Contact:Nel-Mari Loock
- 021 808 2652
Location: Wallenberg Research Centre, STIAS
Jerry Ochola, Senior Lecturer in the Department of Manufacturing,
Industrial and Textile Engineering at Moi University, Kenya and Iso
Lomso Fellow will present a public lecture with the title:
Computational Modelling of Tubular Fibrous Structures for Cardiovascular Graft Applications
Abstract
The design of tubular structures with desirable internal and
external topology represents a challenge for tissue engineering of
cardiovascular grafts. Conventional vascular grafts have the capability
of providing sufficient structural and biological support to tissues;
however, they are quite expensive and susceptible to anatomical
limitations. Even though polymeric electrospun grafts are a viable
option they have limitations in their design in terms of inherent
properties such as: surface topography, mechanical properties, cell
proliferation and cell growth potential. Hence the design of ideal
vascular grafts involves creation of realistic models that would have
optimised properties and performance. Even though, nanofibers form a
major part of the internal structure of electrospun vascular grafts and
influences their performance and mechanical behaviour. Current designs
and in-vitro tests on grafts are mainly based on solid three-dimensional
(3D) structures which does not consider their morphology. The
development of electrospun grafts models at nanofiber level would
therefore be more realistic for in-depth investigation their performance
and further support seamless integration of electrospun structures as
vascular implants. This project therefore aims to design and
characterise tubular electrospun polymeric grafts at nanofiber level in
python®, MATLAB® languages and commercial FE software- ABAQUS®/Explicit
using 3D computational modelling and Finite Element Analysis (FEA). The
results from the deformed 3D tubular graft models will be used to
compute displacement, uniaxial forces, and stress-strains levels in the
structures. It is expected that this research will provide designs of
tubular electrospun vascular grafts for potential application in
surgery, alongside computational models of tubular grafts.
Jerry Ochola is a Senior Lecturer in the Department of
Manufacturing, Industrial and Textile Engineering at Moi University,
Kenya. He holds a PhD in Materials Engineering from Ghent University,
Belgium, with the project title: Mechanical Modelling of Tubular Biomedical Textile Structures for Repair of Ruptured and Degenerated Tendons. He
has held postdoc fellowships as an Africa Research Excellence Fund
(AREF) Fellow at the University of Cape Town, South Africa where he
undertook the project: Development of Electrospun Fibrous Scaffold Structures for Cardiovascular Graft Applications.
and also as a Committee for International Co-operation and Development
(CICOPS) Fellow at the University of Pavia, Italy where he undertook the
project: Fracture propagation studies in femur bone shaft using eXtended Finite Element Methods – XFEM.
Ochola is a member of the fibrous structures standards committee at the
Kenya Bureau of Standards and previously worked at the Kenya Industrial
Research & Development Institute as a Research Scientist. His
publications record includes journals, conference articles and two book
chapters. He is also a reviewer for three journals and has supervised
six MSc students.
Register here by 20 September 2022