Afdeling Molekulêre Biologie & Mensgenetika
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Host-pathogen mycobactomics
Research overview
Our overall research goal is to gain a better understanding of how the pathogen Mycobacterium tuberculosis interacts with its host to cause disease. To achieve this, we use molecular mycobacteriology and in vitro infection models together with data-rich methodologies such as whole genome sequencing, transcriptomics, proteomics and lipidomics. These methods are underpinned by computational approaches. Specific research areas include advancing our understanding of: (a) TB host-pathogen interactions, with a particular focus on persistent mycobacteria, (b) biology of drug resistant strains of M. tuberculosis, and (c) TB/HIV interactions at the molecular level.