​​​​​​​​​​​​​Research

Publications (2007-2023)

​

2023

Journal Articles ​

​BOTHA JC, DEMIROV D, GORDJIN C, KATUSIIME MG, BALE MJ, WU X, WELLS D, HUGHES SH, COTTON MF, MELLORS JW, KEARNEY MF, VAN ZYL GU. The largest HIV-1-infected T cell clones in children on long-term combination antiretroviral therapy contain solo LTRs. mBio 2023; 14(4):e0111623, 14 pages.

 CUPIDO DT, DE BEER C. Screening for viral pathogens in the gastrointestinal tract from cases of sudden unexpected death in infancy at the Tygerberg Medico-legal Mortuary. Virology Journal 2023; 20(1):281.

 DAVIES M, MORDEN E, ROUSSEAU P, ARENDSE J, BAM J, PREISER W, ET AL ET. Outcomes of laboratory-confirmed SARS-CoV-2 infection during resurgence driven by Omicron lineages BA.4 and BA.5 compared with previous waves in the Western Cape Province, South Africa. Journal of Infectious Diseases 2023; 127:63-68.

 DAVIES M-A, MORDEN E, ROUSSEAU P, ARENDSE J, BAM J-L, BOLOKO L, CLOETE K, COHEN C, CHETTY N, DANE P, HEEKES A, HSIAO N, HUNTER M, HUSSEY H, JACOBS T, JASSAT W, KARIEM S, KASSANJEE R, LAENEN IJ, LE ROUX S, LESSELLS R, MAHOMED H, MAUGHAN D, MEINTJES G, MEND. Outcomes of laboratory-confirmed SARS-CoV-2 infection during resurgence driven by Omicron lineages BA.4 and BA.5 compared with previous waves in the Western Cape Province, South Africa. International Journal of Infectious Diseases 2023; 127:63-68.

 DE MOOR WRJ, WILLIAMSON A, SCHÄFER G, DOUGLASS N, GERS S, SUTHERLAND AD, BLUMENTHAL M, MARGOLIN E, SHAW ML, PREISER W, CHAPMAN R. LSDV-Vectored SARS-CoV-2 S and N Vaccine Protects against Severe Clinical Disease in Hamsters. Viruses-Basel 2023; 15(7):1409.

DELANEY KE, NGOBENI T, WOODS C, GORDJIN C, CLAASSEN M, PARIKH UM, HARRIGAN R, VAN ZYL GU. Nano-RECall provides an integrated pipeline for HIV-1 drug resistance testing from Oxford Nanopore sequence data. Tropical Medicine and Health 2023; 28(3):186-193.

 DELPHIN M, DOWNS L, MARTYN E, KELLY G, VAN SCHALKWYK M, HUGO SS, WADDILOVE E, CAMPBELL C, WANG T, LUMLEY S, DE LARA C, GOEDHALS D, VAN RENSBURG CJ, WAREING S, PREISER W, GABRIEL MS, TALJAARD JJ, ANDERSSON MI, MAPONGA TG, FENGOU P. Contrasting immune fingerprints of chronic hepatitis B Virus infection in adults from South Africa and the United Kingdom. JOURNAL OF HEPATOLOGY 2023; 78(1):1108-1109.​

DEWANDEL I, VAN NIEKERK MS, WALTERS E, PALMER M, ANTHONY MG, MCKENZIE C, CROUCAMP R, ALTER G, DEMERS A, VAN ZYL GU, CLAASSEN M, GOUSSARD P, HODDINOTT G, BOSCH C, DUNBAR R, ALLWOOD BW, MCCOLLUM E, SCHAAF HS, HESSELING AC, VAN DER ZALM MM. UMOYA: A prospective longitudinal cohort study to evaluate novel diagnostic tools and to assess long-term impact on lung health in South African children with presumptive pulmonary TB – a study protocol. BMC Pulmonary Medicine 2023; 23:97, 11 pages.

HAKE A, GERMANN A, DE BEER C, THIELEN A, DÄUMER M, PREISER W, VON BRIESEN H, PFEIFER N. Insights toHIV-1coreceptor usage by estimating HLA adaptation with Bayesian generalized linear mixed models. PLoS Computational Biology 2023; 12:1-21.

 INZUALE SC, SIEDNER MJ, LITTLE SJ, VAN ZYL GU, ET AL ET. Recommendations on data sharing in HIV drug resistance research. PLoS Medicine 2023; 20(9):e1004293.

ISA Y, ANDERSSON MI, ET AL ET. Informing a target product profile for rapid tests to identify HBV‑infected pregnant women with high viral loads: a discrete choice experiment with African healthcare workers. BMC Medicine 2023; 21(1):243.

 ISMAEL N, VAN WYK S, TEGALLY H, GIANDHARI J, SAN E J, MOIR MI, PILLAY S, UTPATEL C, SINGH L, NAIDOO Y, RAMPHAL U, XAVIER J, RAMPHAL Y, MAHARAJ A, ANYANEJI UJ, TSHIABUILA DK, LESSELLS R, WILKINSON E, DE OLIVEIRA T. Genomic epidemiology of SARS-CoV-2 during the first four waves in Mozambique. PLOS Global Public Health 2023; 6(3):e0001593, 16 pages.

 JOHANNESSEN A, STOCKDALE A, HENRION MYR, OKEKE E, SEYDI M, WANDELER G, SONDERUP MW, SPEARMAN CW, VINIKOOR M, SINKALA E, DESALEGN H, MAPONGA TG, ET AL E. Systematic review and individual-patient-data meta-analysis of non-invasive fibrosis markers for chronic hepatitis B in Africa. Nature Communications 2023; 14(1):45.

 KEENE C, CASSIDY T, ZHAO Y, GRIESEL R, JACKSON A, SAYED K, OMAR Z, HILL A, NGWENYA O, VAN ZYL GU, FLOWERS T, GOEMAERE E, MAARTENS G, MEINTJIES G. Recycling Tenofovirin Second-line Antiretroviral Treatment With Dolute gravir: Outcomes and Vira lLoad Trajectoriesto 72weeks. CLINICAL SCIENCE 2023; 92(5):422-429.

 MAPONGA TG, JEFFRIES ML, SUTHERLAND AD, TEGALLY H, WILKINSON E, LESSELS R, MSOMI N, VAN ZYL GU, DE OLIVEIRA T, PREISER W. Reply to Molldrem. Clinical Infectious Diseases 2023; 76(9):1702-1703.

 MAPONGA TG, JEFFRIES ML, TEGALLY H, SUTHERLAND AD, WILKINSON E, LESSELS R, MSOMI N, VAN ZYL GU, DE OLIVEIRA T, PREISER W. Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection With accumulation of mutations in a patient with poorly controlled Human Immunodeficiency Virus infection. Infectious Diseases 2023; 76(3):E522-E525.

MARGOLIN E, SCHAFER G, ALLEN JD, GERS S, WOODWARD JD, SUTHERLAND AD, BLUMENTHAL M, MEYERS A, SHAW ML, PREISER W, STRASSER R, CRISPIN M, WILLIAMSON A, RYBICKI EP, CHAPMAN R. A plant-produced SARS-CoV-2 spike protein elicits heterologous immunity in hamsters. Frontiers 2023; 14:1-14.

MARTYN E, EISEN S, LONGLEY N, HARRIS P, SUREY J, NORMAN H, BROWN M, SULTAN B, MAPONGA TG, ET AL ET. The forgotten people: Hepatitis B virus (HBV) infection as a priority for the inclusion health agenda. eLife 2023; 12(E81070):1-22.

MCINZIBA A, WADEMAN DT, VILJOEN L, MYBURGH H, JENNINGS L, DECLOEDT EH, ORRELL C, VAN ZYL GU, VAN SCHALKWYK M, GANDHI M, HODDINOTT G. Perspectives of people living with HIV and health workers about a point-of-care adherence assay: a qualitative study on acceptability. AIDS Care-Psychological and Socio-Medical Aspects of AIDS/HIV 2023; 35(10):1628-1634.

MOFOKENG N, MAPONGA TG, VAN SCHALKWYK M, MOROBADI MD, VAWDA S, BADENHORST L, VAN VUUREN C, PREISER W, VAN RENSBURG CJ, TALJAARD JJ, MILLER V, WANG S, WU D, TUCKER JD, SEELEY J, GOEDHALS D, MATTHEWS P. Barriers that prevent adults living with HBV infection from participating in clinical research: experience from South Africa. Journal of Virus Eradication 2023; 9(1):1-4.

MOOLLA MS, MAPONGA TG, MOOLLA H, ANIE SJ, MOOLLA A, MOODLEY D, LALLA U, ALLWOOD BW, SCHRUEDER N, PREISER W, KOEGELENBERG CFN, PARKER A. A tale of two waves: characteristics and outcomes of COVID-19 admissions during the Omicron-driven fourth wave in Cape Town, South Africa, and implications for the future. IJID Regions 2023; 6:42-47.

MOOSA MS, RUSSOMANNO G, DORFMAN JR, GUNTER H, PATEL C, COSTELLO E, CARR D, MAARTENS G, PIRMOHAMED M, GOLDRING C, COHEN K. Analysis of serum microRNA-122 in a randomized controlled trial of N-acetylcysteine for treatment of antituberculosis drug-induced liver injury. British Journal of Clinical Pharmacology 20223; 89(6):1844-1851.

MWAPE I, LABAN NM, CHIBESA K, MOONO A, SILWAMBA S, MALISHENI MM, CHISENGA C, CHAUWA A, SIMUSIKA P, PHIRI M, SIMUYANDI M, CHILENGI R, DE BEER C, OJOK D. Characterization of Rotavirus Strains Responsible for Breakthrough Diarrheal Diseases among Zambian Children Using Whole Genome Sequencing. Vaccines 2023; 11(12):1759.

NORMAN SA, PALIC D, SAVAGE ACNP, PLÖN SEE, ET AL ET. Editorial: Aquatic one health — the intersection of marine wildlife health, public health, and our oceans. Frontiers 2023; 10:1227121.

OLWAGEN CP, IZU A, MUTSAERTS EAML, JOSE L, KOEN A, DOWNS S, VAN DER MERWE L, LAUBSCHER M, NANA A, MOULTRIE A, CUTLAND C, DORFMAN JR, MADHI SA. Single priming and booster dose of ten-valent and 13-valent pneumococcal conjugate vaccines and Streptococcus pneumoniae colonisation in children in South Africa: a single-centre, open-label, randomised trial. Lancet 2023; 7(5):326-335.

PLÖN SEE, ROUSSOUW N, UREN R, NAIDOO K, SIEBERT U, CLIFF G, BOUWMAN H. Elements in muscle tissue of three dolphin species from the east coast of South Africa. Marine Pollution Bulletin 2023; 188:114707.

 PREISER W, MAPONGA TG. So far, no novel SARS-CoV-2 variants from Beijing—and hopefully better scientific cooperation going forward. Lancet 2023; 401(10377):621-622.

RAMOCHA LM, DORFMAN JR, GROOME MJ, BAILLIE V, VERWEY C, LAUBSCHER M, NUNES MC, MADHI SA. Human Metapneumovirus Associated Hospitalization in HIV-1 Exposed Uninfected and HIV-1 Uninfected Children Less Than 5 Years in South Africa. Journal of Pediatric Infectious Diseases 2023; 12(1):53-55.

REDFERN A, VAN DER ZALM MM, LISHMAN J, GOUSSARD P, SMIT EJ, DAGAN R, BARDAY MM, MARE ML, CLAASSEN M, VAN ZYL GU, RABIE H, VERHAGEN LM. Clinical presentation and outcome of acute respiratory illnesses in South African children during the COVID-19 pandemic. Pediatric Infectious Disease Journal 2023; 42(8):672-678.

RICHES N, VINIKOOR M, GUINGANE A, JOHANNESSEN A, LEMOINE M, MATTHEWS PC, OKEKE E, SHIMAKAWA Y, MAPONGA TG, TALJAARD JJ, ANDERSSON MI, SOMBIE R, STOCKDALE AJ, WANDELER G, DAVWAR PM, DESALEGN H, DUGURU M, FALL F, PAUL DN, SEYDI M, ET AL. Hepatitis B in Africa Collaborative Network: cohort profile and analysis of baseline data. Epidemiology and Infection 2023; 151:1-10.

RUHANYA V, JACOBS GB, PAUL RH, JOSKA JA, SEEDAT S, NYANDORO G, GLASHOFF RH, ENGELBRECHT S. HIV-1 subtype C Vpr amino acid residue 45Y and specific conserved fragments are associated with neurocognitive impairment and markers of viral load. AIDS Research and Human Retroviruses 2023; 39(4):166-175.

SCOTT LE, HSIAO N-Y, DOR G, HANS L, MAROKANE P, DA SILVA MP, PREISER W, VREEDE H, TSOKA J, MLISANA K, STEVENS WS. How South Africa Used National Cycle Threshold (Ct) Values to Continuously Monitor SARS-CoV-2 Laboratory Test Quality. Diagnostics 2023; 13(15):2554.

STEEGEN K, VAN ZYL GU, CLAASSEN M, KHAN A, PILLAY M, GOVENDER S, BESTER PA, VAN STRAATEN JM, KANA V, CUTLER E, KALIMASHE MN, LEBELO RL, MOLOI MBH, HANS L. Advancing HIV Drug Resistance Technologies and Strategies: Insights from South Africa's Experience and Future Directions for Resource-Limited Settings. Diagnostics 2023; 13(13):2209.

SWANEPOEL J, VAN DER ZALM MM, PREISER W, VAN ZYL GU, WHITTAKER E, HESSELING AC, MOORE D, SEDDON JA. SARS-CoV-2 infection and pulmonary tuberculosis in children and adolescents: a case-control study. BMC Infectious Diseases 2023; 23:442, 10 pages.

SWANEPOEL J, VAN ZYL GU, HESSELING AC, JOHNSON SM, MOORE DAJ, SEDDON JA. Human Cytomegalovirus Immunoglobulin G Response and Pulmonary Tuberculosis in Adolescents: A Case-Control Study. Infectious Diseases Now 2023; 10(11):ofad487.

ZHAO Y, GRIESEL R, OMAR Z, SIMMONS B, HILL A, VAN ZYL GU, KEENE C, MAARTENS G, MEINTJIES G. Initial Supplementary Dose of Dolutegravir in Second-Line Antiretroviral Therapy: A Noncomparative, Double-Blind, Randomized Placebo-Controlled Trial. Clinical Infectious Diseases 2023; 76(10):1832-1840.​

2022

Journal Articles 

ABDULLAH IMI, CORNELISSEN HM, MUSEKWA EM, ZEMLIN A, JALAVU TP, MASHIGO N, CHETTY C, NKOSI NP, CHAPANDUKA ZC. Hematological findings in adult patients with SARS CoV-2 infection at Tygerberg Hospital Cape Town South Africa. Health Science Reports 2022; 5(e550):9 pages.

BARENG OT, MOYO S, MARUAPULA D, MORAKA ON, ET AL. HIV-1 drug resistance mutations among individuals with low-level viraemia while taking combination ART in Botswana. Journal of Antimicrobial Chemotherapy 2022; 77(5):1385-1395.

BOTHA JC, STEEGEN K, EDOO M, NEL J, VAN ZYL GU. Low-level viraemia despite emergence of dolutegravir-resistant variants. Southern African Journal of HIV Medicine 2022; 23(1):a1398, 4 pages.

BUNCH CM, MOORE EE, MOORE HB, NEAL MD, THOMAS AV, ZACKARIYA N, ZHAO J, ZACKARIYA S, BRENNER TJ, BERQUIST M, BUCKNER H, WIARDA G, FULKERSON D, HUFF W, KWAAN H, LANKOWICZ G, LAUBSCHER GJ, LOURENS PJ, PRETORIUS E, KOTZE MJ, MOOLLA MS, SITHOLE SH, MAPONGA TG,. Immuno-Thrombotic Complications of COVID-19: Implications for Timing of Surgery and Anticoagulation. Frontiers in Surgery 2022; 9:889999, 23 pages.

BUST L, BERKOWITZ N, ARCHER E, DAVIES M-A, PREISER W, STREET RA, SUCHARD M, LONDON LL. The SACCESS network for COVID-19 wastewater surveillance: a national collaboration for public health responsiveness. South African Health Review 2021; 2021(1):215-223.

CAPUTO M, BOUVEROUX T, VAN DER BANK M, CLIFF G, KISZKA JJ, FRONEMAN PW, PLÖN SEE. Inter- and intra-specific trophic interactions of coastal delphinids off the eastern coast of South Africa inferred from stable isotope analysis. Marine Environmental Research 2022; 182:105784, 10 pages.

DAVIES M-A, KASSANJEE R, ROUSSEAU P, MORDEN E, JOHNSON LF, SOLOMON W, HSIAO M, HUSSEY H, MEINTJES G, PALEKER M, PREISER W, SCHRUEDER N, PROZESKY HW, TALJAARD J, PARKER A, ET AL. Outcomes of laboratory-confirmed SARS-CoV-2 infection in the Omicron-driven fourth wave compared with previous waves in the Western Cape Province, South Africa. Tropical Medicine and International Health 2022; 27:564-573.

DAVIES M-A, KASSANJEE R, ROUSSEAU P, MORDEN E, JOHNSON LF, SOLOMON W, HSIAO N, HUSSEY H, MEINTJIES G, PALEKER M, JACOBS T, RAUBENHEIMER PJ, HEEKES A, DANE P, BAM J, SMITH M, PREISER W, ET AL ET. Outcomes of laboratory-confirmed SARS-CoV-2 infection in theOmicron-driven fourth wave compared with previous waves in theWestern Cape Province, South Africa. Tropical Medicine and International Health 2022; 27(6):564-573.​

DU PLESSIS E, VAN NIEKERK D, ROSENKRANZ BF, PREISER W. After the COVID-19 state of disaster in South Africa. Nature Human Behaviour 2022; 6(7):901.

FOGEL JM, WILSON EA, PIWOWAR-MANNING E, BREAUD A, CLARKE W, PETROPOULOS C, MOORE A, FRASER C, KOSLOFF B, SHANAUBE K, VAN ZYL GU, DUPRÉ M, FLOYD S, BOCK PA, ET AL AL. HIV drug resistance in a community-randomized trial of universal testing and treatment: HPTN071 (PopART). Journal of the International AIDS Society 2022; 25:e25941, 8 pages.

GOUSSARD P, SCHUBERT P, PARKER NM, MYBURGH C, RABIE H, VAN DER ZALM MM, VAN ZYL GU, PREISER W, MAPONGA TG, VERSTER J, GIE AG, ANDRONIKOU S. Fatal SARS-CoV-2 Omicron variant in a young infant: Autopsy findings. Pediatric Pulmonology 2022; 57(5):1363-1365.

GROBBELAAR LM, KRUGER A, VENTER C, BURGER EM, LAUBSCHER GJ, MAPONGA TG, KOTZE MJ, KWAAN H, PRETORIUS E, KELL DB, ET AL ET. Relative Hypercoagulopathy of the SARS-CoV-2 Beta and Delta Variants when Compared to the Less Severe Omicron Variants Is Related to TEG Parameters, the Extent of Fibrin Amyloid Microclots, and the Severity of Clinical Illness. Seminars in Thrombosis and Hemostasis 2022; 48(7):858-868.

HASSAN KM, DOUBELL AF, KYRIAKAKIS CG, JOUBERT LH, ROBBERTSE PS, VAN ZYL GU, ZAHARIE SD, HERBST PG. Comparing the findings and diagnostic sensitivity of cardiovascular magnetic resonance in biopsy confirmed acute myocarditis with infarct-like vs. heart failure presentation. Journal of Cardiovascular Magnetic Resonance 2022; 24:69, 10 pages.

 HASSAN KM, KYRIAKAKIS CG, DOUBELL AF, VAN ZYL GU, CLAASSEN M, ZAHARIE SD, HERBST PG. Prevalence of cardiotropic viruses in adults with clinically suspected myocarditis in South Africa. Open Heart 2022; 9(1):e001942, 7 pages.​

HASSAN KM, KYRIAKAKIS CG, JOUBERT LH, VAN ZYL GU, ZAHARIE SD, DOUBELL AF, HERBST PG. Routine use of fluoroscopic and real-time transthoracic echocardiographic guidance to ensure safety of right ventricular endomyocardial biopsy in a low-volume center. Catheterization and Cardiovascular Interventions 2022; 99:1563-1571.

HENERICO S, LYIMO E, MAKUBI AN, MAGESA D, DESDERIUS B, MUELLER A, CHANGALUCHA J, KALLUVYA SE, VAN ZYL GU, PREISER W, MSHANA SE, KASANG C. Primary resistance against integrase strand transfer inhibitors in integrase strand transfer inhibitor-naive patients failing first- and second-line Art in Tanzania. Journal of Antimicrobial Chemotherapy 2022; 77(11):3138-3143.

HUSSEY H, DAVIES M-A, HEEKES A, WILLIAMSON C, VALLEY-OMAR Z, HARDIE D, KORSMAN SNJ, DOOLABH D, PREISER W, MAPONGA TG, IRANZADEH A, WASSERMAN S, BOLOKO L, SYMONS G, RAUBENHEIMER PJ, PARKER A, SCHRUEDER N, ET AL ET AL. Assessing the clinical severity of the Omicron variant in the Western Cape Province, South Africa, using the diagnostic PCR proxy marker of RdRp target delay to distinguish between Omicron and Delta infections – a survival analysis. International Journal of Infectious Diseases 2022; 118:150-154.

ISMAEL N, WILKINSON E, MAHUMANE I, GEMUSSE H, GIANDHARI J, BAUHOFER A, VUBIL A, MAMBO P, SINGH L, MABUNDA N, BILA D, ENGELBRECHT S, GUDO E, LESSELLS R, DE OLIVEIRA T. Molecular epidemiology and trends in HIV-1 transmitted drug resistance in Mozambique 1999-2018. Viruses-Basel 2022; 14(9):1992, 14 pages.

JENNINGS L, KELLERMANN TA, SPINELLI M, NKANTSU Z, COGILL D, VAN SCHALKWYK M, DECLOEDT EH, VAN ZYL GU, ORRELL C, GANDHI M. Drug resistance, rather than low tenofovir levels in blood or urine, is associated with tenofovir, emtricitabine and efavirenz failure in resource-limited settings. AIDS Research and Human Retroviruses 2022; 38(6):455-462.

JOHNSON R, MANGWANA N, SHARMA JR, MULLER CJF, MALEMELA K, MASHAU F, DIAS SC, RAMHARACK P, KINNEAR CJ, GLANZMANN B, VIRARAGAVAN A, LOUW J, SURUJLAL-NAICKER S, NKAMBULE S, WEBSTER C, MDHLULI M, GRAY G, MATHEE A, PREISER W, VORSTER AA, DALVIE S, STREET RA. Delineating the Spread and Prevalence of SARS-CoV-2 Omicron Sublineages (BA.1–BA.5) and Deltacron Using Wastewater in the Western Cape, South Africa. Journal of Infectious Diseases 2022; 226(8):1418-1427.

JOHNSON R, SHARMA JR, RAMHARACK P, MANGWANA N, KINNEAR CJ, VIRARAGAVAN A, GLANZMANN B, LOUW J, ABDELATIF N, REDDY T, SURUJLAL-NAICKER S, NKAMBULE S, MAHLANGENI N, WEBSTER C, MDHLULI M, GRAY G, MATHEE A, MULLER CJF, PREISER W, STREET RA. Tracking the circulating SARS‑CoV‑2 variant of concern in South Africa using wastewater‑based epidemiology. Scientific Reports 2022; 12:1182, 12 pages.

KARIUKI S, SELHORST P, ANTHONY C, MATTEN D, ABRAHAMS M-R, MARTIN D, ARIËN KK, REBE K, WILLIAMSON C, DORFMAN JR. Compartmentalization and clonal amplification of hiv-1 in the male genital tract characterized using next-generation sequencing. Journal of Virology 2020; 94(12):e00229-20, 18 pages.

KARIUKI S, SELHORST P, NORMAN J, COHEN K, REBE K, WILLIAMSON C, DORFMAN JR. Detectable HIV-1 in semen in individuals with very low blood viral loads. Virology Journal 2020; 17(29):2-5.

KUHLMANN C, MAYER CK, CLAASSEN M, MAPONGA TG, BURGERS WA, KEETON R, RIOU C, SUTHERLAND AD, SULIMAN T, SHAW ML, PREISER W. Breakthrough infections with SARS-CoV-2omicron despite mRNA vaccine booster dose. LANCET Infectious Diseases 2022; 399(10325):625-627.

MAEPA MB, ELY A, KRAMVIS A, BLOOM K, NAIDOO K, SIMANI OE, MAPONGA TG, ARBUTHNOT P. Hepatitis B Virus Research in South Africa. Viruses-Basel 2022; 14:1939, 22 pages.

MAHLAKWANE KL, PREISER W, NKOSI NP, NAIDOO N, VAN ZYL GU. Delays in HIV-1 infant polymerase chain reaction testing may leave children without confirmed diagnoses in the Western Cape province, South Africa. African Journal of Laboratory Medicine 2022; 11(1):a1485, 7 pages.

MANGWANA N, ARCHER E, MULLER CJF, PREISER W, WOLFAARDT GM, KASPRZYK-HORDERN B, CARSTENS A, BRÖCKER JHL, WEBSTER C, MCCARTHY D, STREET RA, MATHEE A, LOUW J, MDHLULI M, JOHNSON R. Sewage surveillance of SARS-CoV-2 at student campus residences in the Western Cape, South Africa. Science of the Total Environment 2022; 851(1):158028, 11 pages.

MATTHEWS PC, MAPONGA TG, GHOSH I, LEMOINE M, OCAMA P, ABUBAKAR I, STORY A, FLANAGAN S. Hepatitis B Virus: Infection, liver disease,carcinogen or syndemic threat? Remodelling the clinical and public health response. PLOS Global Public Health 2022; 2(12):e0001359, 5 pages.

MOYO T, GULEID FH, SCHOMAKER M, WILLIAMSON C, DORFMAN JR. HIV-1 Subtype C Tier 3 Viruses Have Increased Infectivity Compared to Tier 2 Viruses. AIDS Research and Human Retroviruses 2020; 36(12):1010-1019.

MSOMI N, MLISANA K, DE OLIVEIRA T. A genomics network established to respond rapidly to public health threats in South Africa. Lancet 2020; 1:E229-E230.

NELSON A, CASSIDY T, DURAN LT, COX V, WEDDERBURN CJ, GIDDY J, PIETERS P, COTTON MF, MUTSEYEKWA T, RORWANA B, SIBANDA B, BERNHEIMER J, MARITZ J, ET AL E. An analysis of the HIV testing cascade of a group of HIV-exposed infants from birth to 18 months in peri-urban Khayelitsha, South Africa. PLoS One 2022; 17(1):e0262518, 14 pages.

PREISER W, ENGELBRECHT S, MAPONGA TG. No point in travel bans if countries with poor surveillance are ignored. Lancet 2022; 399(10331):1224.

PREISER W, FISH TD. Sisonke: reaching several goals together. LANCET Infectious Diseases 2022; 399(10330):1095-1097.

RABIE H, FRIGATI LJ, NKOSI NP. Cytomegalovirus and tuberculosis disease in children. Lancet 2022; 9(12):e1636-e1637.

RAMOCHA LM, VAN DEN HOOGEN BG, BAILLIE V, VAN NIEUWKOOP S, CUTLAND C, JONES S, MOULTRIE A, IZU A, VERWEY C, MADHI SA, DORFMAN JR. Fetal Transfer of Human Metapneumovirus-Neutralizing Antibodies Is Reduced From Mothers Living With HIV-1. Pediatric Infectious Disease Journal 2022; 11(7):341-344.

ROUSSOUW N, VAN VLIET T, NAIDOO K, ROUSSOUW G, PLÖN SEE. Histomorphological stratification of blubber of three dolphin species from subtropical waters. Journal of Morphology 2022; 283:1411-1423.​

RUHANYA V, JACOBS GB, PAUL RH, JOSKA J, SEEDAT S, NYANDORO G, GLASHOFF RH, ENGELBRECHT S. HIV‑1 subtype C Tat exon‑1 amino acid residue 24K is a signature for neurocognitive impairment. Journal of Neurovirology 2022; 28(3):392-403.

RYDÉN H, NICOLINI LA, ANDERSSON MI, SAID ZNA, SALLAM M, SAHIN GO. Isolated anti-HBc: reflections from clinical microbiology and infectious diseases. Germs 2022; 12(2):155-157.

SCHEEPERS C, EVERATT J, AMOAKO DG, TEGALLY H, WIBMER CK, MNGUNI A, ISMAIL A, MAHLANGU B, LAMBSON BE, MARTIN D, WILKINSON E, SAN JE, GIANDHARI J, MANAMELA N, NTULI N, KGAGUDI P, CELE SC, RICHARDSON SI, PILLAY S, MOHALE T, RAMPHAL U, NAIDOO Y, KHUMALO ZTH. Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage. Nature Communications 2022; 13(1):1976, 9 pages.

SCHOEMAN RP, ERBE C, PLÖN SEE. Underwater Chatter for the Win: A First Assessment of Underwater Soundscapes in Two Bays along the Eastern Cape Coast of South Africa. Journal of Marine Science and Engineering 2022; 10:746, 25 pages.

SCOTT L, NOBLE LD, SINGH-MOODLEY A, KAHAMBA T, HARDIE D, PREISER W, STEVENS W. Challenges and complexities in evaluating severe acute respiratory syndrome coronavirus 2 molecular diagnostics during the COVID-19 pandemic. African Journal of Laboratory Medicine 2022; 11(1):a1429, 5 pages.

SHIMBA H, MIKASI SG, KALLUVYA S, BRAUNER JM, ABDUL S, LYIMO E, DESDERIUS B, KORN K, VAN ZYL GU, JACOBS GB, PREISER W, KASANG C. Prevalence and patterns of HIV drug resistance in patients with suspected virological failure in North-Western Tanzania. Journal of Antimicrobial Chemotherapy 2022; 77(0):483-491.

SMIT EJ, REDFERN A, MURRAY S, LISHMAN J, VAN DER ZALM MM, VAN ZYL GU, VERHAGEN LM, DE VOS C, RABIE H, DYK A, CLAASSEN M, TALJAARD J, AUCAMP M, DRAMOWSKI A. SARS-CoV-2 in children and their accompanying caregivers: Implications for testing strategies in resource limited hospitals. African Journal of Emergency Medicine 2022; 12(3):177-182.

TEGALLY H, BAXTER C, MAPONGA TG, PREISER W, DE OLIVEIRA T, WILKINSON E, ET AL. The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance. Science & Research 2022; 378(6615):42, 15 pages.

TEGALLY H, MOIR MI, EVERATT J, GIOVANETTI M, SCHEEPERS C, WILKINSON E, BAXTER C, MAPONGA TG, SANKO TJ, PREISER W, DE PAIVA NAZARETH ANDRADE DE O T. Emergence of SARS-CoV-2 Omicron lineages BA.4 and BA.5 in South Africa. Nature Medicine 2022; 28:1785-1790.

VALLEY-OMAR Z, MARAIS G, IRANZADEH A, NAIDOO M, KORSMAN SNJ, MAPONGA TG, HUSSEY H, DAVIES M-A, BOULLE A, DOOLABH D, LAUBSCHER M, WOJNO J, DEETLEFS JD, MARITZ J, SCOTT L, MSOMI N, NAICKER C, TEGALLY H, DE OLIVEIRA T, BHIMAN J, WILLIAMSON C, PREISER W, HARD. Reduced amplification efficiency of the RNA-dependent-RNA-polymerase target enables tracking of the Delta SARS-CoV-2 variant using routine diagnostics tests. Journal of Virological Methods 2022; 302:114471;5pp.

VAN ZYL GU, DORFMAN JR, KEARNEY MF. HIV drug resistance in various body compartments. Current Opinion in HIV and AIDS 2022; 17(4):205-212.

VAN ZYL GU, DRAMOWSKI A, PREISER W. Pandemic escape plan: Discontinuing policies that have reached their expiry date. SAMJ South African Medical Journal 2022; 112(3):192-193.​

VAN ZYL GU, JENNINGS L, KELLERMANN TA, NKANTSU Z, COGILL D, VAN SCHALKWYK M, SPINELLI M, DECLOEDT EH, ORRELL C, GANDHI M. Urine tenofovir-monitoring predicts HIV viremia in patients treated with high genetic-barrier regimens. AIDS 2022; 36(14):2057-2062.

VIANA R, MOYO S, AMOAKO DG, TEGALLY H, ENGELBRECHT S, MAPONGA TG, MAHLAKWANE KL, MOIR MI, VAN WYK S, WILKINSON E, PREISER W, DE PAIVA NAZARETH ANDRADE DE O T. Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa. Nature 2022; 603:679-686.

WILLIAMS ME, RUHANYA V, PAUL RH, IPSER JC, STEIN DJ, JOSKA JA, NAUDE PJW. An investigation of the HIV Tat C31S and R57S mutation on peripheral immune. Virology Journal 2022; 94(7):2936-2938.

ZUIDEWIND P, COTTON MF, BARNABAS SL, JANSE VAN RENSBURG A, VAN ZYL GU, GORDJIN C. Approach to the management of paediatric HIV spontaneous controllers. Southern African Journal of Infectious Diseases (Formerly Southern African Journal of Epidemiology and Infection) 2022; 37(1):a399, 7 pages.

2021​

Journal Articles

AGUIRRE AA, GORE M, KAMMER-KERWICK M, CURTIN KM, HEYNS A, PREISER W, SHELLEY LI. Opportunities for Transdisciplinary Science to Mitigate Biosecurity Risks From the Intersectionality of Illegal Wildlife Trade With Emerging Zoonotic Pathogens . Frontiers in Ecology and Evolution 2021; 9:604929, 7 pages.

 BALE MJ, KATUSIIME MG, WELLS D, WU X, SPINDLER J, HALVAS EK, CYKTOR JC, WIEGAND A, SHAO W, COTTON MF, HUGHES SH, MELLORS JW, COFFIN JM, VAN ZYL GU, KEARNEY MF. Early emergence and long-term persistence of HIV-infected t-cell clones in children. mBio 2021; 12(2):e00568-21, 15 pages.

 CROWELL TA, RITZ J, COOMBS RW, ZHENG L, ERON JJ, MELLORS JW, DRAGAVON J, VAN ZYL GU, LAMA JR, RUXRUNGTHAM K, GRINSZTEJN B, ARDUIN RC, FOX L, ANANWORANICH J, DAAR E, ET AL. Novel Criteria for Diagnosing Acute and Early Human Immunodeficiency Virus Infection in a Multinational Study of Early Antiretroviral Therapy Initiation. Clinical Infectious Diseases 2021; 73(3):e643–51.

 DAKURAH OB, TAMANDJOU CRT, DZIKITI M, PREISER W, MAPONGA TG. Viral hepatitis associated hepatocellular carcinoma on the African continent, the past, present, and future: a systematic review. BMC Cancer 2021; 21:715, 13 pages.

 DE BEER C, AYELE BT, DEMPERS JJ. Immune biomarkers as an adjunct diagnostic modality of infection in cases of sudden and unexpected death in infancy (SUDI) at Tygerberg Medico-legal Mortuary, Cape Town, South Africa. Human Pathology: Case Reports 2021; 23:1-5.

 DHEDA K, CHARALAMBOUS S, KARAT A, VON DELFT A, LALLOO UG, VAN ZYL SMIT R, PERUMAL R, ALLWOOD BW, ESMAIL A, WONG ML, DUSE AG, RICHARDS GA, FELDMAN C, MER M, NYAMANDE K, LALLA U, KOEGELENBERG CFN, VENTER F, DAWOOD H, ADAMS S, NTUSI NAB, VAN DER WESTHUIZEN H. A position statement and practical guide to the use of particulate filtering facepiece respirators (N95, FFP2 or equivalent) for South African health workers exposed to respiratory pathogens including Mycobaterium tuberculosis and SARS- CoV-2. African Journal of Thoracic and Critical Care Medicine 2021; 27(4):177-186.

 DOH GN, MKONG EN, IKOMEY GM, OBASA AEA, MESEMBE MT, FOKUNANG C, JACOBS GB. Preinvasive Cervical Lesions and High Prevalence of Human Papilloma Virus among Pregnant Women in Cameroon. Germs 2021; 11(1):78-87.

 DORFMAN JR, BALLA S, PATHIRANA J, GROOME MJ, MADHI SA, MOORE P. In Utero Human Cytomegalovirus Infection Is Associated with Increased Levels of Putatively Protective Maternal Antibodies in Nonprimary Infection: Evidence for Boosting but Not Protection. Clinical Infectious Diseases 2021; 73(4):e981, 7 pages.

 ELLSWORTH GB, STIER EA, CHIAO EY, LENSING SY, DARRAGH T, JAY NP, BERRY-LAWHORN M, EINSTEIN M, BARROSO LF, CRANSTON RD, LEVINE R, GUIOT HM, FRENCH AL, GOLDSTONE SE, PREISER W, CLAASSEN M, PALEFSKY JM, WILKIN TJ, ET AL. Xpert HPV as a screening Tool for Anal Histologic High-Grade Squamous Intraepithelial Lesions in Women Living with HIV. Journal of Acquired Immune Deficiency Syndromes 2021; 87(3):978-984.

 ENGELBRECHT S, DELANEY KE, KLEINHANS B, WILKINSON E, TEGALLY H, STANDER T, VAN ZYL GU, PREISER W, DE OLIVEIRA T. Multiple Early Introductions of SARS-CoV-2 to Cape Town, South Africa. Viruses-Basel 2021; 13:526, 11 pages.

 KARIUKI S, SELHORST P, ABRAHAMS M-R, REBE K, WILLIAMSON C, DORFMAN JR. Neutralization sensitivity of genital tract HIV-1: shift in selective milieu shapes the population available to transmit. AIDS 2021; 35(9):1365-1373.

 KATUSIIME MG, VAN ZYL GU, COTTON MF, KEARNEY MF. HIV-1 Persistence in Children during Suppressive ART. Viruses-Basel 2021; 13(6):1134, 15 pages.

 KEENE C, GRIESEL R, ZHAO Y, GCWABE Z, SAYED K, HILL A, CASSIDY T, NGWENYA O, JACKSON A, VAN ZYL GU, SCHUTZ C, GOLIATH R, FLOWERS T, GOEMAERE S, WIESNER L, SIMMONS B, MAARTENS G, MEINTJIES G. Virologic efficacy of tenofovir, lamivudine and dolutegravir as second-line antiretroviral therapy in adults failing a tenofovir-based first-line regimen. AIDS 2021; 35(9):1423-1432.

LAMPERT S, INGLE RA, JACKSON JA, GOPAL K, PLÖN SEE. Low mitochondrial genetic diversity in the Indian Ocean humpback dolphin Sousa plumbea in South African waters. Endangered Species Research 2021; 46:91-103.

 LINSTRÖM M, PREISER W, NKOSI NP, VREEDE HW, KORSMAN SNJ, ZEMLIN A, VAN ZYL GU. HIV false positive screening serology due to sample contamination reduced by a dedicated sample and platform in a high prevalence environment. PLoS One 2021; 16(1):e0245189, 11 pages.

 MCMULLEN K, BATEMAN KJ, STANLEY A, COMBRINCK M, ENGELBRECHT S, BRYER A. Viral protein R polymorphisms in the pathogenesis of HIV-associated acute ischaemic stroke: a case-control study. Journal of Neurovirology 2021; 27:137-144.

 MEHL C, SCHOEMAN MC, SANKO TJ, BEZUIDENHOUT C, MIENIE CMS, PREISER W, VOSLOO D. Wastewater treatment works change the intestinal microbiomes of insectivorous bats. PLoS One 2021; 16(3): e024747, 15 pages.

 MELLORS JW, VAN ZYL GU. Early Emergence and Long-Term Persistence of HIV-Infected T-Cell Clones in Children. mBio 2021; 12(2):e00568-21, 15 pages.

 MIKASI SG, ISAACS D, IKOMEY GM, SHIMBA H, CLOETE R, JACOBS GB. HIV-1 Drug Resistance Mutation Analyses of Cameroon-Derived Integrase Sequences. AIDS Research and Human Retroviruses 2021; 37(1):54-56.

 NACHEGA JB, GRIMWOOD A, MAHOMED H, FATTI GL, PREISER W, KALLAY O, MBALA-KINGEBENI P, MUYEMBE-TAMFUM JJ, RWAGASORE E, NSANZIMANA S, NGAMIJE D, CONDO J, SIDAT M, NOORMAHOMED EV, REID MJA, LUKENI B, SULEMAN F, MTETA A, ZUMLA A. From Easing Lockdowns to Scaling Up Community-based Coronavirus Disease 2019 Screening, Testing, and Contact Tracing in Africa - Shared Approaches, Innovations, and Challenges to Minimize Morbidity and Mortality. Clinical Infectious Diseases 2021; 72(2):327-331.

 NKOSI NP, PREISER W, VAN ZYL GU, CLAASSEN M, CRONJÉ N, MARITZ J, NEWMAN HM, MCCARTHY KM, NTSHOE G, ESSEL V, KORSMAN SNJ, HARDIE D, SMUTS H. Molecular characterisation and epidemiology of enterovirus-associated aseptic meningitis in the Western and Eastern Cape Provinces, South Africa 2018-2019. Journal of Clinical Virology 2021; 139:104845, 6 pages.

 PLÖN SEE, ATKINS S, COCKCROFT V, CONRY D, DINES SF, ELWEN SH, GENNARI E, GOPAL K, GRIDLEY T, HÖRBST S, JAMES BS, PENRY G, THORNTON M, VARGAS-FONSECA OA, VERMEULEN E. Science Alone Won't Do It! South Africa's Endangered Humpback Dolphins Sousa plumbea Face Complex Conservation Challenges. Journal of Marine Sciences 2021; 8(642226):1-11.

 POSADA-CÉSPEDES S, VAN ZYL GU, MONTAZERI H, KUIPERS J, RHEE S, KOUYOS R, GÜNTHARD HF, BEERENWINKEL N. Comparing mutational pathways to lopinavir resistance in HIV-1 subtypes B versus C. PLoS Computational Biology 2021; 17(9): e100836, 25 pages.

 RABIE H, FRIGATI LJ, NKOSI NP. Cytomegalovirus and tuberculosis disease in children. Lancet 2021; 9(12):e1636 - e1637.

 RUHANYA V, JACOBS GB, NAIDOO S, PAUL RH, JOSKA JA, SEEDAT S, NYANDORO G, ENGELBRECHT S, GLASHOFF RH. Impact of Plasma IP-10/CXCL10 and RANTES/CCL5 Levels on Neurocognitive Function in HIV Treatment-Naïve Patients . AIDS Research and Human Retroviruses 2021; 37(9):657-665.

RUHANYA V, JACOBS GB, PAUL RH, JOSKA JA, SEEDAT S, NYANDORO G, ENGELBRECHT S, GLASHOFF RH. Plasma cytokine biomarker cutoff values for HIV-associated neurocognitive impairment in adults. Viral Immunology 2021; 34(10):689-696.

 RUHANYA V, JACOBS GB, PAUL RH, JOSKA JA, SEEDAT S, NYANDORO G, ENGELBRECHT S, GLASHOFF RH. Plasma cytokine levels as predictors of global and domain-specific human immunodeficiency virus-associated neurocognitive impairment in treatment-naive individuals . JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 2021; 41(4):153-160.

 SHAW JA, MEIRING M, RICHARDSON TR, CHEGOU NN, CLAASSEN CN, DU PLESSIS-BURGER N, FLINN M, HIEMSTRA AM, KLEYNHANS-CORNELISSEN L, LEUKES VN, LOXTON AG, MACDONALD CE, MTALA NS, REUTER H, SIMON D, STANLEY K, TROMP GC, PREISER W, MALHERBE ST, WALZL G. Higher SARS-CoV-2 seroprevalence in workers with lower socioeconomic status in Cape Town, South Africa. PLoS One 2021; 16(2):e024785, 12 pages.

 TAMANDJOU TCHUEM CR, ANDERSSON MI, WIYSONGE CS, MUFENDA J, PREISER W, CLEARY S. Prevention of hepatitis B mother-to-child transmission in Namibia: A cost-effectiveness analysis. VACCINE 2021; 39:3141-3451.

 TEGALLY H, WILKINSON E, GIOVANETTI M, IRANZADEH A, FONSECA V, GIANDHARI J, DOOLABH D, PILLAY S, SAN EJ, MSOMI N, MLISANA K, VON GOTTBERG A, WALAZA S, ALLAM M, ISMAIL A, MOHALE T, GLASS A, ENGELBRECHT S, VAN ZYL GU, PREISER W, PETRUCCIONE F, SIGAL A, HARDI. Detection of a SARS-CoV-2 variant of concern in South Africa. Nature 2021; 592:438-443.

 TEGALLY H, WILKINSON E, LESSELLS R, GIANDHARI J, PILLAY S, MSOMI N, MLISANA K, BHIMAN J, VON GOTTBERG A, WALAZA S, FONSECA V, ALLAM M, ISMAIL A, GLASS A, ENGELBRECHT S, VAN ZYL GU, PREISER W, WILLIAMSON C, PETRUCCIONE F, SIGAL A, GAZY I, HARDIE D, HSIAO N. Sixteen novel lineages of SARS-CoV-2 in South Africa. NATURE MEDICINE 2021; 27:440-446.

 TONGO M, MARTIN D, DORFMAN JR. Elucidation of Early Evolution of HIV-1 Group M in the Congo Basin Using Computational Methods. Genes 2021; 12:517, 12 pages.

 VAN DER MERWE EB, MARITZ J, DELANEY KE, SMIT DP. Adenovirus and human papillomavirus in the pathogenesis of pterygium. South African Ophthalmology Journal(SAOJ) 2021; 16(1):27-32.

 VAN DER ZALM MM, LISHMAN J, VERHAGEN LM, REDFERN A, SMIT EJ, BARDAY MM, RUTTENS DLP, DA COSTA A, SEBITOSI-VAN JAARSVELD SNN, ITANA JN, SCHRUEDER N, VAN SCHALKWYK M, PARKER NM, APPEL IN, FOURIE B, CLAASSEN M, WORKMAN JJ, GOUSSARD P, VAN ZYL GU, RABIE H. Clinical Experience With Severe Acute Respiratory Syndrome Coronavirus 2–Related Illness in Children: Hospital Experience in Cape Town, South Africa. Clinical Infectious Diseases 2021; 72(12):e938-e944.

 VELDSMAN KA, LAUGHTON B, JANSE VAN RENSBURG A, ZUIDEWIND P, DOBBELS EFM, BARNABAS SL, FRY S, COTTON MF, VAN ZYL GU. Viral suppression is associated with HIV-antibody level and HIV-1 DNA detectability in early treated children at 2 years of age. AIDS 2021; 35:1247-1252.

 VERMEULEN M, CHOWDHURY D, SWANEVELDER R, GREBE E, BRAMBILLA D, JENTSCH U, BUSCH M, VAN ZYL GU, MURPHY EL, ET AL. HIV incidence in South African blood donors from 2012 to 2016: a comparison of estimation methods. VOX SANGUINIS 2021; 116:71-80.

 VERMEULEN M, SWANEVELDER R, VAN ZYL GU, LELIE N, MURPHY EL. An assessment of hepatitis B virus prevalence in South African young blood donors born after the implementation of the infant hepatitis B virus immunization of the infant hepatitis B virus immunization program: Implications for transfusion safety. TRANSFUSION 2021; 61:2688-2700.

 WILKINSON E, GIOVANETTI M, TEGALLY H, SAN JE, LESSELLS R, CUADROS D, MARTIN D, RASMUSSEN D, ZEKRI A, KLEINHANS B, VAN ZYL GU, ENGELBRECHT S, PREISER W, DE PAIVA NAZARETH ANDRADE DE O T, ET AL. A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa. Advancements in Life Sciences 2021; 374:423-431.

 WRIGHT IA, BALE MJ, SHAO W, HU W-S, COFFIN JM, VAN ZYL GU, KEARNEY MF. HIVIntact: Python-based tool for HIV-1 genome intactness inference. Retrovirology 2021; 18:16, 6 pages.

 WRIGHT IA, DELANEY KE, KATUSIIME MG, BOTHA JC, ENGELBRECHT S, KEARNEY MF, VAN ZYL GU. NanoHIV: A Bioinformatics Pipeline for Producing Accurate Near Full-Length HIV Proviral Genomes Sequeced Using the Oxford Nanopore Technology. Cells 2021; 10:2577, 12

 ​

​2020​

Journal Articles

CHITONGO R, OBASA AEA, MIKASI SG, JACOBS GB, CLOETE R. Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C Integrase-Dolutegravir binding. PLoS One 2020; 15(5):e0223464, 15 pages.

DHEDA K, JAUMDALLY SZ, DAVIDS M, CHANG Y, GINA P, POORAN AS, MAKAMBWA E, ESMAIL A, VARDAS E, PREISER W. Diagnosis of COVID-19: Considerations, controversies and challenges. African Journal of Thoracic and Critical Care Medicine ( Previously South African Respiratory Journal). 2020; 26(2):1-6.

DOWNS LO, VAWDA S, BESTER PA, LYTHGOE KA, WANG T, MC NAUGHTON AL, SMITH DA, MAPONGA TG, FREEMAN O, VARNAI KA, DAVIES J, WOODS K, FRASER C, BARNES EJ, GOEDHALS D, MATTHEWS P. Bimodal distribution and set point HBV DNA viral loads in chronic infection: retrospective analysis of cohorts from the UK and South Africa. Wellcome Open Research 2020; 5:113, 14 pages.

EL-KHATIB Z, JACOBS GB, IKOMEY GM, NEOGI U. The disproportionate effect of COVID-19 mortality on ethnic minorities: Genetics or health inequalities?. EClinicalMedicine 2020; 23:100430, 2 pages.

FATTI GL, GRIMWOOD A, NACHEGA JB, NELSON JA, LASORDA K, VAN ZYL GU, GROBBELAAR N, AYLES H, HAYES R, BEYERS N, FIDLER S, BOCK PA. Better Virological Outcomes Among People Living With Human Immunodeficiency Virus (HIV) Initiating Early Antiretroviral Treatment (CD4 Counts ≥500 Cells/μL) in the HIV Prevention Trials Network 071 (PopART) Trial in South Africa. Clinical Infectious Diseases 2020; 70(3):395-403.

GEFFERT K, MAPONGA TG, HENERICO S, PREISER W, MONGELLA S, STICH A, KALLUVYA S, MUELLER A, KASANG C. Prevalence of chronic HBV infection in pregnant woman attending antenatal care in a tertiary hospital in Mwanza, Tanzania: a cross-sectional study. BMC Infectious Diseases 2020; 20:395, 16 pages.

GREEN RJ, HOCKMAN MH, FRIEDMAN R, VAN NIEKERK A, FELDMAN C, VARDAS E, QUITTER C, ELS C, VAN BRUWAENE L, NANAN A, PETER J, SEEDAT RY, LEVIN M, BATEMAN C. Chronic rhinitis in South Africa - more than just allergy!. SAMJ South African Medical Journal 2020; 110(7):594-598.

GUIEDEM E, PEFURA-YONE E, IKOMEY GM, NKENFOU C, MESEMBE MT, YIVALA M, CHENDI BH, JACOBS GB, CHEGOU NN, ASSOUMOU MCO. Cytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary disease. BMC IMMUNOLOGY 2020; 21(1):52, 11 pages.

HENDRICKS ML, VARATHAN O, CASSIM F, KIDD M, MOODLEY K. Impact of implementing an online interactive educational tool for future HIV “cure" research in an HIV clinic waiting room in Cape Town, South Africa. AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV 2020; 32(8):965-969.

ISAACS D, MIKASI SG, OBASA AEA, IKOMEY GM, SHITYAKOV S, CLOETE R, JACOBS GB. Structural Comparison of Diverse HIV-1 Subtypes using Molecular Modelling and Docking Analyses of Integrase Inhibitors . Viruses-Basel 2020; 12:936, 12 pages.

KARIUKI S, SELHORST P, ANTHONY C, MATTEN D, ABRAHAMS M-R, MARTIN D, ARIËN KK, REBE K, WILLIAMSON C, DORFMAN JR. Compartmentalization and Clonal Amplification of HIV-1 in the Male Genital Tract Characterized Using Next-Generation Sequencing. JOURNAL OF VIROLOGY 2020; 94(12):e00229-20, 18 pages.

KARIUKI S, SELHORST P, NORMAN J, COHEN K, REBE K, WILLIAMSON C, DORFMAN JR. Detectable HIV-1 in semen in individuals with very low blood viral loads. Virology Journal 2020; 17:29, 5 pages.

KATUSIIME MGK, HALVAS EK, WRIGHT I, JOSEPH K, BALE MJ, KIRBY-MCCULLOUGH B, ENGELBRECHT S, SHAO W, HU W-S, COTTON MF, MELLORS JW, KEARNEY MF, VAN ZYL GU. Intact HIV proviruses persist in children seven to nine years after initiation of antiretroviral therapy in the first year of life. JOURNAL OF VIROLOGY 2020; 94(4):e01519-19, 11 pages.

KELENTSE N, MOYO S, MOGWELE M, LECHIILE K, MORAKA ON, MARUAPULA D, SEATLA KK, ESELE L, MOLEBATSI K, LEEME TB, LAWRENCE DS, MUSONDA R, KASVOSVE I, HARRISON TS, JARVIS JN, GASEITSIWE S. Differences in human immunodeficiency virus-1C viral load and drug resistance mutation between plasma and cerebrospinal fluid in patients with human immunodeficiency virus-associated cryptococcal meningitis in Botswana. Medicine 2020; 99(41):e22606.

MAPONGA TG, GLASHOFF RH, VERMEULEN H, ROBERTSON B, BURMEISTER S, BERNON MM, OMOSHORO-JONES JA, RUFF P, NEUGUT AI, JACOBSON JS, PREISER W, ANDERSSON MI. Hepatitis B virus-associated hepatocellular carcinoma in South Africa in the era of HIV. BMC GASTROENTEROLOGY 2020; 20:226, 10 pages.

MAPONGA TG, LOPES T, CABLE R, PISTORIUS C, PREISER W, ANDERSSON MI. Prevalence and risks of hepatitis E virus infection in blood donors from the Western Cape, South Africa. VOX SANGUINIS 2020; 115:695-702.

MAPONGA TG, MCNAUGHTON AL, VAN SCHALKWYK M, HUGO S, NWANKWO CT, TALJAARD JJ, MOKAYA J, SMITH DA, VAN VUUREN C, GOEDHALS D, GABRIEL MS, ANDERSSON MI, PREISER W, VAN RENSBURG CJ, MATTHEWS P. Treatment advantage in HBV/HIV coinfection compared to HBV monoinfection in a South African cohort. JOURNAL OF INFECTION 2020; 81(1):121-130.

MAYNE E, SCOTT L, SEMETE-MAKOKOTLELA B, JULSING A, JUGWANTH S, MAMPEULE N, DAVID A, GEDEDZHA MP, GOGA A, HARDIE D, PREISER W, CHETTY K, REES H, SANNE I, MLISANA K, GEORGE JA, STEVENS W. The role of serological testing in the SARS-CoV-2 outbreak. SAMJ South African Medical Journal 2020; 110(9):842-845.

MC NAUGHTON AL, LOURENCO J, BESTER PA, MOKAYA J, LUMLEY SF, OBOLSKI U, FORDE D, MAPONGA TG, KATUMBA KR, GOEDHALS D, GUPTA S, SEELEY J, NEWTON R, OCAMA P, MATTHEWS P. Hepatitis B virus seroepidemiology data for Africa: Modelling intervention strategies based on a systematic review and meta-analysis. PLoS Medicine 2020; 17(4):e1003068, 22 pages.

MEHTAR S, PREISER W, LAKHE NA, BOUSSO A, TAMFUM J-JM, KALLAY O, SEYDI M, ZUMLA A, NACHEGA JB. Limiting the spread of COVID-19 in Africa: one size mitigation strategies do not fit all countries. Lancet Global Health 2020; 8(7):e881-e883.

MIKASI SG, GICHANA JO, VAN DER WALT C, BRADO D, OBASA AEA, NJENDA DT, MESSEMBE M, LYONGA E, ASSOUMOU MKO, CLOETE R, IKOMEY GM, JACOBS GB. HIV-1 Integrase Diversity and Resistance-Associated Mutations and Polymorphisms Among Integrase Strand Transfer Inhibitor-Naive HIV-1 Patients from Cameroon. AIDS Research and Human Retroviruses 2020; 36(5):450-455.

MIKASI SG, IKOMEY G, OBASA AEA, CLOETE R, JACOBS GB. HIV-1 diversity and the implementation of integrase strand-transfer inhibitors as part of combination antiretroviral therapy. SAMJ South African Medical Journal 2020; 110(9):827.

MOKAYA J, MAPONGA TG, MCNAUGHTON AL, VAN SCHALKWYK M, HUGO S, SINGER JB, SREENU V, BONSALL D, DE CESARE M, ANDERSSON MI, GABRIEL MS, TALJAARD JJ, BARNES EJ, PREISER W, VAN RENSBURG CJ, MATTHEWS P. Evidence of tenofovir resistance in chronic hepatitis B virus (HBV) infection: An observational case series of South African adults. Journal of Clinical Virology 2020; 129:104548, 4 pages.

MOYO T, GULEID F, SCHOMAKER M, WILLIAMSON C, DORFMAN JR. HIV-1 Subtype C Tier 3 Viruses Have Increased Infectivity Compared to Tier 2 Viruses. AIDS Research and Human Retroviruses 2020; 36(12):1010-1019.

NACHEGA JB, MBALA-KINGEBENI P, OTSHUDIEMA J, MOBULA LM, PREISER W, KALLAY O, MICHAELS-STRASSER S, BREMAN JG, RIMOIN AW, NSIO J, AHUKA-MUNDEKE S, ZUMLA A, TAM-FUM J-JM. Responding to the Challenge of the Dual COVID-19 and Ebola Epidemics in the Democratic Republic of Congo-Priorities for Achieving Control. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 2020; 103(2):597-602.

NEL J, DLAMINI S, MEINTJES G, BURTON R, BLACK J, DAVIES N, HEFER E, MAARTENS G, MANGENA P, MATHE MT, MOOSA M-YS, MULAUDZI MB, MOORHOUSE M, NASH J, NKONYANE TC, PREISER W, RASSOOL MS, STEAD D, VAN DER PLAS H, VAN VUUREN C, VENTER WDF, WOODS JF. Southern African HIV Clinicians Society guidelines for antiretroviral therapy in adults: 2020 update. Southern African Journal of HIV Medicine  2020; 21(1):a1115, 40 pages.

NEWMAN HM, HARDIE D. HIV-1 viral load testing in resource-limited settings: Challenges and solutions for specimen integrity. Reviews in Medical Virology 2020; 10:e2165, 6 pages.

NEWMAN HM, TSHABALALA D, MABUNDA SA, NKOSI NP, CARELSON C. Rapid testing for respiratory syncytial virus in a resource-limited paediatric intensive care setting. African Journal of Laboratory Medicine  2020; 9(1):a1084, 6 pages.

OBASA AEA, MIKASI SG, BRADO D, CLOETE R, SINGH K, NEOGI U, JACOBS GB. Drug resistance Mutations against protease, reverse transcriptase and integrase inhibitors in people living with HIV-1 receiving boosted protease inhibitors in South Africa. Frontiers in Microbiology 2020; 11:438, 8 pages.

PORTER JD, MASH R, PREISER W. Turnaround times - the Achilles' heel of community screening and testing in Cape Town, South Africa : A short report. (Short report). African Journal of Primary Health Care and Family Medicine 2020; 12(1):3.

PREISER W, MENDELSON M, TALJAARD JJ. Optimising influenza vaccination during a SARS-CoV-2 epidemic in South Africa could help maintain the integrity of our healthcare system. SAMJ South African Medical Journal 2020; 110(4):259.

PREISER W, PREISER R. Academic publishing in pandemic times. South African Journal of Science 2020; 116(9/10):Art. #8803, 2 pages.

PREISER W, VAN ZYL GU, DRAMOWSKI A. COVID-19: Getting ahead of the epidemic curve by early implementation of social distancing. SAMJ South African Medical Journal 2020; 110(4):258.

PREISER W, VAN ZYL GU. Pooled testing: A tool to increase efficiency of infant HIV diagnosis and virological monitoring. African Journal of Laboratory Medicine  2020; 9(2):a1035, 8 pages

PUTTER M, SMIT DP, MARITZ J, HAARHOFF AW. A prospective analysis of infectious keratitis at a tertiary facility in South Africa. South African Ophthalmology Journal(SAOJ) 2020; 15(2):17-20.

QUAGLIO GL, PREISER W, PUTOTO G. COVID-19 in Africa. PUBLIC HEALTH 2020; 185:60.

REID JT, VAN ZYL GU, LINSTRÖM M, KORSMAN SNJ, MARAIS G, PREISER W. High positive HIV serology results can still be false positive. IDCases 2020; 21:e00849, 4 pages.

RUHANYA V, JACOBS GB, NYANDORO G, PAUL RH, JOSKA JA, SEEDAT S, GLASHOFF RH, ENGELBRECHT S. Peripheral blood lymphocyte proviral DNA predicts neurocognitive impairment in clade C HIV. Journal of Neurovirology 2020; 26(6):920-928.

 TAMANDJOU TCHUEM CR, BRANDT L, NEL EDLR, COTTON MF, MATTHEWS P, KAINDJEE-TJITUKA F, PREISER W, ANDERSSON MI. Hepatitis B virus drug resistance mutations in HIV/HBV co-infected children in Windhoek, Namibia. PLoS One 2020; 15(9):e0238839, 9 pages.

TAMANDJOU TCHUEM CR, COTTON MF, NEL EDLR, TEDDER R, PREISER W, VIOLARI A, BOBAT R, HOVIND L, AARON L, MONTEPIEDRA G, MITCHELL C, ANDERSSON MI. Viral hepatitis B and C in HIV-exposed South African infants. BMC Pediatrics 2020; 20:563, 8 pages.

 VAN DER COLF BE, VAN ZYL GU, NODEN BH, NTIRAMPEBA D. Seroprevalence of Toxoplasma gondii infection among pregnant women in Windhoek, Namibia, in 2016. Southern African Journal of Infectious Diseases (Formerly Southern African Journal of Epidemiology and Infection) 2020; 35(1):a25, 7 pages.

 VAN DER MERWE TA, VAN ZYL GU, LOMBARD CJ, THERON GB. Intrapartum human immunodeficiency virus transmission rate in a central hospital in the Western Cape province after universal antiretroviral therapy roll-out. Southern African Journal of Infectious Diseases (Formerly Southern African Journal of Epidemiology and Infection) 2020; 35(1):a192, 4 pages.

 VAN DER ZALM MM, WALTERS E, CLAASSEN M, PALMER M, SEDDON JA, DEMERS A, SHAW ML, MCCOLLUM ED, VAN ZYL GU, HESSELING AC. High burden of viral respiratory co-infections in a cohort of children with suspected pulmonary tuberculosis. BMC Infectious Diseases 2020; 20:924, 9 pages.

 BROOKS DR, HOBERG EP, BOEGER WA, GARDNER SL, ARAUJO SBL, BAJER K, BOTERO-CANOLA S, BYRD B, FOLDVARI G, COOK JA, DUNNUM J, DURSAHINHAN AT, GARAMSZEGI LZ, HERCZEG D, JAKAB F, KEMENESI G, KURUCZ K, LEON-REGAGNON V, MEJIA-MADRID HH, MOLNAR O, PREISER W, STUAR. Before the Pandemic ends: Making sure this never happens again. World Complexity Science Academy Journal 2020; 34(4):400-405.

 DHEDA K, JAUMDALLY SZ, DAVIDS M, CHANG Y, GINA P, POORAN AS, MAKAMBWA E, ESMAIL A, VARDAS E, PREISER W. Diagnosis of COVID-19: Considerations, Controversies and Challenges in South Africa. Wits Journal of Clinical Medicine 2020; 2:3-10.

 HSIAO M, DAVIES M-A, KALK E, HARDIE D, NAIDOO M, CENTNER C, VAN ZYL GU, CHAPANDUKA ZC, OPIE JS, MAHOMED H, COIS A, SMITH M, PIENAAR DE, VREDE H, MAYNE E, CHETTY K, BOULLE A. SARS-COV-2 seroprevalence in the Cape Town metropolitan sub-districts after the peak of infections. Covid-19 Special Public Health Surveillance Bulletin 2020; 18(Supplement 5):1-9.

MSOMI N, MLISANA K, WILLIAMSON C, BHIMAN J, GOEDHALS D, ENGELBRECHT S, VAN ZYL GU, PREISER W, HARDIE D, HSIAO M, MULDER N, MARTIN D, CHRISTOFFELS A, YORK D, GIANDHARI J, WILKINSON E, PILLAY S, TEGALLY H, JAMES SE, KANZI A, LESSELLS R, DE OLIVEIRA T. A genomics network established to respond rapidly to public health threats in South Africa. The Lancet Microbe 2020; 20:1-2.

NACHEGA JB, MEHTAR S, PREISER W. The spread of coronavirus across Africa. Africa Health 2020; 42(2):10-12.

 PREISER W, VARDAS E, VAN ZYL GU. Approaches to laboratory testing for Covid-19. Africa Health 2020; July 2020:26-29.​​

Doctorol Completed

​B​OTHA JC. The role of proliferating CD4+ T cells in maintaining HIV reservoirs in aviremic children on treatment. PhD, 2020. 204 pp. Promotor: VAN ZYL GU. Medepromotor: ENGELBRECHT S.

MIKASI SG. Investigating the structural impact of HIV-1 Integrase natural occurring polymorphisms and novel mutations identified among group M subtypes circulating in sub-Saharan Africa. PhD, 2020. 148 pp. Promotor: JACOBS GB. Medepromotor: ENGELBRECHT S, VAN ZYL GU.

NJENDA DT. From bedside to bench and back: Future options for antiretroviral drugs in non-B HIV-1 subtypes. PhD, 2020. 128 pp. Promotor: Neogi U, ENGELBRECHT S. Medepromotor: JACOBS GB.

​VAN DER COLF BE. Seroprevalence and incidence of Toxoplasma gondii, rubella and cytomegalovirus in Namibian women of childbearing potential. **MISSING DEGREE**, 2020. 148 pp. Promotor: VAN ZYL GU.​

Masters Completed 

DELANEY KE. Improved methods to recover HIV integrated proviruses and integration sites. MScGeneeskWet, 2020. 148 pp.

FERREIRA J. A prospective study investigating respiratory viral infections in Sudden Unexpected Death in Infancy (SUDI) cases at the Tygerberg Medico-legal Mortuary. MScGeneeskWet, 2020. 128 pp. Studieleier: DE BEER C. Medestudieleier: DEMPERS JJ.

VENTER ML. Profiling cardiovascular viral pathogens in cases of sudden and unexpected death in infants (SUDI) at the Tygerberg Medico-legal Mortuary and the role of myocarditis as a possible cause of death. MScGeneeskWet, 2020. 128 pp. Studieleier: DE BEER C. Medestudieleier: DEMPERS JJ.

2019

Journal Articles

BESTER PA, DE VRIES A, RIEKERT S, STEEGEN K, VAN ZYL GU, GOEDHALS D. PhyloPi: An affordable purpose built phylogenetic pipeline for the HIV drug resistance testing facility. PLoS One 2019; 14(3):e0213241, 13 pages.

 CHENDI BH, ASSOUMOU MCO, JACOBS GB, YEKWA EL, LYONGA E, MESEMBE MT, EYOH A, IKOMEY GM. Rate of viral load change and adherence of HIV adult patients treated with Efavirenz or Nevirapine antiretroviral regimens at 24 and 48 weeks in Yaoundé, Cameroon: a longitudinal cohort study. BMC Infectious Diseases 2019; 19:194, 8 pages.

 CHOTUN BN, STROBELE S, MAPONGA TG, ANDERSSON MI, NEL EDLR. Successful treatment of a South African pediatric case of acute liver failure caused by perinatal transmission of hepatitis B. Pediatric Infectious Disease Journal 2019; 38(3):e51-e53.

 COHEN K, STEWART A, KENGNE AP, LEISEGANG F, COETZEE M, MAHARAJ S, DUNN L, HISLOP M, VAN ZYL GU. A clinical prediction rule for protease inhibitor resistance in patients failing second-line Antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes 2019; 80(3):325-329.

 DECLOEDT EH, SINXADI PZ, VAN ZYL GU, WIESNER L, KHOO S, JOSKA JA, HAAS DW, MAARTENS G. Pharmacogenetics and pharmacokinetics of CNS penetration of efavirenz and its metabolites. Journal of Antimicrobial Chemotherapy 2019; 74(3):699-709.

 GONESE E, KILMARX PH, VAN SCHALKWYK C, GREBE EE, MUTASA K, NTOZINI R, PAREKH B, DOBBS T, DUONG POTTINGER Y, MASCIOTRA S, OWEN M, NACHEGA JB, VAN ZYL GU, HARGROVE J. Evaluation of the Performance of Three Biomarker Assays for Recent HIV Infection Using a Well-Characterized HIV-1 Subtype C Incidence Cohort. AIDS Research and Human Retroviruses 2019; 35(7):615-627.

 LAUGHTON B, NAIDOO S, DOBBELS EFM, BOIVIN M, JANSE VAN RENSBURG A, GLASHOFF RH, VAN ZYL GU, KRUGER M, COTTON MF. Neurodevelopment at 11 months after starting antiretroviral therapy within 3 weeks of life. Southern African Journal of HIV Medicine  2019; 20(1):a1008, 8 pages.

 MAPONGA TG, NWANKWO CT, MATTHEWS P. Sustainable Development Goals for HBV elimination in South Africa : challenges, progress, and the road ahead. South African Gastroenterology Review 2019; 17(1):15-25.

 MOKAYA J, BURN EAO, TAMANDJOU TCHUEM CR, GOEDHALS D, BARNES EJ, ANDERSSON MI, PINEDO-VILLANUEVA R, MATTHEWS P. Modelling cost-effectiveness of tenofovir for prevention of mother to child transmission of hepatitis B virus (HBV) infection in South Africa. BMC Public Health 2019; 19:829, 9 pages.

 MOTAZE NV, MANAMELA J, SMIT S, RABIE H, HARPER K, DU PLESSIS N, REUBENSON G, COETZEE MPA, BALLOT D, MOORE DP, NUTTALL J, TOOKE L, PREISER W, ET AL E. Congenital Rubella Syndrome Surveillance in South Africa Using a Sentinel Site Approach: A Cross-sectional Study. Clinical Infectious Diseases 2019; 68(10):1658-1664.

 OBASA AEA, ASHOKKUMAR M, NEOGI U, JACOBS GB. Mutations in long terminal repeats kB transcription factor binding sites in plasma virus among South African people living with HIV-1. AIDS Research and Human Retroviruses 2019; 35(6):572-576.

 OBASA AEA, ENGELBRECHT S, JACOBS GB. Near full-length HIV-1 subtype B sequences from the early South African epidemic, detecting a BD unique recombinant form (URF) from a sample in 1985. Scientific Reports 2019; 9:6227, 7 pages.

 PATTEN G, SCHOMAKER M, DAVIES M-A, RABIE H, VAN ZYL GU, TECHNAU K, ELEY B, BOULLE A, VAN DYKE RB, PATEL K, SIPAMBO N, WOOD R, TANSER F, GIDDY J, COTTON MF, NUTTALL J, ESSACK G, KARALIUS B, SEAGE G, SAWRY S, EGGER M, FAIRLIE L. What Should We Do When HIV-positive Children Fail First-line Combination Antiretroviral Therapy? A Comparison of 4 ART Management Strategies. Pediatric Infectious Disease Journal 2019; 38(4):400-405.

 ROSSOUW T, VAN DYK G, VAN ZYL GU. Rapid emergence of resistance to antiretroviral treatment after undisclosed prior exposure: A case report. Southern African Journal of HIV Medicine  2019; 20(1):a965, 3 pages.

 SAEZ-AYALA M, YEKWA EL, MONDIELLI C, ROUX L, HERNÁNDEZ S, BAILLY F, COTELLE P, ROGOLINO D, CANARD B, FERRON F, ALVAREZ K. Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain. ANTIVIRAL RESEARCH 2019; 162:79-89.

 SMIT DP, MEYER D, MARITZ J, DE GROOT-MIJNES JDF. Authors reply to letter to the Editor - In Response to"Smit D, Meyer D, Maritz J, et al. Polymerase Chain Reaction and Goldmann-Witmer Coefficient to Examine the Role of Epstein-Barr Virus in Uveitis". OCULAR IMMUNOLOGY AND INFLAMMATION 2019; 27(1 ):116.

 SMIT DP, MEYER D, MARITZ J, DE GROOT-MIJNES JDF. Polymerase Chain Reaction and Goldmann-Witmer Coefficient to Examine the role of Epstein-Barr Virus in Uveitis. OCULAR IMMUNOLOGY AND INFLAMMATION 2019; 27(1 ):108-113.

 SMIT DP, MEYER D, MARITZ J, DE GROOT-MIJNES JDF. Polymerase chain reaction and Goldmann-Witmer coefficient to examine the role of Epstein-Barr Virus in Uveitis. OCULAR IMMUNOLOGY AND INFLAMMATION 2019; 27(1):108-113.

VAN DOMSELAAR R, NJENDA DT, RAO R, SONNERBORG A, SINGH K, NEOGI U. HIV-1 subtype C with PYxE insertion has enhanced binding of Gag-p6 to host cell protein ALIX and increased replication fitness. JOURNAL OF VIROLOGY 2019; 93(9):e00077-19, 14 pages.

 VAN SCHALKWYK C, MARITZ J, VAN ZYL GU, PREISER W, WELTE A. Pooled PCR testing of dried blood spots for infant HIV diagnosis is cost efficient and accurate. BMC Infectious Diseases 2019; 19:136, 6 pages.

 VAN ZYL GU, BALE MJ, KEARNEY MF. HIV evolution and diversity in ART-treated patients. Retrovirology 2018; 15:14, 12 pages.

VAN ZYL GU, MARITZ J, NEWMAN HM, PREISER W. Lessons in diagnostic virology: expected and unexpected sources of error. Reviews in Medical Virology 2019; 10:e2052, 7 pages.

VARDAS E. Highlights from the European Academy of Allergy and Clinical Immunology (EAACI) Conference, 2019. Current Allergy and Clinical Immunology 2019; 32(4):148-153.

VARDAS E. The fine balance of the microbiome, immunology and allergy - May the Microbiome always be with you. Current Allergy and Clinical Immunology 2019; 32(2):4.

VARDAS E. The tangled web of the immune system: allergy and the microbiome. Current Allergy and Clinical Immunology 2019; 32(2):50-53.

VELDSMAN KA, JANSE VAN RENSBURG A, ISAACS S, NAIDOO S, LAUGHTON B, LOMBARD CJ, COTTON MF, MELLORS JW, VAN ZYL GU. HIV-1 DNA decay is faster in children who initiate ART shortly after birth than later. Journal of the International AIDS Society 2019; 22:e25368, 7 pages.

 VERMEULEN M, LELIE N, COLEMAN C, SYKES W, JACOBS G, SWANEVELDER R, BUSCH MP, VAN ZYL GU, GREBE EE, WELTE A, REDDY R. Assessment of HIV transfusion transmission risk in South Africa: a 10-year analysis following implementation of individual donation nucleic acid amplification technology testing and donor demographics eligibility changes. TRANSFUSION 2019; 59:267-276.

 WILKINSON E, JUNQUEIRA DM, LESSELLS R, ENGELBRECHT S, VAN ZYL GU, DE OLIVEIRA T, SALEMI M. The effect of interventions on the transmission and spread of HIV in South Africa: a phylodynamic analysis. Scientific Reports 2019; 9:2640, 12 pages.

 WOMERSLEY JS, CLAUSS LB, VARATHAN O, ENGELBRECHT S, HEMMINGS SMJ, SEEDAT S, SPIES G. The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance. BMC Research Notes 2019; 12:828, 7 pages.

Doctorol Completed

​KATUSIIME MGK. CHARACTERIZATION OF THE PERSISTING HIV-1 RESERVOIR IN EARLY TREATED CHILDREN ON LONG-TERM SUPPRESSIVE ARV REGIMENS. PhD, 2019. 200 pp. Promotor: VAN ZYL GU.

OBASA AEA. Mechanisms of 2nd-generation integrase inhibitors (INIs) resistance and viral persistence in South African HIV-1 subtype C infection. PhD, 2019. 200 pp. 

TAMANDJOU TCHUEM CR. Hepatitis B virus mother-to-child-transmission in Namibia: transmission dynamics and possibilities for elimination. PhD, 2019. 200 pp. Promotor: ANDERSSON MI. Medepromotor: PREISER W.

Masters Completed

​KOTZE A. Determining the host-specificity of Neoromicia capensis coronavirus by using viral pseudoparticles. MSc, 2019. 200 pp. Studieleier: PREISER W.

VARATHAN O. Molecular characterisation of HIV-1 recombinants and non-subtype C viruses in South Africa. MSc, 2019. 200 pp. Studieleier: JACOBS GB. Medestudieleier: ENGELBRECHT S.

VELDSMAN KA. Investigatin​g HIV-1 DNA and HIV-1 RNA kinetics with ultrasensitive assays in early treated infants and determining predictors associated with kinetics in older treated children. MSc, 2019. 200 pp. Studieleier: VAN ZYL GU.​

2018​

Journal Articles

BRADO DB, OBASA AEA, IKOMEY GM, CLOETE R, SINGH K, ENGELBRECHT S, NEOGI U, JACOBS GB. Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and availability of integrase inhibitors in Cape Town, South Africa. Scientific Reports 2018; 8(4709):1-9.

CIHAMBANYA KL, EBWAMI SB, KASENGI JB, MIYANGA S, BAHATI YL, KAMBALE R, DE BEER C. Human respiratory syncytial virus: prevalence, viral co-infections and risk factors for lower respiratory tract infections in children under 5 years of age at a general hospital in the Democratic Republic of the Congo. JOURNAL OF MEDICAL MICROBIOLOGY 2018; 67(4):514-522.

 CRONJÉ N, SCHWARTZ I, RETIEF L, BASTOS ADS, MATTHEE S, PREISER W, BENNETT NC, MAPHANGA T, GOVENDER NP, COLEBUNDERS R, KENYON C. Attempted molecular detection of the thermally dimorphic human fungal pathogen Emergomyces africanus in terrestrial small mammals in South Africa. MEDICAL MYCOLOGY 2018; 56(4):510-513.

 DOWLING WB, VELDSMAN KA, KATUSIIME MGK, MARITZ J, BOCK PA, MEEHAN S, VAN SCHALKWYK M, COTTON MF, PREISER W, VAN ZYL GU. HIV-1 RNA testing of pooled dried blood spots is feasible to diagnose acute HIV infection in resource limited settings. Southern African Journal of Infectious Diseases (Formerly Southern African Journal of Epidemiology and Infection) 2018; 33(2):50-53.

 HEAPS J, JOSKA J, CABEEN R, BAKER LM, SALMINEN LE, HOARE J, LAIDLAW DH, WAMSER-NANNEY R, PENG C, ENGELBRECHT S, SEEDAT S, PAUL RH, STEIN D. White matter fiber bundle lengths are shorter in cART naive HIV: an analysis of quantitative diffusion tractography in South Africa. Brain Imaging and Behavior 2018; 12(5):1229-1238.

KERR TJ, MATTHEE S, GOVENDER D, TROMP GC, ENGELBRECHT S, MATTHEE CA. Viruses as indicators of contemporary host dispersal and phylogeography: an example of feline immunodeficiency virus (FIVP le) in free-ranging African lion (Panthera leo). JOURNAL OF EVOLUTIONARY BIOLOGY 2018; 31(10):1529-1543.

 MAPONGA TG, ANDERSSON MI, VAN RENSBURG CJ, ARENDS JE, TALJAARD JJ, PREISER W, GLASHOFF RH. HBV and HIV viral load but not microbial translocation or immune activation are associated with liver fibrosis among patients in South Africa. BMC Infectious Diseases 2018; 18:214, 11 pages.

 MAZANDERANI AH, MOYO F, KUFA T, MARITZ J, SHERMAN GG. Differentiating clearly positive from indeterminate results: A review of irreproducible HIV-1 PCR positive samples from South Africa's Early Infant Diagnosis Program, 2010-2015. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 2018; 91(3):248-255.

 MENEZES LJ, POKHAREL U, SUDENGA L, BOTHA MHH, ZEIER MD, ABRAHAMSEN ME, GLASHOFF RH, ENGELBRECHT S, VAN DER LOEFF MFS, VAN DER LAAN LE, KIPPING S, TAYLOR D, GIULIANO AR. Patterns of prevalent HPV and STI co-infections and associated factors among HIV-negative young Western Cape, South African women: the EVRI trial. SEXUALLY TRANSMITTED INFECTIONS 2018; 94(1):55-61.

 NATOLI ME, ROHRMAN BA, DE SANTIAGO C, VAN ZYL GU, RICHARDS-KORTUM RR. Paper-based detection of HIV-1 drug resistance using isothermal amplification and an oligonucleotide ligation assay. ANALYTICAL BIOCHEMISTRY 2018; 544:64-71.

NEWMAN HM, TSHISEVHE V. Simplified approach to uncertainty of measurement in the clinical virology laboratory. Reviews in Medical Virology 2018; 28(6):e2006, 5 pages.

 ROGERS L, OBASA AEA, JACOBS GB, SARAFIANOS SG, SONNERBORG A, NEOGI U, SINGH K. Structural Implications of Genotypic Variations in HIV-1 Integrase from Diverse Subtypes. Frontiers in Microbiology 2018; 9:1754, 9 pages.

 TSHABALALA D, NEWMAN HM, BUSINGE C, MABUNDA SA, KEMP W, BEJA P. Prevalence and determinants of congenital cytomegalovirus infection at a rural South African central hospital in the Eastern Cape. Southern African Journal of Infectious Diseases (Formerly Southern African Journal of Epidemiology and Infection) 2018; 33(4):89-92.

VELDSMAN KA, MARITZ J, ISAACS S, KATUSIIME MGK, JANSE VAN RENSBURG A, LAUGHTON B, MELLORS JW, COTTON MF, VAN ZYL GU. Rapid decline of HIV-1 DNA and RNA in infants starting very early ART may pose a diagnostic challenge. AIDS 2018; 32:629-634.

Doctorol completed 

CHOTUN BN. Hepatitis B virus-related hepatocellular carcinoma in South Africa: Investigations in the risk profile of a previously unscreened population from the Western Cape. PhD, 2018. 230 pp. Promotor: ANDERSSON MI. Medepromotor: PREISER W, FERNANDEZ PW.

Masters completed 

​MATSHAZI DM. Viral infection and immune biomarkers of infection and inflammation in cases of Sudden Unexpected Death in Infancy (SUDI) at the Tygerberg Medico-legal Mortuary. MSc, 2018. 104 pp. Studieleier: DE BEER C. Medestudieleier: DEMPERS JJ.

PISTORIUS C. Dried plasma spot testing - The answer for making blood transfusion testing safer in Africa?. MSc, 2018. 71 pp. 

SAAYMAN JE. Profiling cardiovascular viral pathogens in cases of sudden and unexpected death in infants (SUDI) at the Tygerberg Medico-legal Mortuary and the role of myocarditis as a possible cause of death. MSc, 2018. 95 pp. Studieleier: DE BEER C. Medestudieleier: DEMPERS JJ.

​​

2017

Journal Articles

 CHOTUN BN, PREISER W, VAN RENSBURG C, FERNANDEZ PW, THERON GB, GLEBE D, ANDERSSON MI. Point-of-care screening for hepatitis B virus infection in pregnant women at an antenatal clinic: A South African experience. PLoS One 2017; 12(7):e0181267, 11 pages.

 FRIGATI LJ, WYNBERG E, MARITZ J, HOLGATE SL, COTTON MF, RABIE H. Antiretroviral Treatment Initiated in the First Month of Life. PEDIATRIC INFECTIOUS DISEASE JOURNAL 2017; 36:584-587.

 IKOMEY GM, ASSOUMOU MCO, GICHANA JO, NJENDA DT, MIKASI SG, MESEMBE MT, LYONGA E, JACOBS GB. Observed HIV drug resistance associated mutations amongst naïve immunocompetent children in Yaoundé, Cameroon. GERMS 2017; 7(4):178 - 185.

INNES SEV, VAN TOORN R, OTWOMBE K, DOBBELS EFM, VAN ZYL GU, COTTON MF, LAUGHTON B. Late-onset HIV encephalopathy in children with long-standing virologic suppression followed by slow spontaneous recovery despite no change in antiretroviral therapy: 4 Case Reports. Pediatric Infectious Disease Journal 2017; 36(11):e264-e267.

KERR TJ, MATTHEE CA, MATTHEE S, GOVENDER D, ENGELBRECHT S. Evaluating the diversity of the Feline Immunodeficiency Virus (FIV): a leopard perspective. African Journal of Wildlife Research (formerly: South African Journal of Wildlife Research) 2017; 2(47):92–105.

 LOPES T, CABLE R, PISTORIUS C, MAPONGA TG, IJAZ S, PREISER W, TEDDER R, ANDERSSON MI. Racial differences in seroprevalence of HAV and HEV in blood donors in the Western Cape, South Africa: a clue to the predominant HEV genotype?. EPIDEMIOLOGY AND INFECTION 2017; 145(9):1910-1912.

 MALL AS, HABTE H, MTHEMBU Y, PEACOCKE J, DE BEER C. Mucus and Mucins: do they have a role in the inhibition of the human immunodeficiency virus?. Virology Journal 2017; 14(1):192, 14 pages.

 MARITZ J, MAHARAJ JN, COTTON MF, PREISER W. Interpretation of indeterminate HIV I PCR results are influenced by changing vertical transmission prevention regimens. JOURNAL OF CLINICAL VIROLOGY 2017; 95:86-89.

 MOYO S, KOTOKWE KP, MOHAMMED T, BOLEO C, MUPFUMI L, CHISHALA S, TSALAILE L, BUSSMANN H, GASEITSIWE S, MUSONDA R, MAKHEMA J, BAUM M, MARLINK R, ENGELBRECHT S, ESSEX M, NOVITSKY V. Low False recent Rate of Limiting Antigen-Avidity Assay Combined with HIV-1 Data in Botswana. AIDS RESEARCH AND HUMAN RETROVIRUSES 2017; 33(1):17-18.

 MOYO S, WILKINSON E, VANDORMAEL A, WANG R, WENG J, KOTOKWE KP, GASEITSIWE S, MAKHEMA J, MUSONDA R, ESSEX M, DE OLIVEIRA T, ENGELBRECHT S, NOVITSKY V. Pairwise diversity and tMRCA as potential markers for HIV infection recency. MEDICINE 2017; 96(6):e6041, 6 pages.

 NEWMAN HM, MARITZ J. Basic overview of method validation in the clinical virology laboratory. REVIEWS IN MEDICAL VIROLOGY 2017; 27(5):e1940, 7 pages.

 O HARA GA, MC NAUGHTON AL, MAPONGA TG, JOOSTE P, OCAMA P, CHILENGI R, MOKAYA J, LIYAYI MI, WACHIRA T, GIKUNGI DM, BURBRIDGE L, O DONNELL D, AKIROR CS, SLOAN D, TORIMIRO J, YINDOM LM, WALTON R, ANDERSSON MI, MARSH K, NEWTON R, MATTHEWS P. Hepatitis B virus infection as a neglected tropical disease. PLoS Neglected Tropical Diseases 2017; 11(10): e0005842, 9 pages.

 PAREDES R, TZOU PL, VAN ZYL GU, BARROW G, CAMACHO R, CARMONA S, GRANT PM, GUPTA RK, HAMERS RL, HARRIGAN R, JORDAN M, KANTOR R, KATZENSTEIN DA, KURITZKES D, MALDARELLI F, OTELEA D, WALLIS C, SCHAPIRO M, SHAFER RW. Collaborative update of a rule-based expert system for HIV-1 genotypic resistance test interpretation. PLoS One 2017; 12(7): e0181357, 31 pages.

 PAUL RH, PHILLIPS S, HOARE , LAIDLAW DH, CABEEN R, OLBRICHT GR, SU Y, STEIN DJ, ENGELBRECHT S, SEEDAT S, SALMINEN LE, BAKER LM, HEAPS J, JOSKA J. Neuroimaging abnormalities in clade C HIV are independent of Tat genetic diversity. Journal of Neurovirology 2017; 23(2):319-328.

 RHEE S, VARGHESE V, HOLMES SP, VAN ZYL GU, STEEGEN K, BOYD MA, COOPER DA, NSANZIMANA S, SARAVANAN S, CHARPENTIER C, DE OLIVEIRA T, ETIEBET MA, GARCIA F, GOEDHALS D, GOMES P, GÜNTHARD HF, HAMERS RL, HOFFMANN CJ, HUNT G, JIAMSAKUL A, ET AL . Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regiman: An International Collaboration. EBioMedicine 2017; 18:225-235.

 ROSSOUW T, TUCKER JD, VAN ZYL GU, SIKWESI K, GODFREY C. Barriers to HIV remission research in low- and middle-income countries. Journal of the International AIDS Society 2017; 20(1):21521, 9 pages.

 RUHANYA V, JACOBS GB, GLASHOFF RH, ENGELBRECHT S. Clinical Relevance of Total HIV DNA in Peripheral Blood Mononuclear Cell Compartments as a Biomarker of HIV-Associated Neurocognitive Disorders (HAND). Viruses-Basel 2017; 9(11):324, 17 pages.

 SUDENGA L, TORRES BN, BOTHA MHH, ZEIER MD, ABRAHAMSEN ME, GLASHOFF RH, ENGELBRECHT S, SCHIM VAN DER LOEFF MF, VAN DER LAAN LE, KIPPING S, TAYLOR D, GIULIANO AR. HPV Serostatus Pre- and Post- Vaccination in a Randomized Phase Ii Preparedness Trial among Young Western Cape, South African Women: The EVRI Trial. Papillomavirus Research 2017; 3:50-56.

 VAN ZYL GU, GROBBELAAR CJ, CLAASSEN M, BOCK PA, PREISER W. Moderate levels of pre-therapy drug resistance (PDR) in a generalised epidemic: time for better first-line ART?. AIDS 2017; 31(17):2387-2391.

 VAN ZYL GU, KATUSIIME MGK, WIEGAND A, MCMANUS WR, BALE MJ, HALVAS EK, LUKE B, BOLTZ VF, SPINDLER J, LAUGHTON B, ENGELBRECHT S, COFFIN JM, COTTON MF, ET AL . No evidence of HIV replication in children on antiretroviral therapy. JOURNAL OF CLINICAL INVESTIGATION 2017; 127(10):3827-3834.

ASSOUMOU MKO, NGUEFACK G, JACOBS GB, GUIDEM E, DOH G, MESEMBE MT, LYONGA E, IKOMEY GM. Effects of Storage: Whole Blood Specimens for CD4-T Lymphocytes Determination in Yaoundé, Cameroon. Health Sciences & Diseases 2017; 18(4):15-18.

 CIHAMBANYA KL, DE BEER C. Association between Respiratory Syncytial Virus Infection in Infancy and Subsequent Asthma: A Meta-Analysis of Observational Studies. JSM Allergy Asthma 2017; 2(1):1-5.

 DOH G, IKOMEY GM, NJENDA DT, GICHANA JO, KATUSIIME MGK, NDZE VN, ZEIER M, MESEMBE MT, FOKUNANG C, ASSOUMOU MCO, TEBEU P-M, ATANGANA PA, JACOBS GB. Oncogenic Human Papillomavirus Genotypes 16 and 18 Prevalence Among women with Normal Cervical Cytology and Neoplasia in Cameroon: A systematic Review. Health Sciences & Diseases 2017; 18(3):3-11.

 MAPONGA TG, MATSHA RM, MORIN S, SCHEIBE A, SWAN T, ANDRIEUX-MEYER I, SPEARMAN CW, KLEIN M, ROCKSTROH JK. Highlights from the 3rd international HIV/viral hepatitis Co-infection meeting - HIV/viral hepatitis: improving diagnosis, antiviral therapy and access. Hepatology, Medicine and Policy 2017; 2:8, 9 pages.

​VAN HELDEN L, KORSMAN SNJ, GREWAR JD, THOMPSON P, ISAACS S, PICOZZI K, ANDERSSON MI, PREISER W. Surveillance to investigate the epidemiology of potentially zoonotic hepatitis E in commercial pig herds supplying Cape Town, South Africa. Proceedings of the 3rd International Animal Health Surveillance Conference: Beyond animal health surveillance (ICAHS 3), Rotorua, New Zealand, New Zealand Veterinary Association 2017: 317-319.

Doctoral Completed 

​​CRONJÉ N. The Diversity of Coronaviruses in Southern African Bat Populations. PhD, 2017. 226 pp. Promotor: PREISER W. Medepromotor: ITHETE NL, Schoeman MC.

​

2016

Journal Articles

ANDERSON M, GASEITSIWE S, MOYO S, THAMI KP, MOHAMMED T, SETHARE D, SEBUNYA TK, POWELL EA, MAKHEMA J, BLACKARD JT, MARLINK R, ESSEX M, MUSONDA R. Slow CD4+ T-Cell Recovery in Human Immunodeficiency Virus/Hepatitis B Virus-Coinfected patients initiating Truvada-Based Combination Antiretroviral Therapy in Botswana. Open Forum Infectious Diseases 2016; 3(3):1-7.

 CHINGWARU W, GLASHOFF RH, VIDMAR J, KAPEWANGOLO P, SAMPSON SL. Mammalian cell cultures as models for Mycobacterium tuberculosis - human immunodeficiency virus (HIV) interaction studies: A review. Asian Pacific Journal of Tropical Medicine 2016; 9(9):832-838.

 HESSELING AC, BLAKNEY AK, JONES CE, ESSER MM, DE BEER C, KUHN L, COTTON MF, JASPAN HB. Delayed BCG immunization does not alter antibody responses to EPI vaccines in HIV-exposed and -unexposed South African infants. VACCINE 2016; 34:3702-3709.

 HOFFMANN CJ, MARITZ J, VAN ZYL GU. CD4 count-based failure criteria combined with viral load monitoring may trigger worse switch decisions than viral load monitoring alone. Tropical Medicine and International Health 2016; 21(2):219–223.

JACOBS GB, IKOMEY GM. Biomedical research and capacity building: Bilateral collaboration between research institutes in South Africa and Cameroon. SAMJ SOUTH AFRICAN MEDICAL JOURNAL 2016; 106(10):953.

 KASANG C, KALLUVYA S, MAJINGE C, KONGOLA G, MLEWA M, MASSAWE I, KABYEMERA R, MAGAMBO K, ULMER A, KLINKER H, GSCHMACK E, HORN A, KOUTSILIERI E, PREISER W, HOFMANN D, HAIN J, MULLER A, DÖLKEN L, RETHWILM A, STICH A, SCHELLER C. Effects of Prednisolone on Disease Progression in Antiretroviral-Untreated HIV Infection: A 2-Year Randomized, Double-Blind Placebo-Controlled Clinical Trial. PLoS One 2016; 11(1):): e0146678, 25 pages.

 MAZANDERANI AH, TECHNAU K, HSIAO N-Y, MARITZ J, CARMONA S, SHERMAN GG. Recommendations for the management of indeterminate HIV PCR results within South Africa's early infant diagnosis programme. Southern African Journal of HIV Medicine  2016; 17(1):a451 - a455.

 MOYO S, MOHAMMED T, WIRTH K, PRAGUE M, BENNETT K, HOLMES MD, MUPFUMI L, SEBOGODI P, MORAKA NO, BOLEO C, MAPHORISA CN, SERAISE B, GASEITSIWE S, MUSONDA R, VAN WIDENFELT E, POWIS K, GAOLATHE T, TCHETGEN EJ, MAKHEMA J, ESSEX M, LOCKMAN S, NOVITSKY V. Point-of-Care Cepheid Xpert HIV-1 Viral Load Test in Rural African Communities is feasible and reliable. JOURNAL OF CLINICAL MICROBIOLOGY 2016; 54(12):3050-3054.

 MOYO S, VANDORMAEL A, WILKINSON E, ENGELBRECHT S, GASEITSIWE S, KOTOKWE KP, MUSONDA R, TANSER F, ESSEX M, NOVITSKY V, DE OLIVEIRA T. Analysis of Viral Diversity in Relation ot the Recency of HIV-1C Infection in Botswana. PLoS One 2016; 11(8):e0160649, 18 pages.

 NEOGI U, ENGELBRECHT S, CLAASSEN M, JACOBS GB, VAN ZYL GU, PREISER W, SONNERBORG A. Mutational Heterogeneity in p6 Gag Late Assembly (L) Domains in HIV-1 Subtype C Viruses from South Africa. AIDS RESEARCH AND HUMAN RETROVIRUSES 2016; 32(1):80-84.

 NOVITSKY V, MOYO S, WANG R, GASEITSIWE S, ESSEX M. Deciphering multiplicity of HiV-1C infection: transmission of closely related multiple viral lineages. PLoS One 2016; 10(1371):e0166746, 15 pages.

PARIKH UM, MCCORMICK K, VAN ZYL GU, MELLORS JW. Future technologies for monitoring HIV drug resistance and cure. Current Opinion in HIV and AIDS 2016; 11(00):1-8.

 STEEGEN K, BRONZE M, PAPATHANASOPOULOS MA, VAN ZYL GU, GOEDHALS D, VAN VUUREN C, MACLEOD W, SANNE I, STEVENS WS, CARMONA S. Prevalence of antiretroviral Drug Resistance in Patients who are not responding to Protease Inhibitor-Based treatment: Results from the First National Survey in South Africa. JOURNAL OF INFECTIOUS DISEASES 2016; 214:1826-1830.

 STEEGEN K, CARMONA S, BRONZE M, PAPATHANASOPOULOS MA, VAN ZYL GU, GOEDHALS D, MACLEOD W, SANNE I, STEVENS WS. Moderate levels of Pre-Treatment HIV-1 Antiretroviral Drug Resistance Detected in the First South African National Survey. PLoS One 2016; 11(12):1-12.

 SUDENGA L, TORRES BN, BOTHA MHH, ZEIER MD, ABRAHAMSEN ME, GLASHOFF RH, ENGELBRECHT S, VAN DER LOEFF MFS, VAN DER LAAN LE, KIPPING S, TAYLOR D, GIULIANO AR. Cervical HPV natural history among young Western Cape, South African women: The randomized control EVRI Trial. JOURNAL OF INFECTION 2016; 72:60-69.

VAN ZYL GU, DECLOEDT EH. Is HIV-1C a risk factor for protease inhibitor failure?. Lancet HIV 2016; 3(4):e149 - e151.

 WILKINSON E, RASMUSSEN D, RATMANN O, STADLER T, ENGELBRECHT S, DE OLIVEIRA T. Origin, imports and exports of HIV-1 subtype C in South Africa: A historical perspective. Infection, Genetics and Evolution 2016; 46:200-208.

 IKOMEY GM, JACOBS GB, TANJONG B, MESEMBE MT, EYOH A, LYONGA E, MFOATAW E, NGOH R, TAMANDJOU CR, IKOMEY G, ASSOUMOU MCO. Evidence of Co and Triple Infections of Hepatitis B and C Amongst HIV Infected Pregnant Women in Buea, Cameroon. Science Journal of Public Health 2016; 4(2):127-131.

IKOMEY GM, JULIUS A, JACOBS GB, MESEMBE MT, EYOH A, LYONGA E, CLAIRE OAM. FAS Mediated (CD95L) Periferal T-cell Apotosis Marker in Monitoring HIV-1 Disease Progression in Adults in Yaoundé, Cameroon. International Journal of Immunology 2016; 4(1):1-5.

Doctoral completed 

DE SWARDT D. Blood dendritic cells in chronically HIV-1 infected individuals in South Africa: Phenotype, Function and Immune modulation. PhD, 2016. 195 pp. Promotor: GLASHOFF RH.

MAPONGA TG. Hepatitis B virus-associated hepatocellular carcinoma in South Africa: epidemiology and impact of HIV-1 co-infection and immune dysregulation. PhD, 2016. 240 pp. Promotor: GLASHOFF RH.

MOYO S. HIV-1C Dynamics and Evolutionary Trends in Botswana. PhD, 2016. 45 pp. Promotor: ENGELBRECHT S.​

2015

Journal Articles

ANDERSSON MI, PREISER W, VAN RENSBURG C, TALJAARD JJ, HOFFMANN CJ. The HIV/HBV co-infected patient: Time for proactive management. SAMJ South African Medical Journal 2015; 105(4):281-282.

 ANDERSSON MI, RAJBHANDARI R, KEW MC, VENTO S, PREISER W, HOEPELMAN AIM, THERON GB, COTTON MF, COHN J, GLEBE D, LESI O, THURSZ M, PETERS M, CHUNG R, WIYSONGE CSU. Mother-to-child transmission of hepatitis B virus in sub-Saharan Africa: time to act. Lancet Global Health 2015; 3:e-358-e359.

 ANDERSSON MI, STEAD PA, MAPONGA TG, VAN DER PLAS H, PREISER W. Hepatitis E virus infection: An underdiagnosed infection in transplant patients in Southern Africa?. Journal of Clinical Virology 2015; 70:23-25.

 CHOTUN BN, NEL EDLR, COTTON MF, PREISER W, ANDERSSON MI. Hepatitis B virus infection in HIV-exposed infants in the Western Cape, South Africa. Vaccine 2015; 33(36):4618-4622.

 DREXLER F, CORMAN VM, MATTHEE S, PREISER W, ET AL . Evolutionary origins of hepatitis A virus in small mammals. Proceedings of the National Academy of Sciences of the United States of America 2015; 112:15190-15195.

 FISHER RG, SMITH DM, MURRELL B, SLABBERT R, KIRBY BM, EDSON C, COTTON MF, HAUBRICH R, POND SLK, VAN ZYL GU. Next generation sequencing improves detection of drug resistance mutations in infants after PMTCT failure. Journal of Clinical Virology 2015; 62:48-53.

 GIULIANO AR, BOTHA MHH, ZEIER MD, ABRAHAMSEN ME, GLASHOFF RH, VAN DER LAAN LE, PAPENFUSS M, ENGELBRECHT S, SCHIM VAN DER LOEFF MF, SUDENGA L, TORRES BN, KIPPING S, TAYLOR D. High HIV, HPV and STI Prevalence Among Young Western Cape, South African Women: EVRI HIV Prevention Preparedness Trial. JAIDS-Journal of Acquired Immune Deficiency Syndromes 2015; 68(2):227-235.

 MOYO S, WILKINSON E, NOVITSKY V, VANDORMAEL A, GASEITSIWE S, ESSEX M, ENGELBRECHT S, DE OLIVEIRA T. Identifying Recent HIV Infections: From Serological Assays to Genomics. Viruses-Basel 2015; 7:5508-5524.

 MSIMANGA PW, VARDAS E, ENGELBRECHT S. HIV-1 diversity in an antiretroviral treatment naïve cohort from Bushbuckridge, Mpumalanga Province, South Africa. Virology Journal 2015; 12:1-13.

 NELSON A, MARITZ J, GIDDY J, FRIGATI LJ, RABIE H, VAN CUTSEM G, MUTSEYEKWA T, JANGE N, BERNHEIMER JM, COTTON MF, COX V. HIV testing and antiretroviral therapy initiation at birth: Views from a primary care setting in Khayelitsha. Southern African Journal of HIV Medicine 2015; 16(1):1-4.

 VAN ZYL GU, BEDISON MA, JANSE VAN RENSBURG A, LAUGHTON B, COTTON MF, MELLORS JW. Early Antiretroviral Therapy in South African Children Reduces HIV-1-Infected Cells and Cell-Associated HIV-1 RNA in Blood Mononuclear Cells. Journal of Infectious Diseases 2015; 212(1):39-43.

WILKINSON E, ENGELBRECHT S, DE OLIVEIRA T. History and origin of the HIV-1 subtype C epidemic in South Africa and the greater southern African region. Scientific Reports 2015; 5(16897):1-12.

 WILKINSON E, HOLZMAYER V, JACOBS GB, DE OLIVEIRA T, BRENNAN CA, HACKETT JR J, JANSE VAN RENSBURG E, ENGELBRECHT S. Sequencing and Phylogenetic Analysis of Near Full-Length HIV-1 Subtypes A, B, G and Unique Recombinant AC and AD Viral Strains Identified in South Africa. Aids Research and Human Retroviruses 2015; 31(4):412-420.

 WITKOWSKI PT, KALLIES R, HOVEKA J, AUSTE B, ITHETE NL, SOLTYS K, SZEMES T, DROSTEN C, PREISER W, KLEMPA B, MFUNE KE, KRUGER DH. Novel Arenavirus Isolates from Namaqua Rock Mice, Namibia, Southern Africa. Emerging Infectious Diseases 2015; 21(7):1213-1216.

ZEIER MD, BOTHA MHH, ENGELBRECHT S, MACHEKANO R, JACOBS GB, ISAACS S, VAN SCHALKWYK M, NACHEGA JB. Combination antiretroviral therapy reduces the detection risk of cervical human papilloma virus infection in women living with HIV. Aids 2015; 29:59-66.

2014

Journal Articles

BURGER, M.C., DEMPERS, J.J. & DE BEER, C., 2014. Profiling the approach to the investigation of viral infections in cases of sudden unexpected death in infancy in the Western Cape Province, South Africa. Forensic Science International, 239, pp.27–30. FSIjournal

VICTOR MAX CORMAN, NDAPEWA LAUDIKA ITHETE, LEIGH ROSANNE RICHARDS, M. CORRIE SCHOEMAN, WOLFGANG PREISER, CHRISTIAN DROSTEN AND JAN FELIX DREXLER,2014. Rooting the phylogenetic tree of MERS-Coronavirus by characterization of a conspecific virus from an African Bat. Journal of Virology. JVI

HAYLEY IPP, BONGANI B NKAMBULE, TIMOTHY D REID, DALENE DE SWARDT, LINDA-GAIL BEKKER, RICHARD H GLASHOFF., 2014. CD4+ T cells in HIV infection show increased levels of expression of a receptor for vasoactive intestinal peptide, VPAC2. Immunologic Research, pp.1–5. Immunol res

HAYLEY IPP, ANNALISE E ZEMLIN, RAJIV T ERASMUS, RICHARD H GLASHOFF., 2014. Role of inflammation in HIV-1 disease progression and prognosis. Critical Reviews in Clinical Laboratory Sciences, 51(2), pp.98–111. Pubfacts

GRAEME BRENDON JACOBS, EDUAN WILKINSON, SHAHIEDA ISAACS, GEORGINA SPIES, TULIO DE OLIVEIRA, SORAYA SEEDAT, SUSAN ENGELBRECHT, 2014. HIV-1 Subtypes B and C Unique Recombinant Forms (URFs) and Transmitted Drug Resistance Identified in the Western Cape Province, South Africa. PLoS ONE, 9(3), p.e90845. PLoS

JUSTEN MANASA, RICHARD LESSELLS, THERESA ROSSOUW, KEVINDRA NAIDU, CLOETE VAN VUUREN, DOMINIQUE GOEDHALS, GERT VAN ZYL, ARMAND BESTER, ANDREW SKINGSLEY, KATHARINE STOTT, SIVA DANAVIAH, TERUSHA CHETTY, LAVANYA SINGH, PRAVI MOODLEY, COLLINS IWUJI,  NUALA MCGRATH, CHRISTOPHER J. SEEBREGTS AND TULIO DE OLIVEIRA, 2014. Southern African Treatment Resistance Network (SATuRN) RegaDB HIV drug resistance and clinical management database: supporting patient management, surveillance and research in southern Africa. Database , 2014 .Database

​MOYO SIKHULILE, LECUYER TESSA, WANG RUI, GASEITSIWE SIMANI, WENG JIA, MUSONDA ROSEMARY, BUSSMANN HERMANN, MINE MADISA, ENGELBRECHT SUSAN, MAKHEMA JOSEPH, MARLINK RICHARD, BAUM MARIANNA K., NOVITSKY VLADIMIR, AND ESSEX M., 2014. Evaluation of the false recent classification rates of multiassay algorithms in estimating HIV type 1 subtype C incidence. AIDS Research and Human Retroviruses, 30(1), pp.29–36. ARHR

MTHEMBU Y., LOTZ Z., TYLER M., DE BEER C., RODRIGUES J., SCHOEMAN L. AND  MALL A., 2014. Purified Human Breast Milk MUC1 and MUC4 Inhibit Human Immunodeficiency Virus. Neonatology, 105(3), pp.211–217. KARGER

HOWARD NEWMAN, LUKAS BREUNIG, GERT VAN ZYL, AUGUST STICH AND WOLFGANG PREISER, 2014. A qualitative PCR minipool strategy to screen for virologic failure and antiretroviral drug resistance in South African patients on first-line antiretroviral therapy. Journal of Clinical Virology, 60(4), pp.387–391. JCV

REIKIE, BRIAN A., ADAMS, ROZANNE C. M.,  LELIGDOWICZ, ALEKSANDRA.,  HO, KEVIN., NAIDOO, SHALENA., RUCK, CANDICE E., DE BEER, CORENA., PREISER, WOLFGANG.,  COTTON, MARK F., SPEERT, DAVID P., ESSER, MONIKA., KOLLMANN, TOBIAS R.,2014. Altered Innate Immune Development in HIV-Exposed Uninfected Infants. JAIDS Journal of Acquired Immune Deficiency Syndromes, 66(3). JAIDS

PETER T. WITKOWSKIA,  BORIS KLEMPAA, NDAPEWA L. ITHETE, BRITA AUSTEA, JOHN K.E. MFUNED, JULIA HOVEKAD, SONJA MATTHEEE, WOLFGANG PREISER, DETLEV H. KRUGERA.,2014. Hantaviruses in Africa. Virus Research, 187(0), pp.34–42. Science Direct

DE BEER C, LA GRANGE H. Diagnostic Options for Investigating Viral Respiratory Pathogens in Sudden Unexpected Death in Infancy (SUDI) Cases. Annals of Forensic Research and Analysis 2014; 1(2) : 1-6.

Masters completed

NEWMAN H. A qualitative PCR minipool strategy to screen for virologic failure and antiretroviral drug resistance in South African patients on first-line antiretroviral therapy. MMed, 2014. 31 pp. Studieleier: Preiser W. Medestudieleier: Van Zyl GU.

POOVAN K. Monocytes in Chronic HIV-1 infection: Changes in Phenotypic Marker Expression and their Relationship with Immune Activation. MSc, 2014. 146 pp. Studieleier: Glashoff RH. Medestudieleier: Ipp H.

TAMANDJOU C. A study of the Prevalence of Hepatitis B virus infetion in the infants of HIV positive mothers participating in P1041 in South Africa . MSc, 2014. 144 pp. Studieleier: Andersson MI.​

​

2013​​

Journal Articles

ANDERSSON MI, MAPONGA T, IJAZ S, BARNES JM, THERON GB, MEREDITH SA, PREISER W, TEDDER RS. The epidemiology of hepatitis B virus infection in HIV-infected and HIV-uninfected pregnant women in the Western Cape, South Africa. Vaccine 2013; 31: 5579-5584. PubMed

ANDERSSON MI, PREISER W, MAPONGA T, HEYS I, TALJAARD JJ, VAN RENSBURG CJ, TEDDER RS, IJAZ S. Immune reconstitution hepatitis E: a neglected complication of antiretroviral therapy in Africa?. Aids 2013; 27: 487-492. PubMed

BOYLES TH, BAMFORD CM, BATEMAN K, BLUMBERG L, DRAMOWSKI A, KARSTAEDT A, KORSMAN S, LE ROUX DM, MAARTENS G, MADHI S, NAIDOO R, NUTTALL J, REUBENSON G, TALJAARD J, THOMAS J, VAN ZYL G, VON GOTTBERG , WHITELAW A, MENDELSON M. Guidelines for the management of acute meningitis in children and adults in South Africa. Southern African Journal of Epidemiology and Infection 2013; 28(1): 5-15. SAJEI

FREEMAN N, NEWMAN H. Shigella Keratitis in an HIV-exposed infant. Paediatric Infectious Disease Journal 2013; 32(4): 426-427. PubMed

GOLDSTONE SE, JESSEN H, PALEFSKY JM, GIULIANO AR, EDSON D, MOREIRA C, VARDAS E, ARANDA C, FERRIS DG, COUTLEE F, MARSHALL S, VUOCOLO S, HAUPT RM, GURIS D, GARDNER EM. Quadrivalent HPV vaccine efficacy against disease related to vaccine and non-vaccine HPV types in males. Vaccine 2013; 31: 3849-3855. PubMed

HOSSEINIPOUR MC, GUPTA RK, VAN ZYL G, ERON JJ, NACHEGA JB. Emergence of HIV drug resistance during first- and second-line antiretroviral therapy in resource-limited settings. Journal of Infectious Diseases 2013; 207(S2): S49-S56. PubMed

IPP H, ZEMLIN AE, GLASHOFF RH, VAN WYK J, VANKER N, REID T, BEKKER L. Serum adenosine deaminase and total immunoglobulin G correlate with markers of immune activation and inversely with CD4 counts in asymptomatic, treatment-naive HIV infection. Journal of Clinical Immunology 2013; 33: 605-612. PubMed

ITHETE NL, STOFFBERG S, CORMAN VM, COTTONTAIL VM, RICHARDS LR, SCHOEMAN MC, DROSTEN C, DREXLER JF, PREISER W. Close relative of Human Middle East respiratory syndrome Coronavirus in Bat, South Africa. Emerging Infectious Diseases 2013; 19(10): 1697-1699. PubMed

KABUE J-P, DE SWARDT D, DE BEER C, GLASHOFF RH. Short-Term antiretroviral therapy fails to reduce the expanded activated CCR5-Expressing CD4+ T Lymphocyte population or to restore the depleted naive population in chronically HIV-Infected individuals with active Pulmonary Tuberculosis. Aids Research and Human Retroviruses 2013; 29(5): 769-777. PubMed

MARITZ J, VAN ZYL GU, PREISER W. Irreproducible positive results on the Cobas Ampliperp/Cobas TaqMan HIV-1 Quality test are different qualitatively from confirmed positive results. Journal of Medical Virology 2013; 10.1002: 1-6. PubMed

NEWMAN H, GOODING C. Viral ocular manifestations: a broad overview. Reviews in Medical Virology 2013; 10.1002: rmv.1749. PubMed

PETERSEN DC, LIBIGER O, TINDALL EA, HARDIE R, HANNICK LI, GLASHOFF RH, MUKERJI M, FERNANDEZ P, HAACKE W, SCHORK NJ, HAYES VM. Complex patterns of genomic admixture within Southern Africa. PloS Genetics 2013; 9(3): 1-17. PubMed

PREISER W. Pooled HIV-1 viral load testing using dried blood spots to reduce the cost of monitoring antiretroviral treatment in a resource-limited setting. JAIDS-Journal of Acquired Immune Deficiency Syndromes 2013; 64(2): 134-137. PubMed

REIKIE B, NAIDOO S, RUCK CE, SLOGROVE A, DE BEER C, LA GRANGE H, ADAMS RC, HO K, SMOLEN K, SPEERT D, COTTON MF, PREISER W, ESSER M, KOLLMANN TR. Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life. Clinical and Vaccine Immunology 2013; 20(1): 33-38. PubMed

RENSBURG MA, ESSER M, DE BEER C. The seroprevalence of Bordetella pertussis antibodies in adolescents in the Western Cape. Southern African Journal of Epidemiology and Infection 2013; 28(4): 202-206. SAJEI

TANG MW, RHEE S-Y, BERTAGNOLIO S, FORD N, HOLMES S, SIGALOFF KC, HAMERS RL, DE WIT TFR, FLEURY HJ, KANKI PJ, RUXRUNGTHAM K, HAWKINS CA, WALLIS C, STEVENS WS, VAN ZYL GU. Nucleoside reverse transcriptase inhibitor resistance mutations associated with first-line Stavudine-containing antiretroviral therapy: Programmatic implications for countries phasing out Stavudine. Journal of Infectious Diseases 2013; Suppl 2: S70-S77. PubMed

VAN SCHALKWYK M, ANDERSSON MI, ZEIER MD, LA GRANGE M, TALJAARD JJ, THERON GB. The impact of revised PMTCT guidelines: A view from a public sector ARV clinic in Cape Town, South Africa. JAIDS-Journal of Acquired Immune Deficiency Syndromes 2013; 63(2): 234-238. PubMed

VAN ZYL GU, LIU S, CLAASSEN M, ENGELBRECHT S, DE OLIVEIRA T, PREISER W, WOOD NH, TRAVERS S, SHAFER RW. Trends in Genotypic HIV-1 antiretroviral resistance between 2006 and 2012. PloS ONE 2013; 8(6): e67188. PubMed

​NDEBIA EJ, TCHOKONTE-NANA V, UMAPATHY E, TAMADJOU TCHUEN CR. Anti-ulcerogenic properties of Albuca setosa. Journal of Medicinal Plants Research 2013; 7(47): 3420-3426. JMPR

Doctoral projects completed

ITHETE NL. Investigation of small mammal-borne viruses with zoonotic potential in South Africa. PhD, 2013. 200 pp. Promotor: Preiser W.

WILKINSON E. Origin and phylodynamics of HIV-1 subtype C in South Africa. PhD, 2013. 284 pp. Promotor: Engelbrecht S.

​Masters Projects completed​

MARITZ J. Irreproducible positive results on the Cobas ampliperp/Cobas TaqMan HIV-1 Quality test are different qualitatively from confirmed positive results. MMed, 2013. 6 pp. Studieleier: Van Zyl GU. Medestudieleier: Preiser W.

LOOTS S. Erythrocyte apoptosis (erythroptosis) and anaemia in chronic HIV-1 infection: relationship with immune activation and viraemia. MScGeneeskWet, 2013. 89 pp. Studieleier: Glashoff RH. Medestudieleier: Ipp H.

2012

Journal Articles

ANDERSSON MI, LOW N, IRISH CJ, VERLANDER NQ, CARRINGTON D, HORNER P, STUART JM, HICKMAN M. Investigation of a large community-based outbreak of hepatitis B infection in the United Kingdom. Epidemiology and Infection 2012; 140: 47-57. PubMed

ANDERSSON MI, MAPONGA T, IJAZ S, THERON GB, PREISER W, TEDDER RS. High HBV viral loads in HIV-infected pregnant women at a tertiary hospital, South Africa. JAIDS-Journal of Acquired Immune Deficiency Syndromes 2012; 60(4): 111-112. PubMed

BROWN B, BUDNIK P, DE SWARDT G, DUBY Z, GEFFEN N, KANYEMBA B, MCINTYRE J, MYER L, SCHEIBE A, SCHOWALTER L, SONDERUP M, SPEARMAN W, TOLEDO C, TUCKER T, VAN DYK R, VAN ZYL GU. Southern African guidelines for the safe use of pre-exposure prophylaxis in men who have sex with men who are at risk for HIV infection. Southern African Journal of HIV Medicine 2012; 13(2): 40-55. SAJHIV

CONRADIE F, WILSON D, BASSON A, DE OLIVEIRA T, HUNT G, JOEL D, PAPATHANASOPOULOS MA, PREISER W, KLAUSNER J, SPENCER D, STEVENS WS, VENTER F, VAN VUUREN C, LEVIN L, MEINTJIES G, ORRELL C, SUNPATH H, ROSSOUW T, VAN ZYL GU. The 2012 southern African ARV drug resistance testing guidelines. Southern African Journal of HIV Medicine 2012; 13(4): 162-167.SAHIVSoc

FISHER R, VAN ZYL GU, TRAVERS SAA, KOSAKOVSKY POND SL, ENGELBRECH S, MURRELL B, SCHEFFLER K, SMITH D. Deep Sequencing reveals minor protease resistance mutants in patients failing a protease inhibitor regimen. Journal of Virology 2012; 86(11): 1-8. PubMed

GIULIANO AR, PALEFSKY JM, GOLDSTONE S, MOREIRA ED, VARDAS E, ARANDA C, JESSEN H, FERRIS DG, COUTLEE F, MARSHALL BG, VUOCOLO S, HAUPT RM, GURIS D. Immunogenicity of the quadrivalent Human Papillomavirus (Type 6/11/16/18) vaccine in males 16 to 26 years old. Clinical and Vaccine Immunology 2012; 19(2): 261-267. PubMed

JACOBS GB, BOCK S, SCHUCH A, MOSCHALL R, SCHROM E-M, ZAHN J, REUTER C, PREISER W, RETHWILM A, ENGELBRECHT S, KERKAU T, BODEM J. Construction of a high titer infectious HIV-1 subtype C proviral clone from South Africa. Viruses-Basel 2012; 4: 1830-1843. PubMed

MALNATI MS, HELTAI S, COSMA A, REITMEIR P, ALLGAYER S, GLASHOFF RH, LIEBRICH W, VARDAS E, IMAMI N, WESTROP S, NOZZA S, TAMBUSSI G, BUTTO S, FENALES-BELASIO E, ENSOLI B, ENSOLI F, TRIPICIANO A, FORTIS C, LUSSO P, POLI G, ERFLE V, HOLMES H. A new antigen scanning strategy for monitoring HIV-1 specific T-cell immune responses. Journal of Immunological Methods 2012; 375: 46-56. PubMed

MARITZ J, PREISER W, VAN ZYL GU. Establishing diagnostic cut-off criteria for the COBAS AmpliPrep/COBAS TaqMan HIV-1 qualitative test through validation against the Amplicor DNA test v1.5 for infant diagnosis using dried blood spots. Journal of Clinical Virology 2012; 53: 106-109. JCV

PEACOCKE J, LOTZ ZE, DE BEER C, ROUX P, MALL AS. The role of crude saliva and purified salivary mucins in the inhibition of the Human Immunodeficiency virus type 1. Virology Journal 2012; 9(177): 1-9. PubMed

REIKIE BA, ADAMS RCM, RUCK CE, HO K, LELIGDOWICZ A, PILLAY S, NAIDOO S, FORTUNO ES, DE BEER C, PREISER W, COTTON MF, SPEERT DP, ESSER M, KOLLMANN TR. Ontogeny of Toll-Like receptor mediated Cytokine responses of South African infants throughout the first year of life. PLoS ONE 2012; 7(9): 1-11. PubMed

SLOGROVE A, REIKIE B, NAIDOO S, DE BEER C, HO K, COTTON MF, BETTINGER J, SPEERT D, ESSER M, KOLLMANN TR. HIV-Exposed Uninfected Infants are at Increased Risk for Severe Infections in the First Year of Life. . Journal of Tropical Paediatrics 2012; 58(6): 505-508. PubMed

VARDAS E, STANESCU I, LEINONEN M, ELLEFSEN K, PANTALEO G, VALTAVAARA M, USTAV M, REIJONEN K. Indicators of therapeutic effect in FIT-06, a phase II trial of a DNA vaccine, GTU-multi-HIVB, in untreated HIV-1 infected subjects. Vaccine 2012; 30(27): 4046-4054. PubMed

ANDERSSON MI, VAN RENSBURG CJ. The management of hepatitis C virus infection in difficult-to-treat populations: patients with end stage renal disease, HIV infected patients and children. The South African Gastroenterology Review 2012; 10(1): 27-31. SABINET

DE BEER C, ESSER M, PREISER W. Optimising automation of a manual enzyme-linked immunosorbent assay. Afr J Lab Med 2012: 1-3. AJLM

KOZISEK M, HENKE S, SASKOVA KG, JACOBS GB, SCHUCH A, BUCHHOLZ B, MULLER V, KRAUSSLICH H-G, REZACOVA P, REZACOVA P, KONVALINKA J, BODEM J. Mutations in HIV-1 gag and pol compensate for the loss of viral fitness caused by a highly mutated protease. Antimicrobial Agents and Chemotherapy 2012; 56(8): 4320-4330. PubMed

MURRELL B, SHERWARD DJ, WILLIAMSON C. Degenerate primer IDs and the birthday problem. Proceedings of the National Academy of Sciences of the United States of America 2012; 109(21): 1330. PubMed

​Doctoral Projects completed

​VAN ZYL GU. The investigation of genotypic antiretroviral drug resistance in the context of the South African national antiretroviral roll-out programme. PhD, 2012. 60 pp. Promotor: Preiser W. Medepromotor: Nachega JB.

Masters Projects completed

​CHOTUN BN. The Prevalence of Hepatitis B virus infection in an HIV-Exposed paediatric cohort from the Western Cape, South Africa. MScGeneeskWet, 2012. 125 pp. Studieleier: Van Zyl GU.

MAPONGA T. An investigation of hepatitis B virus in antenatal women tested for human immunodeficiency virus, in the Western Cape Province of South Africa. MScGeneeskWet, 2012. 89 pp. Studieleier: Andersson MI. Medestudieleier: Preiser W.

MAREE L. Investigating the aetiology of respiratory tract infections in children admitted to Tygerberg Children's Hospital using molecular methods and viral culture. MMed, 2012. 103 pp. Studieleier: Van Zyl GU.

NKAMBULE B. Platelet Flow Cytometry and coagulation tests as markers of immune activation in chronic HIV infection. MScGeneeskWet, 2012. 112 pp. Studieleier: Glashoff RH.

SELEKA M. Development of selective real-time PCR (SPCR) assays for the detection of K103N resistance mutation in minor HIV-1 populations. MScGeneeskWet, 2012. 137 pp. Studieleier: Engelbrecht S. Medestudieleier: Van Zyl GU.

​General Presentations

CHOTUN BN, ANDERSSON MI, IJAZ S, COTTON MF, NEL E, TEDDER RS, PREISER W. Prevalence of HBV Infection in a cohort of HIV-Exposed Infants from the Western Cape, South Africa. 56th Annual Academic Day, University of Stellenbosch, August 2012.

DE BEER C. Project Progress, Sample Collection and Technology Transfer. 7th Annual GHRC / CAVD Meeting. Washington, USA, December 2012.

ENGELBRECHT S, CLAASSEN M, WILKINSON E, JACOBS GB, VAN ZYL GU, DE OLIVEIRA T AND PREISER W. Detection of unique HIV-1 recombinant forms in South Africa: is the HIV-1 subtype C epidemic changing? AIDS 2012, XIX International AIDS Conference, July 2012, Washington DC USA.

ENGELBRECHT S, CLAASSEN M, WILKINSON E, JACOBS GB. Detection of unique HIV-1 recombinant forms in South Africa - is the HIV-1 subtype C epidemic changing? XIX International AIDS Conference, Washington, USA, July 2012.

FISHER R, VAN ZYL GU, TRAVIS S, POND SLK, ENGELBRECHT S, MURRELL B, SCHEFFLER K, SMITH D. Deep sequencing reveals minor protease resistance mutations in patients failing a protease inhibitor regimen. IRTG 1522 annual symposium, Wurzburg, Germany, June 2012.

HART D, MOELICH A, VAN ZYL GU. Preparation of a quantitative and stable respiratory syncytial virus standard for optimisation of molecular assays.

JACOBS GB. Construction and characterization of infectious HIV-1 subtype C proviral molecular clones. IRTG 1522 annual symposium, Wurzburg, Germany, June 2012.

JACOBS GB. Construction and characterization of infectious HIV-1 subtype C proviral molecular clones. 56th Annual Academic Day, University of Stellenbosch, August 2012.

JACOBS GB. Construction and characterization of infectious HIV-1 subtype C proviral molecular clones. Postdoctoral Research Day, University of Stellenbosch, November 2012.

JACOBS GB. HIV-1 evolution and recombination in South Africa. Presented at the International Research training group (IRTG 1522) International Meeting of HIV and associate infectious diseases. Wurzburg, Germany, January 2012.

JACOBS GB. HIV-1 resistance analyses from therapy-naïve patients in South Africa. Clinical Haematology, Tygerberg Hospital, February 2012.

LA GRANGE H, ESSER M, DE BEER C. Measles virus IGG levels in exposed uninfected (HEU) and HIV unexposed (UE) babies in response to routine vaccination. International African Vaccinology Conference, Cape Town, November 2012.

LOOTS S, DE SWARDT D, IPP H, GLASHOFF RH. Increased anaemia-associated erythrocyte apoptosis (erythroptosis) in chronic HIV infection: relationship with immune activation and oxidative stress. 56th Annual Academic Day, University of Stellenbosch, August 2012.

NKAMBULE B, IPP H, GLASHOFF RH. Platelet flow cytometry and markers of immune activation in asymptomatic, treatment naïve HIV infection. European Haematology Association (EHA) Conference, Amsterdam, Netherlands, June 2012.

POOVAN K, DE SWARDT D, IPP H, GLASHOFF RH. Decreased responsiveness of monocytes to LPS in chronic hiv-1 infection as detected utilizing an optimized whole blood LPS stimulation assay. 56th Annual Day, University of Stellenbosch, August 2012.

REDDY K. MRC Early Career Scientist conference. MRC, Cape Town, Oct 2012.

REID TD, IPP H, GLASHOFF RH. Ex Vivo characterization of markers of B-Cell activation, exhaustion and apoptosis in asymptomatic HIV-infected individuals. 56th Annual Academic Day, University of Stellenbosch, August 2012.

VAN ZYL GU, CLAASSEN M, ENGELBRECHT S, DE OLIVEIRA T, PREISER W, WOOD NH, TRAVERS SAA, SCHAEFER M. Changing patterns of NRTI and PI resistance mutations between 2006 and 2011 in >1,200 ART-experienced South African patients: association with the introduction of tenofovir (TDF) and abacavir (ABC) and with the cumulative effects of LPV/r therapy. AIDS 2012, XIX International AIDS Conference, July 2012, Washington DC USA.

2011

Journal Articles

ENGELBRECHT S, WILKINSON E, DE OLIVEIRA T. Diversity and molecular epidemiology of HIV-1 in Cape Town; 1984 to 2010. Retrovirology 2011; 8(Suppl 2): 21. Retrovirology

JONES CE, NAIDOO S, DE BEER C, ESSER M, KAMPMANN B, HESSELING C. Maternal HIV Infection and Antibody Responses Against Vaccine-Preventable Diseases in Uninfected infants. Jama-Journal of the American Medical Association 2011; 305(6): 576-584. PubMed

KASANG C, KALLUVYA S, MAJINGE C, STICH A, BODEM J, KONGOLA G, JACOBS G, MILDNER M, HENSEL I, HORN A, PREISER W, VAN ZYL GU, RETHWILM A. HIV Drug Resistance (HIVDR) in Antiretroviral Therapy-Naïve Patients in Tanzania Not Eligible for WHO Threshold HIVDR Survey is Dramatically High. PloS ONE 2011; 6(8): 1-11.PubMed

MARITZ J, PREISER W. Cost-Effectiveness of Nucleic Acid Amplification Tests for Identifying Acute HIV Infections. Journal of Clinical Microbiology 2011; 49(4): 1704. PubMed

OYARO M, MBITHI J, OYUGI F, LATEN A, ANZALA O, ENGELBRECHT S. Molecular Characterization of HIV Type 1 Among HIV-Infected Respondents in a Cohort Being Prepared for HIV Phase III Vaccine Clinical Trials, Western Kenya. Aids Research and Human Retroviruses 2011; 27(3): 257-264. ARHR

SOLOMONS R, SLOGROVE A, SCHOEMAN JF, MARAIS BJ, VAN ZYL GU, MARITZ JS, VAN TOORN R. Acute Extrapyramidal Dysfunction in Two HIV-infected children. Journal of Tropical Paediatrics 2011; 57(3): 227-231.PubMed

VAN ZYL GU, RABIE H, NUTTAL J, COTTON MF. It is time to consider third-line options in antiretroviral-experienced paediatric patients? BMC Medicine 2011; 14: 55-62. PubMed

VAN ZYL GU, VAN DER MERWE L, CLAASSEN M, ZEIER MD, PREISER W.

Antiretroviral Resistance Patterns and Factors Associated with Resistance in Adult Patients Failing NNRTI-Based Regimens in the Western Cape, South Africa. Journal of Medical Virology  2011; 83: 1764-1769. PubMed

VAN ZYL GU, VAN MENS TE, MCILLERON H, ZEIER MD, NACHEGA JB, DECLOEDT E, MALAVAZZI C, SMITH P, HUANG Y, VAN DER MERWE L, GANDHI M, MAARTENS G. Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting. JAIDS-Journal of Acquired Immune Deficiency Syndromes 2011; 56(4): 333-339. JAIDS

VARDAS E, GOLDSTONE S, PALEFSKY JM, MOREIRA ED, PENNY ME, ARANDA C, JESSEN H, MOI H, FERRIS K-L. External Genital Human Papillomavirus Prevalence and Associated Factors among Heterosexual men on 5 Continents. Journal of Infectious Diseases 2011; 203: 58-65. PubMed

CHARMAN A, WALZL G, PREISER W. The Capacity of African Research Institutions to Respond to HIV/M.tuberculosis Co-Infection. The Open Infectious Diseases Journal, 1874-2793/11 2011; 5(Suppl-1-M6): 60-80. Open Infect Dis J

NACHEGA JB, MARCONI VC, VAN ZYL GU, GARDNER EM, PREISER W, HONG SY, MILLS EJ, GROSS R. HIV Treatment Adherence, Drug Resistance, Virologic Failure: Evolving Concepts. Infectious Disorders - Drug Targets; 1871-5265/11 2011; 11: 167-174. PubMed

Proceedings International

ADAMS RCM, COTTON MF, ESSER M, DE BEER C. Pilot study of the innate immune abnormalities in HIV exposed uninfected infants. Virology Africa 2011. Virology Africa 2011, V&A Waterfront, Cape Town, South Africa, 2011: 1.

AFRICA LD, ISAACS S, ENGELBRECHT S. Molecular Characterization of Unique HIV-1 BC recombinants. Virology Africa 2011. Virology Africa 2011, V&A Waterfront, Cape Town, South Africa, 2011: 1.

ANDERSSON MI. HBV vaccination in the era of HIV. Virology Africa 2011. Virology Africa 2011. V&A Waterfront, Cape Town, South Africa, 2011: 1.

ANDERSSON MI. The prevalence and character of HBV infection in HIV-infected and uninfected pregnant women in the Western Cape. Virology Africa 2011. Virology Africa 2011, V&A Waterfront, Cape Town, South Africa, 2011: 1.

ANDERSSON MI. The prevalence of HBV infection in HIV-exposed babies. Virology Africa 2011. Virology Africa 2011, V&A Waterfront, Cape Town, South Africa, 2011: 1.

CHOTUN BN, ANDERSSON MI, COTTON MF, PREISER W. A cross-sectional study of the prevalence of Hepatitis B virus infection in HIV-exposed infants at Tygerberg Hospital, Cape Town.

Virology Africa 2011. Virology Africa 2011, V&A Waterfront, Cape Town, South Africa, 2011: 1.

DE SWARDT D, IPP H, GLASHOFF RH. Phenotypic characterization of Blood dendritic cells in chronically HIV-infected individuals in South Africa. Virology Africa 2011. Virology Africa Congress, V&A Waterfront, Cape Town, South Africa, 2011: 1.

ENGELBRECHT S, CLAASSEN M, VAN ZYL GU, PREISER W. Detection of unique HIV-1 recombinants in South Africa. 18th HIV Dynamics & Evolution, Ireland. 18th HIV Dynamics & Evolution, Radisson Blue Hotel & Spa, Galway, 2011: 73.

ENGELBRECHT S. Frequent detection of unique recombinants in South Africa. 5th SA AIDS Conference, Durban. 5th SA AIDS Conference, International Conference Centre, Durban, South Africa, 2011: 587.

FISHER R, ENGELBRECHT S, PREISER W, TRAVIS S, SMITH D, HAUBRICH R, SCHEFFLER K, VAN ZYL GU. Ultra deep pyrosequencing reveals minor variant evolution in HIV patients on therapy. Virology Africa 2011. Virology Africa 2011, V&A Waterfront, Cape Town, South Africa, 2011: 1.

IPP H, DE SWARDT D, GLASHOFF RH. The VIP receptor VPAC2 on CD4T cells as a novel marker of immune activation in HIV infection and potential target for immune modulation. 6th International AIDS Society (IAS) Conference on HIV Pathogenesis and treatment; 2011. 6th International AIDS Society (IAS) Conference on HIV Pathogenesis and treatment, Rome, Italy, 2011:1.

IPP H, GLASHOFF RH, ABAYOMI EA. Myeloperoxidase and MPXI as markers of inflammation in asymptomatic HIV-1 infection. Virology Africa 2011. Virology Africa 2011, V&A Waterfront, Cape Town, South Africa, 2011: 1.

ISAACS S, GLASHOFF RH, SEEDAT S, JOSKA J, ENGELBRECHT S. Molecular characterization of tat: A possible mediator of HIV-1 associated dementia (HAD). Virology Africa 2011. Virology Africa 2011, V&A Waterfront, Cape Town, South Africa, 2011: 1.

ITHETE NL, MATTHEE CA, AUSTE B, KLEMPA B, WITKOWSKI P, PREISER W. Evidence of Hantavirus infection in South Africa. Virology Africa 2011. Virology Africa 2011, V&A Waterfront, Cape Town, South Africa, 2011: 1.

​LA GRANGE H, ESSER M, DE BEER C. Measles virus IgG levels in response to routine vaccines in HIV exposed uninfected (HEU) and HIV unexposed (EU) infants. Virology Africa 2011. Virology Africa 2011, V&A Waterfront, Cape Town, South Africa, 2011: 1.

LOOTS S, DU PLESSIS M, JOOSTE AEC, IPP H, GLASHOFF RH. Erythrocytes apoptosis (Erythroptosis) and Anaemia in chronic HIV infection: Relationship with immune activation, Oxidative stress and Viraemia. Virology Africa 2011. Virology Africa 2011, V&A Waterfront, Cape Town, South Africa, 2011: 1.

MAPONGA T, ANDERSSON MI, THERON GB, PREISER W. Cross sectional analysis of the prevalence and character of Hepatitis B virus infection in HIV infected and HIV uninfected pregnant women in the Western Cape. Virology Africa 2011. Virology Africa 2011, V&A Waterfront, Cape Town, South Africa, 2011: 1.

NAIDOO S, ESSER M, IPP H, DE BEER C. Longitudinal investigation of vaccine specific antibody levels and surrogate markers of adaptive immune responses in HIV exposed uninfecte4d (HEU) and unexposed (UE) infants. Virology Africa 2011. Virology Africa 2011, V&A Waterfront, Cape Town, South Africa, 2011: 1.

SAMPSON N, PREISER W. Novel positive controls for viral immunohistochemistry. Virology Africa 2011. Virology Africa 2011, V&A Waterfront, Cape Town, South Africa, 2011: 1.

VAN ZYL GU, PREISER W. Antiretroviral drug resistance poses more challenges in children than in adults Western Cape resistance data 2007-2010. Virology Africa 2011. Virology Africa 2011, V&A Waterfront, Cape Town, South Africa, 2011: 1.

VAN ZYL GU. "To test of not to Test?" That is the question: A Southern African perspective on ART failure monitoring. 6th South African HIV&TB Drug Resistance and Treatment Monitoring Workshop. 6th South African HIV&TB Drug Resistance and Treatment Monitoring Workshop, University of Botswana, Gaborone, Botswana, 2011: 1.

VAN ZYL GU. Protagonist: Genotyping and a 3rd line therapy option must be available in the state Sector. In: Treatment of HIV- the changing face of ART in 2011. FIDSSA 2011. 8-11 July 2011. FIDSSA 2011, Durban, South Africa, 2011: 1.

VAN ZYL GU. South African HIV Clinicians Society: Paediatric Skills Building Workshop at the South African AIDS Conference. South African HIV Clinicians Society. 8 June 2011, 2011: 1.

​WILKINSON E, ENGELBRECHT S, DE OLIVEIRA T. Origin of the heterosexual subtype C HIV-1 epidemic in Southern Africa. Virology Africa 2011. Virology Africa 2011, V&A Waterfront, Cape Town, South Africa, 2011: 1.

WILKINSON E. History and Evolution of the Subtype C HIV-1 Epidemic in Southern Africa. 5th SA AIDS Conference, Durban. 5th SA AIDS Conference, International Convention Centre, Durban, South Africa, 2011: 125.

Proceedings National

ANDERSSON MI. HBV infection in the era of HIV. HBV Genotype Conference; September 2011. HBV Genotype Conference, 2011: 1.

​ANDERSSON MI. The prevalence and character of HBV infection HIV infected women at Tygerberg Hospital. FIDSSA. September 2011. FIDSSA 2011, Tygerberg Hospital, Cape Town, South Africa, 2011: 1.

​Doctoral Projects Completed

ROMANI B. Mutagenesis and functional studies of the HIV-1 vpr gene and vpr protein obtained from South African virus strains. Supervisors: Engelbrecht S; Glashoff RH. PhD, 2011. 100 pp. Promotor: Engelbrecht S. Medepromotor: Glashoff RH.

General Presentations

ADAMS A, BOUIC P, ESSER M, DE BEER C. Ontogeny of the innate immune response in a South African infant cohort. 55th Annual Academic Day, 2011.

ANDERSSON MI, PREISER W, THERON GB. Prevalence and characterization of HBV infection in HIV infected women. 55th Annual Academic Day, 2011.

FISHER R, PREISER W, ENGELBRECHT S, VAN ZYL GU. Ultra deep pyrosequencing reveals minor variant evolution in HIV patients on therapy. 55th Academic Day, 2011.

ISAACS S, GLASHOFF RH, ENGELBRECHT S. Molecular characterization and analysis of HIV-1 tat. 55th Annual Academic Day, 2011.

ITHETE NL, PREISER W, MATTHEE CA. Do Hantavirus infections occur in South Africa? 55th Annual Academic Day, 2011.

MARITZ J, VAN ZYL GU. Refining diagnostic HIV-1 PCR criteria for early infant diagnosis. 55th Annual Academic Day, 2011.

NAIDOO S, ESSER M, DE BEER C. Longitudinal investigation of vaccine specific antibody levels and surrogate markers of adaptive immune responses in HIV exposed uninfected infants. 55th Annual Academic Day, 2011.

REID TD, WIEHAHN A, ABAYOMI EA, GLASHOFF RH, IPP H. B-cell activation in chronic asymptomatic HIV infection: potential markers of immune activation. 55th Annual Academic Day, 2011.

SMITH K, DE BEER C, ESSER M. Pitfalls of portable rapid Haemoglobin testing: evaluation of heel prick method versus venous blood. 55th Academic Year Day, 2011.

VAN ZYL GU, PREISER W. Antiretroviral drug resistance poses more challenges in children than in adults: Western Cape resistance data 2007-2010. 55th Annual Academic Day, 2011.

​WILKINSON E, ENGELBRECHT S, DE OLIVEIRA T. Unusual transmission clusters of subtype C HIV-1 in a small cohort of heterosexual patients from Cape Town. 55th Annual Academic Day, 2011.

2010

Journal Articles

ANDERSSON MI, VAN ZYL GU, PREISER W, LANGENEGGER E, THERON GB. Pandemic flu (H1N1) 2009 and pregnancy. SAMJ South African Medical Journal 2010; 100(4): 192-194. SAMJ

COTTON MF, RABIE H, VAN ZYL GU. Another Milestone in Minimizing Risks to Mothers Exposed to Single-Dose Nevirapine for Prevention of Vertical Transmission of HIV-1 to Infants: What Next? Clinical Infectious Diseases 2010; 50(6): 909-911 CID

COTTON MF, RABIE H, VAN ZYL GU. Antiretroviral Therapy in Children with Tuberculosis: Progress toward Defining the Issues. Journal of Infectious Diseases 2010; 201(8): 1113-1114.PubMed

DE SWARDT D, GLASHOFF RH. ARV fails to normalize the reduction of blood plasmacytoid and myeloid dendritic cells in HIV infected South African individuals with active TB. Aids Research and Human Retroviruses 2010; 26(10): 74. ARHR

HABTE HH, DE BEER C, LOTZ ZE, ROUX P, MALL AS. Anti-HIV-1 activity of salivary MUC5B and MUC7 mucins from HIV patients with different CD4 counts. Virology Journal 2010; 7(269): 1-9.Virologyj

MAREE L, VAN ZYL GU, LOTTER S L, DE BEER C, ESSER M, PREISER W. Young Age a Predictor of Weak Reactivity in a Rapid Antibody Test in Infants Infected With HIV. Journal of Medical Virology 2010; 82: 1314-1317. PubMed

MARITZ J, BENATAR M, DAVE JA, HARRISON TB, BADRI M, LEVITT N, HECKMANN JM. HIV Neuropathy in South Africans: frequency, characteristics and risk factors. Muscle & Nerve 2010; 1: 1-9. PubMed

MARITZ J, MAREE L, PREISER W. Pandemic influenza A (H1N1) 2009: the experience of the first six months. Clinical Chemistry and Laboratory Medicine 2010; 48(1): 11-21. PubMed

PAPATHANASOPOULOS MA, VARDAS E, WALLIS C, GLASHOFF RH, BUTTO S, POLI G, MALNATI MS, CLERICI M, ENSOLI B. Characterization of HIV Type 1 genetic diversity among South African participants enrolled in the AIDS vaccine integrated project (AVIP) study. Aids Research and Human Retroviruses 2010; 26(6): 1-5. ARHR

PREISER W. Klinik, Epidemiologie und diagnostik tropischer virusinfektionen. Pharmazie 2010; 39: 34-40. Pharmazie

RABENAU HF, LENNEMANN T, KIRCHER C, GURTLER L, STASZEWSKI S, PREISER W, MCPHERSON P, ALLWINN R, DOERR HW. Prevalence- and gender-specific immune response to opportunistic infections in HIV-infected patients in Lesotho. Sexually Transmitted Diseases 2010; 37(7): 454-459. PubMed

ROMANI B, ENGELBRECHT S, GLASHOFF RH. Functions of Tat: the versatile protein of human immunodeficiency virus type 1. Journal of General Virology 2010; 91: 1-12.PubMed

ROMANI B, GLASHOFF RH, ENGELBRECHT S. Functional integrity of naturally occurring mutants of HIV-1 subtype C vpr. Virus Research 2010; 153: 288-298. Science direct

VAN ZYL GU, COTTON MF, CLAASSEN M, ABRAHAMS C, PREISER W. Surveillance of transmitted resistance to antiretroviral drug classes among young children in the Western Cape Province of South Africa. Paediatric Infectious Disease Journal 2010; 29(3): 1-2. PubMed

VAN ZYL GU, KORSMAN SNJ, MAREE L, PREISER W. Nuclisens EasyQ HIV-1 V1.2 system: Detection of human plasma-derived background signal. Journal of Virological Methods 2010; 165: 318-319. PubMed

Proceedings International

​DE BEER C. HIV/AIDS Outreach in Africa – An all-in-one Mobile BSL-3 Health Unit which translates HIV Research from workbench to the clinic. 5th Annual CAVD Meeting. The Collaboration for AIDS Vaccine Discovery, The Hyatt Hotel, Washington, 2010: 0.

DE BEER C. Project Progress, Sample Collection and Technology Transfer. 5th Annual CAVD Meeting, The Collaboration for AIDS Vaccine Discovery, 2010: 0.

DE SWARDT D, GLASHOFF RH. Anti-retroviral (ARV) therapy fails to normalize the exacerbated reduction of blood plasmacytoid and myeloid dendritic cells (pDC and mDC) in HIV and TB co-infected South African individuals. AIDS Vaccine conference 2010, Atlanta, 2010: 0.

ENGELBRECHT S, MSIMANGA P, VARDAS E, GLASHOFF RH. HIV-1 recombinants identified in Mpumalanga and Eastern Cape Provinces of South Africa. 10th International Conference on Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases (MEEGID X), Amsterdam, Netherlands, 2010: 0.

ENGELBRECHT S, MSIMANGA P, WILKINSON E, GLASHOFF RH, VARDAS E. HIV-1 recombinants in Mpumalanga Province, South Africa. 17th International HIV Dynamics and Evolution Conference, Pacific Grove, CA, USA, 2010: 0.

ROMANI B, GLASHOFF RH, ENGELBRECHT S. Functional integrity of naturally mutated forms of HIV-1 subtype C Vpr: comparison with subtype B and the consensus sequence of the protein. XVIII International AIDS Conference, Austria, 2010: 0.

SCHNEIDER JW, MOOLLA AY, JORDAAN HF, ENGELBRECHT S, MUNBODH R, WASSERMAN E. The value of polymerase chain reaction in the laboratory diagnosis of clinically suspected onychomycosis. XXVIIIth International Congress of the International Academy of Pathology, Transamerica Hotel Conference Centre, Sao Paulo, Brazil, Wiley-Blackwell 2010: 196-197.

WILKINSON E, DE OLIVEIRA T, ENGELBRECHT S. History and evolution of HIV-1 subtype C in Cape Town, South Africa. 16th International Bioinformatics Workshop on Virus Evolution and Molecular Epidemiology, Johns Hopkins University, Baltimore, Bethesda, 2010: 0.

MARITZ J, HENRICKSON R, ENGELBRECHT S, VAN ZYL GU. Development and optimization of a loop-mediated amplification (LAMP) assay for the detection of Human Immunodeficiency Virus subtype C strains. Oral presentation, EMBO Global Exchange Lecture Course, Stellenbosch, Western Cape.

Masters Projects completed

​ITHETE NL. Molecular identification and characterisation of Rodent- and Shrew-borne hantaviruses. MScGeneeskWet, 2010. 120 pp. Studieleier: Preiser W.

PILLAY S. Phenotypic and functional characterization of cytotoxic T lymphocytes in HIV infected South African adults. MScGeneeskWet, 2010. 135 pp. Studieleier: Glashoff RH.

General Presentations

​ADAMS R, ESSER M, DE BEER C. Innate immune abnormalities of South African HIV exposed and unexposed infants: 54th Annual Academic day, Tygerberg.

BURGER M, DEMPERS JJ, DE BEER C. Profiling the approach to the investigation of viral infections in cases of Sudden Unexpected Death in Infancy (SUDI) in the Western Cape Province: 54th Annual Academic day, Tygerberg.

BURGER M, DEMPERS JJ, DE BEER C. Profiling the approach to the investigation of viral infections in cases of Sudden Unexpected Death in Infancy (SUDI) in the Western Cape Province: FSASP (PATHVINE) Congress, Somerset West.

DE BEER C, NAIDOO S, STEENKAMP J, ESSER M. A pilot study of HIV exposed uninfected and unexposed infants in the Western Cape: SAIS Conference, Cradle of Humankind, Johannesburg.

DE BEER C. Some ethical considerations in animal research: 5th Academic day (SMLTSA) Pinelands.

ESSER M, COTTON MF, DE BEER C. The HIV exposed infant – not infected but affected: 54th Annual Academic day, Tygerberg.

IPP H, DE SWARDT D, GLASHOFF RH. The VIP receptor VPAC-2 as a novel marker of T cell activation in HIV and a potential target for immune modulation: South African Immunology Society (SAIS) Annual Congress, Johannesburg.

IPP H, GREWAL R, FORBES AN, GLASHOFF RH. A novel lymphocyte differential count as a cost-effective method in the assessment of immune activation in chronic HIV-infection: A Pilot Study: PATHVINE 2010, 50TH Annual Congress of the federation of South African Societies of Pathology (FSASP), Somerset West.

NAIDOO S, ESSER M, DE BEER C. Post-vaccine levels of specific antibodies in HIV-exposed uninfected and healthy infants: 54th Annual Academic day, Tygerberg.

SMIT K, ESSER M, DE BEER C. Pitfalls of portable rapid haemoglobin testing: 54th Annual Academic day, Tygerberg.

VAN WYK J, ZEMLIN AE, GLASHOFF RH. Serum ADA levels and CD26 expression as markers of generalized immune activation in chronic HIV infection: PATHVINE 2010, 50th Annual Congress of the federation of South African Societies of Pathology (FSASP), Somerset West.

MARITZ J, MOELICH A, PREISER W, VAN ZYL GU. Performance of the Cobas AmpliPrep/Cobas TaqMan HIV-1 Qualitative test in the diagnosis of HIV-1 in young children. Oral presentation, 54th Annual Academic Day of the Faculty of Health Sciences, University of Stellenbosch.

2009

Journal Articles

JACOBS GB, LOXTON AG, LATEN JD, ROBSON BA, JANSE VAN RENSBURG E, ENGELBRECHT S. Emergence Q1 and diversity of different HIV-1 subtypes in South Africa, 2000-2001. Journal of Medical Virology 2009; 81 : 1852-1859.
No PubMed entry. External link.

MARINDA ET, HARGROVE JW, PREISER W, SLABBERT JT, VAN ZYL GU, LEVIN J, MOULTON LH, WELTE A. Significantly diminished long-term specificity of the BED capture enzyme immunoassay among patients with HIV-1 with very low CD4 counts and those on antiretroviral therapy. Jaids-Journal of Acquired Immune Deficiency Syndromes 2009; 0 : 1-10.
No PubMed entry. External link.

PILLAY S, DE SWARDT D, KABUE J-P, GLASHOFF RH. TB co-infection is associated with increased cytotoxic phenotype marker expression in CD8+ T lymphocytes, but reduced HIV-specific degranulation. RETROVIROLOGY 2009; 6(3) : 249.
No PubMed entry. External link.

ROMANI B, ENGELBRECHT S, GLASHOFF RH. Antiviral roles of APOBEC proteins against HIV-1 and suppression by Vif. Archives of Virology 2009; 154 : 1579-1588.
PMID - 19669862

ROMANI B, ENGELBRECHT S. Human immunodeficiency virus type 1 Vpr: functions and molecular interactions. Journal of General Virology 2009; 90 : 1795-1805.
PMID - 19458171

ROMANI B, GLASHOFF RH, ENGELBRECHT S. Molecular and Phylogenetic Analysis of HIV Type 1 vpr Sequences of South African Strains. Aids Research and Human Retroviruses 2009; 25(3) : 1-6.
PMID - 19271970

VAN LOO KMJ, VAN SCHIJNDEL JE, VAN ZWEEDEN M, VAN MANEN D, TRIP MD, PETERSEN DC, SCHUITEMAKER H, HAYES V, MARTENS GJM. Correlation between HIV-1 seropositivity and prevalence of a y-Secretase polymorphism in two distinct ethnic populations. Journal of Medical Virology 2009; 81 : 1847-1851.
No PubMed entry. External link.

VAN ZYL GU, COTTON MF, CLAASSEN M, ABRAHAMS C, PREISER W. Surveillance of transmitted resistance to antiretroviral drug classes amongst young children in the Western Cape Province of South Africa. Pediatric Infectious Disease Journal 2009; 29 : 1-3.No PubMed entry. External link.

VAN ZYL GU, VAN DER MERWE L, CLAASSEN M, COTTON MF, RABIE H, PROZESKY HW, PREISER W. Protease inhibitor resistance in South African children with virologic failure. Pediatric Infectious Disease Journal 2009; 28(12) : 1-3.
PMID - 19779394

VAN ZYL GU. Susceptibility to serious viral disease in pregnancy - a problem of immune regulation?. Current Allergy & Clinical Immunology 2009; 22(4) : 166-167.
No PubMed entry. External link.

WILKINSON E, ENGELBRECHT S. Molecular characterization of non-subtype C and recombinant HIV-1 viruses from Cape Town, South Africa. Infection Genetics and Evolution 2009; 9 : 840-846.
PMID - 19446657

2008

Journal Articles

CLAASSEN M, VAN ZYL GU, PREISER W. Extraction buffer contaminated bacterially as a cause of invalid HIV-1 viral load results on the NucliSens EasyQ system. Journal of Virological Methods 2008; 150 : 80-81.
PMID - 18423634

ENGELBRECHT S, JACOBS GB, LOXTON AG, LATEN JD, ROBSON BA. Emergence and Diversity of Different HIV-1 Subtypes in Cape Town, South Africa. Aids Research and Human Retroviruses 2008; 24(1) : 159.
PMID - 19774685

HABTE HH, DE BEER C, LOTZ ZE, TYLER MG, KAHN D, MALL AS. Inhibition of Human Immunodeficiency virus Type 1 Activity by Purified Human Breast Milk Mucin (MUC1) in an Inhibition Assay. Neonatology 2008; 93 : 162-170.
PMID - 17878743

HABTE HH, DE BEER C, LOTZ ZE, TYLER MG, SCHOEMAN L, KAHN D, MALL AS. The inhibition of the Human Immunodeficiency virus type 1 activity by crude and purified human pregnancy plug mucus and mucins in an inhibition assay. VIROLOGY JOURNAL 2008; 5(59) : 1-10.
PMID - 18489743

JACOBS GB, LATEN JD, JANSE VAN RENSBURG E, BODERN J, WEISSBRICH B, RETHWILM A, PREISER W, ENGELBRECHT S. Phylogenetic Diversity and Low Level Antiretroviral Resistance Mutations in HIV Type 1 Treatment-Naive Patients from Cape Town, South Africa. Aids Research and Human Retroviruses 2008; 24(7) : 1-3.
PMID - 18593350

JACOBS GB, NISTAL M, LATEN JD, JANSE VAN RENSBURG E, RETHWILM A, PREISER W, BODERN J, ENGELBRECHT S. Molecular Analysis of HIV Type 1 vif Sequences from Cape Town, South Africa. Aids Research and Human Retroviruses 2008; 24(7) : 991-994.
PMID - 18593349

KOEHL U, DIRKWINKEL E, KOENIG M, ERBEN S, SOERENSEN J, BADER P, DOERR HW, PREISER W, WEISSINGER E, KLINGEBIEL T, MARTIN H, LEHRNBECHER T. Reconstitution of Cytomegalovirus Specific T Cells after Pediatric Allogeneic Stem Cell Transplantation: Results from a Pilot Study Using a Multi-Allele CMV Tetramer Group. Klinische Padiatrie 2008; 220 : 348-352.​
PMID - 18949669

VAN ZYL GU, CLAASSEN M, ENGELBRECHT S, LATEN JD, COTTON MF, THERON GB, PREISER W. Zidovudine with nevirapine for the prevention of HIV mother-to-child transmission reduces nevirapine resistance in mothers from the Western Cape, South Africa. Journal of Medical Virology 2008; 80 : 942-946.
PMID - 18428139

2007

Journal Articles

HABTE HH, DE BEER C, LOTZ ZE, TYLER MG, KAN D, MALL AS. Inhibition of Human Immunodeficiency Virus Type 1 Activity by Purified Human Breast Milk Mucin (MUC1) in an Inhibition Assay. Neonatology 2007, 18, 93(3) : 162-170. 
PMID - 17878743

JACOBS GB, LOXTON AG, LATEN A, ENGELBRECHT S. Complete genome sequencing of a non-syncytium-inducing HIV type 1 subtype D strain from Cape Town, South Africa. AIDS Res Hum Retroviruses. 2007,23(12) : 1575-1578. 
PMID - 18160016​