The main focus of the research is to identify immune biomarkers that can be taken into future trials for novel diagnostics and vaccines. The group is part of several international consortia that identify - together with several US, European and African partners - large cohorts of participants with well-characterised MTB infection and disease phenotypes to search for biomarkers of TB. The laboratory work entails a range of modern immunological and molecular biology techniques. It spans the divide between clinical and basic sciences in a high TB prevalence area. The group has worked as an immunology specialist laboratory on subcontracts for IMPAACT and ACGT network studies, and is performing the immunology tests for the phase IIa TB vaccine trials in infants.