Various in depth histology studies are carried out in conjunction with the Division of Medical Physiology. In the past, the histologically observable changes in various organs such as the liver, kidney, pancreas, intestinal goblet cells and peri-aortic fat have been studied in rat models under various treatment conditions. Examples of conditions studied include the effects of a high calorie diet combined with antiretroviral treatment (ART) and the supplementation of melatonin and rooibos tea in rats receiving ART. Current studies look at the ameliorating effects of green rooibos supplementation (GRT) in rats fed a high calorie diet on the liver, pancreas and kidney and gastrointestinal tract as observed on histology. A PhD study on the effects of a high sucrose diet on brain histology is currently underway.