Immunology Research Group
Welcome to Stellenbosch University

​Stellenbosch University Immunology Research Group



1. du Plessis N, Kleynhans L, Thiart L, van Helden P D, Brombacher F, Horsnell W G C and Walzl G. Acute helminth infection enhances early macrophage mediated control of mycobacterial infection. Mucosal Immunol (2013) 6:931-941.

2. Kleynhans La, Plessis N D, Allie N, Jacobs M, Kidd M, Helden P D v, Walzl G and Ronacher K. The Contraceptive Depot Medroxyprogesterone Acetate Impairs Mycobacterial Control and Inhibits Cytokine Secretion in Mice Infected with Mycobacterium tuberculosis. Infect. Immun. (2013) 81:1234-1244.

3. Cobat A, Hoal E G, Gallant C J, Simkin L, Black G F, Stanley K, Jaïs J-P, Yu T-H, Boland-Auge A, Grange G, Delacourt C, Helden P v, Casanova J-L, Abel L, Alcaïs A and Schurr E. Identification of a Major Locus, TNF1, That Controls BCG-Triggered Tumor Necrosis Factor Production by Leukocytes in an Area Hyperendemic for Tuberculosis. Clin Infect Dis. (2013) 57:963-970.

4. Cliff J M, Lee J-S, Constantinou N, Cho J-E, Clark T G, Ronacher K, King E C, Lukey P T, Duncan K, Helden P D V, Walzl G and Dockrell H M. Distinct Phases of Blood Gene Expression Pattern Through Tuberculosis Treatment Reflect Modulation of the Humoral Immune Response. J Infect Dis. (2013) 207:18-29.

5. Hemmings S MJ, Martin L I, Klopper M, van der Merwe L, Aitken L, de Wit E, Black G F, Hoal E G, Walzl G and Seedat S.BDNF Val66Met and DRD2 Taq1A polymorphisms interact to influence PTSD symptom severity: A preliminary investigation in a South African population. Progress in Neuro-Psychopharmacology and Biological Psychiatry (2013) 40:273-280.

6. Baumann R, Kaempfer S, Chegou N N, Nene N F, Veenstra H, Spallek R, Bolliger C T, Lukey P T, van Helden P D, Singh M and Walzl G. Serodiagnostic markers for the prediction of the outcome of intensive phase tuberculosis therapy. Tuberculosis (2013) 93:239-245.

7. Mihret A, Bekele Y, Bobosha K, Kidd M, Aseffa A, Howe R and Walzl G. Plasma cytokines and chemokines differentiate between active disease and non-active tuberculosis infection. Journal of Infection (2013) 66:357-365.

8. Chegou N N, Detjen A K, Thiart L, Walters E, Mandalakas A M, Hesseling A C and Walzl G. Utility of Host Markers Detected in Quantiferon Supernatants for the Diagnosis of Tuberculosis in Children in a High-Burden Setting. PLoS ONE (2013) 8:e64226.

9. Axelsson-Robertson R, Loxton A G, Walzl G, Ehlers M M, Kock M M, Zumla A and Maeurer M. A broad profile of co-dominant epitopes shapes the peripheral Mycobacterium tuberculosis specific CD8+ T-cell immune response in South African patients with active tuberculosis. PLoS ONE (2013) 8:e58309.

10. Ayepola O R, Chegou N N, Brooks N L and Oguntibeju O O. Kolaviron, a Garcinia biflavonoid complex ameliorates hyperglycemia-mediated hepatic injury in rats via suppression of inflammatory responses. BMC Complement Altern Med (2013) 13:363.

11. du Plessis N, Loebenberg L, Kriel M, von Groote-Bidlingmaier F, Ribechini E, Loxton A G, van Helden P D, Lutz M B and Walzl G. Increased frequency of myeloid-derived suppressor cells during active tuberculosis and after recent mycobacterium tuberculosis infection suppresses T-cell function. Am. J. Respir. Crit. Care Med. (2013) 188:724-732.

12. Kleinsteuber K, Heesch K, Schattling S, Kohns M, Sander-Jülch C, Walzl G, Hesseling A, Mayatepek E, Fleischer B, Marx F M and Jacobsen M. Decreased expression of miR-21, miR-26a, miR-29a, and miR-142-3p in CD4⁺ T cells and peripheral blood from tuberculosis patients. PLoS ONE (2013) 8:e61609.

13. Mandalakas A M, van Wyk S, Kirchner H L, Walzl G, Cotton M, Rabie H, Kriel B, Gie R P, Schaaf H S and Hesseling A C.Detecting tuberculosis infection in HIV-infected children: a study of diagnostic accuracy, confounding and interaction. Pediatr. Infect. Dis. J. (2013) 32:e111-118..

14. Phalane K G, Kriel M, Loxton A G, Menezes A, Stanley K, van der Spuy G D, Walzl G and Chegou N N. Differential expression of host biomarkers in saliva and serum samples from individuals with suspected pulmonary tuberculosis. Mediators Inflamm. (2013) 2013:981984.

15. Shenai S, Amisano D, Ronacher K, Kriel M, Banada P P, Song T, Lee M, Joh J S, Winter J, Thayer R, Via L E, Kim S, Barry C E 3, Walzl G and Alland D. Exploring alternative biomaterials for diagnosis of pulmonary tuberculosis in HIV-negative patients by use of the GeneXpert MTB/RIF assay. J. Clin. Microbiol. (2013) 51:4161-4166.

16. Sutherland J S, Lalor M K, Black G F, Ambrose L R, Loxton A G, Chegou N N, Kassa D, Mihret A, Howe R, Mayanja-Kizza H, Gomez M P, Donkor S, Franken K, Hanekom W, Klein M R, Parida S K, Boom W H, Thiel B A, Crampin A C, Ota M, Walzl G, Ottenhoff T H M, Dockrell H M, Kaufmann S H E and and the GCGH Biomarkers for TB consortium . Analysis of Host Responses to Mycobacterium tuberculosis Antigens in a Multi-Site Study of Subjects with Different TB and HIV Infection States in Sub-Saharan Africa. PLoS ONE (2013) 8:e74080.