TB Host genetics
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Division of Molecular Biology & Human Genetics


Tuberculosis Host Genetics


Gene-Gene Interactions

​Increasing evidence show that host genetic factors determine susceptibility to developing disease. These factors are complex, and examining them in isolation may result in missing the effect of factors that do not act independently, i.e. when the effect of one gene on disease outcome is modified by the variant of another gene.

It is therefore important to understand the role of gene-gene interactions, commonly referred to as epistasis, in susceptibility to tuberculosis infection.

The statistical tools and methods we use to find interactions in our large tuberculosis case-control sample bank are also relevant to other complex diseases with multiple underlying genetic causes.