Biochemistry
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Recent Publications

Journal Articles (subsidised)

ABRAHAMS S, SAMODIEN S, LILLY M, JOUBERT E, GELDERBLOM WCA. Differential Modulation of Gene Expression Encoding Hepatic and Renal Xenobiotic Metabolizing Enzymes by an Aspalathin-Enriched Rooibos Extract and Aspalathin. PLANTA MEDICA 2019; 85:6-13.

AFZAN A, BRÉANT L, BELLSTEDT DU, GRANT JR, QUEIROZ EF, WOLFENDER J-L, KISSLING J. Can biochemical phenotype, obtained from herbarium samples, help taxonomic decisions? – A case study using Gentianaceae. TAXON 2019; 68(4):771-782.

ALBERTS JF, SCHATZMAYR G, MOLL W-D, DAVIDS I, RHEEDER JP, BURGER H-M, SHEPHARD GS, GELDERBLOM WCA. Detoxification of the Fumonisin Mycotoxins in Maize: An Enzymatic Approach. Toxins 2019; 11:art no. 523, 15 pages.

BADENHORST M, BARRY CJ, SWANEPOEL CJ, VAN STADEN CT, WISSING J, ROHWER JM. Workflow for Data Analysis in Experimental and Computational Systems Biology: Using Python as 'Glue'. Processes 2019; 7:art. no. 460, 17 pages.

CLOETE WJ, HAYWARD S, SWART P, KLUMPERMAN L. Degradation of proteins and starch by combined immobilization of protease, alpha-amylase and beta-galactosidase on a single electrospun nanofibrous membrane. Molecules 2019; 24(3):508: 9.

DE JAGER C, ANECK-HAHN N, VAN ZIJL MC, HAYWARD S, SWART P, GENTHE B. Endocrine disrupting chemicals in commercially available cling film brands in South Africa. Human and Ecological Risk Assessment (HERA) 2019; 25(6):1633-1644.

DOMINGO RW, VAN DER WESTHUYZEN R, HAMANN AR, MOSTERT KJ, BARNARD L, PAQUET T, TJHIN ET, SALIBA KJ, VAN OTTERLO WAL, STRAUSS E. Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801. MedChemComm 2019; 10:2118-2125.

DREYER J, RAUTENBACH M, BOOYSEN E, VAN STADEN ADP, DEANE SM, DICKS LMT. Xenorhabdus khoisanae SB10 produces Lys-rich PAX lipopeptides and a Xenocoumacin in its antimicrobial complex. BMC MICROBIOLOGY 2019; 19(1):art no. 132, 11 pages.

GENT R, DU TOIT T, BLOEM LM, SWART AC. The 11β-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C19 steroids with 11βHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis. Journal of Steroid Biochemistry and Molecular Biology 2019; 189:116-126.

GENT R, DU TOIT T, SWART AC. 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro. Journal of Steroid Biochemistry and Molecular Biology 2019; 191:105369. 11 pages.

GUSTAVSSON A-K, BANAEIYAN AA, VAN NIEKERK DD, SNOEP JL, ADIELS CB, GOKSÖR M. Studying Glycolytic Oscillations in Individual Yeast Cells by Combining Fluorescence Microscopy with Microfluidics and Optical Tweezers. Current Protocols in Cell Biology 2019; 82(1):e70, 26 pages.

HAFERKAMP P, TJADEN B, SHEN L, BRÄSEN C, KOURIL T, SIEBERS B. The Carbon Switch at the Level of Pyruvate and Phosphoenolpyruvate in Sulfolobus solfataricus P2. Frontiers in Microbiology 2019; 10:art. no. 757, 13 pages.

JOUBERT E, DE BEER D, MALHERBE CJ, MULLER M, LOUW A, GELDERBLOM WCA. Formal honeybush tea industry reaches 20 year milestone- progress of product research targeting phenolic composition, quality and bioactivity. South African Journal of Botany 2019; 127:58-79.

JUHL DW, VAN RENSBURG W, BOSSIS X, VOSLOO JA, RAUTENBACH M, BECHINGER B. Tyrocidine A interactions with saccharides investigated by CD and NMR spectroscopies. JOURNAL OF PEPTIDE SCIENCE 2019; 25(5):e3163, 11 Pages.

LE MAITRE NC, PIRIE MD, BELLSTEDT DU. An approach to determining anthocyanin synthesis enzyme gene expression in an evolutionary context: an example from Erica plukenetii. Annals of Botany 2019; 124:121-129.

LE MAITRE NC, PIRIE MD, BELLSTEDT DU. Floral Color, Anthocyanin Synthesis Gene Expression and Control in Cape Erica Species. Frontiers in Plant Science 2019; 10:e1565, 9 pages.

LOOS B, KLIONSKY DJ, DU TOIT A, HOFMEYR JS. On the relevance of precision autophagy flux control in vivo - Points of departure for clinical translation. Autophagy 2019; 2019:13 pages.

LOUW A. GR Dimerization and the Impact of GR Dimerization on GR Protein Stability and Half-Life. Frontiers in Immunology 2019; 10:e1693, 15 pages.

NAGHILOO S, BELLSTEDT DU, CLABEN-BOCKHOFF R. The plasticity of breeding system in arid-adapted Zygophylloideae. JOURNAL OF ARID ENVIRONMENTS 2019; 162:1-9.

NEAL ML, KÖNIG M, NICKERSON D, MISIRLI G, KALBASI R, DRÄGER A, ATALAG K, CHELLIAH V, COOLING MT, COOK DL, CROOK S, DE ALBA M, FRIEDMAN SH, GARNY A, GENNARI H, GLEESON P, GOLEBIEWSKI M, HUCKA M, JUTY N, MYERS C, OLIVIER BG, SAURO HM, SCHARM M, SNOEP JL, ET. Harmonizing semantic annotations for computational models in biology. BRIEFINGS IN BIOINFORMATICS 2019; 20(2):540-550.

OAKES JA, LI N, WISTOW BRC, GRIFFIN A, BARNARD L, STORBECK K, CUNLIFFE VT, KRONE NP. Ferredoxin 1b Deficiency Leads to Testis Disorganization, Impaired Spermatogenesis, and Feminization in Zebrafish. Endocrinology 2019; 160(10):2401-2416.

PERKINS MS, LOUW-DU TOIT R, AFRICANDER DJ. Hormone therapy and breast cancer: emerging steroid receptor mechanisms. JOURNAL OF MOLECULAR ENDOCRINOLOGY 2019; 61(4):R133-R160.

PIRIE MD, KANDZIORA M, NÜRK NM, LE MAITRE NC, MUGRABI DE KUPPLER AL, GEHRKE B, OLIVER EGH, BELLSTEDT DU. Leaps and bounds: geographical and ecological distance constrained the colonisation of the Afrotemperate by Erica. BMC Evolutionary Biology 2019; 19:art. no. 222, 12 pages.

RÉGNIER M, POLIZZI A, LUKOWICZ C, SMATI S, LASSERRE F, LIPPI Y, NAYLIES C, LAFFITTE J, BÉTOULIÈRES C, MONTAGNER A, DUCHEIX S, GOURBEYRE P, ELLERO-SIMATOS S, GELDERBLOM WCA, ET AL. The protective role of liver X receptor (LXR) during fumonisin B1-induced hepatotoxicity. ARCHIVES OF TOXICOLOGY 2019; 93:505-517.

SAASA V, BEUKES M, LEMMER Y, MWAKIKUNGA B. Blood Ketone Bodies and Breath Acetone Analysis and their Correlations in Type 2 Diabetes Mellitus. Diagnostics 2019; 9(4):art no: 224, 10 pages.

SCHIFFER L, BARNARD L, BARANOWSKI ES, GILLIGAN L, TAYLOR AE, ARLT W, SHACKLETON CHL, STORBECK K. Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review. Journal of Steroid Biochemistry and Molecular Biology 2019; 194:art. no. 105439, 25 pages.

SHEPHARD GS, BURGER H-M, RHEEDER JP, ALBERTS JF, GELDERBLOM WCA. The effectiveness of regulatory maximum levels for fumonisin mycotoxins in commercial and subsistence maize crops in South Africa. Food Control 2019; 97:77-80.

SKOSANA SB, WOODLAND JG, CARTWRIGHT M, ENFIELD K, KOMANE M, LOUW-DU TOIT R, VAN DER SPUY ZM, AVENANT C, AFRICANDER DJ, STORBECK K, HAPGOOD JP. Differential metabolism of clinically-relevant progestogens in cell lines and tissue: Implications for biological mechanisms. Journal of Steroid Biochemistry and Molecular Biology 2019; 189:145-153.

STANDER MA, REDELINGHUYS H, MASIKE K, LONG H, VAN WYK B-E. Patterns of Variation and Chemosystematic Significance of Phenolic Compounds in the Genus Cyclopia (Fabaceae, Podalyrieae). Molecules 2019; 24:2352, 20 pages.

STEYN HM, VON STADEN L, BELLSTEDT DU, VAN DER MERWE PDW, VAN WYK AE. Notes on the phytogeography and conservation status of the genus Acanthopsis (Acantheae, Acanthaceae). Phytotaxa 2019; 415(4):157-178.

STORBECK K, SCHIFFER L, BARANOWSKI ES, CHORTIS V, PRETE A, BARNARD L, GILLIGAN L, TAYLOR AE, IDKOWIAK J, ARLT W, SHACKLETON CHL. Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism. ENDOCRINE REVIEWS 2019; 40(6):1605-1625.

SWART AC, JOHANNES ID, SATHYAPALAN T, ATKIN SL. The Effect of Soy Isoflavones on Steroid Metabolism. Frontiers in Endocrinology 2019; 10:art. no. 229, 10 Pages.

VAN NIEKERK DD, GUSTAVSSON A-K, MOJICA-BENAVIDES M, ADIELS CB, GOKSÖR M, SNOEP JL. Phosphofructokinase controls the acetaldehyde-induced phase shift in isolated yeast glycolytic oscillators. BIOCHEMICAL JOURNAL 2019; 476:353-363.

VOLKE DC, ROHWER JM, FISCHER R, JENNEWEIN S. Investigation of the methylerythritol 4‑phosphate pathway for microbial terpenoid production through metabolic control analysis. Microbial Cell Factories 2019; 18:e192, 15 pages.

VOSLOO JA, SNOEP JL, RAUTENBACH M. Modelling the variable incorporation of aromatic amino acids in the tyrocidines and analogous cyclodecapeptides. Journal of Applied Microbiology 2019; 127:1665-1676.

WIUM M, JONKER HI, OLIVIER A, BELLSTEDT DU, BOTES A. DNA vaccines against Mycoplasma elicit humoral immune responses in ostriches. Frontiers in Immunology 2019; 10:art. no. 1061, 9 pages.

Chapters in Books

STANFORD NJ, SCHARM M, DOBSON PD, GOLEBIEWSKI M, HUCKA M, KOTHAMACHU VB, NICKERSON D, OWEN S, PAHLE J, WITTIG U, WALTEMATH D, GOBLE C, MENDES P, SNOEP JL. Data Management in Computational Systems Biology: Exploring Standards, Tools, Databases, and Packaging Best Practices. In: Oliver SG, Castilla JC (eds.) Yeast Systems Biology. Methods in Molecular Bilogy, vol 2049, Humana, New York, USA, 2019: 285-314.

Doctorals completed

BALCOMB BH. The Staphylococcus aureus redoxome: Characterization of enzymes involved in oxidative stress resistance and survival. PhD, 2019. 214 pp. Promotor: STRAUSS E.

DU TOIT A. Measuring and Modelling Autophagic Flux. PhD, 2019. 232 pp. Promotor: LOOS B. Medepromotor: HOFMEYR JS.

JANA C. Synthesis, profiling and mode of action studies of PanSulfAms as inhibitors of coenzyme A biosynthesis and utilization. PhD, 2019. 182 pp. Promotor: STRAUSS E. Medepromotor: DE VILLIERS M.

Masters completed

BRINK D. Investigating progestin-mediated crosstalk between the androgen receptor and estrogen receptor subtypes in breast cancer cell lines. MSc, 2019. 136 pp. Studieleier: AFRICANDER DJ.

EKSTEEN A. Investigating the role of inflammation, progestins and steroid receptors in breast cancer. MSc, 2019. 118 pp. Studieleier: AFRICANDER DJ. Medestudieleier: VERHOOG NJD.

HORN S. A Comparative Analysis of Within-host Models of Malaria Infection with Immune Response. MSc, 2019. 121 pp. Studieleier: VAN NIEKERK DD. Medestudieleier: SNOEP JL.

MAMHENDE PGM. Investigation of the antifungal activity of tryptophan-rich cyclic peptides. MSc, 2019. 162 pp. Studieleier: RAUTENBACH M.

MUIYSER SM. The role of PFK in the oscillatory yeast strain x2180. MSc, 2019. 93 pp. Studieleier: VAN NIEKERK DD. Medestudieleier: SNOEP JL.

ODENDAAL JCW. Glycolytic Flux Control of Glyceraldehyde 3-Phosphate Dehydrogenase in Yeast. MSc, 2019. 154 pp. Studieleier: SNOEP JL. Medestudieleier: VAN NIEKERK DD.

VAN WYK M. The eect of adenylate kinase on the glycolytic oscillations of Saccharomyces cerevisiae. MSc, 2019. 86 pp. Studieleier: SNOEP JL. Medestudieleier: VAN NIEKERK DD, KOURIL T.

VAN WYK RJ. Development of cyclodecapeptides from the tyrothricin complex as anticancer peptides. MSc, 2019. 174 pp. Studieleier: RAUTENBACH M.