous presentation of acute myeloid leukaemia and multiple myeloma. South African Journal of Oncology. 2020;4, a147