​​​​​​​​​​Division of Molecular Biology & Human Genetics


​Mycobacteriology​​​: Host-Pathogen Mycobactomics​​


​Recent peer-reviewed​ publications


Kapp E, Calitz H, Streicher EM, Dippenaar A, Egieyeh S, Jordaan A, Warner DF,  Joubert J, Malan SF, Sampson SL. Discovery and biological evaluation of an adamantyl-amide derivative with likely MmpL3 inhibitory activity. Tuberculosis (Edinb). 2023 May 13;141:102350. doi: 10.1016/j.tube.2023.102350. https://www.sciencedirect.com/science/article/pii/S1472979223000483?via%3Dihub



Parbhoo T, Schurz H, Mouton JM, Sampson SL. Persistence of Mycobacterium tuberculosis in response to infection burden and host-induced stressors. Front Cell and Infect Microbiol. 2022 12:981827. doi: 10.3389/fcimb.2022.981827. PMID: 36530432 https://www.frontiersin.org/articles/10.3389/fcimb.2022.981827/full

Ncube P, Bagheri B, Goosen WJ, Miller MA, Sampson SL. Evidence, challenges, and knowledge gaps regarding latent tuberculosis in animals. Microorganisms. 10(9): 1845. doi: https://doi.org/10.3390/microorganisms10091845. PMID: 36144447 https://www.mdpi.com/2076-2607/10/9/1845

Parbhoo T, Sampson SL, Mouton JM. Phenotypic Adaptation of Mycobacterium tuberculosis to Host-Associated Stressors that Induce Persister Formation. Front Cell and Infect Microbiol. 2022 12:956607. doi: 10.3389/fcimb.2022.956607. PMID: 36237425 https://www.frontiersin.org/articles/10.3389/fcimb.2022.956607/full

Kriel NL, Newton-Foot M, Bennion OT, Aldridge BB, Mehaffy C, Belisle JT, Walzl G, Warren RM, Sampson SL, Gey van Pittius NC. Localization of EccA3 at the growing pole in Mycobacterium smegmatis. BMC Microbiol. 2022 22(1):140. doi: 10.1186/s12866-022-02554-6. PMID: 35590245 https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-022-02554-6

D'Souza S, Du Plessis SM, Egieyeh S, Bekale RB, Maphasa RE, Irabin AF, Sampson SL, Dube A. Physicochemical and Biological Evaluation of Curdlan-Poly(Lactic-Co-Glycolic Acid) Nanoparticles as a Host-Directed Therapy Against Mycobacterium tuberculosis. J Pharm Sci. 2022 111(2):469-478. doi: 10.1016/j.xphs.2021.09.012.  PMID: 34534573 https://www.sciencedirect.com/science/article/pii/S0022354921004810?via%3Dihub

Apiyo D, Mouton JM, Louw C, Sampson SL, Louw TM. Dynamic mathematical model development and validation of in vitro Mycobacterium smegmatis growth under nutrient- and pH-stress. J Theor Biol. 2022 7;532:110921. doi: 10.1016/j.jtbi.2021.11092. PMID: 34582827 https://www.sciencedirect.com/science/article/pii/S0022519321003404?via%3Dihub


Cloete R, Shahbaaz M, Grobbelaar M, Sampson SL, Christoffels A. In silico repurposing of a Novobiocin derivative for activity against latency associated Mycobacterium tuberculosis drug target nicotinate-nucleotide adenylyl transferase (Rv2421c). PLOS One. 2021 2;16(11):e0259348. doi: 10.1371/journal.pone.0259348. PMID: 34727137 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0259348

Chisompola NK, Streicher EM, Dippenaar A, Whitfield MG, Tembo M, Mwanza S, Warren RM, Sampson SL. Drug resistant tuberculosis cases from the Copperbelt province and Northern regions of Zambia: Genetic diversity, demographic and clinical characteristics. Tuberculosis. 2021 130:102122. doi: 10.1016/j.tube.2021.102122. PMID: 34517268 https://www.sciencedirect.com/science/article/pii/S147297922100072X?via%3Dihub

Paarwater BA, Mouton JM, Sampson SL, Malherbe ST, Shaw J, Walzl G, Kotze LA, Du Plessis N. Inhaled particulate matter affects immune responsiveness of human lung phagocytes to mycobacterial species. Am J Physiol Lung Cell Mol Physiol. 2021 1;321(3):L566-L575. doi: 10.1152/ajplung.00014.2021. PMID: 34287085 https://journals.physiology.org/doi/full/10.1152/ajplung.00014.2021

Gallant J, Heunis T, Beltran C, Schildermans K, Bruijns S, Mertens I, Bitter W, Sampson SL. PPE38-Secretion-Dependent Proteins of M. tuberculosis Alter NF-kB Signalling and Inflammatory Responses in Macrophages. Front Immunol. 2021 12 doi: 10.3389/fimmu.2021.702359/full. PMID: 34276695 https://www.frontiersin.org/articles/10.3389/fimmu.2021.702359/full

Kapp E, Joubert J, Sampson SL, Warner DF, Seldon R, Jordaan A, De Vos M, Sharma R, Malan SF. Antimycobacterial activity, synergism and mechanism of action evaluation of novel polycyclic amines against Mycobacterium tuberculosis. Adv Pharmacol Pharm Sci. 2021 11;2021:5583342. doi: 10.1155/2021/5583342. PMID: 34240057 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238621/


Full publication list available here​​​