Anxiety disorders
Welcome to Stellenbosch University

Division of Molecular Biology & Human Genetics

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​Anxiety disorders

 

Publications

Suliman S, Hemmings SMJ, Seedat S. (2013). Brain-Derived Neurotrophic Factor (BDNF) protein levels in anxiety disorders: systematic review and meta-regression analysis. Manuscript accepted for publication in Frontiers in Integrative Neuroscience


Malan-Müller S, Hemmings SM, Spies G, Kidd M, Fennema-Notestine C, Seedat S. (2013) Shorter telomere length--a potential susceptibility factor for HIV-associated neurocognitive impairments in South African woman. PLoS One. 2013;8(3):e58351. doi: 10.1371/journal.pone.0058351. Epub 2013 Mar 5.

 

Botha M, Grace L, Bugarith K, Russell VA, Kidd M, Seedat S, Hemmings SM. (2013) The impact of voluntary exercise on relative telomere length in a rat model of developmental stress. BMC Research Notes. 2012 Dec 27;5:697. doi: 10.1186/1756-0500-5-697


S Evelyn Stewart, Dongmei Yu, Jeremiah M Scharf, Benjamin M Neale, Jesen A Fagerness JD, Carol A Mathews, Paul D Arnold, Patrick D Evans PhD, Eric R Gamazon, Lisa Osiecki, Stephen Haddad, Jacquelyn Crane, Dianne Hezel, Cornelia Illman, Catherine Mayerfeld, Anuar Konkashbaev, Chunyu Liu, Anna Pluzhnikov, Anna Tikhomirov, Christopher K. Edlund, Scott L Rauch, Rainald Moessner, Peter Falkai, Wolfgang Maier, Stephan Ruhrmann, Hans-Jörgen Grabe, Leonard Lennertz, Michael Wagner, Laura Bellodi, Maria Cristina Cavallini, Margaret A Richter, Edwin H Cook Jr, James L Kennedy, David Rosenberg, Dan J Stein, Sian MJ Hemmings, Christine Lochner, et al. (2012). Genome-wide Association Study of Obsessive-Compulsive Disorder. Manuscript accepted for publication in Molecular Psychiatry


Warwick JM, Carey PD, Cassimjee N, Lochner C, Hemmings S, Moolman-Smook H, Beetge E, DuPont P, Stein DJ (2012). Dopamine transporter binding in social anxiety disorder: the effect of treatment with escitalopram. Metab Brain Dis. 2012 Jun;27(2):151-8


Malan S, Hemmings S, Kidd M, Martin L, Seedat S (2011). Investigation of telomere length and psychological stress in rape victims. Depress Anxiety. Dec 21;28(12):1081-5


C Lochner, P Serebro, L van der Merwe, SM Hemmings, CJ Kinnear, S Seedat, DJ Stein (2011) Comorbid obsessive-compulsive personality disorder in obsessive-compulsive disorder (OCD): A marker of severity Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jun 1;35(4):1087-92


Boardman L, van der Merwe L, Lochner C, Kinnear C, Seedat S, Stein DJ, Moolman-Smook JC, Hemmings SMJ (2011) Investigating SAPAP3 variants in the aetiology of obsessive-compulsive disorder and trichotillomania in the South African Caucasian population. Compr Psychiatry 52(2): 181-7 (Epub Jul 2010)


Katerberg H, Lochner C, Cath DC, de JP, Bochdanovits Z, Moolman-Smook JC, Hemmings SM, Carey PD, Stein DJ, Sondervan D, Boer JA, van Balkom AJ, Polman A and Heutink P (2009) The role of the brain-derived neurotrophic factor (BDNF) val66met variant in the phenotypic expression of obsessive-compulsive disorder (OCD). Am. J. Med. Genet. B Neuropsychiatr. Genet. Dec 5;150B(8):1050-62


Lochner C, Hemmings SM, Kinnear CJ, Nel D, Hemmings SM, Seedat S, Moolman-Smook JC and Stein DJ (2008) Cluster analysis of obsessive-compulsive symptomatology: identifyingobsessive-compulsive disorder subtypes. Isr. J. Psychiatry Relat Sci. 45:164-176


Lochner C, Seedat S, Hemmings SM, Moolman-Smook JC, Kidd M and Stein DJ (2007) Investigating the possible effects of trauma experiences and 5-HTT on the dissociative experiences of patients with OCD using path analysis and multiple regression. Neuropsychobiology 56:6-13


Hemmings SM, Kinnear CJ, Van der ML, Lochner C, Corfield VA, Moolman-Smook JC and Stein DJ (2008) Investigating the role of the brain-derived neurotrophic factor (BDNF) val66met variant in obsessive-compulsive disorder (OCD). World J. Biol. Psychiatry 9:126-134


Hemmings SM, Kinnear CJ, Lochner C, Seedat S, Corfield VA, Moolman-Smook JC and Stein DJ (2006) Genetic correlates in trichotillomania--A case-control association study in the South African Caucasian population. Isr. J. Psychiatry Relat Sci. 43:93-101


Hemmings SM and Stein DJ (2006) The current status of association studies in obsessive-compulsive disorder. Psychiatr. Clin. North Am. 29:411-444


Lochner C, Kinnear CJ, Hemmings SM, Seller C, Niehaus DJ, Knowles JA, Daniels W, Moolman-Smook JC, Seedat S and Stein DJ (2005) Hoarding in obsessive-compulsive disorder: clinical and genetic correlates. J. Clin. Psychiatry 66:1155-1160


Lochner C, Hemmings SM, Kinnear CJ, Niehaus DJ, Nel DG, Corfield VA, Moolman-Smook JC, Seedat S and Stein DJ (2005) Cluster analysis of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder: clinical and genetic correlates. Compr. Psychiatry 46:14-19


Hemmings SM, Kinnear CJ, Lochner C, Niehaus DJ, Knowles JA, Moolman-Smook JC, Corfield VA and Stein DJ (2004) Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates. Psychiatry Res. 128:175-182


Lochner C, Seedat S, Hemmings SM, Kinnear CJ, Corfield VA, Niehaus DJ, Moolman-Smook JC and Stein DJ (2004) Dissociative experiences in obsessive-compulsive disorder and trichotillomania: clinical and genetic findings. Compr. Psychiatry 45:384-391


Lochner C, Hemmings SM, Kinnear CJ, Moolman-Smook JC, Corfield VA, Knowles JA, Niehaus DJ and Stein DJ (2004) Gender in obsessive-compulsive disorder: clinical and genetic findings. Eur. Neuropsychopharmacol. 14:105-113


Hemmings SM, Kinnear CJ, Niehaus DJ, Moolman-Smook JC, Lochner C, Knowles JA, Corfield VA and Stein DJ (2003) Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder. Eur. Neuropsychopharmacol. 13:93-98


Psychiatric Genetics Group Member Publications

Kalungi A, Seedat S, Hemmings SMJ, van der Merwe L, Joloba ML, Nanteza A, Nakassujja N, Birabwa H, Serwanga J, Kaleebu P, Kinyanda E.  Association between serotonin transporter gene polymorphisms and increased suicidal risk among HIV positive patients in Uganda.  BMC Genet.  2017 Jul;18(1):71.   doi: 10.1186/s12863-017-0538-y.

Hemmings SMJ, Malan-Muller S, van den Heuvel LL, Demmitt BA, Stanislawski MA, Smith DG, Bohr AD, Stamper CE, Hyde ER, Morton JT, Marotz CA, Siebler PH, Braspenning M, Van Criekinge W, Hoisington AJ, Brenner LA, Postolache TT, McQueen MB, Krauter KS, Knight R, Seedat S, Lowry CA.  The Microbiome in Posttraumatic Stress Disorder and Trauma-Exposed Controls: An Exploratory Study.  Psychosom Med. 2017 Jul. doi: 10.1097/PSY.0000000000000512

 
Womersley JS, Seedat S, Hemmings SMJChildhood maltreatment and HIV-associated neurocognitive disorders share similar pathophysiology: a potential sensitisation mechanism?  Metab Brain Dis. 2017 Jul. doi: 10.1007/s11011-017-0062-9.

 

Malan-Müller S, Fairbairn L, Hart S, Daniels WMU, Jalali Sefid Dashti M, Kidd M, Seedat S, Gamieldien J, Hemmings SMJThe role of microRNAs in the therapeutic action of D-cycloserine in a post-traumatic stress disorder animal model: an exploratory study.  Psychiatr Genet. 2017 Aug;27(4):139-151. doi: 10.1097/YPG.0000000000000176.

Zass LJ, Hart SA, Seedat S, Hemmings SM, Malan-Müller S. Neuroinflammatory genes associated with post-traumatic stress disorder: implications for comorbidity. Psychiatr Genet. 2017 Feb;27(1):1-16. doi: 10.1097/YPG.0000000000000143.

Malan-Müller S, Hemmings SM. The Big Role of Small RNAs in Anxiety and Stress-Related Disorders. Vitam Horm. 2017;103:85-129. doi: 10.1016/bs.vh.2016.08.001.

Brombacher TM, Nono JK, De Gouveia KS, Makena N, Darby M, Womersley J, Tamgue O, Brombacher F. IL-13-Mediated Regulation of Learning and Memory. J Immunol. 2017 Feb 15. pii: 1601546. doi: 10.4049/jimmunol.1601546.

McGregor NW, Hemmings SM, Erdman L, Calmarza-Font I, Stein DJ, Lochner C. Modification of the association between early adversity and obsessive-compulsive disorder by polymorphisms in the MAOA, MAOB and COMT genes. Psychiatry Res. 2016 Dec 30;246:527-532. doi: 10.1016/j.psychres.2016.10.044.

van den Heuvel L, Suliman S, Malan-Müller S, Hemmings S, Seedat S. Brain-derived neurotrophic factor Val66met polymorphism and plasma levels in road traffic accident survivors. Anxiety Stress Coping. 2016 Nov;29(6):616-29. doi:10.1080/10615806.2016.1163545.

Lowry CA, Smith DG, Siebler PH, Schmidt D, Stamper CE, Hassell JE Jr, Yamashita PS, Fox JH, Reber SO, Brenner LA, Hoisington AJ, Postolache TT, Kinney KA, Marciani D, Hernandez M, Hemmings SM, Malan-Muller S, Wright KP, Knight R, Raison CL, Rook GA. The Microbiota, Immunoregulation, and Mental Health: Implications for Public Health. Curr Environ Health Rep. 2016 Sep;3(3):270-86. doi: 10.1007/s40572-016-0100-5.

Suliman S, Anthonissen L, Carr J, du Plessis S, Emsley R, Hemmings SM, Lochner C, McGregor N, van den Heuvel L, Seedat S. Posttraumatic Stress Disorder, Overweight, and Obesity: A Systematic Review and Meta-analysis. Harv Rev Psychiatry. 2016 Jul-Aug;24(4):271-93. doi: 10.1097/HRP.0000000000000106.

Womersley JS, Mpeta B, Dimatelis JJ, Kellaway LA, Stein DJ, Russell VA. Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder. Behav Brain Funct. 2016 Jun 17;12(1):18. doi: 10.1186/s12993-016-0102-3.

Aas M, Blokland GA, Chawner SJ, Choi SW, Estrada J, Forsingdal A, Friedrich M,Ganesham S, Hall L, Haslinger D, Huckins L, Loken E, Malan-Müller S, Martin J, Misiewicz Z, Pagliaroli L, Pardiñas AF, Pisanu C, Quadri G, Santoro ML, Shaw AD, Ranlund S, Song J, Tesli M, Tropeano M, van der Voet M, Wolfe K, Cormack FK, DeLisi L. Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12-16 October 2014. Psychiatr Genet. 2016 Feb;26(1):1-47. doi: 10.1097/YPG.0000000000000112.

Malan-Müller S, Fairbairn L, Daniels WM, Dashti MJ, Oakeley EJ, Altorfer M, Kidd M, Seedat S, Gamieldien J, Hemmings SM. Molecular mechanisms of D-cycloserine in facilitating fear extinction: insights from RNAseq. Metab Brain Dis. 2016 Feb;31(1):135-56. doi: 10.1007/s11011-015-9727-4.

McGregor NW, Lochner C, Stein DJ, Hemmings SM. Polymorphisms within the neuronal cadherin (CDH2) gene are associated with obsessive-compulsive disorder (OCD) in a South African cohort. Metab Brain Dis. 2016 Feb;31(1):191-6. doi: 10.1007/s11011-015-9693-x.

Malan-Müller S, Kilian S, van den Heuvel LL, Bardien S, Asmal L, Warnich L, Emsley RA, Hemmings SM, Seedat S. A systematic review of genetic variants associated with metabolic syndrome in patients with schizophrenia. Schizophr Res. 2016 Jan;170(1):1-17. doi: 10.1016/j.schres.2015.11.011.

Khumalo NP, Shaboodien G, Hemmings SM, Moolman-Smook JC, Stein DJ. Pathologic grooming (acne excoriee, trichotillomania, and nail biting) in 4 generations of a single family. JAAD Case Rep. 2016 Jan 30;2(1):51-3. doi: 10.1016/j.jdcr.2015.11.002.

Hemmings SM, Martin LI, van der Merwe L, Benecke R, Domschke K, Seedat S. Serotonin transporter variants play a role in anxiety sensitivity in South African adolescents. World J Biol Psychiatry. 2016;17(1):66-75. doi: 10.3109/15622975.2015.1102324.

Womersley JS, Uys JD. S-Glutathionylation and Redox Protein Signaling in Drug Addiction. Prog Mol Biol Transl Sci. 2016;137:87-121. doi: 10.1016/bs.pmbts.2015.10.001.

Womersley JS, Kellaway LA, Stein DJ, Gerhardt GA, Russell VA. Effect of cocaine on striatal dopamine clearance in a rat model of developmental stress and attention-deficit/hyperactivity disorder. Stress. 2016;19(1):78-82. doi:10.3109/10253890.2015.1096925.

Womersley JS, Kellaway LA, Stein DJ, Gerhardt GA, Russell VA.  The clearance of dopamine from the striatum following methamphetamine stimulation is strain dependent.  Intrinsic Activity.  2016;4(Suppl 2):A18.53.

Gerhardt GA, Miller EM, Womersley J. Tribute to: Dr. Vivienne Russell, Ph.D. on Attention-Deficit/Hyperactivity Disorder (ADHD). J Neurosci Methods. 2015 Aug 30;252:1. doi: 10.1016/j.jneumeth.2015.05.007.

Womersley JS, Dimatelis JJ, Russell VA. Proteomic analysis of maternal separation-induced striatal changes in a rat model of ADHD: The spontaneously hypertensive rat. J Neurosci Methods. 2015 Aug 30;252:64-74. doi:10.1016/j.jneumeth.2015.01.031.

Dimatelis JJ, Hsieh JH, Sterley TL, Marais L, Womersley JS, Vlok M, Russell VA. Impaired Energy Metabolism and Disturbed Dopamine and Glutamate Signalling in the Striatum and Prefrontal Cortex of the Spontaneously Hypertensive Rat Model of Attention-Deficit Hyperactivity Disorder. J Mol Neurosci. 2015 Jul;56(3):696-707. doi: 10.1007/s12031-015-0491-z.

Yu D, Mathews CA, Scharf JM, Neale BM, Davis LK, Gamazon ER, Derks EM, Evans P, Edlund CK, Crane J, Fagerness JA, Osiecki L, Gallagher P, Gerber G, Haddad S, Illmann C, McGrath LM, Mayerfeld C, Arepalli S, Barlassina C, Barr CL, Bellodi L, Benarroch F, Berrió GB, Bienvenu OJ, Black DW, Bloch MH, Brentani H, Bruun RD, Budman CL, Camarena B, Campbell DD, Cappi C, Silgado JC, Cavallini MC, Chavira DA, Chouinard S, Cook EH, Cookson MR, Coric V, Cullen B, Cusi D, Delorme R, Denys D, Dion Y, Eapen V, Egberts K, Falkai P, Fernandez T, Fournier E, Garrido H, Geller D, Gilbert DL, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Hardy J, Heiman GA, Hemmings SM, Herrera LD, Hezel DM, Hoekstra PJ, Jankovic J, Kennedy JL, King RA, Konkashbaev AI, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Lupoli S, Macciardi F, Maier W, Manunta P, Marconi M, McCracken JT, Mesa Restrepo SC, Moessner R, Moorjani P, Morgan J, Muller H, Murphy DL, Naarden AL, Nurmi E, Ochoa WC, Ophoff RA, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner T, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosário MC, Rosenberg D, Ruhrmann S, Sabatti C, Salvi E, Sampaio AS, Samuels J, Sandor P, Service SK, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Turiel M, Valencia Duarte AV, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Weale M, Weiss R, Wendland JR, Westenberg HG, Shugart YY, Hounie AG, Miguel EC, Nicolini H, Wagner M, Ruiz-Linares A, Cath DC, McMahon W, Posthuma D, Oostra BA, Nestadt G, Rouleau GA, Purcell S, Jenike MA, Heutink P, Hanna GL, Conti DV, Arnold PD, Freimer NB, Stewart SE, Knowles JA, Cox NJ, Pauls DL. Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. Am J Psychiatry. 2015 Jan;172(1):82-93. doi:  10.1176/appi.ajp.2014.13101306.

McGrath LM, Yu D, Marshall C, Davis LK, Thiruvahindrapuram B, Li B, Cappi C, Gerber G, Wolf A, Schroeder FA, Osiecki L, O'Dushlaine C, Kirby A, Illmann C, Haddad S, Gallagher P, Fagerness JA, Barr CL, Bellodi L, Benarroch F, Bienvenu OJ, Black DW, Bloch MH, Bruun RD, Budman CL, Camarena B, Cath DC, Cavallini MC, Chouinard S, Coric V, Cullen B, Delorme R, Denys D, Derks EM, Dion Y, Rosário MC, Eapen V, Evans P, Falkai P, Fernandez TV, Garrido H, Geller D, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Heiman GA, Hemmings SM, Herrera LD, Hounie AG, Jankovic J, Kennedy JL, King RA, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Lochner C, Lowe TL, Lyon GJ, Macciardi F, Maier W, McCracken JT, McMahon W, Murphy DL, Naarden AL, Neale BM, Nurmi E, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Reus VI, Richter MA, Riddle M, Robertson MM, Rosenberg D, Rouleau GA, Ruhrmann S, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Tischfield JA, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Wendland JR, Shugart YY, Miguel EC, Nicolini H, Oostra BA, Moessner R, Wagner M, Ruiz-Linares A, Heutink P, Nestadt G, Freimer N, Petryshen T, Posthuma D, Jenike MA, Cox NJ, Hanna GL, Brentani H, Scherer SW, Arnold PD, Stewart SE, Mathews CA, Knowles JA, Cook EH, Pauls DL, Wang K, Scharf JM. Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. J Am Acad Child Adolesc Psychiatry. 2014 Aug;53(8):910-9. doi: 10.1016/j.jaac.2014.04.022.

Malan-Müller S, Seedat S, Hemmings SM. Understanding posttraumatic stress disorder: insights from the methylome. Genes Brain Behav. 2014 Jan;13(1):52-68. doi: 10.1111/gbb.12102.

Hemmings SM, Lochner C, van der Merwe L, Cath DC, Seedat S, Stein DJ. BDNF Val66Met modifies the risk of childhood trauma on obsessive-compulsive disorder. J Psychiatr Res. 2013 Dec;47(12):1857-63. doi: 10.1016/j.jpsychires.2013.08.012.

Davis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, Neale BM, Yang J, Lee SH, Evans P, Barr CL, Bellodi L, Benarroch F, Berrio GB, Bienvenu OJ, Bloch MH, Blom RM, Bruun RD, Budman CL, Camarena B, Campbell D, Cappi C, Cardona Silgado JC, Cath DC, Cavallini MC, Chavira DA, Chouinard S, Conti DV, Cook EH, Coric V, Cullen BA, Deforce D, Delorme R, Dion Y, Edlund CK, Egberts K, Falkai P, Fernandez TV, Gallagher PJ, Garrido H, Geller D, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Haddad S, Heiman GA, Hemmings SM, Hounie AG, Illmann C, Jankovic J, Jenike MA, Kennedy JL, King RA, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Macciardi F, McCracken JT, McGrath LM, Mesa Restrepo SC, Moessner R, Morgan J, Muller H, Murphy DL, Naarden AL, Ochoa WC, Ophoff RA, Osiecki L, Pakstis AJ, Pato MT, Pato  CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner TJ, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosàrio MC, Rosenberg D, Rouleau GA, Ruhrmann S, Ruiz-Linares A, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Valencia Duarte AV, Vallada H, Van Nieuwerburgh F, Veenstra-Vanderweele J, Walitza S, Wang Y, Wendland JR, Westenberg HG, Shugart YY, Miguel EC, McMahon W, Wagner M, Nicolini H, Posthuma D, Hanna GL, Heutink P, Denys D, Arnold PD, Oostra BA, Nestadt G, Freimer NB, Pauls DL, Wray NR, Stewart SE, Mathews CA, Knowles JA, Cox NJ, Scharf JM. Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet. 2013 Oct;9(10):e1003864. doi: 10.1371/journal.pgen.1003864.

Malan-Müller S, Hemmings SM, Spies G, Kidd M, Fennema-Notestine C, Seedat S. Shorter telomere length - A potential susceptibility factor for HIV-associated neurocognitive impairments in South African women. PLoS One. 2013;8(3):e58351. doi:  10.1371/journal.pone.0058351.

Suliman S, Hemmings SM, Seedat S. Brain-Derived Neurotrophic Factor (BDNF) protein levels in anxiety disorders: systematic review and meta-regression analysis. Front Integr Neurosci. 2013 Jul 29;7:55. doi: 10.3389/fnint.2013.00055.

Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Davis LK, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund CK, Rauch SL, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe HJ, Lennertz L, Wagner M, Bellodi L, Cavallini MC, Richter MA, Cook EH Jr, Kennedy JL, Rosenberg D, Stein DJ, Hemmings SM, Lochner C, Azzam A, Chavira DA, Fournier E, Garrido H, Sheppard B, Umaña P, Murphy DL, Wendland JR, Veenstra-VanderWeele J, Denys D, Blom R, Deforce D, Van Nieuwerburgh F, Westenberg HG, Walitza S, Egberts K, Renner T, Miguel EC, Cappi C, Hounie AG, Conceição do Rosário M, Sampaio AS, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato CN, Pato MT, Voyiaziakis E, Heutink P, Cath DC, Posthuma D, Smit JH, Samuels J, Bienvenu OJ, Cullen B, Fyer AJ, Grados MA, Greenberg BD, McCracken JT, Riddle MA, Wang Y, Coric V, Leckman JF, Bloch M, Pittenger C, Eapen V, Black DW, Ophoff RA, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs JR, Cookson MR, Singleton A; North American Brain Expression Consortium., Hardy J; UK Brain Expression Database., Crenshaw AT, Parkin MA, Mirel DB, Conti DV, Purcell S, Nestadt G, Hanna GL, Jenike MA, Knowles JA, Cox N, Pauls DL. Genome-wide association study of obsessive-compulsive disorder. Mol Psychiatry. 2013 Jul;18(7):788-98. doi: 10.1038/mp.2012.85.

Malan-Müller S, Hemmings SM, Seedat S. Big effects of small RNAs: a review of microRNAs in anxiety. Mol Neurobiol. 2013 Apr;47(2):726-39. doi: 10.1007/s12035-012-8374-6.

Hemmings SM, Martin LI, Klopper M, van der Merwe L, Aitken L, de Wit E, Black GF, Hoal EG, Walzl G, Seedat S. BDNF Val66Met and DRD2 Taq1A polymorphisms interact to influence PTSD symptom severity: a preliminary investigation in a South African population. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:273-80. doi: 10.1016/j.pnpbp.2012.10.011.

Botha M, Grace L, Bugarith K, Russell VA, Kidd M, Seedat S, Hemmings SM. The impact of voluntary exercise on relative telomere length in a rat model of developmental stress. BMC Res Notes. 2012 Dec 27;5:697. doi: 10.1186/1756-0500-5-697.

Womersley JS, Hsieh JH, Kellaway LA, Gerhardt GA, Russell VA. Maternal separation affects dopamine transporter function in the spontaneously hypertensive rat: an in vivo electrochemical study. Behav Brain Funct. 2011 Dec 1;7:49. doi: 10.1186/1744-9081-7-49.

Boardman L, van der Merwe L, Lochner C, Kinnear CJ, Seedat S, Stein DJ, Moolman-Smook JC, Hemmings SM. Investigating SAPAP3 variants in the etiology of obsessive-compulsive disorder and trichotillomania in the South African white population. Compr Psychiatry. 2011 Mar-Apr;52(2):181-7. doi: 10.1016/j.comppsych.2010.05.007.

Katerberg H, Lochner C, Cath DC, de Jonge P, Bochdanovits Z, Moolman-Smook JC, Hemmings SM, Carey PD, Stein DJ, Sondervan D, Boer JA, van Balkom AJ, Polman A, Heutink P. The role of the brain-derived neurotrophic factor (BDNF) val66met variant in the phenotypic expression of obsessive-compulsive disorder (OCD). Am J Med Genet B Neuropsychiatr Genet. 2009 Dec 5;150B(8):1050-62. doi: 10.1002/ajmg.b.30930.

Lochner C, Hemmings SM, Kinnear CJ, Nel D, Hemmings SM, Seedat S, Moolman-Smook JC, Stein DJ. Cluster analysis of obsessive-compulsive symptomatology: identifying obsessive-compulsive disorder subtypes. Isr J Psychiatry Relat Sci. 2008;45(3):164-76.

Lochner C, Seedat S, Hemmings SM, Moolman-Smook JC, Kidd M, Stein DJ. Investigating the possible effects of trauma experiences and 5-HTT on the dissociative experiences of patients with OCD using path analysis and multiple regression. Neuropsychobiology. 2007;56(1):6-13.

Hemmings SM, Kinnear CJ, Van der Merwe L, Lochner C, Corfield VA, Moolman-Smook JC, Stein DJ. Investigating the role of the brain-derived neurotrophic factor (BDNF) val66met variant in obsessive-compulsive disorder (OCD). World J Biol Psychiatry. 2008;9(2):126-34.

Hemmings SM, Kinnear CJ, Lochner C, Seedat S, Corfield VA, Moolman-Smook JC, Stein DJ. Genetic correlates in trichotillomania--A case-control association study in the South African Caucasian population. Isr J Psychiatry Relat Sci. 2006;43(2):93-101.

Hemmings SM, Stein DJ. The current status of association studies in obsessive-compulsive disorder. Psychiatr Clin North Am. 2006 Jun;29(2):411-44.

Lochner C, Kinnear CJ, Hemmings SM, Seller C, Niehaus DJ, Knowles JA, Daniels W, Moolman-Smook JC, Seedat S, Stein DJ. Hoarding in obsessive-compulsive disorder: clinical and genetic correlates. J Clin Psychiatry. 2005 Sep;66(9):1155-60.

Lochner C, Hemmings SM, Kinnear CJ, Niehaus DJ, Nel DG, Corfield VA, Moolman-Smook JC, Seedat S, Stein DJ. Cluster analysis of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder: clinical and genetic correlates. Compr Psychiatry. 2005 Jan-Feb;46(1):14-9.

Hemmings SM, Kinnear CJ, Lochner C, Niehaus DJ, Knowles JA, Moolman-Smook JC,Corfield VA, Stein DJ. Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates. Psychiatry Res. 2004 Sep 30;128(2):175-82.

Lochner C, Hemmings SM, Kinnear CJ, Moolman-Smook JC, Corfield VA, Knowles JA, Niehaus DJ, Stein DJ. Corrigendum to "gender in obsessive-compulsive disorder: clinical and genetic findings". Eur Neuropsychopharmacol. 2004 Oct;14(5):437-45.

Lochner C, Seedat S, Hemmings SM, Kinnear CJ, Corfield VA, Niehaus DJ, Moolman-Smook JC, Stein DJ. Dissociative experiences in obsessive-compulsive disorder and trichotillomania: clinical and genetic findings. Compr Psychiatry. 2004 Sep-Oct;45(5):384-91.​

Hemmings SM, Kinnear CJ, Niehaus DJ, Moolman-Smook JC, Lochner C, Knowles JA, Corfield VA, Stein DJ. Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder. Eur Neuropsychopharmacol. 2003 Mar;13(2):93-8. ​