Experimental Medicine
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Experimental Medicine

Publications​


  1. Van de Vyver M, Powrie YSL, Smith C. Targeting stem cells in chronic inflammatory diseases. Adv Exp Med Biol 2021; 1286:163-181. doi: 10.1007/978-3-030-55035-6_12
  2. Ollewagen T, Myburgh KH, Van de Vyver M, Smith C. Rheumatoid cachexia: the underappreciated role of myoblast, macrophage and fibroblast interplay in the skeletal muscle niche. J Biomedical Sciences 2021; 28:15. doi: 10.1186/s12929-021-00714-w
  3. Van Staden AD, Van Zyl WF, Trindade M, Dicks LMT, Smith C. Therapeutic application of lantibiotics and other lanthipeptides: old and new findings. Applied Environmental Microbiology 2021; doi: 10.1128/AEM.00186-21
  4. Ollewagen T, Myburgh KH, Powrie YSL, Smith C. Unresolved intramuscular inflammation, not diminished skeletal muscle regenerative capacity, is at the root of rheumatoid cachexia: insights from a rat CIA model. Physiological Reports 2021 Nov;9(22):e15119. doi: 10.14814/phy2.15119. 
  5. Boodhoo K, De Swardt D, Smith C, Van de Vyver M. Ex vivo tolerization and M2 polarisation of macrophages dampens both pro- and anti-inflammatory cytokine production in response to diabetic wound fluid stimulation. Biochimie 2022, S0300-9084(21)00297-2. doi: 10.1016/j.biochi.2021.12.009
  6. Pretorius L, Van Staden AD, Van der Merwe JJ, Henning N, Smith C. Alterations to microbial secretome by estrogen may contribute to sex bias in irritable bowel syndrome. Inflammopharmacology 2022 Jan 13. 30(1):267-281. Doi: 10.1007/s10787-021-00906-8
  7. López V, Casedas G, Petersen-Ross KS; Powrie YSL, Smith C. Neuroprotective and anxiolytic potential of green rooibos (Aspalathus linearis) polyphenolic extract. Food & Function 2022 Jan 4; 13(1):91-101. doi: 10.1039/d1fo03178c
  8. Ollewagen T, Tarr GS, Myburgh KH, Reuter H, Smith C. Therapeutic benefit in rheumatoid cachexia illustrated using a novel primary human triple cell coculture model. International Journal of Inflammation 2022. doi: 10.1155/2022/1524913
  9. Pretorius L, Van Staden AD, Kellermann T, Henning N, Smith C. Rooibos (Aspalathus linearis) alters secretome trace amine profile of probiotic and commensal microbes in vitro. J Ethnopharmacology 2022 (in print). doi: 10.1016/j.jep.2022.115548
  10. Powrie YSL, Strydom M, Aucamp M, Schellack N, Steenkamp V, Smith C. Zebrafish behavioural response to ivermectin: insights into potential neurological risk. Medicine in Drug Discovery (2022). doi: 10.1016/j.medidd.2022.100141
  11. Pretorius L, Smith C. Aspalathus linearis (Rooibos) and agmatine may act synergistically to beneficially modulate intestinal tight junction integrity and inflammatory profile. Pharmaceuticals (2022) 15(9):1097. doi: 10.3390/ph15091097.
  12. Pretorius L, Smith C. Tyramine-induced gastrointestinal dysregulation is attenuated via estradiol associated mechanisms in a zebrafish larval model. Toxicology and Applied Pharmacology (2023) 461:116399. doi: 10.1016/j.taap.2023.116399.
  13. Smith C, Du Toit R, Ollewagen T. Potential of bone morphogenetic protein-7 in treatment of lupus nephritis: addressing the hurdles to implementation. Inflammopharmacology (2023). doi: 10.1007/s10787-023-01321-x.
  14. Henning N, Smith C, Kellermann T. Dolutegravir quantification in wistar rat tissue following chronic administration. Heliyon (2023) doi: 10.1016/j.heliyon.2023.e22541)
  15. Pretorius L, Smith C. Translation of preclinical ethnomedicine data in LMICs: the example of rooibos. .Front Pharmacol. 2023 Dec 19;14:1328828. doi: 10.3389/fphar.2023.1328828
  16. Pretorius L, Smith C. Green rooibos (Aspalathus linearis) promotes gut health: Insight into mechanisms. Journal of Ethnopharmacology 2024 Jan 30;319(Pt 3):117379. doi: 10.1016/j.jep.2023.117379
  17. Gericke J, Harvey BH, Pretorius L, Ollewagen T, Benecke RM, Smith C. Sceletium tortuosum-derived mesembrine significantly contributes to the anxiolytic effect of Zembrin®, but its anti-depressant effect may require synergy of multiple plant constituents. Journal of Ethnopharmacology (2023) 319: 117113. doi: 10.1016/j.jep.2023.117113.
  18. Ollewagen T, Benecke RM, Smith C. High species homology potentiates quantitative inflammation profiling in zebrafish using immunofluorescence Heliyon. 2023 Dec 13;10(1):e23635. doi: 10.1016/j.heliyon.2023.e23635
  19. Bosch C, Toplis B, Van Staden AD, Volschenk H, Smith C, Dicks L, Botha A. Exposure of Cryptococcus neoformans to low nitrogen levels enhances virulence. International Microbiology. 2024 Mar 14. doi: 10.1007/s10123-024-00504-y. 
  20. Van Staden AD, Visser JG, Powrie YSL, Smith C. Harnessing microbial effectors for macrophage-mediated drug delivery. ACS Omega 2024 Apr 11;9(16):18260-18272.  doi: 10.1021/acsomega.3c10519
  21. Van de Vyver M, Benecke RM, Van der Heuvel L, Kruger MJ, Powrie YSL, Seedat S, Smith C. Posttraumatic stress disorder is characterized by functional dysregulation of dermal fibroblasts. Biochimie 2024 May 06. https://doi.org/10.1016/j.biochi.2024.05.006
  22. Pretorius L, Balshaw A, Ross KS, Smith C. Modelling sex-bias in anxiety: pros and cons of a larval zebrafish model. Chronic Stress. 2024 vol 8, pp. 1-10. https://doi.org/10.25384/SAGE.26053893.v1
  23. Smith C. The potential of zebrafish as drug discovery research tool in immune-mediated inflammatory disease. Inflammopharmacology 2024; doi: 10.1007/s10787-024-01511-1. (invited review)