GROEPLEIER: Dr Nicky Verhoog
Posisie: Senior Lektor
Kantoor: A101, JC Smuts gebou
Foon: +27-(0)21-808-5875
Faks: +27-(0)21-808-5863
Epos: nverhoog@sun.ac.za
Opvoedkundige Agtergrond
PhD, University of Cape Town, Molecular and Cell Biology, 2010
Nadoktorale genoot, Universiteit Stellenbosch, 2011-2015
Navorsingsklem
Steroid receptor signalling, gene regulation, cross-talk between glucocorticoids and inflammatory mediators, insulin signalling.
Navorsingsopsomming
Ons hoof navorsingsfokus is op die effek wat glukokortikoïede via die glukokortikoïedreseptor en inflammasie op insulien seintransduksie het.
Samewerkers
Prof Ann Louw, University of Stellenbosch
Dr Donita Africander, University of Stellenbosch
Dr Carmen Pheiffer, Medical Research Council South Africa
Prof Holger Reichardt, Univeritatsmedizin Göttingen. Germany
Geselekteerde publikasies
N.J.D.
Verhoog, F. Allie-Reid, W. Vanden Berghe, G. Haegeman, J. Hapgood, and
A. Louw, Inhibition of Corticosteroid-binding Globulin Gene Expression
by Glucocorticoids involves C/EBPβ, PLoS One, 2014 21;9(10):e110702
Y.
Govender, C. Avenant, N.J.D. Verhoog, R. Ray, N.J. Grantham, D.
Africander and J.P. Hapgood, The injectable-only contraceptive
medroxyprogesterone acetate, unlike norethisterone acetate, suppresses
inflammation in endocervical cells by genomic actions via the
glucocorticoid receptor, PLoS One, 2014, 9(5)e96497.
N.J.D
Verhoog, A. Du Toit, C. Avenant and J Hapgood,
Glucocorticoid-independent repression of tumor necrosis factor (TNF)
alpha-stimulated interleukin (IL)-6 expression by the glucocorticoid
receptor: a potential mechanism for protection against an excessive
inflammatory response, Journal of Biological Chemistry, 286(22);
19297-19310, 2011
D. Africander, R. Louw, N. Verhoog, D. Noeth and
J. Hapgood, Differential regulation of endogenous pro-inflammatory
cytokine genes by medroxyprogesterone acetate and norethisterone acetate
in cell lines of the female genital tract, Contraception, 84(4);
423-435, 2011.
D. Africander, N.J.D. Verhoog and J Hapgood,
Molecular mechanisms of steroid receptor-mediated actions by synthetic
progestins used in HRT and contraception, Steroids, 76(7); 636-652,
2011.
N.J.D. Verhoog, E. Joubert and A. Louw, Evaluation of the
Phytoestrogenic Activity of Cyclopia genistoides (Honeybush) Methanol
Extracts and Relevant Polyphenols, Journal of Agricultural and Food
Chemistry, 55(11); 4371-4381, 2007
N.J.D. Verhoog, E. Joubert and
A. Louw, Screening of four Cyclopia (honeybush) species for putative
phyto-oestrogenic activity by oestrogen receptor binding assays, South
African Journal of Science 103: 13-21, 2007