​Clinical Endocrinology

Research

Areas of Interest

• Original Clinical Research
• Diabetes Mellitus
• Metabolic Bone Disease
• Male hypogonadism
• Pituitary disease
• Thyroid disease
• Contract Research
• Diabetes Mellitus Type 2
• Metabolic Bone Disease

Active Studies

• Original Clinical Research:
• The prevalence and significance of acanthosis nigricans in diabetic and non-diabetic women of mixed ancestry.  M Hoffmann, Prof BH Ascott-Evans et al (PhD)
• Bone health in post-menopausal patients with breast cancer treated with aromatase inhibitors: factors predicting the risk for osteoporosis. Dr KJ Baatjes, M Conradie et al(PhD) 
• The prevalence and predictive factors of sustained dysglycemia in patients with Gestational Diabetes presenting to a tertiary facility: Assessment at 6–12 weeks post-partum. Dr A Coetzee, M Conradie (MPhil)
• The prevalence and associations of hypogonadism in coloured males with type 2 diabetes. E Pretorius, BH Ascott-Evans (MPhil)
• Stem cell impairment associated with type 2 diabetes mellitus: Investigating the effect of obesity-associated systemic inflammation on mesenchymal stem cell behaviour in three different cohorts of patients Mari van de Vyfer and Endocrine clinical team.
• Understanding the progression of obesity towards metabolic syndrome and type 2 Diabetes Mellitus in reproductive aged females with diverse African ethnicities K Ronacher et al, M Conradie. (acting as clinical consultant to study team).
• Screening for Gestational Diabetes – examining a breakfast meal test and comparing different measures of glycemic control." Colin Marais, M Conradie et al
• Bone Health in Graves' disease: A Comparison of black and white South-African women." W de Lange, Riana Eagar
• Novel methods for detecting and minimizing chronic cardiovascular metabolic, respiratory, renal and bone disease in HIV infected children treated with antiretroviral therapy in Southern Africa. Steve Innes, Riana Eagar et al
• Contract Research
• A Multicenter, International, Randomized, Double-blind, Alendronate-controlled Study to Determine the Efficacy and Safety of AMG 785 in the Treatment of Postmenopausal Women with Osteoporosis AMGEN
• A Multicentre Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Effect of Dapaglifloxazin 10mg Once Daily on the Incidence of Cardiovascular Death, Myocardial Infarction or Ischaemic Stroke in Patients with Type 2 Diabetes DAPA-DECLARE.
• A 5-year study to compare the durability of glycemic control of a combination regimen with vildagliptin & metformin versus standard-of-care monotherapy with metformin, initiated in treatment-naïve patients with type 2 diabetes mellitus CLAF.

Capacity

• Actively involved in collaborative clinical research
• Oversee MMed projects
• Oversee MPhil projects
• Oversee PhD projects
  

For a list of publications click here.